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1. 发明申请

WO2006116720A3 BODY FOR A CATHETER OR SHEATH 审中-公开
公开(公告)号：WO2006116720A3
公开(公告)日：2006-11-02
申请号：PCT/US2006/016373
申请日：2006-04-28
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , STEHR, Richard, E.
发明人： GUO, Xiaoping , STEHR, Richard, E.
IPC分类号： A61M5/178
摘要： A body (2) for a catheter or sheath is disclosed. The body (2) includes strips (8, 10) formed longitudinally from the proximal (6) portion of the body (2) to the distal (4) portion of the body (2). The strips are formed of different materials. The strips can have different radiopacities, or can be splittable/peelable. The splittable/peelable body comprises a peel mechanism longitudinally extending along its respective length. The peel mechanism can be formed by longitudinally extending regions of interfacial bonding between first and second longitudinally extending strips of polymer material. A region of stress concentration extends along the region of interfacial bonding. The stress concentration facilitates the splitting of the body (2) along its peel mechanism. The polymer material of the first strip (8) can have a greater amount of radiopaque filler than the polymer material of the second strip (10). Each strip forms at least a portion of an outer circumferential surface of the body (2).

2. 发明申请

WO2006116719A2 PEELABLE ATRAUMATIC TIP AND BODY FOR A CATHETER OR SHEATH 审中-公开
标题翻译：用于导管或护套的柔软的拉伸头和身体
公开(公告)号：WO2006116719A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/016372
申请日：2006-04-28
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , STEHR, Richard, E. , EPSHTEYN, Vitaliy, G. , HOLMAN, Bruce, P. , SAUTER, Donald, A. , POTTER, Daniel, J. , THORSTENSON, Chad, A. , PERERA, Nalin, S.
发明人： GUO, Xiaoping , STEHR, Richard, E. , EPSHTEYN, Vitaliy, G. , HOLMAN, Bruce, P. , SAUTER, Donald, A. , POTTER, Daniel, J. , THORSTENSON, Chad, A. , PERERA, Nalin, S.
IPC分类号： A61M25/02
CPC分类号： A61M25/001 , A61M25/0668 , A61M2025/0687 , Y10T29/49826
摘要： A splittable/peelable tubular body (2) of a catheter or sheath wherein the tubular body (2) has a splittable/peelable atraumatic tip (14) is disclosed. The atraumatic tip (4) is generally softer than the tubular body (2). The tubular body (2) and atraumatic tip (4) each comprise a peel mechanism longitudinally extending along their respective lengths. The peel mechanisms are formed by longitudinally extending regions of interfacial bonding (11) between first and second longitudinally extending strips (8, 10) of polymer material. Each strip (8, 10) forms at least a portion of an outer circumferential surface of the tubular body (2) and atraumatic tip (4). A region of stress concentration extends along the region of interfacial bonding. The stress concentration facilitates the splitting of the tubular body (2) and atraumatic tip (4) along their respective peel mechanisms.
摘要翻译：公开了一种导管或护套的可分离/可剥离的管状体（2），其中管状体（2）具有可分离/可剥离的无创伤尖端（14）。无创尖端（4）通常比管状体（2）更软。管状体（2）和无创尖端（4）各自包括沿其各自长度纵向延伸的剥离机构。剥离机构由在聚合物材料的第一和第二纵向延伸的条带（8,10）之间的纵向延伸的界面结合区域（11）形成。每个条带（8,10）形成管状体（2）和无创尖端（4）的外周表面的至少一部分。应力集中区域沿界面粘合区域延伸。应力集中有利于管状体（2）和无创尖端（4）沿其各自的剥离机构分裂。

3. 发明申请

WO2009085531A1 CATHETER SHAFT AND METHOD OF ITS MANUFACTURE 审中-公开
标题翻译：导管轴及其制造方法
公开(公告)号：WO2009085531A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/085185
申请日：2008-12-01
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , STEHR, Richard E.
发明人： GUO, Xiaoping , STEHR, Richard E.
IPC分类号： A61M25/16
CPC分类号： A61M25/0012 , A61M25/0045 , A61M25/005
摘要： A method of manufacturing a catheter shaft includes the steps of forming an inner layer (26) of a first polymeric material, forming a plait matrix layer (30) including a second polymeric material about the inner layer (26), and forming an outer layer (32) of a third polymeric material about the plait matrix layer (30). The plait matrix layer (30) includes a braided wire mesh (28) partially or fully embedded within the second polymeric material, which is different from at least one of the first polymeric material forming the inner layer (26) and the third polymeric material forming the outer layer (32). The second polymeric material has a higher yield strain and/or a lower hardness than at least the first polymeric material, and preferably both the first and the third polymeric materials. The catheter shaft may be formed by stepwise extrusion, co-extrusion, and/or reflow processes.
摘要翻译：制造导管轴的方法包括以下步骤：形成第一聚合物材料的内层（26），形成围绕内层（26）的包含第二聚合材料的辫状基质层（30），并形成外层（30）的第三聚合物材料（32）。辫子基质层（30）包括部分或完全嵌入第二聚合物材料内的编织丝网（28），其不同于形成内层（26）的第一聚合物材料和形成外层（32）。第二聚合物材料具有比至少第一聚合物材料更高的屈服应变和/或更低的硬度，优选第一和第三聚合物材料。导管轴可以通过逐步挤出，共挤出和/或回流工艺形成。

4. 发明申请

WO2007127792A2 BIOCOMPATIBLE SELF-LUBRICATING POLYMER COMPOSITIONS AND THEIR USE IN MEDICAL AND SURGICAL DEVICES 审中-公开
标题翻译：生物易燃自润滑聚合物组合物及其在医疗和外科设备中的应用
公开(公告)号：WO2007127792A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/067407
申请日：2007-04-25
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , STEHR, Richard, E.
发明人： GUO, Xiaoping , STEHR, Richard, E.
IPC分类号： A61M31/00
CPC分类号： A61L29/049 , A61M25/00 , A61M25/0021 , A61M2025/0048 , A61M2025/006 , A61M2025/0062 , C08L83/04
摘要： The invention comprises self-lubricating polymer compositions that are especially useful in medical devices 10 and valves 200 and gaskets 43 of medical devices 10. In a preferred embodiment the poly met compositions comprise a theimοsetting or thermoplastic silicone elastomer in combination with a lubricity enhancing polyfluQiopoiyether fluid or hydrocarbon-based synthetic oil In other preferred embodiments, the poly met compositions contain only biocompatible components The improved ami-friction properties of the self-lubricating polymers can be demonstrated over a course of insertion and w ithdrawal cycles, where conventional polymers have changing and mostly increasing force required for each insertion and withdrawal, while the polymer compositions of the invention remain stable.
摘要翻译：本发明包括在医疗装置10和阀200以及医疗装置10的垫圈43中特别有用的自润滑聚合物组合物。在一个优选实施方案中，聚合物组合物包含一种或多种热塑性硅氧烷弹性体，其结合润滑性增强聚氟代醚流体或烃基合成油在其它优选实施方案中，聚甲基丙烯酸酯组合物仅含有生物相容性组分。自润滑聚合物的改进的摩擦摩擦性能可以在常规聚合物具有的插入和取出循环过程中得到证明改变和增加每次插入和抽出所需的力，而本发明的聚合物组合物保持稳定。

5. 发明申请

WO2009085486A1 CATHETER SHAFT WITH MULTIPLE REINFORCING LAYERS AND METHOD OF ITS MANUFACTURE 审中-公开
标题翻译：带有多层增强层的导管轴及其制造方法
公开(公告)号：WO2009085486A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/084560
申请日：2008-11-24
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , JOHNSON, David P. , STEHR, Richard E.
发明人： GUO, Xiaoping , JOHNSON, David P. , STEHR, Richard E.
IPC分类号： A61M25/00
CPC分类号： A61M25/0012 , A61M25/0045 , A61M25/005
摘要： A catheter shaft (12) includes an inner layer (26) of a first polymeric material, an intermediate layer (30) of a second polymeric material, an outer layer (34) of a third polymeric material, a first wire reinforcing layer (28) encapsulated between the inner and intermediate layers (26, 30), and a second wire reinforcing layer (32) encapsulated between the outer and intermediate layers (34, 30). Typically, the first wire reinforcing layer (28) includes one or more metallic wires helically wound in one direction and the second wire reinforcing layer (32) includes one or more metallic wires helically wound in the opposite direction. The intermediate layer (30) is bonded to the inner and outer layers (26, 34), as by extruding layers over one another or by thermal lamination or reflow bonding. Typically, the intermediate layer (30) has a larger yield strain and/or a lower flexural modulus and/or a lower durometer than at least one of the inner layer (26) and the outer layer (34).
摘要翻译：导管轴（12）包括第一聚合材料的内层（26），第二聚合材料的中间层（30），第三聚合物材料的外层（34），第一丝线增强层（28））封装在内层和中间层（26,30）之间，以及封装在外层和中间层（34,30）之间的第二丝线加强层（32）。通常，第一线加强层（28）包括在一个方向上螺旋缠绕的一个或多个金属线，而第二线增强层（32）包括沿相反方向螺旋缠绕的一个或多个金属线。中间层（30）通过彼此挤压层或通过热层压或回流焊接而结合到内层和外层（26,34）。通常，中间层（30）具有比内层（26）和外层（34）中的至少一个更大的屈服应变和/或较低的弯曲模量和/或较低的硬度。

6. 发明申请

WO2009085470A1 DEFLECTABLE CATHETER WITH DISTAL DEFLECTABLE SEGMENT 审中-公开
标题翻译：具有远程可分离部分的防盗导管
公开(公告)号：WO2009085470A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/084330
申请日：2008-11-21
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , TEGG, Troy, T. , STEHR, Richard, E.
发明人： GUO, Xiaoping , TEGG, Troy, T. , STEHR, Richard, E.
IPC分类号： A61M31/00
CPC分类号： A61M25/0147 , A61B5/042 , A61B18/1492 , A61B2017/003 , A61M25/0052 , A61M25/0144
摘要： A steerable medical catheter (18) is provided having proximal and distal portions and a selectively deflectable distal segment (24) having anisotropic bending stiffness for deflection of the shaft (16) in individual planes. Upon actuation of pull wires (26), the distal deflectable segment deflects to move/sweep the distal catheter tip (20) through a sweeping plane (100). The anisotropic bending stiffness of the distal deflectable segment permits in-plane movement of the distal catheter tip (20) in the sweeping plane (100) while resisting out-of-plane movements. In one arrangement, stiffening elements are selectively disposed within the distal deflectable segment (24) such that the out-of-plane bending stiffness increases to a value greater than the in-plane bending stiffness in the sweeping plane. In another arrangement, the cross section of a distal deflectable segment is altered to produce anisotropic area inertias of moment about its centroidal axes, and thus anisotropic bending stiffnesses
摘要翻译：提供了一种可操纵的医疗导管（18），其具有近端部分和远端部分以及具有用于各个平面中的轴（16）的偏转的各向异性弯曲刚度的可选择性偏转的远端部分（24）。在牵引线（26）致动时，远端可偏转段偏转以使远端导管尖端（20）移动/扫掠通过扫掠平面（100）。远端可偏转段的各向异性弯曲刚度允许远侧导管尖端（20）在扫掠平面（100）内的平面内运动，同时抵抗平面外运动。在一种布置中，加强元件选择性地设置在远侧可偏转节段（24）内，使得平面外弯曲刚度增加到大于扫掠平面内的平面内弯曲刚度的值。在另一种布置中，改变远侧可偏转节段的横截面以产生绕其重心轴线的力矩的各向异性面积惯性，因此各向异性弯曲刚度

7. 发明申请

WO2006138356A2 BRAIDED PEELABLE SHEATH 审中-公开
公开(公告)号：WO2006138356A2
公开(公告)日：2006-12-28
申请号：PCT/US2006/023136
申请日：2006-06-14
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , STEHR, Richard, E. , GUO, Xiaoping
发明人： STEHR, Richard, E. , GUO, Xiaoping
IPC分类号： B32B9/02
CPC分类号： A61M25/005 , A61M25/0668 , A61M2025/0188
摘要： The present invention is a splitable/peelable reinforced flexible tubular body (10) for a catheter or sheath (12). The body (10) comprises a proximal end (14), a distal end (16), a wall structure (18), and a lumen (20) defined by the wall structure (18). The wall structure (18) extends between the ends and includes a reinforcement layer (22) within the wall structure (18) and a separation line (26) extending longitudinally along the wall structure (18) . The separation line (26) is adapted to facilitate the splitting/peeling of the wall structure (18) to allow a medical device such as a pacemaker lead to be removed from within the tubular body (10).
摘要翻译：本发明是一种用于导管或护套（12）的可分离/可剥离的增强柔性管状体（10）。主体（10）包括近端（14），远端（16），壁结构（18）和由壁结构（18）限定的内腔（20）。壁结构（18）在端部之间延伸并且包括壁结构（18）内的加强层（22）和沿着壁结构（18）纵向延伸的分离线（26）。分离线（26）适于促进壁结构（18）的分裂/剥离，以允许诸如起搏器引线的医疗装置从管状体（10）内被移除。

8. 发明申请

WO2012091794A1 HYDROPHOBIC CATHETER AND COMPOSITION 审中-公开
标题翻译： HYDROPHOBIC导管和组合物
公开(公告)号：WO2012091794A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/059115
申请日：2011-11-03
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , GUO, Xiaoping , KAUPHUSMAN, James, V. , JOHNSON, David, P. , ARMSTRONG, Karen, L.
发明人： GUO, Xiaoping , KAUPHUSMAN, James, V. , JOHNSON, David, P. , ARMSTRONG, Karen, L.
IPC分类号： A61M25/00
CPC分类号： A61L29/085 , A61L2420/08 , A61M25/0012 , C08L27/20 , C08L77/12
摘要： In various embodiments, a surgical catheter 10 is provided. The catheter 10 may comprise one or more hydrophobic barrier layers made from an ethylene-perfluoroethylenepropylene ("EFEP") copolymer. Additionally, the catheter 10 may comprise another polymer layer made from a reactive polar polymer. In at least one embodiment, the reactive polar polymer may be a modified- poly(ether block amide) ("PEBA") copolymer, such as an amine-terminated PEBA. Moreover, in various embodiments, a composition is provided that may comprise a reactive polar polymer bonded to an EFEP copolymer.
摘要翻译：在各种实施例中，提供了外科导管10。导管10可以包括由乙烯 - 全氟乙烯丙烯（“EFEP”）共聚物制成的一个或多个疏水屏障层。此外，导管10可以包括由反应极性聚合物制成的另一聚合物层。在至少一个实施方案中，反应性极性聚合物可以是改性聚（醚嵌段酰胺）（“PEBA”）共聚物，例如胺封端的PEBA。此外，在各种实施方案中，提供了可以包含与EFEP共聚物结合的反应性极性聚合物的组合物。

9. 发明公开

EP1879637A2 BODY FOR A CATHETER OR SHEATH 有权
标题翻译：身体的导管或套管
公开(公告)号：EP1879637A2
公开(公告)日：2008-01-23
申请号：EP06751861.3
申请日：2006-04-28
申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.
发明人： GUO, Xiaoping , STEHR, Richard, E.
IPC分类号： A61M25/00
CPC分类号： A61M25/0668 , A61M25/0009 , A61M25/0023 , A61M25/005 , A61M25/0108
摘要： A body (2) for a catheter or sheath is disclosed. The body (2) includes strips (8, 10) formed longitudinally from the proximal (6) portion of the body (2) to the distal (4) portion of the body (2). The strips are formed of different materials. The strips can have different radiopacities, or can be splittable/peelable. The splittable/peelable body comprises a peel mechanism longitudinally extending along its respective length. The peel mechanism can be formed by longitudinally extending regions of interfacial bonding between first and second longitudinally extending strips of polymer material. A region of stress concentration extends along the region of interfacial bonding. The stress concentration facilitates the splitting of the body (2) along its peel mechanism. The polymer material of the first strip (8) can have a greater amount of radiopaque filler than the polymer material of the second strip (10). Each strip forms at least a portion of an outer circumferential surface of the body (2).

10. 发明公开

EP2627391A1 HYDROPHOBIC CATHETER AND COMPOSITION 有权
标题翻译：疏水导管及组成
公开(公告)号：EP2627391A1
公开(公告)日：2013-08-21
申请号：EP11852471.9
申请日：2011-11-03
申请人： St. Jude Medical, Atrial Fibrillation Division, Inc.
发明人： GUO, Xiaoping , KAUPHUSMAN, James, V. , JOHNSON, David, P. , ARMSTRONG, Karen, L.
IPC分类号： A61M25/00
CPC分类号： A61L29/085 , A61L2420/08 , A61M25/0012 , C08L27/20 , C08L77/12
摘要： In various embodiments, a surgical catheter is provided. The catheter may comprise one or more hydrophobic barrier layers made from an ethylene-pertfluoroethylenepropylene (“EFEP”) copolymer. Additionally, the catheter may comprise another polymer layer made from a reactive polar polymer. In at least one embodiment, the reactive polar polymer may be a modified-poly(ether block amide) (“PEBA”) copolymer, such as an amine-terminated PEBA. Moreover, in various embodiments, a composition is provided that may comprise a reactive polar polymer bonded to an EFEP copolymer.

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