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1. 发明申请

WO2007038314A2 FUSED HETEROCYCLIC COMPOUNDS USEFUL AS KINASE MODULATORS 审中-公开
标题翻译：熔化的杂环化合物作为激酶调节剂有用
公开(公告)号：WO2007038314A2
公开(公告)日：2007-04-05
申请号：PCT/US2006037056
申请日：2006-09-22
申请人： SQUIBB BRISTOL MYERS CO , VACCARO WAYNE , CHEN ZHONG , DODD DHARMPAL S , HUYNH TRAM N , LIN JAMES , LIU CHUNJIAN , MUSSARI CHRISTOPHER P , TOKARSKI JOHN S , TORTOLANI DAVID R , WROBLESKI STEPHEN T
发明人： VACCARO WAYNE , CHEN ZHONG , DODD DHARMPAL S , HUYNH TRAM N , LIN JAMES , LIU CHUNJIAN , MUSSARI CHRISTOPHER P , TOKARSKI JOHN S , TORTOLANI DAVID R , WROBLESKI STEPHEN T
IPC分类号： C07D487/04 , A61K31/437 , A61P29/00
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, and hydrates, thereof, (I) are useful as kinase modulators, including MK2 modulation, wherein one of E and F is a nitrogen atom and the other of E and F is a carbon atom, and Z is N or CR 3 , and R 1 , R 2 , R 3 , X and Y are as defined herein.
摘要翻译：具有式（I）的化合物及其对映异构体和非对映异构体，其药学上可接受的盐和水合物，（I）可用作激酶调节剂，包括MK2调节，其中E和F之一是氮原子，另一个的E和F是碳原子，Z是N或CR 3，R 1，R 2，R 3 X和Y如本文所定义。

2. 发明专利

IL274816D0 Sulfone pyridine alkyl amide-substituted heteroaryl compounds 未知
公开(公告)号：IL274816D0
公开(公告)日：2020-07-30
申请号：IL27481620
申请日：2020-05-20
申请人： SQUIBB BRISTOL MYERS CO , YANG MICHAEL G , XIAO ZILI , CHEN LING , LIU CHUNJIAN , MOSLIN RYAN M , TOKARSKI JOHN S , WEINSTEIN DAVID S , WROBLESKI STEPHEN T
发明人： YANG MICHAEL G , XIAO ZILI , CHEN LING , LIU CHUNJIAN , MOSLIN RYAN M , TOKARSKI JOHN S , WEINSTEIN DAVID S , WROBLESKI STEPHEN T
IPC分类号： A61K31/501 , A61P29/00 , A61P37/00 , C07F9/6558
摘要： Compounds having the following formula I:or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

3. 发明申请

WO2006017054A3 TRICYCLIC-HETEROARYL COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译： TRICYCLIC-HETEROARYL化合物作为激酶抑制剂有用
公开(公告)号：WO2006017054A3
公开(公告)日：2006-03-16
申请号：PCT/US2005023683
申请日：2005-06-30
申请人： SQUIBB BRISTOL MYERS CO , LIN JAMES , WROBLESKI STEPHEN T , LIU CHUNJIAN , LEFTHERIS KATERINA
发明人： LIN JAMES , WROBLESKI STEPHEN T , LIU CHUNJIAN , LEFTHERIS KATERINA
IPC分类号： C07D487/14 , A61K31/53 , A61P3/10 , A61P9/04 , A61P19/02
CPC分类号： C07D487/14
摘要： The present invention relates to compounds having the formula (I) wherein, Q is optionally substituted aryl or heteroaryl, R
摘要翻译：本发明涉及具有式（I）的化合物，其中Q是任选取代的芳基或杂芳基，R 1是

4. 发明申请

WO2004098528A3 PYRAZOLE-AMINE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：吡唑胺化合物作为激酶抑制剂有用
公开(公告)号：WO2004098528A3
公开(公告)日：2005-07-14
申请号：PCT/US2004013786
申请日：2004-05-03
申请人： SQUIBB BRISTOL MYERS CO , DYCKMAN ALARIC , DAS JAGABANDHU , LEFTHERIS KATERINA , LIU CHUNJIAN , MOQUIN ROBERT V , WROBLESKI STEPHEN T
发明人： DYCKMAN ALARIC , DAS JAGABANDHU , LEFTHERIS KATERINA , LIU CHUNJIAN , MOQUIN ROBERT V , WROBLESKI STEPHEN T
IPC分类号： A61K20060101 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/535 , A61K31/675 , C07D20060101 , C07D231/04 , C07D231/14 , C07D231/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/12 , C07D413/14
CPC分类号： C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
摘要： The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
摘要翻译：本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中W，X，R 1，R 2，R 3，R 4，R 5，R 6和m如本文所定义。本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。

5. 发明申请

WO2004098518A3 PYRAZOLE-AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：吡唑酰胺化合物可用作激酶抑制剂
公开(公告)号：WO2004098518A3
公开(公告)日：2005-01-27
申请号：PCT/US2004013594
申请日：2004-05-03
申请人： SQUIBB BRISTOL MYERS CO , DYCKMAN ALARIC , DAS JAGABANDHU , LEFTHERIS KATERINA , LIU CHUNJIAN , MOQUIN ROBERT V , WROBLESKI STEPHEN T
发明人： DYCKMAN ALARIC , DAS JAGABANDHU , LEFTHERIS KATERINA , LIU CHUNJIAN , MOQUIN ROBERT V , WROBLESKI STEPHEN T
IPC分类号： A61K20060101 , A61K31/415 , A61K31/4152 , A61K31/4155 , A61K31/416 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/535 , A61K31/675 , C07D20060101 , C07D231/04 , C07D231/14 , C07D231/18 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/12 , C07D413/12 , C07D413/14
CPC分类号： C07D231/14 , C07D231/12 , C07D231/40 , C07D401/12 , C07D413/12
摘要： The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.
摘要翻译：本发明提供了可用于治疗p38激酶相关病症的式（I）的吡唑衍生化合物，其中G，X，R 1，R 2，R 3，R 4，R 5，R 6和m如本文所定义。本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。

6. 发明申请

WO03090912A9 PYRROLO-TRIAZINE ANILINE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：吡咯啉 - 三嗪化合物作为激酶抑制剂有用
公开(公告)号：WO03090912A9
公开(公告)日：2004-01-08
申请号：PCT/US0312426
申请日：2003-04-15
申请人： SQUIBB BRISTOL MYERS CO , DYCKMAN ALARIC , HYNES JOHN , LEFTHERIS KATHERINA , LIU CHUNJIAN , WROBLESKI STEPHEN T
发明人： DYCKMAN ALARIC , HYNES JOHN , LEFTHERIS KATHERINA , LIU CHUNJIAN , WROBLESKI STEPHEN T
IPC分类号： B01F3/12 , A61K31/53 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P37/06 , A61P43/00 , C07D253/10 , C07D401/06 , C07D403/06 , C07D487/04
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R1, R2, R3, R4, R5, R6, X and Z are as described in the specification.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R1，R2，R3，R4，R5，R6，X和Z如说明书中所述。

7. 发明申请

WO2007016392A3 BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：苯并噻唑和亚苄基唑类化合物作为激酶抑制剂有用
公开(公告)号：WO2007016392A3
公开(公告)日：2007-05-24
申请号：PCT/US2006029520
申请日：2006-07-28
申请人： SQUIBB BRISTOL MYERS CO , LIU CHUNJIAN , LEFTHERIS KATERINA , LIN JAMES
发明人： LIU CHUNJIAN , LEFTHERIS KATERINA , LIN JAMES
IPC分类号： C07D417/04 , A61K31/428 , C07D513/04
CPC分类号： C07D513/04 , C07D417/04
摘要： A compound of Formula (I), or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: (a); (b); (c); or (d), further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also disclosed is a compound of Formula (II), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: (a); (b); (c); (d); or (e), further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.
摘要翻译：式（I）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中A独立地选自：（a）; （B）; （C）; 或（d），其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和W如本文所述。还公开了式（II）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X 或Y为N，G，X或Y中的两个为CH; 和B独立地选自：（a）; （B）; （C）; （D）; 或（e），其中R1，R2，R3，R4，R5，R8，R9和Z如本文所述。还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

8. 发明申请

WO2007103839A2 PYRROLOTRIAZINE ANILINE PRODRUG COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：吡咯烷酮苯胺衍生物化合物作为激酶抑制剂有用
公开(公告)号：WO2007103839A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063250
申请日：2007-03-05
申请人： SQUIBB BRISTOL MYERS CO , LIU CHUNJIAN , LEFTHERIS KATERINA , VRUDHULA VIVEKANANDA M , LIN JAMES
发明人： LIU CHUNJIAN , LEFTHERIS KATERINA , VRUDHULA VIVEKANANDA M , LIN JAMES
CPC分类号： C07D487/04
摘要： Compounds having the Formula (I), including pharmaceutically acceptable salts thereof, [INSERT CHEMICAL STRUCTURE HERE] (I), wherein at least one of X1, X2 or X3 is {INSERT CHEMICAL STRUCTURE HERE] (i), and any remaining X1, X2 or X3 is hydrogen, which are useful as kinase inhibitors, wherein R1 , R2, R3, R4, R5, R6, A1, A2and m are as described herein.
摘要翻译：具有式（I）的化合物，包括其药学上可接受的盐，其中X 1，X 2或X 3中的至少一个为（其中的化学结构）（i），以及任何剩余的X1， X2或X3是氢，其可用作激酶抑制剂，其中R1，R2，R3，R4，R5，R6，A1，A2和m如本文所述。

9. 发明申请

WO2004032875A3 PROCESS FOR THE PREPARATION OF TRI-NITROGEN CONTAINING HETEROARYL-DIAMINE DERIVATIVES USEFUL AS PHARMACEUTICAL AGENTS AND METHODS OF PRODUCING PHARMACEUTICAL AGENTS 审中-公开
标题翻译：制备用作药物的含三硝基的杂芳基二胺衍生物的方法和生产药物的方法
公开(公告)号：WO2004032875A3
公开(公告)日：2004-12-23
申请号：PCT/US0332236
申请日：2003-10-10
申请人： SQUIBB BRISTOL MYERS CO , LIU CHUNJIAN
发明人： LIU CHUNJIAN
IPC分类号： C07D249/14 , C07D251/48 , C07D413/12 , A61K31/41 , A61K31/53 , C07D253/00
CPC分类号： C07D413/12 , C07D249/14 , C07D251/48
摘要： This invention provides a process for producing at least one tri-nitrogen containing heteroaryl-diamine derivatives, which are useful as pharmaceutical agents and components, particularly as IMPDH inhibitors, comprising reacting an isothiocyanate with a hydrogencyanamide salt to produce an N-cyanothiourea salt, then reacting the salt with a hydrazine or amidine in the presence of a peptide-coupling reagent to provide the at least one tri-nitrogen containing heteroaryl-diamine derivative.
摘要翻译：本发明提供了生产至少一种含三氮的杂芳基 - 二胺衍生物的方法，其可用作药物和组分，特别是作为IMPDH抑制剂，包括使异硫氰酸酯与氢甲酰胺盐反应以产生N-氰基硫脲盐，然后使所述盐与肼或脒在肽偶联剂存在下反应以提供所述至少一种含三氮的杂芳基 - 二胺衍生物。

10. 发明申请

WO2008116064A3 FUSED HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE, ALLERGIC, AUTOIMMUNE OR INFLAMMATORY DISEASES 审中-公开
标题翻译：用于治疗增生性，过敏性，自身免疫性或炎性疾病的融合的杂环化合物
公开(公告)号：WO2008116064A3
公开(公告)日：2010-01-21
申请号：PCT/US2008057656
申请日：2008-03-20
申请人： SQUIBB BRISTOL MYERS CO , LIU CHUNJIAN , LEFTHERIS KATERINA , TEBBEN ANDREW J
发明人： LIU CHUNJIAN , LEFTHERIS KATERINA , TEBBEN ANDREW J
IPC分类号： C07D487/04 , A61K31/4188 , A61K31/53 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04
摘要： Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, [PLEASE INSERT CHEMICAL STRUCTURE HERE] (I) are useful as kinase modulators, including Btk modulation, wherein R1, R2, R4, Q, Y, A and D are as defined herein.
摘要翻译：具有式（I）的化合物及其对映异构体和非对映体药学上可接受的盐可用作激酶调节剂，包括Btk调节，其中R1，R2，R4，Q， Y，A和D如本文所定义。

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