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1. 发明申请

WO2014170870A3 A PROSTHETIC HEART VALVE 审中-公开
标题翻译：一种人造心脏瓣膜
公开(公告)号：WO2014170870A3
公开(公告)日：2014-10-23
申请号：PCT/IB2014/060816
申请日：2014-04-17
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： PARK, Kenneth Stuart , APPA, Harish , VISAGIE, Claude , BEZUIDENHOUT, Deon , ZILLA, Peter Paul
IPC分类号： A61F2/24
摘要： A prosthetic heart valve (10) which includes a stent (14) having three leaflets (12) attached thereto is provided. The stent (14) is compressible so as to be capable of being introduced into a patient's body through a minimally invasive procedure and has a ring-like body (16) defining in its height three arch-shaped elements (18). Each element (18) includes an arc (20) and a pair of haunches (22) extending from opposite sides thereof, with three commissural posts (26) formed by the haunches (22) of adjacent elements (18). The leaflets (12) each have an attachment edge (28) and a free edge (30) with a belly (32) extending therebetween. The leaflets (12) are movable between a coapted condition, in which the free edges (30) abut and prevent fluid flow through the valve (10), and an open condition, in which fluid flow through the valve (10) is permitted. The leaflets (12) are made from a polymeric material and are moulded directly onto the stent (14) so as to provide for continuous attachment thereof.
摘要翻译：提供了一种假体心脏瓣膜（10），该假体心脏瓣膜（10）包括具有附接到其上的三个小叶（12）的支架（14）。支架（14）是可压缩的，以便能够通过微创手术引入患者体内并且具有在其高度上限定三个弓形元件（18）的环状主体（16）。每个元件（18）包括弧（20）和从其相对侧延伸的一对隆起（22），并具有由相邻元件（18）的隆起（22）形成的三个连合柱（26）。小叶（12）每个都具有附接边缘（28）和自由边缘（30），并具有在其间延伸的腹部（32）。小叶12可在其中自由边缘30邻接并防止流体流过阀10的合适状态和允许流体流过阀10的打开状态之间移动。小叶（12）由聚合材料制成并直接模制在支架（14）上以提供其连续附接。

2. 发明申请

WO2014030078A1 INFLATABLE DISTENDER 审中-公开
标题翻译：可燃物
公开(公告)号：WO2014030078A1
公开(公告)日：2014-02-27
申请号：PCT/IB2013/054010
申请日：2013-05-16
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： ZILLA, Peter Paul , ROBINSON, Timothy W. , MURPHY, Andrew , PARK, Kenneth Stuart
IPC分类号： A61M29/02 , A61B17/02 , A61M25/10
CPC分类号： A61B17/0218 , A61B2017/00557 , A61B2017/00778 , A61B2017/00783 , A61M25/1002 , A61M25/1027 , A61M25/1029 , A61M2025/1013 , A61M2025/1052 , A61M2025/1093 , A61M2025/1097
摘要： An inflatable distender is provided comprising at least one inflatable support tube (1) that has a collapsed condition in which the at least one inflatable support tube is collapsed to enable introduction and removal of the distender to and from an operative site in a vessel or other hollow organ of a patient and an inflated operative condition in which it assumes the form of an elongated tube extending in a generally spiral path along the length of the distender. The at least one inflatable support tube in the inflated operative condition defines a self supporting spiral configuration of generally annular shape in cross-section with an inner diameter of the annular shape being equal to at least one diameter of the inflatable support tube so as to define a generally straight tubular flow passage through the distender between a proximal end (2) and a distal end (5) thereof.
摘要翻译：提供了一种可膨胀的膨胀器，其包括至少一个充气支撑管（1），该充气支撑管具有塌缩状态，其中所述至少一个可充气支撑管被折叠，以使得能够将膨胀器引入和移出容器或其他患者的中空器官和充气的手术状态，其中其呈现沿着扩张器的长度在大致螺旋路径中延伸的细长管的形式。处于膨胀的操作状态的至少一个充气支撑管限定了一个自支撑的螺旋形结构，其横截面为大致环形形状，其中环形形状的内径等于可充气支撑管的至少一个直径，以便限定大致直的管状流动通道，其通过远端（2）和远端（5）之间的扩张器。

3. 发明申请

WO2019038608A1 INVAGINATING DEVICE 审中-公开
公开(公告)号：WO2019038608A1
公开(公告)日：2019-02-28
申请号：PCT/IB2018/055054
申请日：2018-07-10
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： ZILLA, Peter Paul , VAN BREDA, Braden Sydney Clive , BEZUIDENHOUT, Deon
IPC分类号： A61B17/34 , A61B1/00 , A61M25/01
摘要： An invaginating device (10) includes an inner elongate member (12) and an outer flexible tube (14) with invaginated axial ends. The outer flexible tube is: disposed at a first axial end of the inner elongate member; concentric with the inner elongate member; sized to provide a radial gap (24) there between; sealably connected at the axial ends of the outer flexible tube to the inner elongate member, with the axial spacing between such sealed axial ends being less than the axial length of the outer tube; and extendable to protrude from the first axial end of the inner elongate member and retractable to reduce such protrusion from the first axial end of the inner elongate member. Fluid contained within the radial gap (24) defined between the inner elongate member and the outer flexible tube is either pressurized or a non-compressible fluid. An actuator (16) is: movable relative to the inner elongate member; and engageable with the outer flexible tube to extend the outer flexible tube relative to the first axial end of the inner elongate member.

4. 发明申请

WO2018232425A1 VALVE LEAFLET CONNECTING DEVICE 审中-公开
公开(公告)号：WO2018232425A1
公开(公告)日：2018-12-20
申请号：PCT/ZA2018/050034
申请日：2018-06-11
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： COUSINS, Michael Alan , ROWSELL, Gary Steven , PERUMALL, Preyen Agasthian , JARMAN, Jeremy Douglas , MUDGE, Edward Charles , HENCHIE, Travis Foster , COOMBES, Heather Madeleine , ZILLA, Peter Paul , BEZUIDENHOUT, Deon
IPC分类号： A61B17/00 , A61B17/064 , A61B17/068 , A61B17/10 , A61B17/128 , A61B17/08
摘要： A valve leaflet connecting device includes: a base; and first and second followers extending from the base. A first arm extends from the first follower in a direction away from the second follower and away from the base to define an acute angle between the first follower and first arm for capturing a first leaflet there between. A second arm extends from the second follower in a direction away from the first follower and away from the base to define an acute angle between the second follower and second arm for capturing a second leaflet there between, The first and second followers are resiliently deformable between: (i) an open condition, in which: the point from which the first arm extends from the first follower; and the point from which the second arm extends from the second follower, are spaced more than 15mm; and (ii) a closed condition, in which: the point from which the first arm extends from the first follower; and the point from which the second arm extends from the second follower, are spaced less than 5mm. Deforming means deform the followers towards the closed condition. A positioner extends from the base, between the first and second followers, and a fastener releasably secured to the positioner, includes first and second fastener jaws. The first and second jaws: extend away from the base; and are movable between: (i) a splayed condition in which leaflets may be received between the first and second fastener jaws; and (ii) a securing condition in which the first and second fastener jaws secure the leaflets there between. In use: (i) the first and second followers may be: passed axially through a valve, between first and second valve leaflets; and resiliently deformed by opening and closing of the valve leaflets; (ii) the first arm may capture the first leaflet between the first arm and the first follower, and the second arm may capture the second leaflet between the second arm and the second follower, with the first and second followers disposed between the first and second leaflets; (iii) the deforming means may deform the first and second followers towards the closed condition, thereby moving the first and second leaflets towards each other; (iv) the fastener may receive the first and second leaflets between the fastener jaws when the fastener jaws are in the spayed condition; and (v) moving the fastener jaws towards the securing condition secures the first and second leaflets to each other. Alternatively, the arms and fastener jaws may extend towards the base.

5. 发明申请

WO2016110760A1 HEART VALVE LEAFLET CAPTURE DEVICE 审中-公开
标题翻译：心阀叶片捕获装置
公开(公告)号：WO2016110760A1
公开(公告)日：2016-07-14
申请号：PCT/IB2015/059785
申请日：2015-12-18
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： COUSINS, Michael, Alan , GERHARDT, Thomas , MUDGE, Edward Charles , JARMAN, Jeremy Douglas , COOMBES, Heather Madeleine , ZILLA, Peter Paul , BEZUIDENHOUT,, Deon
IPC分类号： A61B17/128 , A61B17/064 , A61B17/068 , A61B17/29
CPC分类号： A61B17/1285 , A61B17/00234 , A61B17/0643 , A61B17/0682 , A61B17/122 , A61B17/29 , A61B2017/00243 , A61B2017/00309 , A61B2017/00336 , A61B2017/00473 , A61B2017/00783 , A61B2017/2926 , A61B2090/064 , A61F2/2463 , A61F2/2466
摘要： The invention provides a heart valve leaflet capture device (250) comprising a cardiac catheter probe having a proximal end for manipulating the device (250) and a distal end terminating in a transvalve element (256). The transvalve element (256) is configured to pass through a heart valve generally parallel to a longitudinal axis of the catheter and includes two or three leaflet gripping elements (252). The leaflet gripping elements (252) are individually movable by operation of an associated actuating mechanism (260) between a radially retracted position, in which they are withdrawn with respect to the transvalve element (256), and a capture position, in which they diverge outwardly at an acute angle from the transvalve element (256). In the capture position, each leaflet gripping element (252) defines a convergent capture zone that is directed towards the edges of a target valve leaflet and in which the target valve leaflet may be captured.
摘要翻译：本发明提供了一种包括心脏导管探针的心脏瓣膜小叶捕获装置（250），所述心脏导管探针具有用于操纵装置（250）的近端和终止于跨阀元件（256）的远端。跨阀元件（256）构造成通过大致平行于导管的纵向轴线的心脏瓣膜，并且包括两个或三个小叶夹持元件（252）。小叶夹紧元件（252）可以通过相关联的致动机构（260）的操作在径向缩回位置之间单独移动，在径向缩回位置，它们相对于转阀元件（256）被抽出，并且捕获位置发生分离向外与转阀元件（256）成锐角。在捕获位置中，每个叶片夹持元件（252）限定了一个会聚捕获区，该收敛区指向目标瓣叶的边缘，并且其中可捕获目标瓣叶。

6. 发明申请

WO2018152556A1 DILATATION DEVICE 审中-公开
公开(公告)号：WO2018152556A1
公开(公告)日：2018-08-23
申请号：PCT/ZA2018/050010
申请日：2018-02-14
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： ZILLA, Peter Paul , BEZUIDENHOUT, Deon , MUDGE, Edward Charles Teddy
IPC分类号： A61M25/10 , A61F2/958
摘要： A dilatation device (10) includes a support (14) and at least one inflatable tube (16). The inflatable tube is wound helically around the support and also defines a series of inflatable zones (26) along its length, with successive inflatable zones spaced by an intermediate zone (28) that is more resistive to radial expansion than the inflatable zones. The inflatable tube further defines a fluid inlet (22,24) for: introducing fluid to inflate the inflatable zones; and extracting fluid from the inflatable tube to deflate it, with each inflatable zone being in fluid communication with its successive inflatable zones via the intermediate zones. The axial critical buckling load of the inflatable zones is less than the radial critical buckling load of the inflatable zones, to cause the inflatable zones to concertina axially when the inflatable tube is depressurized, thereby causing the intermediate zones to displace towards each other.

7. 发明申请

WO2017149471A1 AN INFLATABLE INSERTION DEVICE FOR PERCUTANEOUS INSERTION 审中-公开
标题翻译：一种用于经皮插入的充气插入装置
公开(公告)号：WO2017149471A1
公开(公告)日：2017-09-08
申请号：PCT/IB2017/051196
申请日：2017-03-01
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： GELDENHUYS, Giuseppe , GILDENHUYS, Fourie , VAN BREDA, Braden Sydney Clive , PARK, Kenneth Stuart , VAN ZYL, Nick Carl , DE VILLIERS, Jandre , ZILLA, Peter Paul , BEZUIDENHOUT, Deon
IPC分类号： A61F2/958 , A61B17/12 , A61M25/01 , A61M25/10 , A61F2/24
摘要： The invention provides an inflatable insertion device (10) capable of being percutaneously introduced into a patient's body. The insertion device (10) comprises an inflatable element (12) having a distal end (18) and a proximal end (16) and which is operable between a collapsed condition and an inflated condition by introducing an inflating fluid therein. An elongate member (22) extends internally of the inflatable element (12) from its distal end (18). The internal member (22) is capable of being withdrawn towards the proximal end (16) of the inflatable element (12) to result in the distal end (18) of the element (12) being withdrawn towards the proximal end (16) internally of the element (12). The invention further provides a locating device comprising a catheter having a catheter tube fitted with one or more inflatable insertion devices at a distal end thereof.
摘要翻译：本发明提供了一种能够经皮引入患者体内的可膨胀插入装置（10）。插入装置（10）包括具有远端（18）和近端（16）的可膨胀元件（12），并且可通过将膨胀流体引入其中而在塌缩状态和膨胀状态之间操作。细长构件（22）从可膨胀元件（12）的远端（18）内部延伸。内部构件（22）能够朝着可膨胀元件（12）的近端（16）撤回以导致元件（12）的远端（18）在内部朝向近端（16）撤回（12）。本发明还提供了一种定位装置，其包括具有导管管的导管，所述导管管在其远端装配有一个或多个可膨胀的插入装置。

8. 发明申请

WO2016178177A1 A NON-OCCLUSIVE DILATION AND DEPLOYMENT CATHETER DEVICE 审中-公开
标题翻译：一个非潜力的放电和部署导管器件
公开(公告)号：WO2016178177A1
公开(公告)日：2016-11-10
申请号：PCT/IB2016/052571
申请日：2016-05-05
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： GERHARDT, Thomas , HAW, Peter Rudi , JARMAN, Jeremy Douglas , GELDENHUYS, Giuseppe , PARK, Kenneth Stuart , VAN BREDA, Braden Sydney Clive , MUDGE, Edward Charles , BEZUIDENHOUT, Deon , ZILLA, Peter Paul
IPC分类号： A61M25/10 , A61F2/95
CPC分类号： A61F2/2433 , A61F2/013 , A61F2/243 , A61F2/90 , A61F2/95 , A61F2/958 , A61F2230/0034 , A61F2230/0078 , A61F2230/0091 , A61F2250/0003 , A61F2250/0039 , A61M25/10
摘要： The invention provides a non-occlusive dilation and deployment catheter device (10) which includes a catheter (12) having a distal end (14) configured for entering a patient and a proximal end for manipulating the device. A distender (16) is provided at or near the distal end (14) which is movable between a collapsed configuration which enables introduction and removal thereof to and from an operative site in a vessel or other hollow organ of a patient, and an expanded configuration in which the distender (16) assumes a radially expanded condition and defines a flow path (18) therethrough. The distender (16) includes a substantially tubular, radially expandable frame (20) having a plurality of spaced apertures (22) and at least one inflatable tube (24) threaded through the apertures (22) and shaped to extend in a spiral when inflated. The distender (16) is movable to the expanded configuration by inflating the tube (24), and movable to the collapsed configuration from the expanded configuration by deflating the tube (24).
摘要翻译：本发明提供了一种非闭塞性扩张和展开导管装置（10），其包括导管（12），该导管（12）具有构造成用于输入患者的远端（14）和用于操纵该装置的近端。在远端（14）处或附近设置扩张器（16），所述扩张器（16）可在收缩构型之间移动，该折叠构型能够将其引入和移出患者的容器或其他中空器官中的手术部位和扩张构型其中所述膨胀器（16）呈现径向膨胀状态并且限定穿过其中的流动路径（18）。膨胀器（16）包括具有多个间隔开的孔（22）的基本上管状的可径向扩张的框架（20）和穿过孔（22）的至少一个可充气管（24），并且在充气时成形为螺旋状延伸。膨胀器（16）通过使管（24）膨胀而可移动到膨胀构型，并且通过使管（24）放气而从膨胀构型移动到收缩构型。

9. 发明申请

WO2014207699A1 ORIENTATION DEVICE FOR USE IN MITRAL VALVE REPAIR 审中-公开
标题翻译：用于麻醉阀维修的定位装置
公开(公告)号：WO2014207699A1
公开(公告)日：2014-12-31
申请号：PCT/IB2014/062630
申请日：2014-06-26
申请人： STRAIT ACCESS TECHNOLOGIES HOLDINGS (PTY) LTD
发明人： GERHARDT, Thomas , COUSINS, Michael Alan , HAW, Peter Rudi , JARMAN, Jeremy, Douglas , MUDGE, Edward, Charles , COOMBES, Heather Madeleine , BEZUIDENHOUT, Deon , ZILLA, Peter Paul
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/00234 , A61B5/02158 , A61B17/3468 , A61B2017/00022 , A61B2017/00243 , A61B2017/00327 , A61B2017/00557 , A61B2017/00867 , A61B2017/22068 , A61B2017/22098 , A61B2017/3425 , A61B2017/3488 , A61B2090/064 , A61M25/0074 , A61M25/04 , A61M2025/0002
摘要： An orientation device (200) for use in mitral valve repair surgery is provided and includes a catheter (202) catheter insertable percutaneously through the mitral valve into a chamber of a heart. At least one pressure sensor (216, 218) and two generally arcuate commissural arms (208, 210) are provided at or near the distal end (204) of the catheter (202). The arms (208, 210) are deployable from a stowed condition, in which the catheter (202) can be introduced percutaneoulsy into the heart, to an operative condition in which they extend outwardly in generally opposite directions. Each arm (208, 210) is shaped to be locatable within a mitral valve commissure and has an indentation (212) shaped to extend, in use, at least partially about a mitral valve commissure to limit movement of the device (200) relative to the mitral valve in the axial direction of the catheter (202).
摘要翻译：提供了用于二尖瓣修复手术的定向装置（200），并且包括可经由二尖瓣经皮插入到心脏腔室中的导管（202）导管。至少一个压力传感器（216,218）和两个大体上弓形的连合臂（208,210）设置在导管（202）的远端（204）处或附近。臂（208,210）可以从收起的状态展开，其中导管（202）可以通过胆管内引入心脏，达到操作状态，其中它们在大致相反的方向上向外延伸。每个臂（208,210）成形为可定位在二尖瓣合并中，并且具有成形为在使用中至少部分地围绕二尖瓣连接延伸的凹陷（212），以限制装置（200）相对于二尖瓣在导管（202）的轴向上。

10. 发明授权

EP3242609B1 HEART VALVE LEAFLET CAPTURE DEVICE 有权
公开(公告)号：EP3242609B1
公开(公告)日：2020-02-12
申请号：EP15825960.6
申请日：2015-12-18
申请人： Strait Access Technologies Holdings (PTY) LTD
发明人： COUSINS, Michael, Alan , GERHARDT, Thomas , MUDGE, Edward Charles , JARMAN, Jeremy Douglas , COOMBES, Heather Madeleine , ZILLA, Peter Paul , BEZUIDENHOUT, Deon
IPC分类号： A61B17/128 , A61B17/064 , A61B17/068 , A61B17/29

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