专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004043912A3 METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：用于制备可用作激酶抑制剂的吡咯并三嗪化合物的方法
公开(公告)号：WO2004043912A3
公开(公告)日：2004-07-01
申请号：PCT/US0335220
申请日：2003-11-03
申请人： SQUIBB BRISTOL MYERS CO , GODFREY JOLLIE DUAINE JR , HYNES JOHN JR , DYCKMAN ALARIC J , LEFTHERIS KATERINA , SHI ZHONGPING , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A
发明人： GODFREY JOLLIE DUAINE JR , HYNES JOHN JR , DYCKMAN ALARIC J , LEFTHERIS KATERINA , SHI ZHONGPING , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00 , A61K31/53
CPC分类号： C07D487/04 , C07D207/50
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
摘要翻译：制备具有式（I）的激酶抑制药物化合物或其药学上可接受的盐或溶剂合物的方法，其中R 1至R 6和Z如说明书中所述。根据本发明的方法利用胺化方法，其中吡咯与卤代胺，优选氯胺反应。该步骤之后是环化以形成吡咯并三嗪核心。

2. 发明公开

EP1562949A4 METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权
标题翻译：用于生产VONPYRROLOTRIAZINVERBINDUNGEN引致的，激酶抑制剂适合...
公开(公告)号：EP1562949A4
公开(公告)日：2007-09-12
申请号：EP03781756
申请日：2003-11-03
申请人： SQUIBB BRISTOL MYERS CO
发明人： GODFREY JOLLIE DUAINE JR , HYNES JOHN JR , DYCKMAN ALARIC J , LEFTHERIS KATERINA , SHI ZHONGPING , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00 , A61K31/53
CPC分类号： C07D487/04 , C07D207/50

3. 发明专利

BR0316056A 未知
公开(公告)号：BR0316056A
公开(公告)日：2005-09-27
申请号：BR0316056
申请日：2003-11-03
申请人： SQUIBB BRISTOL MYERS CO
发明人： GODFREY JOLLIE DUAINE , HYNES JOHN , DYCKMAN ALARIC J , LEFTHERIS KATHERINA , SHI ZHONGPING , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00 , A61K31/53
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 through R 6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.

4. 发明专利

CO5560547A2 METODOS PARA LA PREPARACION DE COMPUESTOS DE PIRROLOTRIAZINA UTILES COMO INHIBIDORES DE CINASA 未知
公开(公告)号：CO5560547A2
公开(公告)日：2005-09-30
申请号：CO05043491
申请日：2005-05-05
申请人： SQUIBB BRISTOL MYERS CO
发明人： DYCKMAN ALARIC J , KATERINA LEFTHERIS , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00
摘要： 1.- Un método de formar un pirrol aminado que comprende: hacer reaccionar un compuesto de la Fórmula IV en donde R1 se selecciona de H, alquilo, aralquilo, OR1, OC(O)R1, OC(O)OR1, OC(O)NR1AND#39R1", OS(O)2R1"AND#39, y OS(O)2NR1AND#39R1", en donde los grupos R1AND#39 y R1" pueden ser cada uno en forma independiente H, alquilo, arilo, aralquilo, heterociclo, o grupos cicloalquilo, o pueden tomarse conjuntamente para formar un grupo cicloalquilo, arilo, o heterocíclico, cualquiera de los cuales puede sustituirse de manera opcional, y el grupo R1AND#39" se define como un alquilo, arilo, aralquilo, heterociclo, o cicloalquilo; -SCH3, -OC(=O)R21, -S(=O)R22, -SO2R22, -SO2NR24R25, -CO2R21, -C(=O)NR24R25, -NH2, -NR24R25, NR21SO2NR24R25, -NR21SO2R22, -NR24C(=O)R25, -NR24CO2R25, NR21C(=O)NR24R25, halógeno, nitro, o ciano;A se selecciona de R2X o E, donde X se selecciona de -O-, -OC(=O)-, -S-, -S(=O)-, -SO2- -C(=O)-, -CO2-, -NR10-, -NR10C(=O)-, NR10C(=O)NR11-, -NR10CO2-, -NR10SO2-, -NR10SO2NR11-, SO2NR10-, -C(=O)NR10-, halógeno, nitro, y ciano, o X está ausente; y E es un grupo de retiro de electrones; o R1, tomado conjuntamente con A, puede formar un anillo heterocíclico o aromático, saturado o insaturado, sustituido de manera opcional; R2 se selecciona de: (i) hidrógeno, con la condición de que R2 no es hidrógeno si X es -S(=O)-, -SO2-, -NR10CO2-, o -NR10SO2-; (ii) alquilo, alquenilo, y alquinilo sustituido de manera opcional con hasta cuatro R26; (iii) arilo y heteroarilo sustituido de manera opcional con hasta tres R27; (iv) heterocicIo y cicIoalquilo sustituido de manera opcional con ceto (=O), hasta tres R27, y/o con un puente carbono-carbono de 3 a 4 átomos de carbono; o (v) -C(O)Rb donde Rb es H, OH, alquilo, aralquilo, halo, ORbAND#39, OC(O)RbAND#39, OC(O)ORbAND#39, OC(O)NRbRbAND#39, OS(O)RbAND#39, OS(O)NRbRbAND#39, y Rb y RbAND#39 se seleccionan cada uno independientemente de H, alquilo, aralquilo, heterocicIo o cicIoalquilo, o Rb y RbAND#39 conjuntamente forman un grupo cicIoalquilo, arilo o heterocicIo; sin embargo, R2 está ausente si X es halógeno, nitro o ciano; ...

5. 发明专利

CA2505365A1 METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 未知
公开(公告)号：CA2505365A1
公开(公告)日：2004-05-27
申请号：CA2505365
申请日：2003-11-03
申请人： SQUIBB BRISTOL MYERS CO
发明人： HYNES JOHN JR , DYCKMAN ALARIC J , SHI ZHONGPING , LEFTHERIS KATERINA , GODFREY JOLLIE DUAINE JR , GROSSO JOHN A , DOUBLEDAY WENDEL WILLIAM , WROBLESKI STEPHEN T
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00 , A61K31/53
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, where in R1 through R6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.

6. 发明专利

AU2003287514A1 METHODS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 未知
公开(公告)号：AU2003287514A1
公开(公告)日：2004-06-03
申请号：AU2003287514
申请日：2003-11-03
申请人： SQUIBB BRISTOL MYERS CO
发明人： HYNES JOHN JR , DYCKMAN ALARIC J , LEFTHERIS KATERINA , SHI ZHONGPING , WROBLESKI STEPHEN T , DOUBLEDAY WENDEL WILLIAM , GROSSO JOHN A , GODFREY JOLLIE DUAINE JR
IPC分类号： A61P11/06 , A61P19/02 , A61P19/10 , C07D207/50 , C07D487/04 , C07D519/00
摘要： Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 through R 6 and Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式