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1. 发明申请

WO2007002308A9 PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 审中-公开
标题翻译：制备三唑取代的阿拉伯糖氧基哌嗪衍生物和其中产生的新盐形式的方法
公开(公告)号：WO2007002308A9
公开(公告)日：2007-03-01
申请号：PCT/US2006024335
申请日：2006-06-21
申请人： SQUIBB BRISTOL MYERS CO , SOUNDARARAJAN NACHIMUTHU , QIU YUPING , HU WENHAO , KRONENTHAL DAVID R , SIRARD PIERRE , LAJEUNESSE JEAN , DROGHINI ROBERTO , CHIDAMBARAM RAMAKRISHNAN , QIAN XINHUA , NATALIE JR KENNETH J , PACK SHAWN K , REISING NATHAN , TANG ERQING , FAKES MICHAEL G , GAO QI , QIAN FENG , VAKKALAGADDA BLISSE J , LAI CHIAJEN , KUANG SHAN-MING
发明人： SOUNDARARAJAN NACHIMUTHU , QIU YUPING , HU WENHAO , KRONENTHAL DAVID R , SIRARD PIERRE , LAJEUNESSE JEAN , DROGHINI ROBERTO , CHIDAMBARAM RAMAKRISHNAN , QIAN XINHUA , NATALIE JR KENNETH J , PACK SHAWN K , REISING NATHAN , TANG ERQING , FAKES MICHAEL G , GAO QI , QIAN FENG , VAKKALAGADDA BLISSE J , LAI CHIAJEN , KUANG SHAN-MING
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoleoxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供了制备三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的方法。还提供了在上述方法中产生的新中间体以及1,2,3-三唑取代的氮杂吲哚氧乙酸哌嗪衍生物的新型N-1和无定形形式以及制备这种新型形式的方法。

2. 发明申请

WO2007002308A3 PROCESS FOR PREPARING TRIAZOLE SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES AND NOVEL SALT FORMS PRODUCED THEREIN 审中-公开
标题翻译：制备三唑取代的氮杂双环氧哌嗪衍生物及其生产的新型盐形式的方法
公开(公告)号：WO2007002308A3
公开(公告)日：2007-07-12
申请号：PCT/US2006024335
申请日：2006-06-21
申请人： SQUIBB BRISTOL MYERS CO , SOUNDARARAJAN NACHIMUTHU , QIU YUPING , HU WENHAO , KRONENTHAL DAVID R , SIRARD PIERRE , LAJEUNESSE JEAN , DROGHINI ROBERTO , CHIDAMBARAM RAMAKRISHNAN , QIAN XINHUA , NATALIE JR KENNETH J , PACK SHAWN K , REISING NATHAN , TANG ERQING , FAKES MICHAEL G , GAO QI , QIAN FENG , VAKKALAGADDA BLISSE J , LAI CHIAJEN , KUANG SHAN-MING
发明人： SOUNDARARAJAN NACHIMUTHU , QIU YUPING , HU WENHAO , KRONENTHAL DAVID R , SIRARD PIERRE , LAJEUNESSE JEAN , DROGHINI ROBERTO , CHIDAMBARAM RAMAKRISHNAN , QIAN XINHUA , NATALIE JR KENNETH J , PACK SHAWN K , REISING NATHAN , TANG ERQING , FAKES MICHAEL G , GAO QI , QIAN FENG , VAKKALAGADDA BLISSE J , LAI CHIAJEN , KUANG SHAN-MING
IPC分类号： C07D471/04 , A61K31/4745 , A61P31/12
CPC分类号： C07D471/04 , C07C311/49 , C07D213/26
摘要： A process is provided for preparing triazole substituted azaindoleoxoacetic piperazine derivative. Novel intermediates produced in the above process, and novel N-1 and amorphous forms of a 1,2,3-triazole substituted azaindoleoxoacetic piperazine derivatives and processes for producing such novel forms are also provided.
摘要翻译：提供了制备三唑取代的氮杂糊精乙酸哌嗪衍生物的方法。还提供了在上述方法中制备的新型中间体和新的N-1和无定形形式的1,2,3-三唑取代的氮杂糊精乙酸哌嗪衍生物和制备这种新型的方法。

3. 发明申请

WO2005077945A3 PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS 审中-公开
标题翻译：制备2-氨基噻唑-5-芳族羧酰胺作为激酶抑制剂的方法
公开(公告)号：WO2005077945A3
公开(公告)日：2006-05-18
申请号：PCT/US2005003728
申请日：2005-02-04
申请人： SQUIBB BRISTOL MYERS CO , CHEN BANG-CHI , DROGHINI ROBERTO , LAJEUNESSE JEAN , DIMARCO JOHN D , GALELLA MICHAEL , CHIDAMBARAM RAMAKRISHNAN
发明人： CHEN BANG-CHI , DROGHINI ROBERTO , LAJEUNESSE JEAN , DIMARCO JOHN D , GALELLA MICHAEL , CHIDAMBARAM RAMAKRISHNAN
IPC分类号： C07C235/28 , C07C237/42 , C07D277/56 , C07D417/12 , C07D417/14 , A61P31/04 , A61P31/12 , C07D239 , C07D241 , C07D277
CPC分类号： C07D417/12 , C07C235/28 , C07C237/42
摘要： The invention relates to processes for preparing compounds having the formula (I) and crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R 2 , R 3 , R 4 , and R 5 , are as defined in the specification herein, which compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.
摘要翻译：本发明涉及制备具有式（I）的化合物及其结晶形式的方法，其中Ar为芳基或杂芳基，L为任选的亚烷基连接基，R 2，R 3， R 4，R 4和R 5如本说明书中所定义，该化合物可用作激酶抑制剂，特别是蛋白酪氨酸激酶抑制剂和 p38激酶。

4. 发明申请

WO03039456A2 PROCESS FOR THE PREPARATION OF ANILINE-DERIVED THYROID RECEPTOR LIGANDS 审中-公开
标题翻译：制备苯胺衍生的甲状腺受体配体的方法
公开(公告)号：WO03039456A2
公开(公告)日：2003-05-15
申请号：PCT/US0234592
申请日：2002-10-28
申请人： SQUIBB BRISTOL MYERS CO , CHIDAMBARAM RAMAKRISHNAN , KANT JOYDEEP , WEAVER RAYMOND E JR , YU JURONG , GHOSH ARUN
发明人： CHIDAMBARAM RAMAKRISHNAN , KANT JOYDEEP , WEAVER RAYMOND E JR , YU JURONG , GHOSH ARUN
IPC分类号： C07C45/00 , C07C205/11 , C07C205/12 , C07C205/37 , C07C205/38 , C07C205/43 , C07C231/02 , C07C233/25 , C07C309/24 , C07C309/65 , A61K
CPC分类号： C07C309/65 , C07C45/00 , C07C201/12 , C07C205/12 , C07C205/37 , C07C205/38 , C07C205/43 , C07C213/02 , C07C231/02 , C07C233/25 , C07C309/24 , C07C47/575 , C07C217/90
摘要： Provided are processes for the synthesis of aniline derivatives, specifically certain aniline derivatives which have activity as thyroid receptor ligands.
摘要翻译：提供了合成苯胺衍生物的方法，特别是某些具有甲状腺受体配体活性的苯胺衍生物。

5. 发明申请

WO2010022383A2 CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA 审中-公开
标题翻译：交联剂交联聚合物，组合物和用于治疗高血压
公开(公告)号：WO2010022383A2
公开(公告)日：2010-02-25
申请号：PCT/US2009054706
申请日：2009-08-22
申请人： RELYPSA INC , MANSKY PAUL , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , CHIDAMBARAM RAMAKRISHNAN , MILLS JONATHAN , STRUEVER WERNER
发明人： MANSKY PAUL , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , CHIDAMBARAM RAMAKRISHNAN , MILLS JONATHAN , STRUEVER WERNER
IPC分类号： C08F4/68
CPC分类号： A61K31/78 , A61K9/14 , A61K31/7004 , A61K47/26 , B01J39/20 , C08F212/36 , C08F220/22
摘要： The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译：本发明涉及包含氟基团和酸基团的交联阳离子交换聚合物，这些聚合物的药物组合物，线型多元醇的组合物和这种聚合物的盐。还描述了具有有益物理性质的交联阳离子交换聚合物，包括粒度，颗粒形状，粒度分布，粘度，屈服应力，压缩性，表面形态和/或溶胀比的组合。这些聚合物和组合物可用于结合胃肠道中的钾。

6. 发明申请

WO2010022380A3 LINEAR POLYOL STABILIZED POLYFLUOROACRYLATE COMPOSITIONS 审中-公开
标题翻译：线性多元醇稳定的聚氟丙烯酸酯组合物
公开(公告)号：WO2010022380A3
公开(公告)日：2010-04-22
申请号：PCT/US2009054703
申请日：2009-08-22
申请人： RELYPSA INC , ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CHIDAMBARAM RAMAKRISHNAN , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , MILLS JONATHAN , STRUEVER WERNER
发明人： ALBRECHT DETLEF , BURDICK MICHAEL , CHANG HAN-TING , CHARMOT DOMINIQUE , CHIDAMBARAM RAMAKRISHNAN , CONNOR ERIC , HALFON SHERIN , HUANG I-ZU , LIU MINGJUN , MILLS JONATHAN , STRUEVER WERNER
IPC分类号： A61K31/7004 , A61K31/78 , A61P7/08
CPC分类号： A61K31/78 , A61K31/7004 , C08K5/053 , A61K2300/00
摘要： The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
摘要翻译：本发明涉及直链多元醇和包含氟基团和酸基团的交联阳离子交换聚合物的盐的组合物。这些组合物可用于在胃肠道中结合钾。

7. 发明专利

HRP20100166T4 POSTUPAK ZA PRIPREMU 2-AMINOTIAZOL-5-AROMATIÄŚNIH KARBOKSAMIDA KAO INHIBITORA KINAZE 未知
公开(公告)号：HRP20100166T4
公开(公告)日：2013-09-30
申请号：HRP20100166
申请日：2010-03-22
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHEN BANG-CHI , DROGHINI ROBERTO , LAJEUNESSE JEAN , DIMARCO JOHN D , GALELLA MICHAEL , CHIDAMBARAM RAMAKRISHNAN
IPC分类号： C07D277/56 , A61P31/04 , A61P31/12 , C07C235/28 , C07C237/42 , C07D417/12 , C07D417/14

8. 发明专利

RU2444513C2 УЛУЧШЕННЫЙ КРИСТАЛЛИЧЕСКИЙ МАТЕРИАЛ 未知
公开(公告)号：RU2444513C2
公开(公告)日：2012-03-10
申请号：RU2008142528
申请日：2007-03-27
申请人： KAROBIO AB , SQUIBB BRISTOL MYERS CO
发明人： CHIDAMBARAM RAMAKRISHNAN , GARG NEERAJ , RASMUSON OKE , GRASIN SANDRA
IPC分类号： A61K31/167 , A61P3/04 , A61P9/10 , A61P35/00 , C07C233/25 , C07C235/74 , C07C235/76
摘要： Изобретениеотноситсяк новымкристаллическимформам 3-[[3,5-дибром-4-[4-гидрокси-3-(1-метилэтил)фенокси]фенил]амино]-3-оксопропановойкислоты, характеризующимсяпорошковойрентгенодифрактограммой, имеющейосновныепикилибопри 2θ=16,1±0,2, 20,1±0,2, 20,7±0,2, и 24,2±0,2, либопри 2θ=9,0±0,2, 14,7±0,2, 19,6±0,2, 21,6±0,2 и 24,3±0,2. Такжеизобретениеотноситсяк способамполучениязаявленныхкристаллическихформ, фармацевтическойкомпозиции, обладающейсвойствамиагонистатиреоидногобета-рецептора, способуселективногоагонистическоговоздействиянатиреоидныйбета-рецептор, кприменениюдляизготовлениялекарственногосредстваи кспособулечениямлекопитающего, страдающегосостоянием, связаннымс тиреоиднойдисфункцией. Техническийрезультат - новыекристаллическиеформы 3-[[3,5-дибром-4-[4-гидрокси-3-(1-метилэтил)фенокси]фенил]амино]-3-оксопропановойкислоты, обладающиесвойствамиагонистатиреоидногобета-рецептора. 9 н. и 10 з.п. ф-лы, 3 табл., 7 ил., 7 пр.

9. 发明专利

BRPI0710120A2 未知
公开(公告)号：BRPI0710120A2
公开(公告)日：2011-08-02
申请号：BRPI0710120
申请日：2007-03-27
申请人： KAROBIO AB , SQUIBB BRISTOL MYERS CO
发明人： CHIDAMBARAM RAMAKRISHNAN , GARG NEERAJ , RASMUSON AKE , GRACIN SANDRA
IPC分类号： C07C233/25 , A61K31/167 , A61P3/04
摘要： The invention relates to a novel crystalline form of 3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-phonoxy]-phenyl]-amino]-3-oxopropanoic acid, said crystalline form being characterised by a powder X-ray diffraction pattern having major peaks at 2¸ = 9.0±0.2, 14.7±0.2, 19.6±0.2, 21.6±0.2, and 24.3±0.2.

10. 发明专利

GEP20094804B PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS 未知
公开(公告)号：GEP20094804B
公开(公告)日：2009-10-26
申请号：GEAP2005009607
申请日：2005-02-04
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHIDAMBARAM RAMAKRISHNAN , GALELLA MICHAEL , DIMARCO JOHN D , LAJEUNESSE JEAN , DROGHINI ROBERTO , CHEN BANG-CHI
IPC分类号： A61K31/425 , C07C235/28 , C07C237/42 , C07D277/42 , C07D277/56 , C07D417/12 , C07D417/14
摘要： The invention relates to compounds having the formula (I) and processes for preparing crystalline forms thereof, wherein Ar is aryl or heteroaryl, L is an optional alkylene linker, and R2, R3, R4, and R5, are as defined in the specification herein. Said compounds are useful as kinase inhibitors, in particular, inhibitors of protein tyrosine kinase and p38 kinase.

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