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1. 发明申请

WO2004076636A3 A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY23, EXPRESSED HIGHLY IN KIDNEY 审中-公开
标题翻译：一种新的人类G蛋白偶联受体，HGPRBMY23，在KIDNEY高度表达
公开(公告)号：WO2004076636A3
公开(公告)日：2006-01-26
申请号：PCT/US2004005535
申请日：2004-02-26
申请人： SQUIBB BRISTOL MYERS CO , BARBER LAUREN E , CACACE ANGELA , FEDER JOHN N , NELSON THOMAS C , RAMANATHAN CHANDRA S , RYSECK ROLF-PETER , NEUBAUER MICHAEL G , KORNACKER MICHAEL G
发明人： BARBER LAUREN E , CACACE ANGELA , FEDER JOHN N , NELSON THOMAS C , RAMANATHAN CHANDRA S , RYSECK ROLF-PETER , NEUBAUER MICHAEL G , KORNACKER MICHAEL G
IPC分类号： C07K14/705 , C07K16/28 , C12N20060101 , C12N1/00 , C12N15/12 , C12Q1/68 , G01N33/50 , G01N33/566 , G01N33/574 , G01N33/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法以及与异常NFκB调节相关的疾病和病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明申请

WO2005048951A3 A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY8, EXPRESSED HIGHLY IN BRAIN 审中-公开
标题翻译：一种新的人类G蛋白偶联受体，HGPRBMY8，在脑中表现出来
公开(公告)号：WO2005048951A3
公开(公告)日：2006-05-11
申请号：PCT/US2004038387
申请日：2004-11-12
申请人： SQUIBB BRISTOL MYERS CO , BATTAGLINO PETER , FEDER JOHN N , MINTIER GABRIEL , NELSON THOMAS C , RAMANATHAN CHANDRA S , WESTPHAL RYAN , CACACE ANGELA M , BARBER LAUREN E , HAWKEN DONALD R , KORNACKER MICHAEL G
发明人： BATTAGLINO PETER , FEDER JOHN N , MINTIER GABRIEL , NELSON THOMAS C , RAMANATHAN CHANDRA S , WESTPHAL RYAN , CACACE ANGELA M , BARBER LAUREN E , HAWKEN DONALD R , KORNACKER MICHAEL G
IPC分类号： C07H21/04 , A61K20060101 , A61K38/00 , C07K14/705 , C12N1/15 , C12N1/21 , C12N15/63 , C12N15/85
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the brain are illustrated.
摘要翻译：本发明描述了新发现的人G-蛋白偶联受体及其编码多核苷酸。还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。此外，还说明了治疗，诊断，预防和筛选与异常细胞生长，神经病症以及与脑相关的疾病或病症相关疾病的方法。

3. 发明申请

WO2004035606A3 BACE BINDING PEPTIDES AND USES THEREOF 审中-公开
标题翻译： BACE BINDING PEPTIDES及其用途
公开(公告)号：WO2004035606A3
公开(公告)日：2004-11-18
申请号：PCT/US0332893
申请日：2003-10-15
申请人： SQUIBB BRISTOL MYERS CO , KORNACKER MICHAEL G , COPELAND ROBERT A , HENDRICK JOSEPH , LAI ZHIHONG , MAPELLI CLAUDIO , WITMER MARK RICHARD , MARCINKEVICIENE JOVITA , METZLER WILLIAM , LEE VING , RIEXINGER DOUGLAS
发明人： KORNACKER MICHAEL G , COPELAND ROBERT A , HENDRICK JOSEPH , LAI ZHIHONG , MAPELLI CLAUDIO , WITMER MARK RICHARD , MARCINKEVICIENE JOVITA , METZLER WILLIAM , LEE VING , RIEXINGER DOUGLAS
IPC分类号： C07K1/04 , C07K7/06 , C07K7/08 , C07K14/16 , C07K14/47 , C07K1/00 , A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07K7/08 , C07K1/04 , C07K1/042 , C07K7/06 , C07K14/005 , C07K14/4702 , C07K14/4711 , C12N2740/16122
摘要： The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
摘要翻译：本发明提供了在新发现的外部位点特异性结合BACE的肽。本发明还提供了鉴定与BACE外部位点结合的肽的方法。本发明还提供用于鉴定结合BACE外部位点并调节BACE活性的化合物的方法。另一方面，本发明提供了通过施用与BACE外部位点结合并调节BACE活性的化合物来治疗或预防神经变性疾病如阿尔茨海默病的方法。

4. 发明申请

WO0226987A3 A HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY6, EXPRESSED HIGHLY IN SMALL INTESTINE 审中-公开
标题翻译：人类G蛋白偶联受体，HGPRBMY6，在小型中表现出色
公开(公告)号：WO0226987A3
公开(公告)日：2003-05-15
申请号：PCT/US0130614
申请日：2001-09-26
申请人： SQUIBB BRISTOL MYERS CO
发明人： FEDER JOHN N , MINTIER GABE , RAMANATHAN CHANDRA SEKAR , HAWKEN DONALD R , CACACE ANGELA , BARBER LAUREN , KORNACKER MICHAEL G
IPC分类号： A61K38/00 , A61P1/00 , A61P15/00 , C07K14/705 , C12N15/12 , A61K38/17 , C07K16/28 , C12N5/10 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing and screening for disorders associated with aberrant cell growth and those related to the small intestine and colon are illustrated.
摘要翻译：本发明描述了新发现的人G-蛋白偶联受体及其编码多核苷酸。还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。另外，说明了用于治疗，诊断，预防和筛选与异常细胞生长有关的疾病以及与小肠和结肠相关的疾病的方法。

5. 发明申请

WO0226823A3 A NOVEL HUMAN G-PROTEIN COUPLED RECEPTOR, HGPRBMY7, EXPRESSED HIGHLY IN SPINAL CORD 审中-公开
标题翻译：一种新型人类G蛋白偶联受体，HGPRBMY7，表现为脊髓高
公开(公告)号：WO0226823A3
公开(公告)日：2002-11-07
申请号：PCT/US0130351
申请日：2001-09-26
申请人： SQUIBB BRISTOL MYERS CO
发明人： BATTAGLINO PETER , FEDER JOHN N , MINTIER GABE , RAMANATHAN CHANDRA SEKAR , WESTPHAL RYAN , HAWKEN DONALD R , CACACE ANGELA , BARBER LAUREN , KORNACKER MICHAEL G
IPC分类号： A61K38/00 , A61P35/00 , C07K14/705 , A61K31/713 , A61K38/17 , C07K16/28 , C12N5/10 , C12N15/12 , G01N33/566 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and/or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, immunological diseases, neurological conditions, and diseases or disorders related to the spinal cord and brain, as well as breast and colon, are illustrated.
摘要翻译：本发明描述了新发现的人G-蛋白偶联受体及其编码多核苷酸。还描述了与本发明的多核苷酸和/或多肽相关的表达载体，宿主细胞，激动剂，拮抗剂，反义分子和抗体。此外，示出了用于治疗，诊断，预防和筛选与异常细胞生长，免疫疾病，神经病症以及与脊髓和脑以及乳腺和结肠相关的疾病或病症的疾病的方法。

6. 发明公开

EP0963376A4 PROKARYOTIC TWO-HYBRID SYSTEM 失效
标题翻译：原核双杂交系统
公开(公告)号：EP0963376A4
公开(公告)日：2002-10-09
申请号：EP97952369
申请日：1997-12-10
申请人： SQUIBB BRISTOL MYERS CO
发明人： KORNACKER MICHAEL G
IPC分类号： G01N33/50 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/70 , C12Q1/68 , G01N33/15 , C12N15/63
CPC分类号： C12Q1/6897 , C07K2319/00 , C12N15/1055 , C12N15/70 , C12Q1/68 , C12Q2565/201

7. 发明专利

CA2871640A1 PAR4 AGONIST PEPTIDES 未知
公开(公告)号：CA2871640A1
公开(公告)日：2013-10-31
申请号：CA2871640
申请日：2013-04-24
申请人： SQUIBB BRISTOL MYERS CO
发明人： KORNACKER MICHAEL G , MAPELLI CLAUDIO , RIEXINGER DOUGLAS JAMES
IPC分类号： C07K7/06 , A61K38/00 , C07K14/705
摘要： The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

8. 发明专利

DK0963376T3 未知
公开(公告)号：DK0963376T3
公开(公告)日：2005-04-25
申请号：DK97952369
申请日：1997-12-10
申请人： SQUIBB BRISTOL MYERS CO
发明人： KORNACKER MICHAEL G
IPC分类号： C07H21/04 , C12N1/21 , C12N15/09 , C12N15/63 , C12N15/70 , C12Q1/68 , G01N33/53

10. 发明专利

AT289353T 未知
公开(公告)号：AT289353T
公开(公告)日：2005-03-15
申请号：AT97952369
申请日：1997-12-10
申请人： SQUIBB BRISTOL MYERS CO
发明人： KORNACKER MICHAEL G
IPC分类号： G01N33/50 , C12N1/21 , C12N15/09 , C12N15/10 , C12N15/70 , C12Q1/68 , C12Q1/6897 , G01N33/15 , C12N15/63
摘要： A two-hybrid system that can detect homo- and heterodimeric protein interactions in E. coli and other cells. This system is useful for the same applications as a yeast two-hybrid system; i.e. interaction cloning, mapping protein interaction domains, analyzing protein interactions, detecting protein interactions and detecting modulators thereof. The invention concerns a prokaryotic host cell comprising: (a) a fusion protein having (i) a first DNA-binding domain and (ii) a first interacting domain; (b) a fusion protein having (i) a second DNA-binding domain and (ii) a second interacting domain capable of binding to the first interacting domain; and (c) a nucleic acid molecule having a reporter gene operatively linked to (i) a promoter, (ii) a first operator site capable of binding to the first DNA-binding domain, located upstream of the promoter, and (iii) a second operator site capable of binding the second DNA-binding domain, located downstream of the promoter of the reporter gene; wherein binding of the first interacting domain to the second interacting domain is signaled by altered expression of the reporter gene.

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