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1. 发明申请

WO2012091765A1 DYNAMIC ADAPTIVE RESPIRATION COMPENSATION WITH AUTOMATIC GAIN CONTROL 审中-公开
标题翻译：动态自适应呼叫补偿与自动增益控制
公开(公告)号：WO2012091765A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/051447
申请日：2011-09-13
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , KOYRAKH, Lev A. , VOTH , Eric J , HAUCK, John A. , SCHWEITZER, Jeffrey A.
发明人： KOYRAKH, Lev A. , VOTH , Eric J , HAUCK, John A. , SCHWEITZER, Jeffrey A.
IPC分类号： A61M25/095
CPC分类号： A61B5/7207 , A61B5/0044 , A61B5/053 , A61B5/0536 , A61B5/0538 , A61B5/06 , A61B5/061 , A61B5/063 , A61B5/6801 , A61B5/7203 , A61B5/721 , A61B5/7267 , A61B5/742 , H04L25/0278 , H04L25/03019
摘要： A system for determining a location of an electrode of a medical device ( e.g. , a catheter) in a body of a patient (11) includes a localization block 32 ()for producing an uncompensated electrode location (33), a motion compensation block (34) for producing a compensation (signal 35) ( i.e ., for respiration, cardiac, etc.), and a mechanism (37) for subtracting the compensation signal (35) from the uncompensated electrode location (33). The result is a corrected electrode location (38) substantially free of respiration and cardiac artifacts. The motion compensation block (34) includes a dynamic adaptation feature which accounts for changes in a patient's respiration patterns as well as intentional movements of the medical device to different locations within the patient's body. The system further includes an automatic compensation gain control (36) which suppresses compensation when certain conditions, such as noise or sudden patch impedance changes, are detected.
摘要翻译：用于确定患者体内医疗装置（例如，导管）的电极的位置的系统包括用于产生未补偿的电极位置（33）的定位块32（），运动补偿块用于产生补偿（信号35）（即，用于呼吸，心脏等）的机构（37）以及用于从未补偿的电极位置（33）减去补偿信号（35）的机构（37）。结果是基本上没有呼吸和心脏伪像的校正电极位置（38）。运动补偿块（34）包括动态适应特征，其考虑患者呼吸模式的变化以及医疗装置对病人体内不同位置的有意移动。该系统还包括自动补偿增益控制（36），其在检测到某些条件（例如噪声或突发阻抗变化）时抑制补偿。

2. 发明申请

WO2013101270A1 ELECTRICALLY TRANSPARENT INTRODUCER SHEATH 审中-公开
标题翻译：电动透明导板
公开(公告)号：WO2013101270A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/026979
申请日：2012-02-28
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , KOYRAKH, Lev A. , POTTER, Daniel J. , SCHWEITZER, Jeffrey A. , DENO, D. Curtis , HILL, Anthony D. , JUST, Dale E.
发明人： KOYRAKH, Lev A. , POTTER, Daniel J. , SCHWEITZER, Jeffrey A. , DENO, D. Curtis , HILL, Anthony D. , JUST, Dale E.
IPC分类号： A61M5/178
CPC分类号： A61B5/04 , A61B5/02444 , A61B5/0538 , A61B5/14503 , A61B2560/06 , A61M25/005 , A61M25/0662
摘要： An introducer sheath for a medical device is provided. The sheath includes a defomnabie, elongate body disposed about a longitudinal axis. The body has proximal and distal ends and defines a lumen extending between the proximal and distal ends and configured to allow passage of the medical device therethrough. The body is configured to allow an electric current to pass radially between a space outside of the body and the lumen such that the position of the medical device within a patient can be monitored and electrogram readings from body tissues can be measured while the device is in the sheath. In some embodiments of the invention, the body may include a one or more apertures extending from the radially outer surface of the body to the lumen or a portion of the body may be made from a conductive and/or fluid permeable material.
摘要翻译：提供了一种用于医疗装置的引导器护套。护套包括围绕纵向轴线设置的可修整体，细长体。主体具有近端和远端并且限定在近端和远端之间延伸并且构造成允许医疗装置通过的内腔。身体被构造成允许电流在身体外部的空间与内腔之间径向通过，使得可以监测患者内的医疗装置的位置，并且可以在装置处于状态时测量来自身体组织的电描记图读数护套。在本发明的一些实施例中，主体可以包括从主体的径向外表面延伸到内腔的一个或多个孔，或者主体的一部分可以由导电和/或流体可渗透的材料制成。

3. 发明申请

WO2013039564A3 CATHETER NAVIGATION USING IMPEDANCE AND MAGNETIC FIELD MEASUREMENTS 审中-公开
公开(公告)号：WO2013039564A3
公开(公告)日：2013-03-21
申请号：PCT/US2012/030925
申请日：2012-03-28
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , OLSON, Eric S. , CARBONERA, Carlos , KOYRAKH, Lev A. , STARKS, Daniel R.
发明人： OLSON, Eric S. , CARBONERA, Carlos , KOYRAKH, Lev A. , STARKS, Daniel R.
IPC分类号： A61M25/00
摘要： A method of operating a positioning system 10 by registering a first coordinate system 14 of a first positioning system 12 in a second coordinate system 18 of a second positioning system 16 includes determining an interpolation function configured to register the first, non-orthonormal coordinate system in the second, orthonormal coordinate system. Fiducial pairs are collected by the respective positioning systems 12, 16, each of which contain a respective coordinate in the respective coordinate system 14, 18, both of which refer to the same physical point in three dimensional space. Establishing a working interpolation function involves an analysis of the fiducial pairs using a thin-plate spline algorithm. The method further includes repeatedly obtaining a first coordinate in the first coordinate system 14 and determining a corresponding second coordinate in the second coordinate system 18 in accordance with the interpolation function.

4. 发明申请

WO2014172524A1 SYSTEMS AND METHODS FOR VISUALIZING AND ANALYZING CARDIAC ARRHYTHMIAS USING 2-D PLANAR PROJECTION AND PARTIALLY UNFOLDED SURFACE MAPPING PROCESSES 审中-公开
标题翻译：使用二维平面投影和部分未经修正的表面绘图过程可视化和分析心脏脑膜炎的系统和方法
公开(公告)号：WO2014172524A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034467
申请日：2014-04-17
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： KOYRAKH, Lev A. , VOTH, Eric J.
IPC分类号： A61B5/042 , G06T19/00
CPC分类号： G06T19/20 , A61B5/0408 , A61B5/0422 , G06T11/00 , G06T17/205 , G06T19/00 , G06T2210/41 , G06T2219/008 , G06T2219/2004 , G06T2219/2008
摘要： A method for projecting a 3D surface geometry onto a planar projection 52 comprises: obtaining a 3D geometry 50 of a chamber surface 51 using an algorithm that generates angles and distances between points on the chamber surface 51 that represent mapping information; applying a cutting curve 86 to at least two points on the chamber surface 51; and at least partially unfolding at least a portion of the chamber surface 51 along the cutting curve 86 to form a planar projection 52 that optimally preserves the angles and distances between points on the chamber surface 52.
摘要翻译：用于将3D表面几何投影到平面突起52上的方法包括：使用生成表面映射信息的腔表面51上的点之间的角度和距离的算法获得腔表面51的3D几何体50; 将切割曲线86施加到腔表面51上的至少两个点; 并且沿着切割曲线86至少部分地展开腔表面51的至少一部分，以形成最佳地保持腔表面52上的点之间的角度和距离的平坦突起52。

5. 发明申请

WO2014149472A1 SYSTEM FOR DETECTING CATHETER ELECTRODES ENTERING INTO AND EXITING FROM AN INTRODUCER 审中-公开
标题翻译：用于检测导入电极的输入和输出系统
公开(公告)号：WO2014149472A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/018706
申请日：2014-02-26
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： POTTER, Daniel J. , KOYRAKH, Lev A.
IPC分类号： A61B5/06 , A61B18/14 , A61B19/00 , A61M25/01
CPC分类号： A61B34/20 , A61B5/062 , A61B5/063 , A61B5/065 , A61B5/066 , A61B18/1492 , A61B2017/00243 , A61B2018/00023 , A61B2018/00351 , A61B2018/00577 , A61B2018/00892 , A61B2018/00988 , A61B2034/2051 , A61B2034/2053 , A61B2090/061 , A61B2090/0811 , A61B2562/0257 , A61M25/0097 , A61M25/0105 , A61M25/0147 , A61M2025/0166
摘要： Systems for detecting when catheter electrodes enter into and exit from an introducer are disclosed. In one form, a system detects a relative position of a catheter (comprising a marker band and an electrode) and an introducer (comprising a proximity sensor adapted to sense the marker band), while the catheter and introducer are in a human body. The system may comprise an electronic control unit to analyze signals from the catheter and/or the introducer, to determine whether the catheter electrode is within the introducer; and to disregard data collected from the electrode when that electrode is in the introducer. The sensor may be on the catheter and the sensed element may be on the introducer. The sensed element may comprise one or several marker bands. A marker band may be applied during the manufacture of a medical device or during use and is any element capable of electromagnetic detection.
摘要翻译：公开了用于检测何时导管电极进入和离开导引器的系统。在一种形式中，当导管和导引器在人体内时，系统检测导管（包括标记带和电极）和导引器（包括适于感测标记带的接近传感器）的相对位置。该系统可以包括电子控制单元，用于分析来自导管和/或导入器的信号，以确定导管电极是否在导引器内; 并且当该电极在导引器中时忽略从电极收集的数据。传感器可以在导管上，并且感测的元件可以在导引器上。感测元件可以包括一个或多个标记带。可以在制造医疗装置期间或在使用期间施加标记带，并且是能够进行电磁检测的任何元件。

6. 发明申请

WO2015026733A1 SYSTEM AND METHOD FOR GENERATING ELECTROPHYSIOLOGY MAPS 审中-公开
标题翻译：用于产生电生理学的系统和方法
公开(公告)号：WO2015026733A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/051517
申请日：2014-08-18
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： KOYRAKH, Lev A. , HAGFORS, Mark , PRANAITIS, Simon T. , MULLINS, Nathan A.
IPC分类号： A61B5/042 , A61B5/00
CPC分类号： A61B5/04011 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0488 , A61B5/06 , A61B5/066 , A61B5/7246 , A61B5/742 , A61B2034/2051
摘要： An electrophysiology map can be generated from a plurality of electrophysiology data points added automatically in response to defined inclusion criteria. Inclusion criteria can generally be grouped into two categories: location-based (e.g., velocity, distance moved, dwell time, and proximity) and rhythm-based (e.g., cycle length and EKG matching). As each electrophysiology data point is collected, it can be tested against one or more defined inclusion criteria, and added to the electrophysiology map when it satisfies all such criteria. Inclusion criteria can also be employed to generate the geometric model underlying the electrophysiology map.
摘要翻译：可以从响应于所定义的包含标准自动添加的多个电生理学数据点产生电生理学图谱。包含标准通常可以分为两类：基于位置的（例如，速度，距离移动，停留时间和接近度）和基于节律的（例如，周期长度和EKG匹配）。随着每个电生理学数据点被收集，它可以针对一个或多个定义的包含标准进行测试，并且当它满足所有这些标准时被添加到电生理学图谱中。纳入标准也可用于产生电生理学图下的几何模型。

7. 发明申请

WO2014028114A1 CORRECTION OF SHIFT AND DRIFT IN IMPEDANCE-BASED MEDICAL DEVICE NAVIGATION USING MAGNETIC FIELD INFORMATION 审中-公开
标题翻译：使用磁场信息对基于阻抗的医疗设备导航中的移位和干扰进行校正
公开(公告)号：WO2014028114A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/045885
申请日：2013-06-14
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： KOYRAKH, Lev A. , VYLKOV, Vasily , OLSON, Eric S.
IPC分类号： A61B5/06 , A61B19/00
CPC分类号： A61B5/062 , A61B5/063 , A61B34/20
摘要： A system and method for navigating a medical device within a body are provided. The system includes an electronic control unit configured to determine operating positions for electrical and magnetic position sensors on the medical device within corresponding first and second coordinate systems. The first and second coordinate systems are defined by an electric field based positioning system and a magnetic field based positioning system, respectively. The magnetic position sensor is disposed proximate the electrical position sensor. The ECU is further configured to apply a mapping function correlating the operating positions which generates a mapped position for the magnetic position sensor in the first coordinate system responsive to the operating position of the magnetic position sensor in the second coordinate system. The ECU determines an adjusted operating position for the electrical position sensor in the first coordinate system responsive to the mapped position of the magnetic position sensor.
摘要翻译：提供了一种用于在身体内导航医疗装置的系统和方法。该系统包括电子控制单元，其被配置为确定对应的第一和第二坐标系统内的医疗装置上的电和磁位置传感器的操作位置。第一和第二坐标系分别由基于电场的定位系统和基于磁场的定位系统来定义。磁性位置传感器设置在电气位置传感器附近。 ECU还被配置为响应于第二坐标系中的磁性位置传感器的操作位置，将与第一坐标系中的磁位置传感器的映射位置相对应的操作位置相关联的映射函数。 ECU响应于磁性位置传感器的映射位置，确定第一坐标系中的电气位置传感器的调整的操作位置。

8. 发明申请

WO2014150014A1 REGULARIZATION SCHEMES FOR NON-CONTACT MAPPING WITH A MEDICAL DEVICE 审中-公开
标题翻译：用于与医疗设备的非接触式映射的定期方案
公开(公告)号：WO2014150014A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/021858
申请日：2014-03-07
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC.
发明人： VOTH, Eric J. , DENO, D. Curtis , KOYRAKH, Lev A. , ELIASON, Braden J.
IPC分类号： A61B5/0402 , A61B5/042
CPC分类号： G16H50/50 , A61B5/0402 , A61B5/0422
摘要： An embodiment of a method for solving the inverse problem of electrophysiology and determining a voltage distribution on a surface of a tissue may comprise receiving a plurality of voltages collected by a plurality of electrodes (32) adjacent to the surface, discretizing the problem using a Finite Element Method (FEM) or a Boundary Element Method (BEM), introducing one or more regularization terms to an error minimization formulation, and solving, by a processor, the voltage distribution according to the plurality of voltages and according to the regularization terms. The regularization terms may comprise one or more of a Laplacian smoothness operator, a Tikhonov regularization matrix, a confidence matrix, and a linear operator that interpolates the plurality of electrode voltages to the tissue voltage distribution.
摘要翻译：用于解决电生理学的逆问题并确定组织表面上的电压分布的方法的实施例可以包括接收由与表面相邻的多个电极（32）收集的多个电压，使用有限的方法离散该问题元素方法（FEM）或边界元素方法（BEM），将一个或多个正则化项引入误差最小化公式，以及根据多个电压并根据正则化项由处理器求解电压分布。正则化项可以包括拉普拉斯平滑度算子，Tikhonov正则化矩阵，置信矩阵和将多个电极电压内插到组织电压分布的线性算子中的一个或多个。

9. 发明授权

EP2797648B1 ELECTRICALLY TRANSPARENT INTRODUCER SHEATH 失效
标题翻译：电透明导线护套
公开(公告)号：EP2797648B1
公开(公告)日：2018-04-11
申请号：EP12861474.0
申请日：2012-02-28
申请人： St. Jude Medical Atrial Fibrillation Division Inc.
发明人： KOYRAKH, Lev A. , POTTER, Daniel J. , SCHWEITZER, Jeffrey A. , DENO, D. Curtis , HILL, Anthony D. , JUST, Dale E.
IPC分类号： A61M5/178
CPC分类号： A61B5/04 , A61B5/02444 , A61B5/0538 , A61B5/14503 , A61B2560/06 , A61M25/005 , A61M25/0662
摘要： An introducer sheath for a medical device is provided. The sheath includes a deformable, elongate body disposed about a longitudinal axis. The body has proximal and distal ends and defines a lumen extending between the proximal and distal ends and configured to allow passage of the medical device therethrough. The body is configured to allow an electric current to pass radially between a space outside of the body and the lumen such that the position of the medical device within a patient can be monitored and electrogram readings from body tissues can be measured while the device is in the sheath. In some embodiments of the invention, the body may include a one or more apertures extending from the radially outer surface of the body to the lumen or a portion of the body may be made from a conductive and/or fluid permeable material.

10. 发明公开

EP2797648A1 ELECTRICALLY TRANSPARENT INTRODUCER SHEATH 失效
标题翻译：电气透明包皮
公开(公告)号：EP2797648A1
公开(公告)日：2014-11-05
申请号：EP12861474.0
申请日：2012-02-28
申请人： St. Jude Medical Atrial Fibrillation Division Inc.
发明人： KOYRAKH, Lev A. , POTTER, Daniel J. , SCHWEITZER, Jeffrey A. , DENO, D. Curtis , HILL, Anthony D. , JUST, Dale E.
IPC分类号： A61M5/178
CPC分类号： A61B5/04 , A61B5/02444 , A61B5/0538 , A61B5/14503 , A61B2560/06 , A61M25/005 , A61M25/0662
摘要： An introducer sheath for a medical device is provided. The sheath includes a defomnabie, elongate body disposed about a longitudinal axis. The body has proximal and distal ends and defines a lumen extending between the proximal and distal ends and configured to allow passage of the medical device therethrough. The body is configured to allow an electric current to pass radially between a space outside of the body and the lumen such that the position of the medical device within a patient can be monitored and electrogram readings from body tissues can be measured while the device is in the sheath. In some embodiments of the invention, the body may include a one or more apertures extending from the radially outer surface of the body to the lumen or a portion of the body may be made from a conductive and/or fluid permeable material.

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