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    • 4. 发明专利
    • COMPOSITE PRESSURE SENSITIVE HYDROPHILIC ADHESIVE AND METHOD OF PREPARING THE SAME
    • CA2191488A1
    • 1995-11-23
    • CA2191488
    • 1995-05-10
    • SULC JIRIKRCOVA ZUZANA
    • SULC JIRIKRCOVA ZUZANA
    • A61K9/70A61L15/00A61L15/58C08K5/06C08L5/06C09J5/00C09J9/00C09J101/04C09J133/10C09J133/14C09J201/00
    • Composite pressure sensitive hydrophilic adhesive, permeable for water vapor and losing its adhesiveness in contact with liquid water, particularly suitable for temporary glueing medical means to the body surface, comprising a gelled mixture of: (a) a water swellable, water insoluble polymer, soluble in polar water-miscible solvents boiling at atmospheric pressure at temperatures higher than 100 .degree.C as well as in their mixtures with minor amounts of water, (b) a hydrophilic water swellable polymer, insoluble in water as well as in polar water-miscible solvents boiling at atmospheric pressure at temperatures higher than 100 .degree.C, (c) a polar water-miscible innocuous solvent boiling at atmospheric pressure at temperatures higher than 100 .degree.C, if desired mixed with a minor amount of water. A feature of the composite pressure sensitive hydrophilic adhesive of the invention is that the separate polymers (a) and (b) are replaced by a non-crosslinked copolymer of hydrophilic and hydrophobic monomers, only partially soluble in the component (c) but swellable therein. The invention further comprises a method of preparing the composite pressure sensitive hydrophilic adhesive of the invention consisting in the intensive stirring of the dry powdered polymer (a), the water swellable, water insoluble polymer, soluble in polar water-miscible solvents boiling at atmospheric pressure at temperatures higher than 100 .degree.C as well as in their mixtures with minor amounts of water and polymer (b), the hydrophilic water swellable polymer, insoluble in water as well as in polar water-miscible solvents boiling at atmospheric pressure at temperatures higher than 100 .degree.C, in the (c) a polar water-miscible innocuous solvent boiling at atmospheric pressure at temperatures higher than 100 .degree.C, if desired mixed with a minor amount of water, spreading the paste thus obtained on a pad, and setting it to a gelled layer. The method of using the composite pressure sensitive hydrophilic adhesive consists in that the mixing of components is with advantage carried out at temperatures not exceeding 15 .degree.C and the thus received mass is afterwards spread to the surface of the medical means to be glued to the body surface, and subsequently the spread layer is left to set at temperatures in the range of from 15 .degree.C to about 100 .degree.C either by prolonged storage or by heating.