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    • 1. 发明授权
    • Process for producing benzodiazepine derivatives
    • 生产苯二酸衍生物的方法
    • US3817984A
    • 1974-06-18
    • US23015772
    • 1972-02-28
    • SUMITOMO CHEMICAL CO
    • MORIYAMA HYAMAMOTO HINABA SNAGATA H
    • C07D243/16C07D53/06
    • C07D243/16
    • R1 - NH - CH2 - CH2 - NH2 wherein R1 is as defined above, preferably in the presence of a catalyst such as copper acetate and an acid binding agent such as anhydrous potassium carbonate, anhydrous sodium acetate, pyridine or N-ethylmorpholine.

      WHEREIN R1 is a hydrogen atom, a lower alkyl group or a cycloalkylmethyl group; R2 is a hydrogen atom, a halogen atom, a nitro group, a lower alkoxy group or a trifluoromethyl group; and R3 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, are produced by reacting a diphenylmethyleneimine derivative of the formula,

      Novel process for producing 2,3-dihydro-III-1,4-benzodiazepine derivatives. 2,3-Dihydro-1H-1,4-benzodiazepine derivatives of the formula,
    • 制备2,3-二氢-III-1,4-苯并二氮杂衍生物的新方法。 下式的2,3-二氢-1H-1,4-苯并二氮杂衍生物,其中R 1是氢原子,低级烷基或环烷基甲基; R2是氢原子,卤素原子,硝基,低级烷氧基或三氟甲基; R3是氢原子,卤素原子,低级烷基,低级烷氧基或三氟甲基,通过使下式的二苯基亚甲基亚胺衍生物反应来制备,其中R2和R3如上定义; 和X是卤素原子,其中R1-NH-CH2-CH2-NH2的乙二胺衍生物,其中R 1如上定义,优选在催化剂如乙酸铜和酸结合剂如无水物 碳酸钾,无水乙酸钠,吡啶或N-乙基吗啉。