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3. 发明专利

DK1255752T3 未知
公开(公告)号：DK1255752T3
公开(公告)日：2007-11-26
申请号：DK01914376
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN CO LLC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD S , HAWLEY MICHAEL
IPC分类号： C07D401/14 , C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/12 , C07D403/14 , C07D521/00
摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

5. 发明专利

CA2399358A1 PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS 未知
公开(公告)号：CA2399358A1
公开(公告)日：2001-08-23
申请号：CA2399358
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN
发明人： HAWLEY MICHAEL , SUN LI , LI XIAOYUAN , TANG PENG CHO , MILLER TODD , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , NEMATALLA ASAAD S , VOJKOVSKY TOMAS , LIANG CONGXIN
IPC分类号： C07D401/14 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/06 , C07D403/12 , C07D403/14 , C07D521/00
摘要： The present invention relates to pyrrole substituted 2-indolinone compounds of formula (I): and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefor are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such a s cancer.

6. 发明专利

DE60129794T2 未知
公开(公告)号：DE60129794T2
公开(公告)日：2007-12-06
申请号：DE60129794
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN CO LLC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD S , HAWLEY MICHAEL
IPC分类号： C07D401/14 , C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/12 , C07D403/14 , C07D521/00
摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

8. 发明专利

DE60129794D1 未知
公开(公告)号：DE60129794D1
公开(公告)日：2007-09-20
申请号：DE60129794
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN CO LLC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD S , HAWLEY MICHAEL
IPC分类号： C07D401/14 , C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/12 , C07D403/14 , C07D521/00
摘要： The present invention relates to pyrrole substituted-2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

9. 发明专利

ME00415B PIROL SUPSTITUISANI 2-INDOL PROTEIN KINAZNI INHIBITORI 未知
公开(公告)号：ME00415B
公开(公告)日：2011-10-10
申请号：MEP53008
申请日：2001-02-15
申请人： PHARMACIA & UPJOHN CO LLC , SUGEN INC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD , LIANG CONGXIN , VOJKOVSKY TOMAS , NEMATALLA ASAAD S , HAWLEY MICHAEL
IPC分类号： C07D207/33 , C07D401/14 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/06 , C07D403/12 , C07D403/14 , C07D521/00
摘要： Ovaj pronalazak se odnosi na jedinjenja 2-indolininona supstituisana pirolom formule (I): Ovaj pronalazak se odnosi na jedinjenja 2-indolininona supstituisana pirolom formule (I): i njihove farmaceutski prihvatljive soli, koja modulišu aktivnost protein kinaza, pa se stoga očekuje da budu korisna za prevenciju i tretman ćelijskih poremećaja povezanih sa protein kinazom, kao što je kancer. i njihove farmaceutski prihvatljive soli, koja modulišu aktivnost protein kinaza, pa se stoga očekuje da budu korisna za prevenciju i tretman ćelijskih poremećaja povezanih sa protein kinazom, kao što je kancer.

10. 发明专利

ES2290117T3 INHIBIDORES DE PROTEINA QUINASA 2-INDOLINA SUSTITUIDA CON PIRROL. 未知
公开(公告)号：ES2290117T3
公开(公告)日：2008-02-16
申请号：ES01914376
申请日：2001-02-15
申请人： SUGEN INC , PHARMACIA & UPJOHN CO LLC
发明人： TANG PENG CHO , MILLER TODD , LI XIAOYUAN , SUN LI , WEI CHUNG CHEN , SHIRAZIAN SHAHRZAD
IPC分类号： C07D401/14 , C07D403/06 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61P3/10 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D207/32 , C07D207/33 , C07D209/44 , C07D401/12 , C07D403/00 , C07D403/12 , C07D403/14 , C07D521/00
摘要： Un compuesto de fórmula (I) o una sal farmacéuticamente aceptable del mismo, en la que: R1 se selecciona entre hidrógeno, alquilo (C1-C4), -(CH2)rR16 y -C(O)NR8R9; R2 se selecciona entre hidrógeno, halógeno, arilo y -S(O)2NR13R14; R3 se selecciona entre hidrógeno, alquilo (C1-C4), alcoxi (C1-C4), arilo, heteroarilo, y -C(O)R15; R4 es hidrógeno; R5 se selecciona entre hidrógeno y alquilo (C1-C4); R6 es -C(O)R10; R7 se selecciona entre hidrógeno, alquilo (C1-C4) y arilo; R8 y R9 se seleccionan independientemente entre hidrógeno, alquilo y arilo; R10 es -N(R11)(CH2)nR12, en la que n es 1, 2 ó 3, R11 es hidrógeno y R12 se selecciona entre hidroxi, alcoxi (C1-C4), -C(O)R15, heteroarilo y -NR13R14; R13 y R14 se seleccionan independientemente entre el grupo constituido por hidrógeno. alquilo (C1-C4), cicloalquilo, arilo y heteroarilo; o R13 y R14 pueden combinarse para formar un grupo heterociclo; R15 se selecciona entre el grupo constituido por hidrógeno, hidroxi, alcoxi (C1-C4) y ariloxi; R16 se selecciona entre hidroxi y -C(O)R15; y r es 2 ó 3; y en el que: alcoxi se refiere a O-alquilo u O-cicloalquilo; ariloxi se refiere a O-arilo u O-heteroarilo; heteroarilo se refiere a un grupo de anillo monocíclico o condensado de 5 a 12 átomos en el anillo que contiene uno, dos o tres heteroátomos en el anillo seleccionados entre N, O o S, siendo los restantes átomos en el anillo C; grupo heterociclo se refiere a un radical cíclico saturado de 3 a 8 átomos en el anillo en el que uno o dos átomos en el anillo son heteroátomos seleccionados entre N, O o S(O)n donde n es un número entero de 0 a 2, siendo los restantes átomos en el anillo C, donde uno o dos átomos de C está opcionalmente sustituidos por un grupo carbonilo; los grupos alquilo, alcoxi y cicloalquilo están no sustituidos; los grupos arilo y heteroarilo están opcionalmente sustituidos con uno o dos sustituyentes seleccionados independientemente entre halo, alquilo (C1-C4), trihaloalquilo (C1-C4), hidroxi, mercapto, ciano, N-amido, mono- o dialquil (C1-C4)amino, carboxi y N-sulfonamido; el grupo heterociclo está opcionalmente sustituido con uno o dos sustituyentes seleccionados independientemente entre halo, -alquil (C1-C4), -alquil (C1-C4)-carboxi, -alquil (C1-C4)-éster, hidroxilo y mono- o dialquil (C1-C4)amino.

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