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1. 发明申请

WO2003059169A1 TISSUE IMAGING AT SUPERHARMONIC FREQUENCIES 审中-公开
标题翻译：组织成像在超级频率
公开(公告)号：WO2003059169A1
公开(公告)日：2003-07-24
申请号：PCT/EP2003/000517
申请日：2003-01-17
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , BOUAKAZ, Ayache , DE JONG, Nico
发明人： BOUAKAZ, Ayache , DE JONG, Nico
IPC分类号： A61B8/14
CPC分类号： G01S7/52038 , A61B8/14 , G01S7/52046 , G01S15/8993
摘要： Ultrasound imaging of tissue in medical applications is carried out by transmitting ultrasound energy into a target volume at least a first fundamental frequency, receiving reflected and/or scattered ultrasound energy from the target volume; and detecting components of the received signal at multiple harmonics of the fundamental frequency or at one or more of the third to fifth harmonics of the fundamental frequency. A image of the target volume is generated using the detected harmonic components of the received signal.
摘要翻译：医疗应用中组织的超声成像通过将至少第一基频发射超声能量到目标体积中，从目标体积接收反射和/或散射的超声能量，并在基波的多次谐波处检测接收信号的分量频率或基频的第三至第五谐波中的一个或多个。使用检测到的接收信号的谐波分量来产生目标音量的图像。

2. 发明申请

WO2006021400A1 TECHNIQUES FOR IMPROVING ULTRASOUND CONTRAST RATIO 审中-公开
标题翻译：改善超声对比度比的技术
公开(公告)号：WO2006021400A1
公开(公告)日：2006-03-02
申请号：PCT/EP2005/009046
申请日：2005-08-19
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , BOUAKAZ, Ayache , BORSBOOM, Jerome, Maria, George , DE JONG, Nicolaas
发明人： BOUAKAZ, Ayache , BORSBOOM, Jerome, Maria, George , DE JONG, Nicolaas
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , G01S7/52036 , G01S7/52039 , G01S15/8959
摘要： An ultrasound technique exploits differences in statefulness of response in order to distinguish between the objects of interest. The method comprises transmitting a primary excitation signal and one or more secondary excitation signals; into a target medium receiving a corresponding plurality of responses from the target medium respectively resulting from the plurality of discrete excitation signals; and generating an output signal comprising the difference between the response to the primary excitation signal and either (i) the sum of the responses to the secondary excitation signals, or (ii) the sum of the response to a single secondary excitation signal and one or more time-shifted copies of the response to the single secondary excitation signal, the time shift being selected for appropriate alignment of the copy relative to the first response and the second response .
摘要翻译：超声技术利用了响应状态的差异，以便区分感兴趣的对象。该方法包括发送主激励信号和一个或多个次激励信号; 分别接收从所述多个离散激励信号分别产生的来自所述目标介质的相应多个响应的目标介质; 并且产生包括对主激励信号的响应之间的差异的输出信号和（i）对辅助激励信号的响应的总和，或者（ii）对单次辅激励信号的响应之和，以及对单个辅助激励信号的响应的更多的时移副本，选择时间偏移以用于副本相对于第一响应和第二响应的适当对准。

3. 发明申请

WO2005013822A1 METHOD AND APPARATUS FOR THE ASSESSMENT OF BIOMECHANICAL PROPERTIES USING ULTRASOUND 审中-公开
标题翻译：使用超声波评估生物体特性的方法和装置
公开(公告)号：WO2005013822A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/007576
申请日：2004-07-06
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , BOUAKAZ, Ayache , DE JONG, Nicolaas , SNIJDERS, Christiaan, Johannes , VLAANDEREN, Ester
发明人： BOUAKAZ, Ayache , DE JONG, Nicolaas , SNIJDERS, Christiaan, Johannes , VLAANDEREN, Ester
IPC分类号： A61B5/103
CPC分类号： A61B5/4528 , A61B5/0048 , A61B5/0051 , A61B5/441 , A61B5/6843 , A61B8/0875 , G01N29/07 , G01N29/12 , G01N29/348 , G01N2291/02483 , G01N2291/02836
摘要： A method and apparatus for measuring mechanical properties of a system under investigation, such as the biomechanical properties and dynamic characteristics of a musculoskeletal system in the human body. The system under investigation includes multiple component parts (eg. bones, muscles, ligaments, etc) having differing ultrasound reflection / transmission properties and whose relative spatial relationship can vary due to the resilience, plasticity and or elasticity of at least one of the component parts. Movement in the system is induced by way of a mechanical stimulator. Ultrasound detection signals are directed into the system at times such that at least some induced movement has occurred in target structures within the system, between a first detection signal and a second detection signal. Ultrasound echo signals are used to determine mechanical properties of the system.
摘要翻译：一种用于测量正在研究的系统的机械性能的方法和装置，例如人体肌肉骨骼系统的生物力学性质和动态特性。正在研究的系统包括具有不同超声反射/透射性质的多个组成部分（例如骨骼，肌肉，韧带等），并且其相对空间关系可以由于至少一个部件的弹性，可塑性和/或弹性而变化。系统中的运动是通过机械刺激器引起的。有时，超声检测信号被引导到系统中，使得在第一检测信号和第二检测信号之间的至少一些诱发的运动已经发生在系统内的目标结构中。超声回波信号用于确定系统的机械性能。

4. 发明申请

WO2005071437A1 CONTRAST DUAL FREQUENCY IMAGING 审中-公开
标题翻译：对比双频成像
公开(公告)号：WO2005071437A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/000668
申请日：2005-01-20
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN , DE JONG, Nicolaas , BOUAKAZ, Ayache
发明人： DE JONG, Nicolaas , BOUAKAZ, Ayache
IPC分类号： G01S15/89
CPC分类号： G01S7/52022 , G01S7/52041 , G01S15/8952 , G01S15/8961 , G01S15/8963 , G01S15/899
摘要： A method and apparatus for ultrasound imaging which uses dual frequency excitation of a target. The target is simultaneously irradiated with a relatively low frequency ultrasound conditioning signal and a relatively high frequency ultrasound detection signal. The conditioning signal modulates a physical property (e.g. size) of first structures (e.g. gas bubbles) within the target, which modulation causes changes in the echo signal response of the first structures to the detection signal. A signal processor is adapted to process the received echo signals to detect the presence of the first structures by virtue of a first magnitude of detection signal echo arising from periods when the conditioning signal is in a first phase and a second, different, magnitude of detection signal echo arising from periods when the conditioning signal is in a second phase.
摘要翻译：一种用于超声成像的方法和装置，其使用目标的双频激励。用相对较低频率的超声波调理信号和较高频率的超声波检测信号同时照射靶。调节信号调制目标内的第一结构（例如气泡）的物理性质（例如大小），该调制使得第一结构的回波信号响应变化到检测信号。信号处理器适于处理所接收的回波信号，借助于第一幅度的检测信号回波来检测第一结构的存在，所述检测信号回波是在调节信号处于第一阶段和第二，不同大小的检测当调节信号处于第二阶段时产生的信号回波。

5. 发明公开

EP1469779A1 TISSUE IMAGING AT SUPERHARMONIC FREQUENCIES 审中-公开
标题翻译：组织中谐波谐波成像
公开(公告)号：EP1469779A1
公开(公告)日：2004-10-27
申请号：EP03702475.9
申请日：2003-01-17
申请人： STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN
发明人： BOUAKAZ, Ayache , DE JONG, Nico
IPC分类号： A61B8/14 , G01S7/52 , G01S15/89
CPC分类号： G01S7/52038 , A61B8/14 , G01S7/52046 , G01S15/8993
摘要： Ultrasound imaging of tissue in medical applications is carried out by transmitting ultrasound energy into a target volume at least a first fundamental frequency, receiving reflected and/or scattered ultrasound energy from the target volume; and detecting components of the received signal at multiple harmonics of the fundamental frequency or at one or more of the third to fifth harmonics of the fundamental frequency. A image of the target volume is generated using the detected harmonic components of the received signal.

6. 发明公开

EP1656066A1 METHOD AND APPARATUS FOR THE ASSESSMENT OF BIOMECHANICAL PROPERTIES USING ULTRASOUND 审中-公开
标题翻译：方法和设备进行评估生物力学特性借助超声波
公开(公告)号：EP1656066A1
公开(公告)日：2006-05-17
申请号：EP04740857.0
申请日：2004-07-06
申请人： Stichting voor de Technische Wetenschappen
发明人： BOUAKAZ, Ayache , DE JONG, Nicolaas , SNIJDERS, Christiaan, Johannes , VLAANDEREN, Ester
IPC分类号： A61B5/103 , A61B8/08
CPC分类号： A61B5/4528 , A61B5/0048 , A61B5/0051 , A61B5/441 , A61B5/6843 , A61B8/0875 , G01N29/07 , G01N29/12 , G01N29/348 , G01N2291/02483 , G01N2291/02836
摘要： A method and apparatus for measuring mechanical properties of a system under investigation, such as the biomechanical properties and dynamic characteristics of a musculoskeletal system in the human body. The system under investigation includes multiple component parts (eg. bones, muscles, ligaments, etc) having differing ultrasound reflection / transmission properties and whose relative spatial relationship can vary due to the resilience, plasticity and or elasticity of at least one of the component parts. Movement in the system is induced by way of a mechanical stimulator. Ultrasound detection signals are directed into the system at times such that at least some induced movement has occurred in target structures within the system, between a first detection signal and a second detection signal. Ultrasound echo signals are used to determine mechanical properties of the system.

7. 发明申请

WO2009133207A1 A METHOD FOR COMPENSATING A HARMONIC COMPONENT OF AN EMITTED ULTRASOUND WAVE. 审中-公开
标题翻译：一种用于补偿发射超声波的谐波分量的方法。
公开(公告)号：WO2009133207A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055355
申请日：2009-05-04
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , BOUAKAZ, Ayache , NOVELL, Anthony
发明人： BOUAKAZ, Ayache , NOVELL, Anthony
IPC分类号： G01S15/89 , G01S7/52
CPC分类号： G01S15/8952 , G01S7/52038 , G01S7/52046
摘要： Method for compensating an harmonic component (Hn) of an emitted ultrasound wave (es), comprising an ultrasound transducer (10). An excitation signal (e) is generated and comprises a first signal (e1) having a first harmonic component (H1) at a first fundamental frequency (f1) and being applied to the ultrasound transducer (10) for transmitting the emitted ultrasound wave (es). The emitted ultrasound wave (es) comprises the harmonic component (Hn) at a harmonic frequency higher and natural number multiple of the first fundamental frequency. The excitation signal (e) further comprises a second signal (e2) added to the first signal (e1), comprising parameters one of which is tuned so that the harmonic component has a minimal amplitude, the parameters being at least a predetermined frequency, a predetermined amplitude, a predetermined phase with respect to the first signal (e1), and a predetermined bandwidth. The predetermined frequency is different than the harmonic frequency.
摘要翻译：用于补偿包括超声换能器（10）的发射超声波的谐波分量（Hn）的方法。产生激励信号（e），并且包括具有第一基频（f1）的第一谐波分量（H1）的第一信号（e1）并且被施加到超声换能器（10），用于传输发射的超声波）。发射的超声波包括谐波频率高于第一基频的自然数倍的谐波分量（Hn）。激励信号（e）还包括添加到第一信号（e1）的第二信号（e2），包括其中一个被调谐的参数，使得谐波分量具有最小振幅，参数至少为预定频率，预定幅度，相对于第一信号（e1）的预定相位和预定带宽。预定频率不同于谐波频率。

8. 发明申请

WO2007015176A2 CHIRP REVERSAL ULTRASOUND CONTRAST IMAGING 审中-公开
标题翻译： CHIRP REVERSAL超声造影成像
公开(公告)号：WO2007015176A2
公开(公告)日：2007-02-08
申请号：PCT/IB2006/002954
申请日：2006-06-23
申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , BOUAKAZ, Ayache
发明人： BOUAKAZ, Ayache
IPC分类号： G01S15/89
CPC分类号： G01S15/8954 , G01S7/52039 , G01S15/104 , G01S15/8959 , G01S15/8961
摘要： The invention relates to a method for detecting and imaging ultrasound echo signals returned from a target object comprising microbubbles, said microbubbles being characterized by a resonance frequency, said method comprising the steps of irradiating said target object with at least a first and second successive excitation signals, said first excitation signal being a sweep of increasing frequency with time, and said second excitation signal being a sweep of decreasing frequency with time, detecting echo signals of said first and second excitation signals from said target object, and, combining said echo signals. The maximum frequencies of said first and second excitation signals are lower than said resonance frequency. The invention also relates to an imaging apparatus.
摘要翻译：本发明涉及一种用于检测和成像从包含微泡的目标物体返回的超声回波信号的方法，所述微泡的特征在于共振频率，所述方法包括以下步骤：用at 至少第一和第二连续激励信号，所述第一激励信号是随时间增加的频率的扫描，并且所述第二激励信号是频率随时间降低的扫描，检测来自所述目标物体的所述第一和第二激励信号的回波信号，并且组合所述回声信号。所述第一和第二激励信号的最大频率低于所述谐振频率。本发明还涉及一种成像装置。

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