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1. 发明申请

WO2008005457A3 PYRIDINONYL PDK1 INHIBITORS 审中-公开
标题翻译：吡哆醛PDK1抑制剂
公开(公告)号：WO2008005457A3
公开(公告)日：2008-07-24
申请号：PCT/US2007015397
申请日：2007-07-02
申请人： SUNESIS PHARMACEUTICALS , BIOGEN IDEC INC , LIND KENNETH EGNARD , CAO KATHY , LIN EDWARD YIN-SHIANG , NGUYEN THINH BA , TANGONAN BRADLEY T , ERLANSON DANIEL A , GUCKIAN KEVIN , SIMMONS ROBERT LOWELL , LEE WEN-CHERNG , SUN LIHONG , HANSEN STIG , PATHAN NUZHAT , ZHANG LEI
发明人： LIND KENNETH EGNARD , CAO KATHY , LIN EDWARD YIN-SHIANG , NGUYEN THINH BA , TANGONAN BRADLEY T , ERLANSON DANIEL A , GUCKIAN KEVIN , SIMMONS ROBERT LOWELL , LEE WEN-CHERNG , SUN LIHONG , HANSEN STIG , PATHAN NUZHAT , ZHANG LEI
IPC分类号： C07D401/12
CPC分类号： C07D471/04 , A61K31/4412 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D211/86 , C07D213/64 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention provides pyridinonyl PDKl inhibitors and methods of treating cancer using the same.
摘要翻译：本发明提供吡啶基PDK1抑制剂和使用其治疗癌症的方法。

3. 发明专利

ES2431466T3 Inhibidores de piridinonil pdk1 未知
公开(公告)号：ES2431466T3
公开(公告)日：2013-11-26
申请号：ES07810166
申请日：2007-07-02
申请人： SUNESIS PHARMACEUTICALS INC , BIOGEN IDEC INC , MILLENNIUM PHARMACEUTICALS INC.
发明人： LIND KENNETH EGNARD , CAO KATHY , LIN EDWARD YIN-SHIANG , NGUYEN THINH BA , TANGONAN BRADLEY T , ERLANSON DANIEL A , GUCKIAN KEVIN , SIMMONS ROBERT LOWELL , LEE WEN-CHERNG , SUN LIHONG , HANSEN STIG , PATHAN NUZHAT , ZHANG LEI
IPC分类号： C07D213/64 , C07D401/12 , C07D401/14 , C07D407/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Un compuesto que tiene la fórmula: donde n es un número entero de 1 a 5; L1 es -NH-L1A-, formando así un sustituyente con la fórmula R1-NH-L1A (cuando X está ausente y L2 estáausente), donde L1A está ausente, o es alquileno sustituido o sin sustituir, o heteroalquileno sustituido o sinsustituir; L2, independientemente, está ausente o es -O-, -NH-, -S-, -S(O)-, S(O)2-, alquileno sustituido o sin sustituir, oheteroalquileno sustituido o sin sustituir; X está ausente, cicloalquileno sustituido o sin sustituir, heterocicloalquileno sustituido o sin sustituir, arilenosustituido o sin sustituir, o heteroarileno sustituido o sin sustituir; R1 es pirimidinilo sustituido o sin sustituir; R2, R4, R5, R6, R7 y R8 son independientemente hidrógeno, halógeno, -OH, -CF3, -NO2, -OR10, -S(O)nR11, -C(O)R12, -NR13R14, alquilo sustituido o sin sustituir, heteroalquilo sustituido o sin sustituir, cicloalquilo sustituidoo sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, o heteroarilo sustituido osin sustituir; R3 es hidrógeno, -OH, -CF3, -OR10, -S(O)nR11, -C(O)R12, alquilo sustituido o sin sustituir, heteroalquilo sustituidoo sin sustituir, cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido osin sustituir, o heteroarilo sustituido o sin sustituir, donde R3 está opcionalmente unido a X formando así uncicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, oheteroarilo sustituido o sin sustituir; R10 es independientemente -C(O)R15, alquilo sustituido o sin sustituir, heteroalquilo sustituido o sin sustituir,cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, oheteroarilo sustituido o sin sustituir; R11 es independientemente hidrógeno, alquilo sustituido o sin sustituir, heteroalquilo sustituido o sin sustituir,cicloalquilo sustituido o sin sustituir, heterocicloalquilo sustituido o sin sustituir, arilo sustituido o sin sustituir, oheteroarilo sustituido o sin sustituir, donde si n es 2, entonces R11 es opcionalmente -NR17R18, y donde si n es 1o 2, entonces R11 no es hidrógeno.

4. 发明专利

EA030538B1 БИАРИЛЬНОЕ СОЕДИНЕНИЕ, ПРИМЕНЯЕМОЕ ПРИ ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ ЧЕЛОВЕКА В ОНКОЛОГИИ, НЕВРОЛОГИИ И ИММУНОЛОГИИ 未知
公开(公告)号：EA030538B1
公开(公告)日：2018-08-31
申请号：EA201691114
申请日：2014-12-11
申请人： BIOGEN IDEC INC , SUNESIS PHARMACEUTICALS INC
发明人： HOPKINS BRIAN T , MA BIN , CHAN TIMOTHY RAYMOND , SUN LIHONG , ZHANG LEI , KUMARAVEL GNANASAMBANDAM , LYSSIKATOS JOSEPH P , KOCH KEVIN , MIAO HUA
IPC分类号： C07D403/12 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Внастоящемизобретениипредложеносоединение I-21илиегофармацевтическиприемлемаясоль, которыеявляютсяприменимымив качествеингибиторовтирозинкиназыБрутонаи проявляюттребуемыедлятехжецелейхарактеристики.

5. 发明申请

WO2014018891A8 COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS 审中-公开
标题翻译：化合物是S1P调节剂和/或ATX调节剂
公开(公告)号：WO2014018891A8
公开(公告)日：2015-02-05
申请号：PCT/US2013052329
申请日：2013-07-26
申请人： BIOGEN IDEC INC
发明人： GUCKIAN KEVIN , KUMARAVEL GNANASAMBANDAM , MA BIN , MI SHA , PENG HAIRUO , SHAO ZHAOHUI , SUN LIHONG , TAVERAS ARTHUR , XIN ZHILI , ZHANG LEI
IPC分类号： A61K31/54
CPC分类号： C07F7/0818 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0809 , A61K2300/00
摘要： Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).
摘要翻译：式（I）化合物可以调节一种或多种S1P受体的活性和/或自分泌素（ATX）的活性。

6. 发明申请

WO2014018881A8 ATX MODULATING AGENTS 审中-公开
标题翻译： ATX调节剂
公开(公告)号：WO2014018881A8
公开(公告)日：2014-12-04
申请号：PCT/US2013052316
申请日：2013-07-26
申请人： BIOGEN IDEC INC
发明人： GUCKIAN KEVIN , KUMARAVEL GNANASAMBANDAM , MA BIN , MI SHA , PENG HAIRUO , SHAO ZHAOHUI , SUN LIHONG , TAVERAS ARTHUR , WANG DEPING , XIN ZHILI , ZHANG LEI
IPC分类号： A61K31/015 , A61K31/4375 , A61K31/44
CPC分类号： C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08
摘要： Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
摘要翻译：公开了式（I）的双环芳基化合物，其可以调节autotaxin（ATX）酶的活性。本发明进一步涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗因损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。

7. 发明公开

EP2930061A4 INTELLIGENT CONTROL METHOD AND SYSTEM FOR AUTOMOBILE HEADLIGHTS 有权转让
标题翻译：智慧型STEUERUNGSVERFAHREN UND -SYSTEMFÜRKRAFTFAHRZEUGSCHEINWERFER
公开(公告)号：EP2930061A4
公开(公告)日：2016-07-20
申请号：EP13855167
申请日：2013-11-16
申请人： ZHENGZHOU YUTONG BUS CO LTD , LI FEI , ZHANG LEI , LI HUIXIAN
发明人： LI FEI , ZHANG LEI , LI HUIXIAN
IPC分类号： B60Q1/08 , B60Q1/14 , B60Q11/00
CPC分类号： B60Q1/08 , B60Q1/143 , B60Q11/005 , B60Q2300/314 , B60Q2300/337 , B60Q2300/42
摘要： Disclosed are an intelligent control method and system for automobile headlights, which is used for improving traveling safety and comfort, and meanwhile solving the problem that monitoring the control result is not provided by existing automobile control systems. The intelligent control system for automobile headlights of the invention can control turning on and off of the automobile headlights automatically according to the changes of ambient light intensity, and switching between high/low beam lights can be automatically realized when automobiles meet at night, and meanwhile a self-diagnostic function is provided. Whether the control system for automobile headlights operates in an automatic mode or a manual mode, the operating status of the headlights can be monitored by the self-diagnostic function of the system and a fault point can be located accurately, which is output by means of a fault display lamp or a fault code. It is convenient for maintenance personnel to repair or monitor the illumination condition of an automobile on the basis of the automobile operational system of the automobile network, and for a driver or relevant service staffs to know the operating status of automobile headlights in real time.
摘要翻译：公开了一种汽车前照灯的智能控制方法和系统，用于提高行驶安全性和舒适性，同时解决了现有汽车控制系统不提供监控控制结果的问题。本发明的汽车前照灯智能控制系统可以根据环境光强的变化自动控制汽车前照灯的开关，并可以在夜间汽车相遇时自动实现高/低光束之间的切换提供了自我诊断功能。汽车前大灯的控制系统是否以自动模式或手动模式运行，可以通过系统的自我诊断功能监控前灯的运行状态，故障点可以精确定位，通过故障显示灯或故障代码。维修人员可以根据汽车网络的汽车操作系统，驾驶员或相关服务人员实时了解汽车前灯的运行状况，维修或监控汽车的照明状况。

8. 发明专利

ZA202208915B TOWER-TYPE WIND POWER GENERATION SYSTEM 未知
公开(公告)号：ZA202208915B
公开(公告)日：2022-11-30
申请号：ZA202208915
申请日：2022-08-10
申请人： ZHANG LEI
发明人： ZHANG LEI

9. 发明专利

CA2879589C COMPOUNDS THAT ARE SIP MODULATING AGENTS AND/OR ATX MODULATING AGENTS 未知
公开(公告)号：CA2879589C
公开(公告)日：2021-02-02
申请号：CA2879589
申请日：2013-07-26
申请人： BIOGEN IDEC INC
发明人： GUCKIAN KEVIN , KUMARAVEL GNANASAMBANDAM , MA BIN , MI SHA , PENG HAIRUO , SHAO ZHAOHUI , SUN LIHONG , TAVERAS ARTHUR , XIN ZHILI , ZHANG LEI
IPC分类号： C07D451/02 , A61K31/196 , A61K31/47 , A61P19/02 , A61P25/02 , A61P25/28 , A61P29/00 , A61P37/06 , C07C229/50 , C07D215/16
摘要： Compounds of formula (IIa) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX) and are useful for preventing, treating, or reducing symptoms of a condition mediated by SIP activity or ATX activity in a mammal. Such compounds of formula (IIa) are represented as follows: (see formula II) or a pharmaceutically acceptable salt thereof.

10. 发明专利

CO7350623A2 Agentes moduladores de autotaxina (atx) 未知
公开(公告)号：CO7350623A2
公开(公告)日：2015-08-10
申请号：CO15040227
申请日：2015-02-24
申请人： BIOGEN IDEC INC
发明人： GUCKIAN KEVIN , KUMARAVEL GNANASAMBANDAM , MA BIN , MI SHA , PENG HAIRUO , SHAO ZHAOHUI , SUN LIHONG , TAVERAS ARTHUR , WANG DEPING , XIN ZHILI , ZHANG LEI
IPC分类号： A61K31/4375 , A61K31/4748 , A61P35/00
摘要： VER ANEXOS

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