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1. 发明申请

WO2005107582A1 DETECTION OF DIASTOLIC HEART FAILURE 审中-公开
标题翻译：检测白内障心脏失败
公开(公告)号：WO2005107582A1
公开(公告)日：2005-11-17
申请号：PCT/SE2004/000698
申请日：2004-05-06
申请人： ST. JUDE MEDICAL AB , TORPO, Maria , ÖHLANDER, Malin , BJÖRLING, Anders , LJUNGSTRÖM, Karin
发明人： TORPO, Maria , ÖHLANDER, Malin , BJÖRLING, Anders , LJUNGSTRÖM, Karin
IPC分类号： A61B5/02
CPC分类号： A61N1/3627 , A61B8/06 , A61B8/13
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, comprises a DHF determining device for determining at least one DHF parameter for detecting a DHF state of the heart of a patient. The DHF determining device comprises a means for determining, as said DHF parameter, the time length (DT,IVRT) of a predetermined phase of diastole. A pacemaker comprises such an apparatus and control means for optimising pacing therapy and pacemaker settings depending on the determined time length. A corresponding method of detecting diastolic heart failure, DHF, comprises the step of determining at least one DHF parameter for detecting a DHF state of the heart of a patient. This step comprises determining, as said DHF parameter, the time length (DT,IVRT) of a predetermined phase of diastole.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF包括DHF确定装置，用于确定用于检测患者心脏的DHF状态的至少一个DHF参数。 DHF确定装置包括用于根据所述DHF参数确定舒张期的预定阶段的时间长度（DT，IVRT）的装置。起搏器包括用于根据确定的时间长度优化起搏治疗和起搏器设置的这种装置和控制装置。检测舒张性心力衰竭DHF的相应方法包括确定至少一个DHF参数以检测患者心脏的DHF状态的步骤。该步骤包括根据所述DHF参数确定舒张期的预定相位的时间长度（DT，IVRT）。

2. 发明申请

WO2008105698A1 DEVICE AND METHOD OF A MEDICAL IMPLANT FOR MONITORING PROGRESSION OF HEART FAILURE IN A HUMAN HEART 审中-公开
标题翻译：用于监测人心脏心脏衰竭进展的医用植入物的装置和方法
公开(公告)号：WO2008105698A1
公开(公告)日：2008-09-04
申请号：PCT/SE2007/000855
申请日：2007-09-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
发明人： BJÖRLING, Anders , ÖHLANDER, Malin , ERIKSSON, Tom , ECKERDAL, Johan , LÖNN, Urban , NILSSON, Kenth , TUVSTEDT, Cecilia , SVAHN, Johan , JOHANSSON, Anna-Karin , NOREN, Kjell , BROOME, Michael
IPC分类号： A61N1/372 , A61B5/0205 , A61B5/145
CPC分类号： A61B5/14542 , A61B5/0031 , A61B5/076 , A61B5/1459 , A61B2562/0219 , A61N1/3627 , A61N1/36542 , A61N1/36557 , A61N1/36585
摘要： A device and method of a medical implant for monitoring progression of heart failure in a human heart. An activity sensor provides information related to the activity level of a patient and an oxygen sensor provides information related to the level of oxygen content in venous blood. A determined level of venous oxygen content at a determined activity level is obtained, and that level of venous oxygen content is compared to stored values at a corresponding activity level. The result of the comparison is used as a basis for determining a degree of heart failure.
摘要翻译：用于监测人类心脏心脏衰竭进展的医用植入物的装置和方法。活动传感器提供与患者的活动水平相关的信息，氧传感器提供与静脉血中氧含量水平相关的信息。在确定的活性水平获得确定水平的静脉氧含量，并将静脉氧含量的水平与在相应活动水平的储存值进行比较。将比较结果用作确定心力衰竭程度的基础。

3. 发明申请

WO2008103077A1 DETECT EATING TO INITIATE GASTRIC PACING 审中-公开
标题翻译：检测启动烟道喷雾
公开(公告)号：WO2008103077A1
公开(公告)日：2008-08-28
申请号：PCT/SE2007/000154
申请日：2007-02-21
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , NOREN, Kjell , ÖHLANDER, Malin
发明人： BJÖRLING, Anders , NOREN, Kjell , ÖHLANDER, Malin
IPC分类号： A61N1/08 , A61N1/36 , A61B5/026 , A61B8/06
CPC分类号： A61N1/36007 , A61B5/026 , A61B5/0261 , A61B5/0265 , A61B5/028 , A61B5/0295 , A61B5/0535 , A61B5/4238 , A61B5/6876 , A61B5/6884 , A61B8/06
摘要： Methods and devices for detecting the intake of food in a subject wherein at least one parameter related to the blood flow and/or perfusion of a blood vessel and/or an organ in the digestive system of a patient is monitored by a sensor attached to, or in, a blood vessel or organ of the digestive system. The value of each monitored parameter is analysed and may b used to control the activity of a gastric stimulator.
摘要翻译：用于检测受试者中食物摄入的方法和装置，其中与患者的消化系统中的血流和/或器官的血流和/或器官的血流和/或灌注有关的至少一个参数由附接到患者的传感器监测，或在消化系统的血管或器官中。分析每个监测参数的值，并且可以用于控制胃刺激剂的活性。

4. 发明申请

WO2003051457A1 AN IMPLANTABLE HEART STIMULATING DEVICE, A SYSTEM INCLUDING SUCH A DEVICE AND A MANNER OF USING THE SYSTEM 审中-公开
标题翻译：可植入心脏刺激装置，包括这样一个装置的系统和使用该系统的手段
公开(公告)号：WO2003051457A1
公开(公告)日：2003-06-26
申请号：PCT/SE2002/001817
申请日：2002-10-04
申请人： ST. JUDE MEDICAL AB , NORÉN, Kjell , LJUNGSTRÖM, Karin , KALLING, Sven , MANDAL, Lars , BJÖRLING, Anders
发明人： NORÉN, Kjell , LJUNGSTRÖM, Karin , KALLING, Sven , MANDAL, Lars , BJÖRLING, Anders
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： The invention concerns an implantable heart stimulating device (10) comprising, inter alia, a control circuit (14) adapted to enable at least the following: a) delivering electrical stimulating pulses to the two ventricles (RV, LV) of a heart with a variable time interval (ΔT) between the pulses; b) sensing signals receivable from electrodes (31, 32; 41, 42; 51 , 52; 61, 62) positionable at two different positions in the heart, c) deriving an impedance value (Z) based on said sensed signals, d) determining a minimum value (Z min ) and a maximum value (Z max ) of said impedance value (Z) during a heart cycle, e) determining a relationship between said minimum (Z min ) and maximum (Z max )values, f) varying said time interval (ΔT) and monitoring said relationship over a plurality of heart cycles, g) setting said time interval (ΔT) such that said relationship fulfi1s a predetermined requirement. The invention also concerns a system including such a heart stimulating device (10) as well as a manner of using such a system.
摘要翻译：本发明涉及一种植入式心脏刺激装置（10），其特别地包括控制电路（14），该控制电路适于至少能够实现以下功能：a）将电刺激脉冲输送到心脏的两个心室（RV，LV）脉冲之间的可变时间间隔（DeltaT）; b）感测可定位在心脏中两个不同位置的电极（31,32; 41,42; 51,52; 61,62）的信号，c）基于所述感测信号导出阻抗值（Z），d）在心脏周期中确定所述阻抗值（Z）的最小值（Z> min <）和最大值（Z> max <），e）确定所述最小值（Z> min <）和最大值（Z > max <）值，f）改变所述时间间隔（DeltaT）并监视多个心脏周期的所述关系，g）设置所述时间间隔（DeltaT）使得所述关系满足预定要求。本发明还涉及包括这种心脏刺激装置（10）的系统以及使用这种系统的方式。

5. 发明申请

WO2006049538A1 DEVICE FOR EVALUATING POSITIONS OF AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用于评估可植入医疗装置的位置的装置
公开(公告)号：WO2006049538A1
公开(公告)日：2006-05-11
申请号：PCT/SE2004/001600
申请日：2004-11-02
申请人： ST. JUDE MEDICAL AB , LJUNGSTRÖM, Karin , BJÖRLING, Anders , STRANDBERG, Hans
发明人： LJUNGSTRÖM, Karin , BJÖRLING, Anders , STRANDBERG, Hans
IPC分类号： A61N1/05
CPC分类号： A61N1/372 , A61B5/029 , A61B5/0452 , A61N1/08
摘要： The present invention relates to a device for evaluating positions of a medical lead during an implantation procedure, wherein the medical lead comprises at least one electrode and at least one sensor. The sensor is arranged to provide signals related to heart pumping activity. Furthermore, the device comprises measuring means arranged to record sensor signals and signals characteristic of the heart activity at different lead positions; storing means arranged to store the sensor signals; and processing means connected to the measurement means and is arranged to determine a measure of the heart activity at each lead position based on the recorded signals. Thus, physiologic parameters reflecting hemodynamic performance are derived and evaluated for each lead position in order to determine the optimal site with respect to a desired heart muscle reaction.
摘要翻译：本发明涉及一种用于在植入过程期间评估医用引线的位置的装置，其中所述医用引线包括至少一个电极和至少一个传感器。传感器布置成提供与心脏泵送活动有关的信号。此外，该装置包括测量装置，其被设置为在不同的引导位置记录心脏活动特征的传感器信号和信号; 存储装置，被布置成存储传感器信号; 以及连接到所述测量装置的处理装置，并且被布置成基于所记录的信号来确定每个引导位置处的心脏活动度量。因此，针对每个引导位置导出和评估反映血液动力学性能的生理参数，以便确定相对于所需心脏肌肉反应的最佳位置。

6. 发明申请

WO2008076014A1 IMPLANTABLE SENSOR ARRANGEMENT 审中-公开
标题翻译：可植入传感器布置
公开(公告)号：WO2008076014A1
公开(公告)日：2008-06-26
申请号：PCT/SE2006/001468
申请日：2006-12-20
申请人： ST. JUDE MEDICAL AB , BLOMQVIST, Andreas , BJÖRLING, Anders , BUDGIFVARS, Göran , RIVAS, Dominic , TORPO, Maria
发明人： BLOMQVIST, Andreas , BJÖRLING, Anders , BUDGIFVARS, Göran , RIVAS, Dominic , TORPO, Maria
IPC分类号： A61N1/372 , A61N1/365 , A61B5/00
CPC分类号： A61N1/056 , A61B5/0422 , A61B5/416 , A61B5/418 , A61N1/365 , Y10T29/49002
摘要： The invention relates to a sensor arrangement (1) comprising a sensor body (10), to which at least one sensor head (30) is connected through at least one connective wire (40; 45). The sensor head(s) (30) and at least a portion of the connective wire(s) (40; 45) are tightly packed and enclosed by a protective sensor shell (20). This sensor shell (20) is of a dissolvable material that will dissolve or can be triggered to dissolve following introduction of the sensor arrangement (1) into a subject.
摘要翻译：本发明涉及一种包括传感器本体（10）的传感器装置（1），至少一个传感器头（30）通过至少一个连接线（40; 45）连接在该传感器装置上。所述传感器头（30）和所述连接线（40; 45）的至少一部分被紧密包装并由保护传感器外壳（20）包围。该传感器外壳（20）是可溶解的材料，其在将传感器装置（1）引入到受试者中之后将溶解或可被触发以溶解。

7. 发明申请

WO2005110535A1 DETECTION OF DIASTOLIC HEART FAILURE 审中-公开
标题翻译：检测白内障心脏失败
公开(公告)号：WO2005110535A1
公开(公告)日：2005-11-24
申请号：PCT/SE2004/000741
申请日：2004-05-13
申请人： ST JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
IPC分类号： A61N1/37
CPC分类号： A61B5/0215 , A61B5/053 , A61B5/0538 , A61N1/3627 , A61N1/36514
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, comprises a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart (4) of a patient. The DHF determining device comprises a pressure measuring means (2,26) for measuring the absolute value of left atrial pressure during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. A comparison means (18) compares the difference between left atrial pressure or pulmonary vein pressure, in said workload and rest situations, with a predetermined pressure difference reference value. A pacemaker comprises such an apparatus and control means (14) for optimising pacing therapy depending on the result of the comparisons with the reference values. A corresponding method of detecting diastolic heart failure, DHF, comprises the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The absolute value of left atrial pressure is measured during the diastasis phase just before atrial contraction, or the absolute value of the pressure in the pulmonary vein when the pulmonary valve is closed, for a predetermined workload situation and a rest situation of the patient. The difference between left atrial pressure or pulmonary vein pressure in said workload and rest situations is compared with a predetermined pressure difference reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF包括DHF确定装置，用于确定用于检测患者心脏（4）的DHF状态的至少一个血压参数。 DHF判定装置包括压力测定装置（2,26），用于在心房收缩前的舒张阶段测量左心房的绝对值，或者肺动脉瓣关闭时肺静脉压的绝对值，用于预定工作情况和患者的休息状态。比较装置（18）将所述工作负荷和静止状况下的左心房压力或肺静脉压力之间的差与预定的压力差参考值进行比较。起搏器包括用于根据与参考值的比较的结果来优化起搏治疗的这种装置和控制装置（14）。检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个血压参数的步骤。左心房压力的绝对值是在心房收缩前的舒张期或肺动脉瓣关闭时肺静脉压力的绝对值，在预定的工作情况和患者的休息状态下测量的。将所述工作负荷和静止情况下的左心房压力或肺静脉压力之间的差异与预定的压力差参考值进行比较。

8. 发明申请

WO2005102451A1 DETECTION OF DIASTOLIC HEART FAILURE 审中-公开
标题翻译：检测失神经失败
公开(公告)号：WO2005102451A1
公开(公告)日：2005-11-03
申请号：PCT/SE2004/000636
申请日：2004-04-26
申请人： ST JUDE MEDICAL AB , HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
发明人： HEDBERG, Sven-Erik , BJÖRLING, Anders , TORPO, Maria , LJUNGSTRÖM, Karin
IPC分类号： A61N1/365
CPC分类号： A61B5/021 , A61B5/02154 , A61N1/3627 , A61N1/36564 , A61N1/3702 , G06F19/00
摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, comprises a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device comprises a pressure measuring means (2,10,12,16) for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as said blood pressure parameter, and a comparison means (14) compares the measured pulse pressure with a predetermined reference value. A pacemaker comprises such an apparatus and control means (20) for optimising pacing therapy depending on the result of the comparison of the measured pulse pressures with said predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, comprises the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. This step of determining at least one blood parameter comprises determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.
摘要翻译：用于检测舒张性心力衰竭的可植入医疗装置DHF包括DHF确定装置，用于确定用于检测患者心脏的DHF状态的至少一个血压参数。所述DHF确定装置包括压力测量装置（2,10,12,16），用于在患者的预定工作情况下测量心动周期中的脉搏压力作为所述血压参数，并且比较装置（14）具有预定参考值的脉搏压力。起搏器包括这样的装置和控制装置（20），用于根据所测量的脉搏压力与所述预定参考值的比较结果来优化起搏治疗。检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个血压参数的步骤。确定至少一个血液参数的该步骤包括在患者的预定工作负荷情况下确定作为所述血压参数的心动周期中的脉搏压力，并将所确定的脉搏压力与预定参考值进行比较。

9. 发明申请

WO2011134499A1 ARRHYTHMIA CLASSIFICATION 审中-公开
标题翻译： ARRHYTHMIA分类
公开(公告)号：WO2011134499A1
公开(公告)日：2011-11-03
申请号：PCT/EP2010/055639
申请日：2010-04-27
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
发明人： BJÖRLING, Anders , HOLLMARK, Malin , SVENSSON, Tomas , HJELM, Stefan , NORÉN, Kjell , JÄRVERUD, Karin
IPC分类号： A61B5/0452 , A61B5/053 , A61N1/365
CPC分类号： A61B5/0452 , A61B5/053 , A61B5/0538 , A61B5/7257 , A61B5/7264 , A61N1/3622 , A61N1/36521 , A61N1/36564 , A61N1/36585 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during multiple cardiac cycles. A transform processor (132) generates a spectrum signal by applying a time- to-frequency transform to the cardiogenic impedance signal. The spectrum signal is processed by a distribution processor (133) configured to calculate a distribution parameter indicative of a distribution in at least a portion of the spectrum signal. The calculated distribution parameter is of high diagnostic value and is employed by an arrhythmia classifier (134) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在多个心动周期期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源阻抗信号。变换处理器（132）通过对心源性阻抗信号进行时间 - 频率变换来产生频谱信号。频谱信号由分配处理器（133）处理，分配处理器（133）被配置为计算指示频谱信号的至少一部分中的分布的分布参数。计算出的分布参数具有很高的诊断价值，并被心律失常分类器（134）采用，以便将检测到的心脏心律不齐（10）进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

10. 发明申请

WO2007133130A1 AN IMPLANTABLE HEART STIMULATING DEVICE AND METHOD 审中-公开
标题翻译：可植入心脏刺激装置及方法
公开(公告)号：WO2007133130A1
公开(公告)日：2007-11-22
申请号：PCT/SE2006/000568
申请日：2006-05-16
申请人： ST. JUDE MEDICAL AB , BJÖRLING, Anders
发明人： BJÖRLING, Anders
IPC分类号： A61N1/37 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3682 , A61N1/3684 , A61N1/3712
摘要： The invention concerns an implantable heart stimulating device (10). The device has a control circuit (14). The control circuit (14) is arranged to be able to detect an evoked responses to delivered pacing pulses and to carry out an automatic capture routine. The control circuit (14) is arranged to automatically temporarily disable the automatic capture routine on the basis of at least one of the following criteria: a1) if more than a predetermined number of threshold searches have been performed during a certain time, b1) if the evoked response signals vary more than a predetermined amount, c1) if a variable time delay with which the device (10) operates is changed such that a pacing pulse may be delivered by the device (10) during the evoked response time window. The invention also concerns a method of operating an implantable heart stimulating device.
摘要翻译：本发明涉及可植入心脏刺激装置（10）。该装置具有控制电路（14）。控制电路（14）被布置成能够检测对发送的起搏脉冲的诱发响应并执行自动捕获程序。控制电路（14）被布置成基于以下标准中的至少一个自动临时禁用自动捕获例程：a1）如果在特定时间内已经执行了多于一个预定数量的阈值搜索，则b1）if 诱发响应信号变化大于预定量，c1）如果设备（10）操作的可变时间延迟改变，使得在诱发响应时间窗口期间可由设备（10）传送起搏脉冲。本发明还涉及一种操作可植入心脏刺激装置的方法。

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