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1. 发明申请

WO2013012841A1 HIGH SPATIAL RESOLUTION OPTICAL COHERENCE TOMOGRAPHY ROTATION CATHETER 审中-公开
标题翻译：高空间分辨率光学相干旋转导管
公开(公告)号：WO2013012841A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047017
申请日：2012-07-17
申请人： ST. JUDE MEDICAL, INC. , LIU, Yu , LIU, Jiayin
发明人： LIU, Yu , LIU, Jiayin
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B1/00167 , A61B5/0066 , A61B5/6852 , Y10T29/49826
摘要： An optical coherence tomography rotation catheter comprises a catheter body (40) and a tubular member (10) that rotates around a longitudinal axis in the catheter body. An optical fiber (20) extends along an interior of the tubular member and has an optical fiber distal end. A light reflecting member (22) is distal of the optical fiber distal end and rotates around the longitudinal axis with the tubular member. The light reflecting member includes a light reflecting surface which is spaced from and faces the optical fiber distal end and which is inclined to reflect the light from the optical fiber in a radial direction at an angle with respect to the longitudinal axis. The light reflecting member has a diameter of at most about 0.25 mm. The light reflecting surface is polished and coated with a light reflecting film.
摘要翻译：光学相干断层摄影旋转导管包括导管主体（40）和围绕导管主体中的纵向轴线旋转的管状构件（10）。光纤（20）沿着管状部件的内部延伸并且具有光纤远端。光反射构件（22）在光纤远端的远侧并且与管状构件围绕纵向轴线旋转。光反射构件包括光反射表面，该光反射表面与光纤远端隔开并面对光纤远端，并且倾斜以相对于纵向轴线以一定角度沿径向反射来自光纤的光。光反射部件的直径至多为大约0.25mm。光反射表面被抛光并涂覆有光反射膜。

2. 发明申请

WO2012122000A1 MULTI-CHANNEL OPTICAL COHERENCE TOMOGRAPHY FOR IMAGING AND TEMPERATURE AND FORCE SENSING 审中-公开
标题翻译：用于成像和温度和力感测的多通道光学相干坐标
公开(公告)号：WO2012122000A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/027393
申请日：2012-03-02
申请人： ST. JUDE MEDICAL, INC. , LIU, Yu
发明人： LIU, Yu
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , G01L3/101
摘要： Embodiments of the invention provide multi-channel OCT (Optical Coherence Tomography) for imaging biological tissue or the like, and for temperature and/or force sensing, preferably in real time. In one embodiment, an optical signal processing system (200) comprises: a processor (202); a memory (204); a receiving module (210) to receive in real time input from multiple channels of OCT producing interfering optical signals representing multiple measured distances for a target imaging object; a Fast Fourier Transform (FFT) module (212) to apply FFT on the interfering optical signals in real time to produce Fourier frequencies corresponding to the multiple measured distances; and a calculation module (214) to calculate in real time multiple force components of a force applied on the target imaging object to cause at least some of the multiple measured distances for the target imaging object based on the Fourier frequencies from the FFT module.
摘要翻译：本发明的实施例提供用于成像生物组织等的多通道OCT（光学相干断层扫描），以及优选实时的温度和/或力感测。在一个实施例中，光信号处理系统（200）包括：处理器（202）; 存储器（204）; 接收模块（210），用于从OCT的多个通道实时输入，产生表示用于目标成像对象的多个测量距离的干涉光信号; 快速傅立叶变换（FFT）模块（212），用于实时地对干扰光信号应用FFT，以产生对应于多个测量距离的傅立叶频率; 以及计算模块（214），用于实时地计算施加在所述目标成像对象上的力的多个力分量，以基于来自所述FFT模块的傅里叶频率来引起所述目标成像对象的所述多个测量距离中的至少一些距离。

3. 发明申请

WO2012121999A2 LOW COST HIGH EFFICIENCY SIGNAL INTERROGATION FOR MULTI-CHANNEL OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：低通道高效信号多通道光学相干测量
公开(公告)号：WO2012121999A2
公开(公告)日：2012-09-13
申请号：PCT/US2012/027392
申请日：2012-03-02
申请人： ST. JUDE MEDICAL, INC. , LIU, Yu
发明人： LIU, Yu
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , G01B9/02004 , G01B9/02027 , G01B9/0205 , G01B9/02057 , G01B9/02069 , G01B9/02091 , G01B2290/45
摘要： A signal interrogation system comprises an optical coupler (22) to split input laser beam into a first laser beam as a power reference and a second laser beam, the optical coupler being coupled to a first path (24) for the first laser beam and a second path (25) for the second laser beam; an optical circulator (28) disposed in the second path; a bi-directional optical switch (30) disposed in the second path and having on one side a single channel end oriented toward the optical circulator and on another side multiple channel ends with multiple switchable channels; a plurality of optical fibers (34) coupled to the multiple channel ends of the bi-directional optical switch; an interference optical signals path (44) coupled to the optical circulator to receive the interference optical signals from the bi-directional switch; and a balanced photo detector (50) to measure a power difference between the interference optical signals and the power reference.
摘要翻译：信号询问系统包括将输入激光束分成第一激光束作为功率基准的光耦合器（22）和第二激光束，所述光耦合器耦合到第一激光束的第一路径（24）和用于第二激光束的第二路径（25）设置在所述第二路径中的光循环器（28）设置在第二路径中的双向光开关（30），并且在一侧具有朝向光循环器定向的单通道端，并且在另一侧上多个通道以多个可切换通道结束; 耦合到双向光开关的多通道端的多个光纤（34）; 耦合到所述光环行器的干涉光信号路径（44），以接收来自所述双向开关的干涉光信号; 以及平衡光电检测器（50），用于测量干涉光信号和功率基准之间的功率差。

4. 发明申请

WO2010011820A2 ABLATION AND MONITORING SYSTEM INCLUDING A FIBER OPTIC IMAGING CATHETER AND AN OPTICAL COHERENCE TOMOGRAPHY SYSTEM 审中-公开
标题翻译：包括纤维光学成像导管和光学相干层析摄影系统的消融和监测系统
公开(公告)号：WO2010011820A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051506
申请日：2009-07-23
申请人： ST. JUDE MEDICAL, INC. , NGUYEN, Tho, Hoang , CHEN, Peter, C. , DE LA RAMA, Alan , LIU, Yu
发明人： NGUYEN, Tho, Hoang , CHEN, Peter, C. , DE LA RAMA, Alan , LIU, Yu
IPC分类号： A61B1/005
CPC分类号： A61B18/1492 , A61B1/015 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61B18/1206 , A61B2018/00029 , A61B2018/00351 , A61B2018/00791 , A61B2018/0088 , A61B2018/00982 , A61B2090/064 , A61B2090/065 , A61B2218/002
摘要： An ablation and monitoring system comprises a catheter, an optical coherence tomography (OCT) system, and an ablation generator. The catheter comprises one or more optical fibers to transmit a light beam to a tissue material and collect a reflected light from the tissue material. The OCT system is in optical communication with the catheter via the one or more optical fibers, providing the light beam to the one or more optical fibers and receiving the reflected light from the one or more optical fibers. The ablation generator is in electrical communication with the OCT system and with the catheter. The ablation generator provides radio frequency energy to the catheter for ablating the tissue material, monitors and assesses the ablation based on an information signal received from the OCT system.
摘要翻译：消融和监测系统包括导管，光学相干断层扫描（OCT）系统和消融发生器。导管包括一个或多个光纤以将光束传输到组织材料并收集来自组织材料的反射光。 OCT系统通过一个或多个光纤与导管进行光通信，向一个或多个光纤提供光束并接收来自一个或多个光纤的反射光。消融发生器与OCT系统和导管电通信。消融发生器向导管提供射频能量以消融组织材料，基于从OCT系统接收的信息信号监测和评估消融。

5. 发明申请

WO2012142373A1 OPTICAL COHERENCE TOMOGRAPHY CATHETER FOR ELASTOGRAPHIC PROPERTY MAPPING OF LUMENS UTILIZING MICROPALPATION 审中-公开
标题翻译：用于使用微波的光学的光学性质映射的光学相干导管
公开(公告)号：WO2012142373A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033462
申请日：2012-04-13
申请人： ST. JUDE MEDICAL, INC. , SLIWA, John , LIU, Yu
发明人： SLIWA, John , LIU, Yu
IPC分类号： A61B5/00 , A61B5/02 , A61M25/00
CPC分类号： A61B5/0066 , A61B5/0053 , A61B5/02007 , A61B8/485 , A61M25/007 , A61M25/0082 , A61M29/02
摘要： An optical coherence tomography (OCT) catheter, for performing high performance elastographic deformation mapping of tissues and plaques, comprises: a catheter (20) having an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis, the catheter body including a distal portion (24) at the distal end and a catheter lumen (26); a palpator (30), disposed in the distal portion, to apply one of a directed fluid or a mechanical indenter (130) to produce a surface - applied palpation force to a target area (50) of the interior body to mechanically displace the interior body and cause elastographic deformation of the target area of one or more surface and subsurface tissues and plaques; and an OCT imaging sensor (34), disposed in the distal portion, to direct and deliver an OCT beam (60) for OCT deformation detection including elastographic deformation measurement to provide elastographic mapping of the target area.
摘要翻译：用于执行组织和斑块的高性能弹性变形测绘的光学相干断层扫描（OCT）导管包括：导管（20），其具有沿着纵向轴线在近端和远端之间纵向延伸的细长导管体，所述导管主体包括在远端的远侧部分（24）和导管内腔（26）; 设置在所述远侧部分中的触发器（30），以施加有向流体或机械压头（130）中的一个以产生对所述内部主体的目标区域（50）的表面施加的触诊力，以机械地移动所述内部造成一个或多个表面和地下组织和斑块的目标区域的弹性变形; 以及设置在所述远端部分中的OCT成像传感器（34），用于引导和输送用于OCT变形检测的OCT束（60），包括弹性变形测量以提供所述目标区域的弹性图。

6. 发明申请

WO2012003103A1 FIBEROPTIC DEVICE WITH LONG FOCAL LENGTH GRADIENT-INDEX OR GRIN FIBER LENS 审中-公开
标题翻译：具有长焦长度梯度指数或光纤光学镜片的光纤设备
公开(公告)号：WO2012003103A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/041035
申请日：2011-06-20
申请人： ST. JUDE MEDICAL, INC. , LIU, Yu
发明人： LIU, Yu
IPC分类号： G02B6/32
CPC分类号： G02B6/32
摘要： A fiberoptic device achieves a substantially longer focal length by placing a beam expander between the terminal end of an optical fiber and a gradient-index (GRIN) lens to simulate free space therebetween. In one embodiment, a fiberoptic device comprises an optical fiber having a fiber core and an end through which a light beam emits from the fiber core; a beam expander having a first end coupled to the end of the optical fiber and having a second end, the beam expander permitting the light beam emitting from the fiber core to pass from the first end to the second end and to expand from the first end to a larger size at the second end; and a gradient-index fiber lens coupled to the second end of the beam expander to receive the light beam from the beam expander and focus the light beam.
摘要翻译：光纤设备通过在光纤的终端和梯度折射率（GRIN）透镜之间放置光束扩展器来模拟其间的自由空间来实现更长的焦距。在一个实施例中，光纤设备包括具有光纤芯和光束从光纤芯发射的端部的光纤; 光束扩展器，其具有耦合到光纤端部并具有第二端的第一端，所述光束扩展器允许从光纤芯发射的光束从第一端到第二端并从第一端扩展在第二端更大的尺寸; 以及耦合到光束扩展器的第二端的渐变折射率光纤透镜，以接收来自光束扩展器的光束并聚焦光束。

7. 发明授权

EP2696747B1 OPTICAL COHERENCE TOMOGRAPHY CATHETER FOR ELASTOGRAPHIC PROPERTY MAPPING OF LUMENS UTILIZING MICROPALPATION 失效
标题翻译：光学相干断层成像导管ELASTROGRAFSCHE PICTURE与MIKROPALPATION流明性能的影响
公开(公告)号：EP2696747B1
公开(公告)日：2017-01-11
申请号：EP12719832.3
申请日：2012-04-13
申请人： St. Jude Medical, Inc.
发明人： SLIWA, John , LIU, Yu
IPC分类号： A61B5/00 , A61B5/02 , A61M25/00
CPC分类号： A61B5/0066 , A61B5/0053 , A61B5/02007 , A61B8/485 , A61M25/007 , A61M25/0082 , A61M29/02

8. 发明公开

EP2683289A1 MULTI-CHANNEL OPTICAL COHERENCE TOMOGRAPHY FOR IMAGING AND TEMPERATURE AND FORCE SENSING 失效
标题翻译：多通道光学相干层析成像和温度和功率测量
公开(公告)号：EP2683289A1
公开(公告)日：2014-01-15
申请号：EP12709746.7
申请日：2012-03-02
申请人： St. Jude Medical, Inc.
发明人： LIU, Yu
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , G01L3/101
摘要： Embodiments of the invention provide multi-channel OCT (Optical Coherence Tomography) for imaging biological tissue or the like, and for temperature and/or force sensing, preferably in real time. In one embodiment, an optical signal processing system (200) comprises: a processor (202); a memory (204); a receiving module (210) to receive in real time input from multiple channels of OCT producing interfering optical signals representing multiple measured distances for a target imaging object; a Fast Fourier Transform (FFT) module (212) to apply FFT on the interfering optical signals in real time to produce Fourier frequencies corresponding to the multiple measured distances; and a calculation module (214) to calculate in real time multiple force components of a force applied on the target imaging object to cause at least some of the multiple measured distances for the target imaging object based on the Fourier frequencies from the FFT module.

9. 发明公开

EP2696747A1 OPTICAL COHERENCE TOMOGRAPHY CATHETER FOR ELASTOGRAPHIC PROPERTY MAPPING OF LUMENS UTILIZING MICROPALPATION 失效
标题翻译：光学相干断层成像导管ELASTROGRAFSCHE PICTURE与MIKROPALPATION流明性能的影响
公开(公告)号：EP2696747A1
公开(公告)日：2014-02-19
申请号：EP12719832.3
申请日：2012-04-13
申请人： St. Jude Medical, Inc.
发明人： SLIWA, John , LIU, Yu
IPC分类号： A61B5/00 , A61B5/02 , A61M25/00
CPC分类号： A61B5/0066 , A61B5/0053 , A61B5/02007 , A61B8/485 , A61M25/007 , A61M25/0082 , A61M29/02
摘要： An optical coherence tomography (OCT) catheter, for performing high performance elastographic deformation mapping of tissues and plaques, comprises: a catheter (20) having an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis, the catheter body including a distal portion (24) at the distal end and a catheter lumen (26); a palpator (30), disposed in the distal portion, to apply one of a directed fluid or a mechanical indenter (130) to produce a surface - applied palpation force to a target area (50) of the interior body to mechanically displace the interior body and cause elastographic deformation of the target area of one or more surface and subsurface tissues and plaques; and an OCT imaging sensor (34), disposed in the distal portion, to direct and deliver an OCT beam (60) for OCT deformation detection including elastographic deformation measurement to provide elastographic mapping of the target area.
摘要翻译：一种用于执行组织和斑块的弹性成像形变映射方法包括：将导管的远端部分到患者的内部主体的内部; 施加，从在远端部分的palpator，的一个引导流体或机械压头，以产生表面施加的触诊力到内部身体的目标区域以机械地移动所述内部主体和造成的所述目标区域的弹性成像变形一种或多种表面和表面下的组织和斑块; 和引导，并在远端部分递送（光学相干断层成像）波束华侨城，从在OCT成像传感器，华侨城变形检测包含弹性成像变形测量，以提供目标区域的弹性图映射。

10. 发明公开

EP2683288A2 LOW COST HIGH EFFICIENCY SIGNAL INTERROGATION FOR MULTI-CHANNEL OPTICAL COHERENCE TOMOGRAPHY 失效
标题翻译：成本有效的高信号REQUEST用于多通道光学相干断层扫描
公开(公告)号：EP2683288A2
公开(公告)日：2014-01-15
申请号：EP12709745.9
申请日：2012-03-02
申请人： St. Jude Medical, Inc.
发明人： LIU, Yu
IPC分类号： A61B5/00
CPC分类号： A61B5/0066 , G01B9/02004 , G01B9/02027 , G01B9/0205 , G01B9/02057 , G01B9/02069 , G01B9/02091 , G01B2290/45
摘要： A signal interrogation system comprises an optical coupler (22) to split input laser beam into a first laser beam as a power reference and a second laser beam, the optical coupler being coupled to a first path (24) for the first laser beam and a second path (25) for the second laser beam; an optical circulator (28) disposed in the second path; a bi-directional optical switch (30) disposed in the second path and having on one side a single channel end oriented toward the optical circulator and on another side multiple channel ends with multiple switchable channels; a plurality of optical fibers (34) coupled to the multiple channel ends of the bi-directional optical switch; an interference optical signals path (44) coupled to the optical circulator to receive the interference optical signals from the bi-directional switch; and a balanced photo detector (50) to measure a power difference between the interference optical signals and the power reference.

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