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1. 发明授权

EP0262589B1 Triazole compounds, and their production 失效转让
标题翻译：三唑化合物和它们的制备。
公开(公告)号：EP0262589B1
公开(公告)日：1994-05-04
申请号：EP87113975.4
申请日：1987-09-24
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ikeda, Takaharu , Tada, Kazuhiro
IPC分类号： C07D249/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08

2. 发明授权

EP0240216B1 Process for preparing E-isomer of triazolyl styryl ketone derivative 失效转让
标题翻译：制备三唑啉酮衍生物的异构体的方法
公开(公告)号：EP0240216B1
公开(公告)日：1993-04-21
申请号：EP87302446.7
申请日：1987-03-20
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ikeda, Takaharu , Tada, Kazuhiro , Morino, Haruki
IPC分类号： C07D249/08 , C07B37/08
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08

3. 发明公开

EP0440251A3 Process for preparing optically active cyclopentenones 失效
标题翻译：制备活性环戊二烯的方法
公开(公告)号：EP0440251A3
公开(公告)日：1992-06-03
申请号：EP91101352.2
申请日：1991-02-01
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Minai, Masayoshi , Imazu, Sachiko , Kai, Seiichi , Ikeda, Takaharu , Ikehira, Hideyuki
IPC分类号： C07C69/757 , C12P7/62 , C07C67/08 , C07C67/333 , C07D307/54 , C07C69/738 , C07C67/343 , C07C69/606 , C07C67/317 , C07C67/303
CPC分类号： C07C69/593 , C07C69/606 , C07C69/738 , C07D307/54 , C12P7/62 , C12P41/004
摘要： An improved process for preparing an optically active 4-hydroxycyclopentenone of the formula:
wherein R is a lower alkyl, the symbol = means a double bond or triple bond, and the * marked carbon is an asymmetric carbon, and the corresponding racemic 4-hydroxycyclopentenone, which are useful as an intermediate for preparing medical or agricultural products, particularly pharmaceutically active prostaglandins, and intermediates for preparing the optically active and/or racemic 4-hydroxycyclopentenone.

4. 发明公开

EP0441371A1 Process for preparing haloketo acid derivatives 失效
标题翻译：制备卤代酮酸衍生物的方法
公开(公告)号：EP0441371A1
公开(公告)日：1991-08-14
申请号：EP91101678.0
申请日：1991-02-07
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ikeda, Takaharu , Kai, Seiichi , Minai, Masayoshi
IPC分类号： C07C67/343 , C07C67/313 , C07C69/716 , C07C251/38
CPC分类号： C07C69/716 , C07C67/313 , C07C67/343 , C07C251/38
摘要： Process for preparing haloketo acid derivatives [I]:

wherein R is H or C₁₋₆ alkyl, and X is a chlorine or bromine, which comprises reacting β-oxo-acid ester [II]:

wherein R¹ is C₁₋₆ alkyl, R² is C₁₋₅ alkyl or OR³ (R³ is C₁₋₆ alkyl), and X is the same as above, with nitrosating agent [IV]:

ONOR⁴ [IV]

wherein R⁴ is H, alkyl, halogen or SO₃H to give 7-halo-2-hydroxyiminoheptanoic acid ester [III]:

wherein R¹ and X are the same as above, followed by reacting the product with aldehyde or ketone; and intermediates therefor, and process for preparing said intermediates. Said haloketo acid derivatives are useful as intermediate for synthesis of cilastatin, which is useful as medicament, especially as dehydropeptidase inhibitor.
摘要翻译：制备卤代酮酸衍生物[Ⅰ]的方法：其中R是H或C 1-6烷基，X是氯或溴，该方法包括使β-氧代酸酯[Ⅱ]：其中R 1是C 1-6烷基，R 2 其中R 4是H，烷基，卤素或SO 3 H，其中R 4是C 1-5烷基或OR 3（R 3是C 1-6烷基），X与上述相同，与亚硝基化试剂〔Ⅳ〕反应，得到7-卤代 -2-羟基亚氨基庚酸酯[Ⅲ]：其中R 1和X与上述相同，接着使产物与醛或酮反应; 及其中间体，以及制备所述中间体的方法。所述卤代酮酸衍生物可用作合成西司他丁的中间体，其可用作药物，特别是作为脱氢肽酶抑制剂。

5. 发明公开

EP0319024A3 Process for producing optically active alpha-isopropyl-p-chlorophenylacetic acid 失效
标题翻译：生产光学活性的α-异丙基-P-氯丙烯酸的方法
公开(公告)号：EP0319024A3
公开(公告)日：1991-04-03
申请号：EP88120157.8
申请日：1988-12-02
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Oda, Yoshiaki , Ikeda, Takaharu , Yamachika, Hiroshi
IPC分类号： C07C57/58 , C07C51/09 , C07C69/65
CPC分类号： C07C51/09 , C07C57/58
摘要： A process for producing optically active α-isopropyl-p-chlorophenylacetic acid (ICPA) of the formula:
wherein the symbol * stands for an asymmetric carbon atom, which comprises subjecting an ICPA ester in the form of a racemic mixture corresponding to the formula (II)
wherein X₁, X₂ and X₃ are independently halogen atoms, or two of them are independently halogen atoms and the third is hydrogen atom or a lower alkyl group, and the meaning of the symbol * are the same as defined above,
to optical resolution by preferential crystallization from an organic solvent at a degree of supersaturation of not more than 150 % at the intended crystallization temperature to separate an optically active ICPA ester of the formula (II); subjecting the optically active ICPA ester obtained
to hydrolysis with retaining its configuration to give the corresponding optically active ICPA of the formula (I) ; and
subjecting the undesired optically active ICPA ester remaining in the mother liquor after the optical resolution
to racemization by a strong organic base to form the racemic mixture of the ICPA ester, which can be subjected to another optical resolution.

6. 发明公开

EP0375554A2 Process for producing optically active threo-dihydroxyphenylserine derivatives 失效
标题翻译：苏维埃·瑞斯特朗（Thur Herstellung）von optisch aktiven Threo-dihydroxyphenylserine-Derivaten。
公开(公告)号：EP0375554A2
公开(公告)日：1990-06-27
申请号：EP89403599.7
申请日：1989-12-21
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Noyori, Ryoji , Kitamura, Masato , Ikeda, Takaharu , Yamachika, Hiroshi , Ishizumi, Kikuo , Terashima, Toru
IPC分类号： C07C227/32 , C07B53/00 , C07C229/06
CPC分类号： C07C227/32 , Y02P20/55
摘要： Optically active threo-dihydroxyphenylserine derivatives represented by the forumla:
wherein R₁ and R₂ each represents or form together a protecting group for the phenolic hydroxyl group, R₃ represents a protecting group for the amino group and R₄ represents a protecting group for the carboxyl group, which are intermediates for L-threo-3-(3,4-dihydroxyphenyl)-serine, are prepared by asymmetrical hydrogenation of ketones represented by the formula:
wherein R₁, R₂, R₃ and R₄ are as defined above, in a solvent in the presence of optically active ruthenium phosphine complexes represented by the formula:
wherein X represents a chlorine atom, a bromine atom or an acetoxy group, R₅ represents a lower alkyl group of 1 - 5 carbon atoms, Z represents a phenyl group or a p-tolyl group and n is 0 or 1.
摘要翻译：由forumla表示的光学活性的三 - 二羟基苯基丝氨酸衍生物：其中R1和R2各自表示或形成酚羟基的保护基，R3表示氨基的保护基，R4表示羧基的保护基作为L-苏式-3-（3,4-二羟基苯基） - 丝氨酸的中间体的化合物是通过由下式表示的酮的不对称氢化来制备的：其中R 1，R 2，R 3和R 4如上定义，在由下式表示的光学活性钌膦配合物的存在下在溶剂中：其中X表示氯原子，溴原子或乙酰氧基，R5表示1-5个碳原子的低级烷基，Z表示苯基或对甲苯基，n为0或1。

7. 发明授权

EP0084377B1 Process for preparing biotin 有权
标题翻译：制备生物素的方法
公开(公告)号：EP0084377B1
公开(公告)日：1985-12-27
申请号：EP83100397.5
申请日：1983-01-18
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ohashi, Naohito , Ikeda, Takaharu , Shimago, Kozo , Takahashi, Takeo , Ishizumi, Kikuo
IPC分类号： C07D495/04
CPC分类号： C07D495/04

8. 发明公开

EP0084892A2 Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-furo(3,4-d)imidazole-2,4-dione and its intermediates 有权转让
标题翻译：旋光顺式-1,3-二苄基六氢-1H-呋喃并（3,4-D） - 咪唑烷-2,4-二酮和其中间体的制备。
公开(公告)号：EP0084892A2
公开(公告)日：1983-08-03
申请号：EP83100767.9
申请日：1983-01-27
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ohashi, Naohito , Shimago, Kozo , Ikeda, Takaharu , Ishizumi, Kikuo
IPC分类号： C12P17/10 , C07D233/32
CPC分类号： C07D491/04 , C07D233/32 , C12N9/18 , C12P17/10
摘要： A process for preparing an optically active cis-1,3-diben- zylhexahydro-1 H-furo[3,4-d]imidazole-2,4-dione of the formula:
wherein an asterisk ( * ) indicates an asymmetric carbon, Bzl represents a benzyl group and the 3a- und 6a-positions take the cis-configuration, which comprises reducing selectively an optically acitve cis-imidazolidinedicarboxylic acid monoester of the formula:
wherein R is a C 1 -C 6 alkyl group and Bzl is as defined above with a reducing agent at either one of the carboxyl group and the alkoxycarbonyl group in the said monoester, followed by cyclization, the said monoester being that obtainable by hydrolysis of a cis-imidazolidinedicarboxylic acid diester of the formula:
wherein R and Bzl are each as defined above with an enzymatic material capable of hydrolyzing the ester group in the said diester.

9. 发明授权

EP0084892B2 Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-furo(3,4-d)imidazole-2,4-dione and its intermediates 有权转让
标题翻译：旋光顺式-1,3-二苄基六氢-1H-呋喃并（3,4-D） - 咪唑烷-2,4-二酮和其中间体的制备
公开(公告)号：EP0084892B2
公开(公告)日：1996-10-23
申请号：EP83100767.9
申请日：1983-01-27
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ohashi, Naohito , Shimago, Kozo , Ikeda, Takaharu , Ishizumi, Kikuo
IPC分类号： C12P17/10 , C07D233/32
CPC分类号： C07D491/04 , C07D233/32 , C12N9/18 , C12P17/10

10. 发明授权

EP0441371B1 Process for preparing haloketo acid derivatives 失效
标题翻译：制备卤代酮酸衍生物的方法
公开(公告)号：EP0441371B1
公开(公告)日：1995-01-25
申请号：EP91101678.0
申请日：1991-02-07
申请人： SUMITOMO CHEMICAL COMPANY, LIMITED
发明人： Ikeda, Takaharu , Kai, Seiichi , Minai, Masayoshi
IPC分类号： C07C67/343 , C07C67/313 , C07C69/716 , C07C251/38
CPC分类号： C07C69/716 , C07C67/313 , C07C67/343 , C07C251/38

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