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1. 发明申请

WO2012023979A3 A DEVICE FOR COLLAPSING AND LOADING A HEART VALVE INTO A MINIMALLY INVASIVE DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2012023979A3
公开(公告)日：2012-02-23
申请号：PCT/US2011/001445
申请日：2011-08-17
申请人： ST. JUDE MEDICAL, INC. , DALE, Theodore P. , CHALEKIAN, Aaron J. , GLAZIER, Valerie J. , WANG, Huisun
发明人： DALE, Theodore P. , CHALEKIAN, Aaron J. , GLAZIER, Valerie J. , WANG, Huisun
IPC分类号： A61F2/24
摘要： A device is provided for collapsing a stented bioprosthetic valve, including first section and second sections, each spanning between first and second ends of the device. The second section of the device is associated with the first section to at least partially enclose an internal cavity formed by the first and second sections, the internal cavity tapering from an open insertion portion at a first end of the device to an open exit portion at a second end of the device. The insertion portion has a larger dimension than the exit portion. When the first section and second section are substantially enclosing the internal cavity, a stented bioprosthetic valve may be inserted into the insertion portion and collapsed as it is moved toward and through the exit portion. The valve may then be loaded on an apparatus for insertion into the body.

2. 发明申请

WO2012009006A1 RETAINERS FOR TRANSCATHETER HEART VALVE DELIVERY SYSTEMS 审中-公开
标题翻译： TRANSCATHETER心瓣输送系统的保持器
公开(公告)号：WO2012009006A1
公开(公告)日：2012-01-19
申请号：PCT/US2011/001218
申请日：2011-07-12
申请人： ST. JUDE MEDICAL, INC. , WANG, Huisun , GLAZIER, Valerie, J. , GRAFOV, Alex
发明人： WANG, Huisun , GLAZIER, Valerie, J. , GRAFOV, Alex
IPC分类号： A61F2/84 , A61F2/24
CPC分类号： A61F2/2436 , A61F2/962 , A61F2/966 , A61F2002/9522 , A61F2002/9665
摘要： A delivery device (10) for an implantable medical device having at least one retention member at an end thereof includes a shaft (24) extending in a longitudinal direction, an elongated sheath (22) surrounding a longitudinal portion of the shaft, a compartment (28) defined inside of the sheath and adapted to receive the medical device in an assembled condition, a retainer (30) positioned at one end of the compartment, and at least one acceptance (36) in the retainer adapted to receive the retention member of the medical device in the assembled condition. The sheath is slidable relative to the shaft in the longitudinal direction to uncover and deploy the medical device. The retainer may be rotatable relative to the shaft to reduce torsional forces in the medical device during delivery and deployment. The retainer may have at least one recess facing the compartment for receiving a strut at an end of a stent of the medical device.
摘要翻译：用于可植入医疗装置的输送装置（10）在其一端具有至少一个保持构件，包括沿纵向方向延伸的轴（24），围绕轴的纵向部分的细长护套（22），隔室 28），其限定在所述护套内部并且适于在组装状态下容纳所述医疗装置，定位在所述隔间的一端的保持器（30）以及所述保持器中的至少一个接受部（36），其适于接收所述保持构件医疗器械处于组装状态。护套可以在纵向方向上相对于轴滑动以揭开和展开医疗装置。保持器可以相对于轴可旋转以减少在递送和展开期间医疗装置中的扭转力。保持器可以具有面向隔室的至少一个凹部，用于在医疗装置的支架的端部处接收支柱。

3. 发明申请

WO2012023981A3 TIP FOR MEDICAL IMPLANT DELIVERY SYSTEM 审中-公开
公开(公告)号：WO2012023981A3
公开(公告)日：2012-02-23
申请号：PCT/US2011/001447
申请日：2011-08-17
申请人： ST. JUDE MEDICAL, INC. , WANG, Huisun , GLAZIER, Valerie J.
发明人： WANG, Huisun , GLAZIER, Valerie J.
IPC分类号： A61F2/24 , A61F2/84
摘要： A delivery system for delivering and deploying a medical implant, such as a prosthetic heart valve, includes an elongated support member (28), a sheath (30), and a tip (132). The sheath is movable relative to the elongated support member between a distal position overlying the medical implant and a proximal position exposing the medical implant for release from the delivery system. The tip is attached to the elongated support member and is positioned at a distal end of the sheath when the sheath is in the distal position. The tip has a compressed condition and an expanded condition, and a maximum diameter in the expanded condition that is larger than the outer diameter of the sheath.

4. 发明申请

WO2012036740A2 RETAINERS FOR TRANSCATHETER HEART VALVE DELIVERY SYSTEMS 审中-公开
标题翻译：传送器心脏传送系统的保持器
公开(公告)号：WO2012036740A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/001596
申请日：2011-09-16
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , WANG, Huisun , GLAZIER, Valerie, J. , DALY, Jacob, J. , ST. JUDE MEDICAL, INC.
发明人： WANG, Huisun , GLAZIER, Valerie, J. , DALY, Jacob, J.
IPC分类号： A61M25/08
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/966 , A61F2002/9665 , A61F2230/0054 , A61M2025/0681
摘要： A delivery device 10 for a collapsible prosthetic heart valve includes a catheter assembly 16 including a shaft 26 around which a compartment 23 is defined, the compartment 23 being adapted to receive the valve in an assembled condition, and a retainer 30 including a pusher 32 and a holder 34 adapted to retain a stent portion 106 of the valve. The catheter assembly 16 also includes a distal sheath 24 adapted to selectively cover and uncover the compartment 23 and the valve, the distal sheath 24 extending around the shaft 26 at least when the distal sheath 24 covers the compartment 23. The pusher 32 includes one or more recesses 40 in a retention edge 33 thereof, each recess 40 being adapted to receive a junction 107 at an end of the stent portion 106 of the valve. The holder 34 includes one or more elongated ribs 50, each rib 50 being adapted to fit into a cell opening 108 of the stent portion 106 of the valve.
摘要翻译：用于可折叠人造心脏瓣膜的输送装置10包括导管组件16，导管组件16包括轴26，隔室23围绕该轴26限定，隔室23适于在组装状态下接收瓣膜，以及包括推动器32和适于保持瓣膜的支架部分106的保持器34的保持器30。至少当远侧护套24覆盖隔室23时，导管组件16还包括适于选择性地覆盖和露出隔室23和瓣膜的远侧护套24，远侧护套24围绕轴26延伸。推动器32包括一个或在其保持边缘33中具有更多凹部40，每个凹部40适于在瓣膜的支架部分106的端部处接收接合点107。保持器34包括一个或多个细长肋50，每个肋50适于装配到瓣膜的支架部分106的细胞开口108中。

5. 发明申请

WO2012036742A3 ASSEMBLY AND METHOD FOR LOADING A SELF-EXPANDING COLLAPSIBLE HEART VALVE 审中-公开
公开(公告)号：WO2012036742A3
公开(公告)日：2012-03-22
申请号：PCT/US2011/001598
申请日：2011-09-16
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , JOHNSON, Michael, A. , GLAZIER, Valerie, J. , WANG, Huisun , ST. JUDE MEDICAL, INC.
发明人： JOHNSON, Michael, A. , GLAZIER, Valerie, J. , WANG, Huisun
IPC分类号： A61F2/24 , B23P19/00
摘要： An assembly (200) for collapsing a prosthetic heart valve includes a compression member (202) and a pusher member (204). The compression member has a first open (208) end with a first diameter, a second open (210) end with a second diameter less than the first diameter, and a tapered wall (206) between the first open end and the second open end. The pusher member (204) has a base (232) adapted to engage an end of the valve. The pusher member and the compression member are movable relative to one another between an initial position in which the base of the pusher member is relatively far from the first open end of the compression member and an operative position in which the base of the pusher member is relatively close to the first open end of the compression member. Movement of the pusher and compression members from the initial position to the operative position radially compresses the valve.

6. 发明申请

WO2012106491A1 SYSTEM AND METHOD FOR LOADING A COLLAPSILE HEART VALVE INTO A DELIVERY DEVICE 审中-公开
标题翻译：将收缩心脏瓣膜装载到递送装置中的系统和方法
公开(公告)号：WO2012106491A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023576
申请日：2012-02-02
申请人： ST. JUDE MEDICAL, INC. , ALKHATIB, Yousef F. , DALY, Jacob J. , GLAZIER, Valerie J. , HILLUKKA, Brett A. , THOMAS, Ralph J. , WANG, Huisun
发明人： ALKHATIB, Yousef F. , DALY, Jacob J. , GLAZIER, Valerie J. , HILLUKKA, Brett A. , THOMAS, Ralph J. , WANG, Huisun
IPC分类号： A61F2/24 , A61F2/00 , A61F2/84
CPC分类号： A61F2/2427 , A61F2/0095 , A61F2/2412 , A61F2/2436 , A61F2/97 , A61F2002/9522 , A61F2250/0039 , Y10T29/49826 , Y10T29/53909 , Y10T29/53943
摘要： An assembly (200) for collapsing a self - expanding prosthetic heart valve includes a compression member (202) a support member (204) and a constricting member (300). The compression member has a tapered wall between its first open end and its second open end, the tapered wall defining an open space adapted to receive the valve. The support member has a base (220) and a recess (226) adapted to receive an end of the valve. The support member and the compression member are movable toward one another to compress the valve and push it through a relatively small aperture in the second open end of the compression member. The second end of the constricting member is sized to receive the compressed valve from the second open end of the compression member for loading into a delivery device.
摘要翻译：用于塌陷自膨胀假体心脏瓣膜的组件（200）包括压缩构件（202），支撑构件（204）和收缩构件（300）。压缩构件在其第一开口端和其第二开口端之间具有锥形壁，锥形壁限定适于接收阀的开放空间。支撑构件具有适于容纳阀的端部的底座（220）和凹部（226）。支撑构件和压缩构件可彼此移动以压缩阀并将其推压通过压缩构件的第二开口端中的相对小的孔。收缩构件的第二端的尺寸被设计成从压缩构件的第二开口端接收压缩的阀，以便装载到输送装置中。

7. 发明申请

WO2012023978A2 DELIVERY SYSTEM FOR COLLAPSIBLE HEART VALVE 审中-公开
标题翻译：可拆卸心脏瓣膜输送系统
公开(公告)号：WO2012023978A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/001443
申请日：2011-08-17
申请人： ST. JUDE MEDICAL, INC. , KLIMA, Daniel J. , WANG, Huisun , THOMAS, Ralph J. , GEIGER, Gary W.
发明人： KLIMA, Daniel J. , WANG, Huisun , THOMAS, Ralph J. , GEIGER, Gary W.
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61B17/00234 , A61B2017/00314 , A61F2/966 , Y10T156/1043
摘要： A delivery system for delivering a collapsible prosthetic heart valve includes a valve support structure for supporting a collapsible prosthetic heart valve, and a distal sheath movable in a longitudinal direction relative to the valve support structure between a first position in which the distal sheath is adapted to surround a collapsible prosthetic heart valve supported on the valve support structure, and a second position in which the distal sheath is adapted to expose the collapsible prosthetic heart valve for deployment. The distal sheath is at least partially formed of an inner polymer layer, an outer polymer layer, and a tubular supporting member sandwiched between the inner polymer layer and the outer polymer layer.
摘要翻译：用于递送可折叠的假体心脏瓣膜的递送系统包括用于支撑可折叠的假体心脏瓣膜的瓣膜支撑结构，以及远侧护套，其可在第一位置和第二位置之间沿纵向方向相对于所述瓣膜支撑结构移动，所述远端护套适于围绕支撑在所述阀支撑结构上的可折叠假体心脏瓣膜，以及第二位置，其中所述远侧护套适于暴露可折叠的假体心脏瓣膜用于展开。远侧护套至少部分地由内聚合物层，外聚合物层和夹在内聚合物层和外聚合物层之间的管状支撑构件形成。

8. 发明申请

WO2012036744A3 IMPROVED PREPARATION METHODS FOR TRANSCATHETER HEART VALVE DELIVERY SYSTEMS 审中-公开
公开(公告)号：WO2012036744A3
公开(公告)日：2012-03-22
申请号：PCT/US2011/001600
申请日：2011-09-16
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , WANG, Huisun , ST. JUDE MEDICAL, INC.
发明人： WANG, Huisun
IPC分类号： A61F2/84
摘要： A delivery device (10) for a collapsible prosthetic heart valve (6) includes a support shaft (21) around which a compartment (23) is defined, an inner shaft (26) extending through the support shaft and adapted to slide relative to the support shaft along a longitudinal axis thereof, the inner shaft having a lumen therethrough, and a distal sheath (24) operatively connected at a distal end to the inner shaft and slidable therewith. The compartment may receive the valve in an assembled condition, and may be selectively covered and uncovered by the distal sheath. A first flow path (c) may provide flow communication between the lumen of the inner shaft and the compartment.

9. 发明申请

WO2012036741A2 STAGED DEPLOYMENT DEVICES AND METHODS FOR TRANSCATHETER HEART VALVE DELIVERY 审中-公开
标题翻译：分段部署装置和方法用于运输心脏瓣膜输送
公开(公告)号：WO2012036741A2
公开(公告)日：2012-03-22
申请号：PCT/US2011/001597
申请日：2011-09-16
申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC. , KNIPPEL, Bradley, C. , WANG, Huisun , THOMAS, Ralph, J. , DALY, Jacob, J. , ST. JUDE MEDICAL, INC.
发明人： KNIPPEL, Bradley, C. , WANG, Huisun , THOMAS, Ralph, J. , DALY, Jacob, J.
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/95 , A61F2/962 , A61F2/966 , A61F2002/9517 , A61F2002/9534
摘要： A delivery device for a collapsible heart valve includes an operating handle and a catheter assembly. The operating handle includes a frame defining a movement space therein, a carriage assembly moveable in a longitudinal direction within the movement space, and a coupler having locked and unlocked conditions, the coupler being operatively connected to the carriage assembly for movement therewith. The catheter assembly includes a shaft around which a valve receiving compartment is defined, the shaft being operatively connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly for movement therewith between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve.
摘要翻译：用于可折叠心脏瓣膜的递送装置包括操作手柄和导管组件。操作手柄包括限定其中的移动空间的框架，可在移动空间内沿纵向方向移动的滑架组件和具有锁定和解锁状态的联接器，联接器可操作地连接到滑架组件以与其一起运动。所述导管组件包括轴，围绕所述轴限定了阀接收室，所述轴可操作地连接到所述框架或所述托架组件中的一个，以及可操作地连接到所述托架组件的远侧护套，用于在适于维持隔室中的阀门和适于完全展开阀门的开启状态。

10. 发明申请

WO2013016107A1 EXPANDABLE RADIOPAQUE MARKER FOR TRANSCATHETER AORTIC VALVE IMPLANTATION 审中-公开
标题翻译：可扩展的放射性标记用于运输管道动脉瓣植入
公开(公告)号：WO2013016107A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/047283
申请日：2012-07-19
申请人： ST. JUDE MEDICAL, INC. , WANG, Huisun
发明人： WANG, Huisun
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/06 , A61F2/24 , A61F2/2427 , A61F2/243 , A61F2/246 , A61F2210/0014 , A61F2250/0098
摘要： A delivery device (13) for a collapsible prosthetic heart valve (1) includes a support shaft (21) around which a compartment (23) for the valve is defined, a distal sheath (24) adapted to selectively cover and uncover the compartment and the valve, and a marker cage (30) having a collapsed condition when the distal sheath covers the compartment and an expanded condition when the compartment is uncovered. The marker cage includes at least one rib (33) having a radiopaque marker (34) for determining the positioning of the valve as it is deployed. The valve may be assembled around the marker cage so that the marker cage does not interfere with the radial expansion of the valve during deployment.
摘要翻译：用于可折叠的假体心脏瓣膜（1）的输送装置（13）包括支撑轴（21），围绕所述阀的隔室（23）被限定在所述支撑轴上，远侧护套（24）适于选择性地覆盖和露出隔室，所述阀门以及当所述远端护套覆盖所述隔室时具有折叠状态的标记器保持架（30），并且当所述隔间未被覆盖时，所述标记器保持架（30）处于膨胀状态。所述标记器保持架包括至少一个肋（33），所述肋（33）具有不透射线的标记（34），用于确定在所述阀部署时所述阀的定位。阀可以围绕标记器保持架组装，使得标记器保持架在展开期间不会干扰阀的径向膨胀。

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