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1. 发明申请

WO2007044903A3 BINARY SIGNAL DETECTION ASSAYS 审中-公开
标题翻译：二进制信号检测测定
公开(公告)号：WO2007044903A3
公开(公告)日：2009-04-23
申请号：PCT/US2006040088
申请日：2006-10-11
申请人： STRATAGENE CALIFORNIA , SORGE JOSEPH A , CARSTENS CARSTEN-PETER , MONELL CRAIG ROBERT , BELYAEV ALEXANDER
发明人： SORGE JOSEPH A , CARSTENS CARSTEN-PETER , MONELL CRAIG ROBERT , BELYAEV ALEXANDER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q2565/201 , C12Q2521/301 , C12Q2521/337
摘要： The present invention provides methods, kits and compositions for the detection of an analyte. The invention is particularly suited for the detection and quantification of analytes in solution. In the methods of the invention a complex is formed between two or more analyte specific probes (ASP) and an analyte. The reactive moieties of the probes interact upon the binding of the analyte specific probes to the analyte. The reactive moieties generate a nucleic acid cleavage product which is detected and indicative of the presence of the analyte.
摘要翻译：本发明提供了用于检测分析物的方法，试剂盒和组合物。本发明特别适用于溶液中分析物的检测和定量。在本发明的方法中，在两种或多种分析物特异性探针（ASP）和分析物之间形成复合物。探针的反应性部分在分析物特异性探针与分析物结合时相互作用。反应性部分产生核酸切割产物，其被检测并指示分析物的存在。

2. 发明申请

WO2007044864A2 TARGET NUCLEIC ACID SIGNAL DETECTION 审中-公开
标题翻译：目标核酸信号检测
公开(公告)号：WO2007044864A2
公开(公告)日：2007-04-19
申请号：PCT/US2006039971
申请日：2006-10-11
申请人： STRATAGENE CALIFORNIA , SORGE JOSEPH A , CARSTENS CARSTEN-PETER , MONELL CRAIG ROBERT , BELYAEV ALEXANDER
发明人： SORGE JOSEPH A , CARSTENS CARSTEN-PETER , MONELL CRAIG ROBERT , BELYAEV ALEXANDER
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6816 , C12Q1/6844 , C12Q2537/155 , C12Q2521/101 , C12Q2525/307 , C12Q2521/501 , C12Q2525/155
摘要： Provided herein are methods, compositions and kits for detecting a target nucleic acid. A target nucleic acid can be produced, for example, by a cleavage reaction in an assay for detection of biological samples. In one aspect, a described method comprises the following steps: hybridizing the target nucleic acid having a 5' end and a 3' end to a probe to form a circular hybridization complex; forming a covalent circular target nucleic acid using the probe as a template for nucleic acid synthesis; and detecting the covalent circular target nucleic acid.
摘要翻译：本文提供了用于检测靶核酸的方法，组合物和试剂盒。靶核酸可以例如通过用于检测生物样品的测定中的裂解反应产生。一方面，所述方法包括以下步骤：将具有5'末端和3'末端的靶核酸与探针杂交以形成环状杂交复合物; 使用探针作为核酸合成的模板形成共价环状靶核酸; 并检测共价环状靶核酸。

3. 发明申请

WO2007137261A2 METHODS AND SYSTEMS FOR DETECTING PINHOLES IN A FILM FORMED ON A WAFER OR FOR MONITORING A THERMAL PROCESS TOOL 审中-公开
标题翻译：用于检测形成在膜上的薄膜或用于监测热过程工具的方法和系统
公开(公告)号：WO2007137261A2
公开(公告)日：2007-11-29
申请号：PCT/US2007069465
申请日：2007-05-22
申请人： KLA TENCOR TECH CORP , CHEN DAVID K , STEINBACH ANDREW , KAVALDJIEV DANIEL , BELYAEV ALEXANDER , REICH JUERGEN
发明人： CHEN DAVID K , STEINBACH ANDREW , KAVALDJIEV DANIEL , BELYAEV ALEXANDER , REICH JUERGEN
IPC分类号： G01B9/02
CPC分类号： G01N21/894 , G01N21/47 , G01N21/55 , G01N21/9501 , G01N21/956 , G01N2021/4735 , G01N2021/8822 , G03F7/7065
摘要： Methods and systems for detecting pinholes in a film formed on a wafer or for monitoring a thermal process tool are provided. One method for detecting pinholes in a film formed on a wafer includes generating output responsive to light from the wafer using an inspection system. The output includes first output corresponding to defects on the wafer and second output that does not correspond to the defects. This method also includes detecting the pinholes in the film formed on the wafer using the second output. One method for monitoring a thermal process tool includes generating output responsive to light from a wafer using an inspection system. The output includes the first and second output described above. The wafer was processed by the thermal process tool prior to generating the output. The method also includes monitoring the thermal process tool using the second output.
摘要翻译：提供了用于检测在晶片上形成的膜中的针孔或用于监测热处理工具的方法和系统。用于检测形成在晶片上的膜中的针孔的一种方法包括使用检查系统响应于来自晶片的光而产生输出。输出包括对应于晶片上的缺陷的第一输出和不对应于缺陷的第二输出。该方法还包括使用第二输出来检测在晶片上形成的膜中的针孔。用于监测热处理工具的一种方法包括响应来自使用检查系统的晶片的光产生输出。输出包括上述第一和第二输出。在生成输出之前，通过热处理工具处理晶片。该方法还包括使用第二输出来监测热处理工具。

4. 发明申请

WO2013036660A2 PASSIVE POSITION COMPENSATION OF A SPINDLE, STAGE, OR COMPONENT EXPOSED TO A HEAT LOAD 审中-公开
标题翻译：主轴负载，阶段或元件受热负荷的无源位置补偿
公开(公告)号：WO2013036660A2
公开(公告)日：2013-03-14
申请号：PCT/US2012053990
申请日：2012-09-06
申请人： KLA TENCOR CORP , DOYLE PAUL , BELYAEV ALEXANDER
发明人： DOYLE PAUL , BELYAEV ALEXANDER
IPC分类号： H01L21/66
CPC分类号： G02B7/008 , G01N21/9501 , G01N2201/021 , H01L21/67103 , H01L21/68792 , Y10T403/21
摘要： Disclosed herein is an apparatus for providing passive correction for thermal effects on a mounted mechanical component. Further disclosed is a wafer inspection system employing the passive thermal effect correction apparatus.
摘要翻译：本文公开了一种用于对安装的机械部件上的热效应提供被动校正的装置。还公开了采用被动热效应校正装置的晶片检查系统。

5. 发明公开

EP1948823A4 TARGET NUCLEIC ACID SIGNAL DETECTION 审中-公开
标题翻译： ZIELNUKLEINSÄURESIGNALNACHWEIS
公开(公告)号：EP1948823A4
公开(公告)日：2010-01-27
申请号：EP06825860
申请日：2006-10-11
申请人： STRATAGENE CALIFORNIA
发明人： SORGE JOSEPH A , CARSTENS CARSTEN-PETER , MONELL CRAIG ROBERT , BELYAEV ALEXANDER
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6844 , C12Q2537/155 , C12Q2521/101 , C12Q2525/307 , C12Q2521/501 , C12Q2525/155

6. 发明专利

AU8838901A Protein with cap- and cellulose- binding activity 未知
公开(公告)号：AU8838901A
公开(公告)日：2002-03-13
申请号：AU8838901
申请日：2001-08-27
申请人： BELYAEV ALEXANDER
发明人： BELYAEV ALEXANDER
IPC分类号： C07K14/47 , C07K1/00

7. 发明申请

WO2013022713A2 AIR FLOW MANAGEMENT IN A SYSTEM WITH HIGH SPEED SPINNING CHUCK 审中-公开
标题翻译：在高速旋转切割系统中的空气流量管理
公开(公告)号：WO2013022713A2
公开(公告)日：2013-02-14
申请号：PCT/US2012049369
申请日：2012-08-02
申请人： KLA TENCOR CORP , KREN GEORGE , DOYLE PAUL , BELYAEV ALEXANDER
发明人： KREN GEORGE , DOYLE PAUL , BELYAEV ALEXANDER
IPC分类号： H01L21/687 , H01L21/66
CPC分类号： H01L21/68735 , Y10T279/11 , Y10T279/21 , Y10T279/34
摘要： The present invention is directed to a high speed, spinning chuck for use in a semiconductor wafer inspection system. The chuck of the present disclosure is configured with a turbulence-reducing lip. Spinning of the chuck produces radial airflows proximal to a surface of the wafer and proximal to the bottom of the chuck. The turbulence-reducing lip of the chuck of the present disclosure directs the radial airflows off of the top surface of the wafer and the bottom surface of the chuck in a manner that minimizes the size of the low pressure zone formed between these radial airflows. The minimization of the low pressure zone reduces air turbulence about the periphery of the chuck and substrate, thereby reducing the possibility of contaminants in the system being directed onto the surface of the substrate by such air turbulence.
摘要翻译：本发明涉及一种用于半导体晶片检查系统的高速纺丝卡盘。本公开的卡盘配置有减少湍流的唇部。卡盘的旋转产生靠近晶片表面并靠近卡盘底部的径向气流。本公开的卡盘的减少湍流的唇部以使得在这些径向气流之间形成的低压区域的尺寸最小化的方式引导径向气流离开晶片的顶表面和卡盘的底表面。低压区域的最小化减小了卡盘和基板周边的空气湍流，从而降低了系统中的污染物通过这种空气湍流被引导到基板的表面上的可能性。

8. 发明申请

WO2009151984A3 REFERENCED INSPECTION DEVICE 审中-公开
标题翻译：参考检验设备
公开(公告)号：WO2009151984A3
公开(公告)日：2010-03-18
申请号：PCT/US2009045704
申请日：2009-05-29
申请人： KLA TENCOR CORP , DOYLE PAUL , ZHAO GUOHENG , BELYAEV ALEXANDER , RUNYON J REX
发明人： DOYLE PAUL , ZHAO GUOHENG , BELYAEV ALEXANDER , RUNYON J REX
IPC分类号： H01L21/66
CPC分类号： H01L21/6838
摘要： A tool for investigating a substrate, where the tool has a tool head for investigating the substrate, a chuck for disposing an upper surface of the substrate in proximity to the tool head, and an air bearing disposed on the tool head adjacent the substrate. The air bearing has a pressure source and a vacuum source, where the vacuum source draws the substrate toward the air bearing and the pressure source prevents the substrate from physically contacting the air bearing. The pressure source and the vacuum source work in cooperation to dispose the upper surface of the substrate at a known distance from the tool head. By using the air bearing as part of the tool in this manner, registration of the substrate to the tool head is accomplished relative to the upper surface of the substrate, not the back side of the substrate.
摘要翻译：一种用于调查基板的工具，其中该工具具有用于检查基板的工具头，用于将基板的上表面设置在工具头附近的卡盘以及设置在与基板相邻的工具头上的空气轴承。空气轴承具有压力源和真空源，其中真空源将基板拉向空气轴承，并且压力源防止基板物理接触空气轴承。压力源和真空源协同工作，将衬底的上表面设置在与工具头一段已知距离处。通过以这种方式使用空气轴承作为工具的一部分，基板相对于基板的上表面而不是基板的背面完成对准工具头。

9. 发明申请

WO2009154966A3 CLEAVABLE CATALYTIC BINDING AND DETECTION SYSTEM 审中-公开
标题翻译：可清洁的催化结合和检测系统
公开(公告)号：WO2009154966A3
公开(公告)日：2010-02-25
申请号：PCT/US2009045246
申请日：2009-05-27
申请人： AGILENT TECHNOLOGIES INC , BELYAEV ALEXANDER , MONELL CRAIG R , FELTS KATHERINE A
发明人： BELYAEV ALEXANDER , MONELL CRAIG R , FELTS KATHERINE A
IPC分类号： G01N33/535 , C12Q1/25 , C12Q1/42 , G01N33/53 , G01N33/563
CPC分类号： G01N33/581 , C07K16/00 , C07K2319/50 , C07K2319/61 , C12N9/1247
摘要： The present invention provides a detection reagent for detection of the presence of a substance of interest in a sample. The detection reagent comprises a binding portion, a linking portion, and a catalytic portion. The linking portion comprises a cleavage site for cleavage of the binding portion from the catalytic portion. According to the method, the detection reagent is caused to bind to the substance of interest. The bound reagent is then cleaved by breaking of a bond in the linking portion. Upon cleavage, the catalytic portion is removed from the binding reaction mixture and caused to catalyze a reaction that produces a detectable product.
摘要翻译：本发明提供了用于检测样品中感兴趣物质的存在的检测试剂。检测试剂包括结合部分，连接部分和催化部分。连接部分包括用于从催化部分切割结合部分的切割位点。根据该方法，使检测试剂与感兴趣的物质结合。然后通过断裂连接部分中的键将结合的试剂断裂。在裂解时，将催化部分从结合反应混合物中除去并引起催化产生可检测产物的反应。

10. 发明申请

WO2009012220A2 ANALYTE DETECTION ASSAYS 审中-公开
标题翻译：分析检测分析
公开(公告)号：WO2009012220A2
公开(公告)日：2009-01-22
申请号：PCT/US2008069975
申请日：2008-07-14
申请人： AGILENT TECHNOLOGIES INC , BELYAEV ALEXANDER , MONELL CRAIG , SORGE JOSEPH
发明人： BELYAEV ALEXANDER , MONELL CRAIG , SORGE JOSEPH
IPC分类号： G01N33/543 , C12Q1/68
CPC分类号： G01N33/58 , C12Q1/6804 , C12Q1/6853 , G01N33/543 , C12Q2563/179 , C12Q2525/117 , C12Q2521/101 , C12Q2525/186 , C12Q2521/543
摘要： The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a binding molecule coupled to a first polymerase is incubated with a modified polynucleotide template to form a copy of the modified polynucleotide template without any modified nucleotides. The unmodified copy is detected in a second amplification/primer extension reaction using a second polymerase that is unable to amplify the modified polynucleotide template. Detection of the unmodified copy is indicative of the presence and/or amount of the analyte in the sample. In place of the binding molecule coupled to a first polymerase, a pair of analyte-specific probes can also be used. The first analyte specific probe comprises a first binding moiety and a first portion of a first polymerase and the second analyte specific probe comprises a second binding moiety and a second portion of the first polymerase. When the binding moieties are bound to the analyte the first and second portions of the polymerase interact to form a functional polymerase complex that is used to form a copy of the modified polynucleotide template without any modified nucleotides.
摘要翻译：本发明提供了用于检测分析物的方法，试剂盒和组合物。在本发明的方法中，将与第一聚合酶偶联的结合分子与修饰的多核苷酸模板一起温育以形成修饰的多核苷酸模板的拷贝，而不用任何修饰的核苷酸。使用不能扩增修饰的多核苷酸模板的第二聚合酶在第二扩增/引物延伸反应中检测未修饰的拷贝。未修饰拷贝的检测表明样品中分析物的存在和/或量。代替与第一聚合酶偶联的结合分子，也可以使用一对分析物特异性探针。第一分析物特异性探针包含第一聚合酶的第一结合部分和第一部分，第二分析物特异性探针包含第一聚合酶的第二结合部分和第二部分。当结合部分与分析物结合时，聚合酶的第一和第二部分相互作用以形成功能性聚合酶复合物，其用于形成修饰的多核苷酸模板的拷贝而没有任何修饰的核苷酸。

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