专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2015166434A1 CRYSTALLINE FORM OF BARICITINIB 审中-公开
标题翻译： BARICITINIB的结晶形式
公开(公告)号：WO2015166434A1
公开(公告)日：2015-11-05
申请号：PCT/IB2015/053123
申请日：2015-04-29
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PANDEY, Gyanendra , ..., Javeena , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A01N43/42
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention provides a crystalline form of baricitinib, a process for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
摘要翻译：本发明提供了一种结肠形式的巴利司定，其制备方法，包含它的药物组合物及其用于治疗JAK相关疾病的用途。

2. 发明申请

WO2015145286A1 AMORPHOUS FORM OF BARICITINIB 审中-公开
标题翻译：巴唑替丁的非晶形式
公开(公告)号：WO2015145286A1
公开(公告)日：2015-10-01
申请号：PCT/IB2015/051776
申请日：2015-03-11
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PANDEY, Gyanendra , JAVEENA , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention provides an amorphous form of baricitinib, processes for its preparation, a pharmaceutical composition comprising it, and its use for the treatment of JAK-associated diseases.
摘要翻译：本发明提供无定形形式的巴利司定，其制备方法，包含它的药物组合物及其用于治疗JAK相关疾病的用途。

3. 发明申请

WO2017042700A1 SOLID FORMS OF VALSARTAN AND SACUBITRIL 审中-公开
标题翻译： VALSARTAN和SACUBITRIL的固体形式
公开(公告)号：WO2017042700A1
公开(公告)日：2017-03-16
申请号：PCT/IB2016/055335
申请日：2016-09-07
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PUTAPATRI, Siddamal Reddy , KHAIRNAR, Bhushan B. , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A61K9/14 , A61K31/216 , A61K31/41 , C07C229/34 , C07C257/04
CPC分类号： A61K31/41 , A61K9/14 , A61K31/216 , C07C231/22 , C07C233/47 , A61K2300/00
摘要： The present invention provides solid forms comprising valsartan and sacubitril. The present invention provides solid salt forms comprising valsartan and sacubitril. The present invention further provides an amorphous solid salt form comprising sacubitril and valsartan. The present invention further provides processes for the preparation of the solid forms as described herein. The present invention further provides pharmaceutical compositions and a method of treatment of medical conditions responsive to the solid forms as described herein.
摘要翻译：本发明提供了包含缬沙坦和sacubitril的固体形式。本发明提供了包含缬沙坦和sacubitril的固体盐形式。本发明进一步提供了包含茜素和缬沙坦的无定形固体盐形式。本发明进一步提供了制备本文所述固体形式的方法。本发明还提供药物组合物和治疗对本文所述的固体形式有响应的医学状况的方法。

4. 发明申请

WO2016088094A1 PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF 审中-公开
标题翻译：制备巴西替尼及其中间体的方法
公开(公告)号：WO2016088094A1
公开(公告)日：2016-06-09
申请号：PCT/IB2015/059364
申请日：2015-12-04
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： AZAD, Md Abul Kalam , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D205/04 , C07D231/10
摘要： The present invention provides a process for the preparation of baricitinib and an intermediate thereof. The present invention provides a convenient, economical, and industrially advantageous two-step process for the preparation of [4-(IH-pyrazol-4-yl)-7Hpyrrolo[2,3-d] pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention involves the use of an alkali or alkaline earth metal hydroxide, carbonate, or bicarbonate as a base for reacting 4-chloro-7H-pyrrolo[2,3-d]pyrimidine of Formula (III) with chloromethyl pivalate of Formula (IV), and the use of an unprotected pyrazole borolane of Formula (VIII) for the conversion of (4-chloro-7H-pyrrolo[2,3-d] pynmidin-7- yl)methyl 2,2-dimethylpropanoate of Formula V into [4-(1 H-pyrazol-4-yl)-7Hpyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (II). The process of the present invention provides [4-(1 H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate of Formula (I) in high yield.
摘要翻译：本发明提供了制备巴替西汀及其中间体的方法。本发明提供了一种方便，经济和工业上有利的二步法，用于制备[4-（1H-吡唑-4-基）-7H-吡咯并[2,3-d]嘧啶-7-基]甲基新戊酸酯式（II）。本发明的方法涉及使用碱金属或碱土金属氢氧化物，碳酸盐或碳酸氢盐作为使式（III）的4-氯-7H-吡咯并[2,3-d]嘧啶与新戊酸氯甲酯反应的碱的式（Ⅳ）化合物的用途，以及使用式（Ⅷ）的未保护的吡唑硼烷来转化（4-氯-7H-吡咯并[2,3-d] yn啶-7-基）甲基2,2-二甲基丙酸酯式（II）的[4-（1H-吡唑-4-基）-7H-吡咯并[2,3-d]嘧啶-7-基]甲基。本发明的方法以高产率提供式（I）的[4-（1H-吡唑-4-基）-7H-吡咯并[2,3-d]嘧啶-7-基]甲基。

5. 发明申请

WO2017191620A1 A CRYSTALLINE FORM OF A SALT OF SACUBITRIL AND A PROCESS OF ITS PREPARATION 审中-公开
标题翻译： SACUBITRIL盐的结晶形式及其制备方法
公开(公告)号：WO2017191620A1
公开(公告)日：2017-11-09
申请号：PCT/IB2017/052673
申请日：2017-05-08
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PUTAPATRI, Siddamal Reddy , KHAIRNAR, Bhushan Balasaheb , KUMAR, Ashok , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A61P9/12 , A61P9/04 , A61K31/216 , C07C233/47 , C07C231/24 , C07C231/12
摘要： The present invention provides a process for the preparation of a salt of sacubitril. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril. The present invention further provides a crystalline Form I of sodium salt of sacubitril and its process of preparation.
摘要翻译：本发明提供了一种制备sacubitril盐的方法。具体而言，本发明提供了一种制备沙丙胺醇钠盐的方法。本发明进一步提供了一种sacubitril钠盐的晶型I及其制备方法。

6. 发明申请

WO2017141193A1 PROCESS FOR THE PREPARATION OF SACUBITRIL OR SALTS THEREOF 审中-公开
标题翻译：制备磺酰氯或其盐的方法
公开(公告)号：WO2017141193A1
公开(公告)日：2017-08-24
申请号：PCT/IB2017/050890
申请日：2017-02-16
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PUTAPATRI, Siddamal Reddy , KHAIRNAR, Bhushan Balasaheb , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan , KUMAR, Ashok
IPC分类号： A61K31/21 , A61K31/41 , A61K31/216 , C07C231/02 , C07C231/24 , C07C233/47
CPC分类号： C07C231/02 , C07C227/04 , C07C269/06 , C07C303/28 , C07C303/30 , C07C309/65 , C07C271/22 , C07C229/34 , C07C233/47
摘要： The present invention provides processes for the preparation of sacubitril or salts thereof. The present invention further provides intermediates of Formula IV, V and VI and their use for the preparation of sacubitril or salts thereof.
摘要翻译：本发明提供了用于制备sacubitril或其盐的方法。本发明进一步提供了式IV，V和VI的中间体及其在制备sacubitril或其盐中的用途。

7. 发明申请

WO2016125080A3 PROCESS FOR THE PREPARATION OF BARICITINIB AND AN INTERMEDIATE THEREOF 审中-公开
公开(公告)号：WO2016125080A3
公开(公告)日：2016-08-11
申请号：PCT/IB2016/050529
申请日：2016-02-02
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： AZAD, Md Abul Kalam , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： C07D487/04 , A61K31/397 , A61K31/4353
摘要： The present invention provides processes for the preparation of baricitinib of Formula I and an intermediate of Formula V. The present invention also provides the use of the intermediate of Formula V for the preparation of baricitinib. The present invention provides an environmentally friendly, cost-effective, and industrially advantageous process for the preparation of baricitinib of Formula I. The process of the present invention involves the use of an environmentally benign heterogeneous catalyst, such as a zeolite. The use of a zeolite as a catalyst is beneficial for large scale synthesis, owing to its inexpensive nature, ease of handling, ease of isolation of the product, high reaction yields, and recyclability.

8. 发明申请

WO2017191619A3 A PROCESS FOR THE PREPARATION OF A SALT OF SACUBITRIL AND VALSARTAN 审中-公开
公开(公告)号：WO2017191619A3
公开(公告)日：2017-11-09
申请号：PCT/IB2017/052672
申请日：2017-05-08
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PUTAPATRI, Siddamal Reddy , KHAIRNAR, Bhushan Balasaheb , KUMAR, Ashok , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A61K9/14 , A61K31/216 , A61K31/41
摘要： The present invention provides a process for the preparation of a salt of sacubitril and valsartan. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril and valsartan.

9. 发明申请

WO2017191619A2 A PROCESS FOR THE PREPARATION OF A SALT OF SACUBITRIL AND VALSARTAN 审中-公开
标题翻译：一种制备SACUBITRIL和VALSARTAN盐的方法
公开(公告)号：WO2017191619A2
公开(公告)日：2017-11-09
申请号：PCT/IB2017/052672
申请日：2017-05-08
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： PUTAPATRI, Siddamal Reddy , KHAIRNAR, Bhushan Balasaheb , KUMAR, Ashok , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： A61K31/41 , C07D257/04
摘要： The present invention provides a process for the preparation of a salt of sacubitril and valsartan. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril and valsartan.
摘要翻译：本发明提供了一种制备沙丙胺和缬沙坦盐的方法。具体而言，本发明提供了用于制备沙丙胺醇和缬沙坦的钠盐的方法。

10. 发明申请

WO2015145333A1 PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATE 审中-公开
标题翻译：制备西他汀及其中间体的方法
公开(公告)号：WO2015145333A1
公开(公告)日：2015-10-01
申请号：PCT/IB2015/052119
申请日：2015-03-23
申请人： SUN PHARMACEUTICAL INDUSTRIES LIMITED
发明人： AZAD, Md Abul Kalam , PANDEY, Gyanendra , SINGH, Kaptan , PRASAD, Mohan
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides a process for the preparation of sitagliptin. The present invention also provides a process for the preparation of tert -butyl [(2R)-4-oxo-4- [3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3- a ]pyrazin-7(8 H )-yl]-1-(2,4,5- trifluorophenyl)butan-2-yl]carbamate, an intermediate of sitagliptin.
摘要翻译：本发明提供了西他列汀的制备方法。本发明还提供了制备[（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3- a]吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-基]氨基甲酸酯，西格列汀的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式