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1. 发明授权

US3926979A Dithiocarbonylthioacetyl cephalosporins 失效
标题翻译：二硫羰基硫代乙酰头孢菌素
公开(公告)号：US3926979A
公开(公告)日：1975-12-16
申请号：US46501374
申请日：1974-04-29
申请人： SQUIBB & SONS INC
发明人： TREUNER UWE D , BREUER HERMANN
IPC分类号： A61K31/545 , C07D501/20 , C07D501/28
CPC分类号： C07D501/36 , C07D501/20
摘要： R1 is hydrogen, lower alkyl or cyclo-lower alkyl; R2 is a salt forming metal, lower alkyl or cyclo-lower alkyl; R3 is lower alkyl or phenyl-lower alkyl; and X is hydrogen, hydroxy or lower alkanoyloxy, are useful as antibacterial agents.

wherein R is hydrogen, lower alkyl, trimethylsilyl alkali metal or

Dithiocarbonylthio cephalosporin derivatives of the formula
摘要翻译：式S的二硫羰基硫代头孢菌素衍生物AN-R1-CH ----- CO-NH-CH-CHCH2 ||| SCS-R2 PARALLEL C-NC-CH2-X平行O角SC | C或OR并行O其中R 是氢，低级烷基，三甲基甲硅烷基碱金属或O并原-CH2-OC-R3; R1是氢，低级烷基或环 - 低级烷基; R2是形成盐的金属，低级烷基或环 - 低级烷基; R3是低级烷基或苯基 - 低级烷基; X为氢，羟基或低级烷酰氧基，可用作抗菌剂。

2. 发明授权

US3880902A Indanol diesters with thiocarbonic acid 失效
标题翻译：含有硫代碳酸的茚满二酯
公开(公告)号：US3880902A
公开(公告)日：1975-04-29
申请号：US46000774
申请日：1974-04-11
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN
IPC分类号： C07C329/00 , C07C154/00
CPC分类号： C07C329/00
摘要： New indanol diesters with thiocarbonic acid which have the formula

WHEREIN R and R1 each is hydrogen, lower alkyl, halo or trifluoromethyl are useful as fungistatic agents.
摘要翻译：具有式WHEREIN R和R1各自为氢，低级烷基，卤素或三氟甲基的硫代碳酸的新的茚满二醇可用作抑制剂。

3. 发明授权

US3862941A 2-(Thiocarbonylamino)acetamidocephalosporanic acid compounds 失效
标题翻译： 2-（硫代羰基氨基）乙酰氨基头孢烷酸化合物
公开(公告)号：US3862941A
公开(公告)日：1975-01-28
申请号：US19580771
申请日：1971-11-04
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN , TREUNER UWE
IPC分类号： A23K20/195 , A61K31/545 , C07D501/20 , C07D99/24
CPC分类号： C07D501/20
摘要： New 2-(thiocarbonylamino)acetamidocephalosporanic acid compounds of the following general formula, and their salts,

WHEREIN R is hydrogen, lower alkyl, aralkyl, a salt forming ion or the group

R1 is hydrogen, lower alkyl, lower alkenyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, aryl, aralkyl or a heterocyclic group; R2 is lower alkyl, lower alkoxy-lower alkyl, lower alkylthio-lower alkyl, aryl, aralkyl or a heterocyclic group, R3 is lower alkyl, aryl or aralkyl and X is hydrogen, hydroxy, lower alkanoyloxy, aroyloxy, aralkanoyloxy, the radical of a nitrogen base, a quaternary ammonium radical or together X and R represent a bond linking carbon and oxygen in a lactone ring; are useful as antibacterial agents.
摘要翻译：新的2-（硫代羰基氨基）乙酰氨基头孢烷酸化合物及其盐，WHEREIN R是氢，低级烷基，芳烷基，成盐离子或基团; R1是氢，低级烷基，低级烯基，环低级烷基，不饱和环 - 低级烷基，芳基，芳烷基或杂环基; R2是低级烷基，低级烷氧基 - 低级烷基，低级烷硫基 - 低级烷基，芳基，芳烷基或杂环基，R3是低级烷基，芳基或芳烷基，X是氢，羟基，低级烷酰氧基，芳氧基，芳烷氧基，氮基，季铵基或X和R一起表示在内酯环中连接碳和氧的键; 作为抗菌剂是有用的。

4. 发明授权

US3574210A 2,4-disubstituted-6-nitro-and 6-a minoquinazolines 失效
标题翻译： 2,4-取代-6-硝基和6-A微量元素
公开(公告)号：US3574210A
公开(公告)日：1971-04-06
申请号：US3574210D
申请日：1968-07-12
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN , COHNEN ERICH , ROESCH EGON
IPC分类号： C07D239/94 , C07D51/48
CPC分类号： C07D239/94
摘要： THIS INVENTION RELATES TO CERTAIN NEW 2,4-DISUBSTITUTED6-AMINOQUINAZOLINES AND THE 2,4-DISUBSTITUTED-6-NITROQUINAZOLINES FROM WHICH THEY ARE PRODUCED. THE FORMER ARE USEFUL AS ANTI-INFLAMMATORY AGENTS.

5. 发明授权

US3929782A 1,2,4-Oxadiazolonylacetyl cephalosporins 失效
标题翻译： 1,2,4-恶二唑基乙酰头孢菌素
公开(公告)号：US3929782A
公开(公告)日：1975-12-30
申请号：US48654274
申请日：1974-07-08
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN
IPC分类号： C07D271/06 , C07D271/07 , C07D499/00 , C07D501/36 , C07D501/20 , C07D499/44
CPC分类号： C07D271/07 , C07D499/00
摘要： R4 is lower alkyl, phenyl or phenyl-lower alkyl; and X is hydrogen, lower alkoxy, lower alkanoyloxy, lower alkylmercapto, the radical of a nitrogen base, or certain heterocyclic thio moieties; are disclosed. They are useful as antibacterial agents.

R1 is hydrogen, lower alkyl or phenyl-lower alkyl; R2 is hydrogen, lower alkyl, phenyl, hydroxyphenyl, thienyl, furyl, or pyridyl; R3 is hydrogen, lower alkyl, phenyl-lower alkyl, a salt forming ion, trimethylsilyl, benzhydryl, or

WHEREIN A is either

1,2,4-Oxadiazolonylacetyl penicillins and cephalosporins of the general formula
摘要翻译： 1,2,4-恶二唑乙酰基青霉素和通式为WHEREIN A的头孢菌素是R 1是氢，低级烷基或苯基 - 低级烷基; R2是氢，低级烷基，苯基，羟基苯基，噻吩基，呋喃基或吡啶基; R3是氢，低级烷基，苯基 - 低级烷基，成盐离子，三甲基甲硅烷基，二苯甲基或O并行-CH 2 -O-C-R 4; R4是低级烷基，苯基或苯基 - 低级烷基; X是氢，低级烷氧基，低级烷酰氧基，低级烷基巯基，氮碱基或某些杂环硫基; 被披露。它们可用作抗菌剂。

6. 发明授权

US3929774A Acylthiomethyl esters of cephalosporins 失效
标题翻译：头孢菌素的酰基硫代甲酯
公开(公告)号：US3929774A
公开(公告)日：1975-12-30
申请号：US51656674
申请日：1974-10-21
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN
IPC分类号： C07D501/24 , C07D501/36
CPC分类号： C07D501/36 , C07D501/20
摘要： WHEREIN R1 is tetrazolylmethyl or (lower alkyl)tetrazolylmethyl; R2 is hydrogen or lower alkyl; R3 is lower alkyl; and X is thiadiazolylthio or (lower alkyl)thiadiazolylthio. They are useful as antibacterial agents.

New acylthiomethyl esters of cephalosporins have the formula
摘要翻译：头孢菌素的新的酰硫基甲基酯具有下式：其中R1是四唑基甲基或（低级烷基）四唑基甲基; R2是氢或低级烷基; R3是低级烷基; X是噻二唑基硫代或（低级烷基）噻二唑基硫基。它们可用作抗菌剂。

7. 发明授权

US3886149A Amino substituted dithiocarbonylthioacetyl cephalosporins 失效
标题翻译：氨基取代的二硫代羰基硫代乙酰头孢菌素
公开(公告)号：US3886149A
公开(公告)日：1975-05-27
申请号：US25868672
申请日：1972-06-01
申请人： SQUIBB & SONS INC
发明人： TREUNER UWE D , BREUER HERMANN
IPC分类号： C07D499/62 , C07D501/20 , C07D99/24
CPC分类号： C07D501/20
摘要： Amino substituted dithiocarbonylthioacetylcephalosporins of the general formula
R1 is hydrogen, lower alkyl, aralkyl, aryl or certain heterocyclic groups; R2 and R3 each is hydrogen or lower alkyl; R4 is lower alkyl, aryl or aralkyl; R5 is hydrogen or lower alkyl; R6 is hydrogen, cycloalkyl, lower alkyl; or together R5 and R6 complete certain nitrogen heterocyclics; X is hydrogen, hydroxy, lower alkanoyloxy, aroyloxy, aralkanoyloxy, SR7, OR7, the radical of a nitrogen base, a quaternary ammonium radical, or together X and R represent a bond linking carbon and oxygen in a lactone ring; R7 is lower alkyl; and n is 1, 2, 3 or 4; are useful as antibacterial agents.

WHEREIN R is hydrogen, lower alkyl, aralkyl, tri(lower alkyl)silyl, tri(lower alkyl)stannyl, a salt forming ion or the group
摘要翻译：氨基取代的二硫代羰基硫代乙酰头孢菌素，通式为WHEREIN R为氢，低级烷基，芳烷基，三（低级烷基）甲硅烷基，三（低级烷基）甲锡烷基，成盐离子或R1为氢，低级烷基，芳烷基，芳基或某些杂环基; R2和R3各自为氢或低级烷基; R4是低级烷基，芳基或芳烷基; R5是氢或低级烷基; R6为氢，环烷基，低级烷基; 或者R5和R6一起完成某些氮杂环化合物; X是氢，羟基，低级烷酰氧基，芳酰氧基，芳烷酰氧基，SR7，OR7，氮基的基团，季铵基，或一起X和R表示内酯环中碳和氧连接的键; R7是低级烷基; n为1,2,3或4; 作为抗菌剂是有用的。

8. 发明授权

US3558610A Quinazolinone derivatives 失效
标题翻译：喹诺酮衍生物
公开(公告)号：US3558610A
公开(公告)日：1971-01-26
申请号：US3558610D
申请日：1967-12-18
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN , COHNEN ERICH , ROESCH EGON
IPC分类号： B65D85/24 , C07D239/91 , D05B91/12 , C07D87/16
CPC分类号： C07D239/91 , B65D85/24
摘要： THIS INVENTION RELATES TO NEW QUINAZOLINONE DERIVATIVES HAVING THE GENERAL FORMULA

2-R1,3-R2,6-R3-QUINAZOLIN-4(3H)-ONE

COMPOUNDS WHICH ARE USEFUL AS ANTIINFLAMMATORY AGENTS AND ANTIMICROBIAL AGENTS.

9. 发明授权

US3557099A Nitrofuryl-oxadiazole derivatives 失效
标题翻译：硝基呋喃 - 氧杂唑衍生物
公开(公告)号：US3557099A
公开(公告)日：1971-01-19
申请号：US3557099D
申请日：1967-01-24
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN
IPC分类号： A61K31/41 , C07D413/06 , C07D85/52
CPC分类号： C07D413/06 , A61K31/41
摘要： THIS INVENTION RELATES TO NEW, IMPROVED ANTIMICROBIAL AGENTS OF THE FORMULA

3-((5-(NO2-)FUR-2-YL)-(CH=CH)N-),5-(R1-N(-R2)-)-

1,2,4-OXADIAZOLE

WHEREIN R1 AND R2 EACH REPRESENT HYDROGEN, ALKYL, HYDROXY-ALKYL OR ACYL OR TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED FORM A 3 TO 6 MEMBERED HETEROCYCLIC RING WHICH MAY ALSO CONTAIN OXYGEN OR SULFUR, AND WHEREIN N IS 0, 1 OR 2.

10. 发明授权

US3515787A Compositions and methods for producing a muscle relaxing effect in an animal with 2,3 - substituted - 6 - amino-4-quinazolones 失效
标题翻译：用2,3-二取代的6-氨基-4-喹唑啉酮在动物中产生肌肉松弛作用的组合物和方法
公开(公告)号：US3515787A
公开(公告)日：1970-06-02
申请号：US3515787D
申请日：1967-09-15
申请人： SQUIBB & SONS INC
发明人： BREUER HERMANN , HOEHN HANS , ROESCH EGON
IPC分类号： A61K31/505 , C07D239/91 , A61K27/00
CPC分类号： C07D239/91 , A61K31/505

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