专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明专利

SG11201908947QA PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-4-((2-METHOXY-3-(1-METHYL-1H-1,2,4-TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE 未知
公开(公告)号：SG11201908947QA
公开(公告)日：2019-10-30
申请号：SG11201908947Q
申请日：2018-03-29
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHEN KE , DEERBERG JOERG , LIN DONG , DUMMELDINGER MICHAEL , INANKUR BAHAR , KOLOTUCHIN SERGEI V , LI JUN , ROGERS AMANDA J , ROSSO VICTOR W , SIMMONS ERIC M , SOUMEILLANT MAXIME C D , TREITLER DANIEL S , WANG JIANJI , ZHENG BIN , SMITH MICHAEL J , STROTMAN NEIL A , TYMONKO STEVEN , BENKOVICS TAMAS
IPC分类号： C07D403/12 , A61K31/501 , A61P29/00
摘要： DC, N H 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 October 2018 (04.10.2018) W I PO I PCT omit VIII °nolo OH mil O II (10) International Publication Number WO 2018/183649 Al (51) International Patent Classification: C07D 403/12 (2006.01) A61P 29/00 (2006.01) A61K 31/501 (2006.01) (21) International Application Number: PCT/US2018/025100 (22) International Filing Date: 29 March 2018 (29.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/478,789 30 March 2017 (30.03.2017) US (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (72) Inventors: CHEN, Ke; 42 South Drive, East Brunswick, New Jersey 08816 (US). DEERBERG, Joerg; 11 Irongate Ct., Columbus, New Jersey 08022 (US). LIN, Dong; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). DUM- MELDINGER, Michael; c/o Bristol-Myers Squibb Com- pany, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). INANKUR, Bahar; c/o Bristol-My- ers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). KOLOTUCHIN, Sergei V.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). LI, Jun; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). ROGERS, Amanda J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). ROSSO, Victor W.; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). SIMMONS, Eric M.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). SOUMEILLANT, Maxime C. D.; c/o Bristol-My- ers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). TREITLER, Daniel S.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). WANG, Jianji; 9 Aster Way, Dayton, New Jersey 08810 (US). ZHENG, Bin; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). SMITH, Michael J.; c/o Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). STROTMAN, Neil A.; c/o Bris- tol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). TYMONKO, Steven; 577 Oxford Ln, Lindenhurst, Illinois 60046 (US). BENKOVICS, Tamas; 7 Vincent Court, East Brunswick, New Jersey 08816 (US). (74) Agent: KORSEN, Elliott et al.; Bristol-Myers Squibb Company, Route 206 and Province Line Road, Princeton, New Jersey 08543 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = (54) Title: PROCESS FOR THE PREPARATION OF 6-(CYCLOPROPANEAMIDO)-44(2-METHOXY-3-(1-METHYL-1H-1,2,4- TRIAZOL-3-YL)PHENYL)AMINO)-N-(METHYL-D3)PYRIDAZINE-3-CARBOXAMIDE (57) : The invention relates to an improved process for synthesiz- ing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methy1-1H-1,2,4-triazol-3-y1)phenypamino)-N-(m ethyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory dis- eases such as psoriasis. 0 HN W O 20 18/1836 49 Al f N N ,N Me0 [Continued on next page] WO 2018/183649 Al MIDEDIMOMMIDIREIDIMINIIMINIMEHMEMOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))

3. 发明专利

BR112012014677A2 inibidores do vírus da hepatite c 未知
公开(公告)号：BR112012014677A2
公开(公告)日：2015-09-15
申请号：BR112012014677
申请日：2010-12-13
申请人： SQUIBB BRISTOL MYERS CO
发明人： SU BAO-NING , LAURENT DENIS R ST , WANG GAN , ROMINE JEFFREY LEE , BENDER JOHN A , EASTER JOHN A , BELEMA MAKONEN , SMITH MICHAEL J , MEANWELL NICHOLAS A , XU NINGNING , LOPEZ OMAR D , HEWAWASAM PIYASENA , CHENG QI , NGUYEN N VAN , YANG ZHONG
IPC分类号： C07D403/14 , C07D405/14
摘要： inibidores do vírus da hepatite c . a presente invenção refere-se aos compostos, composições e métodos para o tratamento de infecção pelo vírus da hepatite c (hcv). são também descritas composições farmacêuticas contendo tais compostos e métodos para usar estes compostos no tratamento de infecção por hcv.

4. 发明专利

HRP20120990T1 POSTUPAK SINTEZE SPOJEVA KORISNIH ZA LIJEÄŚENJE HEPATITISA C 未知
公开(公告)号：HRP20120990T1
公开(公告)日：2012-12-31
申请号：HRP20120990
申请日：2012-12-03
申请人： SQUIBB BRISTOL MYERS CO
发明人： PACK SHAWN K , GENG PENG , SMITH MICHAEL J , HAMM JASON
IPC分类号： C07D403/14

5. 发明专利

HK1137454A1 PROCESS FOR SYNTHESIZING COMPOUNDS USEFUL FOR TREATING HEPATITIS C 未知
公开(公告)号：HK1137454A1
公开(公告)日：2010-07-30
申请号：HK10104430
申请日：2010-05-06
申请人： SQUIBB BRISTOL MYERS CO
发明人： PACK SHAWN K , GENG PENG , SMITH MICHAEL J , HAMM JASON
IPC分类号： C07D20060101
摘要： The present disclosure generally relates to a process for synthesizing methyl ((1S)-1-(((2S)-2-(5-(4′-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to intermediates useful in this process.

7. 发明专利

IL269586D0 Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyl-d3)pyridazine-3-carboxamide 未知
公开(公告)号：IL269586D0
公开(公告)日：2019-11-28
申请号：IL26958619
申请日：2019-09-24
申请人： LI JUN , SQUIBB BRISTOL MYERS CO , CHEN KE , DEERBERG JOERG , LIN DONG , DUMMELDINGER MICHAEL , INANKUR BAHAR , KOLOTUCHIN SERGEI V , ROGERS AMANDA J , ROSSO VICTOR W , SIMMONS ERIC M , SOUMEILLANT MAXIME C D , TREITLER DANIEL S , WANG JIANJI , ZHENG BIN , SMITH MICHAEL J , STROTMAN NEIL A , TYMONKO STEVEN , BENKOVICS TAMAS
发明人： LI JUN , CHEN KE , DEERBERG JOERG , LIN DONG , DUMMELDINGER MICHAEL , INANKUR BAHAR , KOLOTUCHIN SERGEI V , ROGERS AMANDA J , ROSSO VICTOR W , SIMMONS ERIC M , SOUMEILLANT MAXIME C D , TREITLER DANIEL S , WANG JIANJI , ZHENG BIN , SMITH MICHAEL J , STROTMAN NEIL A , TYMONKO STEVEN , BENKOVICS TAMAS
IPC分类号： C07D20060101
摘要： The invention relates to an improved process for synthesizing 6-(cyciopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula:Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

8. 发明专利

AU2018244916A1 Process for the preparation of 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide 未知
公开(公告)号：AU2018244916A1
公开(公告)日：2019-11-21
申请号：AU2018244916
申请日：2018-03-29
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHEN KE , DEERBERG JOERG , LIN DONG , DUMMELDINGER MICHAEL , INANKUR BAHAR , KOLOTUCHIN SERGEI V , LI JUN , ROGERS AMANDA J , ROSSO VICTOR W , SIMMONS ERIC M , SOUMEILLANT MAXIME C D , TREITLER DANIEL S , WANG JIANJI , ZHENG BIN , SMITH MICHAEL J , STROTMAN NEIL A , TYMONKO STEVEN , BENKOVICS TAMAS
IPC分类号： C07D403/12 , A61K31/501 , A61P29/00
摘要： The invention relates to an improved process for synthesizing 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide of the formula: [INSERT CHEMICAL STRUCTURE HERE] Compound I is currently in clinical trials for the treatment of auto-immune and auto-inflammatory diseases such as psoriasis.

9. 发明专利

AU2010332034B2 Hepatitis C virus inhibitors 未知
公开(公告)号：AU2010332034B2
公开(公告)日：2016-04-14
申请号：AU2010332034
申请日：2010-12-13
申请人： SQUIBB BRISTOL MYERS CO
发明人： BELEMA MAKONEN , ROMINE JEFFREY LEE , NGUYEN VAN N , WANG GAN , LOPEZ OMAR D , ST LAURENT DENIS R , CHEN QI , BENDER JOHN A , YANG ZHONG , HEWAWASAM PIYASENA , XU NINGNING , MEANWELL NICHOLAS A , EASTER JOHN A , SU BAO-NING , SMITH MICHAEL J
IPC分类号： C07D403/14 , C07D405/14
摘要： The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

10. 发明专利

BRPI0815611A2 Processo para sintetizar compostos úteis para tratar hepatite c 未知
公开(公告)号：BRPI0815611A2
公开(公告)日：2015-03-24
申请号：BRPI0815611
申请日：2008-07-31
申请人： SQUIBB BRISTOL MYERS CO
发明人： PACK SHAWN K , GENG PENG , SMITH MICHAEL J , HAMM JASON
IPC分类号： C07D403/14

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式