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1. 发明授权

US10010558B2 Frankiamicin A compositions and methods 有权
公开(公告)号：US10010558B2
公开(公告)日：2018-07-03
申请号：US15552541
申请日：2016-02-23
申请人： STC.UNM , Charles Melancon , Pamela Hall , Jacob Greenberg , Yasushi Ogasawara , Snezna Rogelj
发明人： Charles Melancon , Pamela Hall , Jacob Greenberg , Yasushi Ogasawara , Snezna Rogelj
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , A61K31/122 , A61K31/192
摘要： In one aspect, this disclosure describes a pharmaceutical composition that generally includes frankiamicin A and a pharmaceutically acceptable carrier. In another aspect, this disclosure describes a method of treating a subject having, or at risk of having, a condition caused by a microbial infection treatable with frankiamicin A. Generally, the method includes administering to the subject an amount of frankiamicin A effective to ameliorate at least one symptom or clinical sign of the condition.

2. 发明申请

US20070006357A1 Protective bib with disposable wipe cloth 审中-公开
标题翻译：带一次性擦拭布的防护围兜
公开(公告)号：US20070006357A1
公开(公告)日：2007-01-11
申请号：US11479019
申请日：2006-06-29
申请人： Pamela Hall
发明人： Pamela Hall
IPC分类号： A41B13/00
CPC分类号： A41B13/103
摘要： This invention is an addition to a bib pouch; the bib has a pouch of absorbent fabric. To store cloth/like inside, to assist the care-giver to wipe away liquid or food that so often Run down the baby mouth when feeding, the inside of the pouch have an absorbent Fabric to keep the cloth/like dry-free inside of the pouch, the sides of the pouch as Velcro Strips to open a close the pouch, the top of pouch have zipper or Velcro Strips for easy access for the care-giver to asset the babies during feeding time, The bib pouch is also washable.
摘要翻译：本发明是围兜袋的补充; 围兜具有一袋吸收性织物。在里面存放衣物，以协助护理人员擦拭液体或经常食用的食物，当喂食时，请将婴儿口罩放下，袋子里面有一层吸水织物，可以将布料/类似物无干燥袋子，袋子的两侧作为魔术贴条打开一个靠近的袋子，顶部的袋子有拉链或魔术贴条，方便进入护理人员在喂养时间资助婴儿，围嘴袋也是可洗的。

3. 发明申请

US20190038735A1 VLP-BASED VACCINES FOR TARGETING STAPHYLOCOCCUS AUREUS SECRETED VIRULENCE FACTORS 审中-公开
公开(公告)号：US20190038735A1
公开(公告)日：2019-02-07
申请号：US16074886
申请日：2017-02-01
申请人： STC.UNM
发明人： Pamela Hall , Bryce Chackerian , David S. Peabody , Seth Michael Daly , Bradley Owen Elmore , Kathleen Triplett
IPC分类号： A61K39/085 , A61P31/04 , A61P37/04
CPC分类号： A61K39/085 , A61K2039/52 , A61K2039/5258 , A61P31/04 , A61P37/04 , C12N2795/18123
摘要： The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

4. 发明授权

US10561648B2 Inhibition and treatment of bacterial infections by sex-specific GPER targeting 有权
公开(公告)号：US10561648B2
公开(公告)日：2020-02-18
申请号：US16067721
申请日：2017-01-09
申请人： STC.UNM
发明人： Pamela Hall , Eric R. Prossnitz , Helen J. Hathaway
IPC分类号： A61K31/473 , A61K45/06 , A61K35/644 , A61K38/14 , C07K14/705 , A61K31/4741 , A61P31/04
摘要： The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition —and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

5. 发明申请

US20190000830A1 INHIBITION AND TREATMENT OF BACTERIAL INFECTIONS BY SEX-SPECIFIC GPER TARGETING 审中-公开
公开(公告)号：US20190000830A1
公开(公告)日：2019-01-03
申请号：US16067721
申请日：2017-01-09
申请人： STC.UNM
发明人： Pamela Hall , Eric R. Prossnitz , Helen J. Hathaway
IPC分类号： A61K31/473 , A61K45/06 , A61P31/04
CPC分类号： A61K31/473 , A61K31/4741 , A61K35/644 , A61K38/14 , A61K45/06 , A61P31/04 , C07K14/70567 , A61K2300/00
摘要： The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition—and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bacterial pathogens, including MRSA are also described.

6. 发明授权

US10821167B2 VLP-based vaccines for targeting Staphylococcus aureus secreted virulence factors 有权
公开(公告)号：US10821167B2
公开(公告)日：2020-11-03
申请号：US16074886
申请日：2017-02-01
申请人： STC.UNM
发明人： Pamela Hall , Bryce Chackerian , David S. Peabody , Seth Michael Daly , Bradley Owen Elmore , Kathleen Triplett
IPC分类号： C12Q1/68 , A61K39/085 , A61P37/04 , A61P31/04 , A61K39/00
摘要： The present invention is directed to virus-like particles (VLPs) which are engineered to present epitopes from Staphylococcus aureus (SA), preferably autoinducing peptides (AIPs) which regulate quorum-sensing dependent virulence in this pathogen, or epitopes from SA toxins and leukocidins. These VLPs may be used to provide immunogenic compositions and efficacious vaccines. In a mouse model of SA dermonecrosis, vaccination with AIP-containing VLPs or SA toxin-containing VLPs induces protective immunity to limit the pathogenesis of SA infection and promote bacterial clearance.

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