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    • 3. 发明申请
    • 1,2-AZABORINE COMPOUNDS AND SYNTHESIS
    • 1,2-亚氨基化合物和合成
    • WO2014018263A1
    • 2014-01-30
    • PCT/US2013/049907
    • 2013-07-10
    • STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF OREGON
    • LIU, Shih-YuanRUDEBUSCH, Gabriel
    • C07F5/02
    • C07F5/02
    • A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of formula (I), wherein R 1 is a substituted aryl or an optionally-substituted heteroaryl, provided that the heteroaryl is not pyridyl or azaborine; and each of R 2 , R 5 , R 6 , R 7 and R 8 is individually H, halide, optionally-substituted alkyl, optionally-substituted cycloalkyl, optionally-substituted heteroalkyl, optionally-substituted arylalkyl, optionally-substituted alkoxy, optionally-substituted aryloxy, optionally-substituted amino, silyl, optionally-substituted alkenyl, optionally-substituted cycloalkenyl, optionally-substituted heteroalkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted heteroaryl, optionally-substituted acyl, carbonyl, carboxylic acid, ester, nitrile, isonitrile, sulfanyl, sulfinyl, sulfonyl, optionally-substituted amido, optionally-substituted phosphoryl, optionally-substituted thiophosphoryl, optionally- substituted phosphinyl, optionally-substituted thiophosphinyl, thioester, nitro, azido, optionally-substituted hydrazinyl, optionally-substituted diazenyl, or thiocarbonyl.
    • 具有式(I)结构的化合物或其药学上可接受的盐或酯,其中R 1是取代的芳基或任选取代的杂芳基,条件是杂芳基不是吡啶基或氮杂硼; R 2,R 5,R 6,R 7和R 8各自为H,卤素,任选取代的烷基,任选取代的环烷基,任选取代的杂烷基,任选取代的芳烷基,任选取代的烷氧基,任选取代的芳氧基,任选取代的芳氧基, 取代的氨基,甲硅烷基,任选取代的烯基,任选取代的环烯基,任选取代的杂烯基,任选取代的炔基,任选取代的芳基,任选取代的杂芳基,任选取代的酰基,羰基,羧酸,酯,腈, ,硫基,亚磺酰基,磺酰基,任选取代的酰胺基,任选取代的磷酰基,任选取代的硫代磷酰基,任选取代的氧膦基,任选取代的硫代氧膦基,硫酯,硝基,叠氮基,任选取代的肼基,任选取代的二氮烯基或硫代羰基 。