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1. 发明申请

WO2010066432A3 ADSORBENT PARTICLES BASED ON POROUS CARRIERS AND POLYELECTROLYTE LAYERS 审中-公开
标题翻译：基于多孔支撑体和聚电解质盘的ADSORBENSPARTIKEL
公开(公告)号：WO2010066432A3
公开(公告)日：2010-08-19
申请号：PCT/EP2009008848
申请日：2009-12-10
申请人： SUED CHEMIE AG , CAPSULUTION PHARMA AG , SCHEPER THOMAS , SOHLING ULRICH , RALLA KATHRIN , KASPER CORNELIA , BURZLAFF ARNE , DAEHNE LARS , SENST STEFFI , BAUDE BARBARA
发明人： SCHEPER THOMAS , SOHLING ULRICH , RALLA KATHRIN , KASPER CORNELIA , BURZLAFF ARNE , DAEHNE LARS , SENST STEFFI , BAUDE BARBARA
IPC分类号： B01J20/32 , C12N11/08
CPC分类号： C12N11/08
摘要： The invention relates to a carrier material, comprising at least: a.) an inert carrier core, which has a surface having a positive or negative overall charge; b.) a first layer which comprises a first polyelectrolyte and is arranged on and connected to the carrier core, said polyelectrolyte having an overall charge of the same type as the surface charge of the inert carrier core; c.) a second layer which comprises a second polyelectrolyte and is arranged on the first layer comprising the first polyelectrolyte, said second polyelectrolyte having an overall charge of the same type as the overall charge of the first polyelectrolyte.
摘要翻译：本发明涉及一种载体材料，其至少包括：a）具有带正电荷或负电荷总量的表面的惰性载体核心; b）设置在惰性载体芯上并邻接其的第一聚电解质的第一层，其具有与惰性载体芯的表面电荷相同方向的总电荷; c），其布置在第二聚电解质的第一聚电解质第二层的第一层上，所述第二聚电解质具有与第一聚电解质总电荷的总电荷相反的总电荷。

2. 发明申请

WO2007031345A3 METHOD FOR THE ENCAPSULATION AND CONTROLLED-RELEASE OF POORLY WATER-SOLUBLE (HYDROPHOBIC) LIQUID AND SOLID ACTIVE INGREDIENTS 审中-公开
标题翻译：方法封装和重水溶性（疏水）液体和固体活性成分的控释
公开(公告)号：WO2007031345A3
公开(公告)日：2007-07-19
申请号：PCT/EP2006009063
申请日：2006-09-18
申请人： CAPSULUTION NANOSCIENCE AG , DAEHNE LARS , SENST STEFFI , BAUDE BARBARA , VOIGT ANDREAS
发明人： DAEHNE LARS , SENST STEFFI , BAUDE BARBARA , VOIGT ANDREAS
IPC分类号： A61K9/50 , A61K9/51
CPC分类号： A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5073 , A61K9/5089 , A61K9/5094 , A61K9/5115
摘要： The invention relates to the filling of hydrophobic or hydrophobically modified porous microparticles with hydrophobic substances and to the subsequent encapsulation of the resultant hydrophobic particles using layer-by-layer (LbL) polyelectrolyte technology in order to produce homogeneous suspensions in water and to enable the controlled release of the encapsulated active ingredients. Adhesion to the target site is improved by a specific modification of the LbL surface.
摘要翻译：本发明涉及一种带有用于在水以及用于包封的活性成分的受控释放的制备均匀的悬浮液的目的，层 - 层（LBL）聚电解质的技术所得到的疏水性颗粒的后续包封的疏水性物质的疏水性或疏水改性的多孔微粒的填充。由层层表面的特定变型中，能够实现在目的地的优选的粘附性。

3. 发明申请

WO2004014540A9 COLOR COATED LAYER-BY-LAYER MICROCAPSULES SERVING AS COMBINATORY ANALYSIS LIBRARIES AND AS SPECIFIC OPTICAL SENSORS 审中-公开
标题翻译：彩色逐层微胶囊作为组合分析文库和特定光学传感器
公开(公告)号：WO2004014540A9
公开(公告)日：2004-04-08
申请号：PCT/EP0308376
申请日：2003-07-29
申请人： CAPSULUTION NANOSCIENCE AG , DAEHNE LARS , BAUDE BARBARA , VOIGT ANDREAS
发明人： DAEHNE LARS , BAUDE BARBARA , VOIGT ANDREAS
IPC分类号： B01J13/02 , B01J13/04 , B01J13/22 , G01N21/75 , G01N21/78 , G01N33/58
CPC分类号： G01N33/587 , B01J13/02 , B01J13/22 , B01J2219/005 , B01J2219/00576 , C40B99/00
摘要： Monodisperse colloids were coated with polyelectrolytes by means of the layer-by-layer method. The template cores can remain inside or can be dissolved. Different fluorescent dyes are covalently bound in a defined amount to the polyelectrolytes. The amount of dye is controlled by varying the label content or by the Co deposition of unlabeled polymers. Different dye layers are separated from one another by intermediate layers thereby suppressing unwanted interactions. Conversely, a FRET signal can be generated between suitable dye pairs situated at short distances (0 - 6 nm) from one another. This signal can be controlled independent of the dye concentration by the number of intermediate layers. The capsule coding is read out by the variation in the excitation wavelength and emission wavelength. Macromolecules can be immobilized inside the capsules and extract complementary substances out of solutions. Particles coated in such a manner or hollow capsules can be used as sensors after inserting a sensitive intermediate layer. Changes in the size/structure of the intermediate layer can be detected either by FRET between adjacent, labeled polyelectrolyte layers or by the self-quenching/aggregate fluorescence of dyes in the sensitive layer.
摘要翻译：单分散胶体用聚电解质通过逐层方法涂布。模板核心可以保留在内部或被溶解。各种荧光染料以限定的量与聚电解质共价结合。通过改变标签含量或共沉积未标记的聚合物来控制染料的量。不同的染料层被中间层分开，从而抑制不需要的相互作用。相反，可以在适当的染料对之间在小距离（0-6nm）处产生FRET信号，其可以通过中间层的数量独立于染料浓度而被控制。通过改变激发和发射波长来读出胶囊编码。在胶囊中可以固定大分子，从溶液中捞出补充物质。在引入敏感的中间层之后，这种涂覆的颗粒或空心胶囊可以用作传感器。夹层的大小/结构的变化可以通过邻近的标记的聚电解质层之间的FRET或通过敏感层中染料的自淬灭/聚集荧光来检测。

4. 发明申请

WO0217888A9 CONTROLLED AND SUSTAINED RELEASE PROPERTIES OF POLYELECTROLYTE MULTILAYER CAPSULES 审中-公开
标题翻译：聚电解质多层胶囊的控制和持续释放性能
公开(公告)号：WO0217888A9
公开(公告)日：2003-05-15
申请号：PCT/EP0109908
申请日：2001-08-28
申请人： MAX PLANCK GESELLSCHAFT , ANTIPOV ALEXEI , VIEIRA EURIDICE , IBARZ GEMMA , SUKHORUKOV GLEB , DAEHNE LARS , GAO CHANGYOU , DONATH EDWIN , MOEHWALD HELMUTH
发明人： ANTIPOV ALEXEI , VIEIRA EURIDICE , IBARZ GEMMA , SUKHORUKOV GLEB , DAEHNE LARS , GAO CHANGYOU , DONATH EDWIN , MOEHWALD HELMUTH
IPC分类号： A61K9/50 , A61K9/52 , A61K47/26 , A61K47/36 , A61K47/42 , A61K47/44 , B01J13/02 , B01J13/20
CPC分类号： A61K9/5073 , B01J13/20
摘要： Method of layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was applied to coat fluorescein particles. These particles with a size of 4-9 mu m were prepared by precipitation of fluorescein at pH 2. Polysterensulfonate (PSS) and polyallylamine (PAH) were used to compose the polyelectrolyte shell on the fluorescein core. The release of fluorescein molecules through the polyelectrolyte shell core dissolution was monitored at pH 8 by increasing fluorescence intensity. The number of polyelectrolyte layers sufficient to sustain fluorescence release was found to be 8-10. Sequentially adsorbed layers prolong core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm is about 10 m/s. Mechanism of fluorescence diffusion and osmotically supported release is under discussion. The features of release profile and possible applications of LbL method for shell formation in order to control release properties for entrapped materials are outlined. Also ambient conditions of pH, temperature and salt concentration were changed to control the permeability of polyelectrolyte multilayer capsules.
摘要翻译：施加相反电荷的聚电解质的逐层（LbL）组装方法来涂覆荧光素颗粒。通过在pH2下沉淀荧光素来制备尺寸为4-9μm的这些颗粒。使用聚苯磺酸钠（PSS）和聚烯丙胺（PAH）来构成荧光素核上的聚电解质壳。通过增加荧光强度，在pH8下监测荧光素分子通过聚电解质壳核溶解的释放。发现足以维持荧光释放的聚电解质层的数量为8-10。连续吸附的层延长核心溶解时间几分钟。厚度为20nm的聚电解质多层膜的磁导率约为10 -8 m / s。正在讨论荧光扩散和渗透支持释放的机制。概述了释放特征和LbL方法用于壳形成以控制被捕获材料释放性能的可能应用。改变pH，温度和盐浓度的环境条件以控制聚电解质多层胶囊的渗透性。

5. 发明申请

WO2012110258A3 SMOKE-FREE CIGARETTE, CIGAR OR PIPE 审中-公开
标题翻译：烟熏香烟，香烟或哨子
公开(公告)号：WO2012110258A3
公开(公告)日：2012-11-29
申请号：PCT/EP2012000727
申请日：2012-02-17
申请人： SURFLAY NANOTEC GMBH , SEVERUS PATENT AG , DAEHNE LARS , EGRI GABRIELLA , TRESCHER HEINRICH
发明人： DAEHNE LARS , EGRI GABRIELLA , TRESCHER HEINRICH
IPC分类号： A24F47/00 , A61M15/00
CPC分类号： A24F47/008 , A24F47/002 , A61M15/0003 , A61M15/0028 , A61M15/06 , A61M16/107 , A61M2205/3613
摘要： The invention relates to a smoke-free cigarette, cigar or pipe with at least one depot (10) for storing nicotine and/or nicotine-containing compounds and for releasing the nicotine and/or nicotine-containing compounds in a defined manner, by delivery of external heat, into an air stream to be conveyed through the depot (10). According to the invention, the depot (10) has at least one heat transfer section (16) for targeted delivery of heat for releasing the nicotine and/or the nicotine compound in a defined manner into the air stream.
摘要翻译：本发明涉及一种无烟香烟，雪茄或烟斗具有至少一个保管库（10），用于存储和用于定义，通过加热外部电源通过所述拱顶（10）用于引导空气流动引起的尼古丁和/或含尼古丁化合物释放到。根据本发明，储存库（10）具有至少一个传热部分（16），用于为烟碱和/或尼古丁化合物向空气流的限定释放而提供目标热量。

6. 发明申请

WO0217888A2 CONTROLLED AND SUSTAINED RELEASE PROPERTIES OF POLYELECTROLYTE MULTILAYER CAPSULES 审中-公开
标题翻译：聚电解质多层胶囊的控制和持续释放性能
公开(公告)号：WO0217888A2
公开(公告)日：2002-03-07
申请号：PCT/EP0109908
申请日：2001-08-28
申请人： MAX PLANCK GESELLSCHAFT , ANTIPOV ALEXEI , VIEIRA EURIDICE , IBARZ GEMMA , SUKHORUKOV GLEB , DAEHNE LARS , GAO CHANGYOU , DONATH EDWIN , MOEHWALD HELMUTH
发明人： ANTIPOV ALEXEI , VIEIRA EURIDICE , IBARZ GEMMA , SUKHORUKOV GLEB , DAEHNE LARS , GAO CHANGYOU , DONATH EDWIN , MOEHWALD HELMUTH
IPC分类号： A61K9/50 , A61K9/52 , A61K47/26 , A61K47/36 , A61K47/42 , A61K47/44 , B01J13/02 , B01J13/20
CPC分类号： A61K9/5073 , B01J13/20
摘要： Method of layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was applied to coat fluorescein particles. These particles with a size of 4-9 mu m were prepared by precipitation of fluorescein at pH 2. Polysterensulfonate (PSS) and polyallylamine (PAH) were used to compose the polyelectrolyte shell on the fluorescein core. The release of fluorescein molecules through the polyelectrolyte shell core dissolution was monitored at pH 8 by increasing fluorescence intensity. The number of polyelectrolyte layers sufficient to sustain fluorescence release was found to be 8-10. Sequentially adsorbed layers prolong core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm is about 10 m/s. Mechanism of fluorescence diffusion and osmotically supported release is under discussion. The features of release profile and possible applications of LbL method for shell formation in order to control release properties for entrapped materials are outlined. Also ambient conditions of pH, temperature and salt concentration were changed to control the permeability of polyelectrolyte multilayer capsules.
摘要翻译：施加相反电荷的聚电解质的逐层（LbL）组装方法来涂覆荧光素颗粒。通过在pH2下沉淀荧光素来制备尺寸为4-9μm的这些颗粒。使用聚苯磺酸钠（PSS）和聚烯丙胺（PAH）来构成荧光素核上的聚电解质壳。通过增加荧光强度，在pH8下监测荧光素分子通过聚电解质壳核溶解的释放。发现足以维持荧光释放的聚电解质层的数量为8-10。连续吸附的层延长核心溶解时间几分钟。厚度为20nm的聚电解质多层膜的磁导率约为10 -8 m / s。正在讨论荧光扩散和渗透支持释放的机制。概述了释放特征和LbL方法用于壳形成以控制被捕获材料释放性能的可能应用。改变pH，温度和盐浓度的环境条件以控制聚电解质多层胶囊的渗透性。

7. 发明专利

DE102010000043A1 Inhalatorsystem für flüchtige Substanzen 未知
公开(公告)号：DE102010000043A1
公开(公告)日：2011-07-14
申请号：DE102010000043
申请日：2010-01-11
申请人： DAEHNE LARS , SURFLAY NANOTEC GMBH
发明人： DAEHNE LARS , EGRI GABRIELLA , ALDENHOVEN CLAUDIA
IPC分类号： A61K9/72 , A24D1/18 , A24F47/00 , A61L9/01 , A61L9/03
摘要： Depot für die Speicherung und Abgabe einer Substanz in eine Gasphase, aufweisend eine Hybridstruktur aus einem offenporigen makroporösen Stützgerüst, durch das ein Gas strömen kann, und am Stützgerüst immobilisierten, nanoporösen Partikeln, die in ihren Poren wenigstens einen freizusetzenden Wirkstoff enthalten, wobei das Stützgerüst aus dauerhaft miteinander verbundenen Partikeln oder Fasern besteht.

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