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1. 发明专利

IL269026D0 Methods of treating tumor 未知
公开(公告)号：IL269026D0
公开(公告)日：2019-10-31
申请号：IL26902619
申请日：2019-08-30
申请人： SQUIBB BRISTOL MYERS CO , CHANG HAN , BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A IV , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
发明人： CHANG HAN , BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A IV , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： C07K20060101
摘要： The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

2. 发明公开

KR20200139724A 종양을 치료하는 방법 审中-公开
公开(公告)号：KR20200139724A
公开(公告)日：2020-12-14
申请号：KR20207030899
申请日：2019-03-29
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN IV GEORGE A , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00
摘要： 본개시내용은비소세포폐암 (NSCLC)으로부터유래된종양을앓고있는대상체에게치료유효량의 (a) 항-PD-1 항체또는그의항원-결합부분또는항-PD-L1 항체또는그의항원-결합부분및 (b) 항-CTLA-4 항체또는그의항원결합부분을투여하는것을포함하며, 여기서종양은높은종양돌연변이부담 (TMB) 상태를갖는것인, 상기대상체를치료하는방법을제공한다. TMB 상태는종양내의핵산을서열분석하고서열분석된핵산내의게놈변경, 예를들어체세포비동의돌연변이를확인함으로써결정될수 있다.

3. 发明专利

SG10202110594UA METHODS OF TREATING TUMOR 未知
公开(公告)号：SG10202110594UA
公开(公告)日：2021-11-29
申请号：SG10202110594U
申请日：2018-03-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
摘要： The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti-PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

4. 发明专利

MA50056A PROCÉDÉS DE TRAITEMENT DE TUMEUR 未知
公开(公告)号：MA50056A
公开(公告)日：2020-02-05
申请号：MA50056
申请日：2018-03-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A IV , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： C07K16/28

5. 发明专利

AU2018243754A1 Methods of treating tumor 未知
公开(公告)号：AU2018243754A1
公开(公告)日：2019-10-17
申请号：AU2018243754
申请日：2018-03-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN IV GEORGE A , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12Q1/68 , C12Q1/6886
摘要： The disclosure provides a method for treating a subject afflicted with a tumor,

6. 发明专利

SG11201908396PA METHODS OF TREATING TUMOR 未知
公开(公告)号：SG11201908396PA
公开(公告)日：2019-10-30
申请号：SG11201908396P
申请日：2018-03-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , C12Q1/68 , C12Q1/6886
摘要： co00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) WIPO I PCT (51) International Patent Classification: CO7K 16/28 (2006.01) A61K 39/395 (2006.01) C12Q 1/68 (2018.01) A61P 35/00 (2006.01) C12Q 1/6886 (2018.01) (21) International Application Number: PCT/US2018/025518 (22) International Filing Date: 30 March 2018 (30.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/479,817 31 March 2017 (31.03.2017) US 62/582,146 06 November 2017 (06.11.2017) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). (72) Inventors: BHAGAVATHEESWARAN, Prabhu Se- shaiyer; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). BOTWOOD, Nicholas Allan John; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). CHANG, Han; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). FU, Yali; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). GEESE, William J.; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). GREEN, George A., IV; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). HEALEY, Diane; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). MAIER, Sabine; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). NATHAN, Faith E.; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). OUKESSOU, Abderrahim; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). SELVAGGI, Giovanni; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). SZUSTAKOWSKI, Joseph Daniel; Rt. 206 & Province Line Road, Princeton, New Jersey 08543 (US). (74) Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, NW, Washington, District of Columbia 20005 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: METHODS OF TREATING TUMOR (57) : The disclosure provides a method for treating a subject afflicted with a tumor, lung cancer, having a high tumor e.g., mutation burden (TMB) status comprising administering to the subject an immunotherapy, an anti- PD-1 antibody or antigen-bind- e.g., ing portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids. ill~~~~~~~~ 011101010VIIIOH olo HE mil moi ono iflo oimIE (10) International Publication Number WO 2018/183928 Al

7. 发明专利

CA3058175A1 METHODS OF TREATING TUMOR 未知
公开(公告)号：CA3058175A1
公开(公告)日：2018-10-04
申请号：CA3058175
申请日：2018-03-30
申请人： SQUIBB BRISTOL MYERS CO
发明人： BHAGAVATHEESWARAN PRABHU SESHAIYER , BOTWOOD NICHOLAS ALLAN JOHN , CHANG HAN , FU YALI , GEESE WILLIAM J , GREEN GEORGE A , HEALEY DIANE , MAIER SABINE , NATHAN FAITH E , OUKESSOU ABDERRAHIM , SELVAGGI GIOVANNI , SZUSTAKOWSKI JOSEPH DANIEL
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00 , C12Q1/68 , C12Q1/6886
摘要： The disclosure provides a method for treating a subject afflicted with a tumor, e.g., lung cancer, having a high tumor mutation burden (TMB) status comprising administering to the subject an immunotherapy, e.g., an anti- PD-1 antibody or antigen-binding portion thereof. The present disclosure also provides a method for identifying a subject suitable for an immunotherapy, e.g., a treatment with an anti-PD-1 antibody or antigen-binding portion thereof, comprising measuring a TMB status of a biological sample of the subject. A high TMB status identifies the patient as suitable for treatment with an anti-PD-1 antibody or antigen-binding portion thereof. The TMB status can be determined by sequencing nucleic acids in the tumor and identifying a genomic alteration, e.g., a somatic nonsynonymous mutation, in the sequenced nucleic acids.

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