专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011140475A3 SYSTEMS FOR DELIVERING A THERAPEUTIC AGENT 审中-公开
标题翻译：用于递送治疗剂的系统
公开(公告)号：WO2011140475A3
公开(公告)日：2012-04-12
申请号：PCT/US2011035573
申请日：2011-05-06
申请人： SPRINGLEAF THERAPEUTICS INC , CHIN TIMOTHY E , GYORY J RICHARD , HAMILTON DANIEL , PIZZOCHERO ALESSANDRO , TAYLOR JON
发明人： CHIN TIMOTHY E , GYORY J RICHARD , HAMILTON DANIEL , PIZZOCHERO ALESSANDRO , TAYLOR JON
IPC分类号： A61M5/142
CPC分类号： A61M5/14586 , A61M5/14248 , A61M5/145 , A61M2005/14252 , A61M2005/14506 , A61M2005/14513
摘要： Devices and methods for delivering a fluid to a patient are disclosed herein. In one embodiment, a delivery system includes a reservoir for containing a fluid and a fluid communicator in fluid communication with the reservoir. An electrochemical actuator is coupled to the reservoir and configured to exert a force on the reservoir upon actuation such that fluid within the reservoir is communicated through the fluid communicator. The actuator includes a first end that is constrained and a second end that is not constrained. The actuator is configured to bend at a location along a length of the actuator when actuated such that the second end of the actuator is displaced in a direction toward the fluid reservoir. The actuator can be an electrochemical actuator. The apparatus can further include a transfer structure disposed between the actuator and the reservoir configured to contact the reservoir upon actuation of the actuator.
摘要翻译：本文公开了用于将流体输送给患者的装置和方法。在一个实施例中，输送系统包括用于容纳流体的储存器和与储存器流体连通的流体通信器。电化学致动器联接到储存器并且构造成在致动时在储存器上施加力，使得储存器内的流体通过流体通信器传递。致动器包括被约束的第一端和不受约束的第二端。致动器构造成在致动器的沿着致动器的长度的位置处弯曲，使得致动器的第二端在朝向流体储存器的方向上移位。致动器可以是电化学致动器。该设备还可以包括设置在致动器和储存器之间的传送结构，该传送结构构造成在致动器致动时接触储存器。

2. 发明申请

WO2012083174A8 ELECTROCHEMICAL ACTUATORS 审中-公开
公开(公告)号：WO2012083174A8
公开(公告)日：2012-07-19
申请号：PCT/US2011065508
申请日：2011-12-16
申请人： MASSACHUSETTS INST TECHNOLOGY , SPRINGLEAF THERAPEUTICS , CHIANG YET-MING , CHIN TIMOTHY E , CIMA MICHAEL J , GYORY J RICHARD
发明人： CHIANG YET-MING , CHIN TIMOTHY E , CIMA MICHAEL J , GYORY J RICHARD
IPC分类号： F03G7/00 , H01M4/02
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.

3. 发明申请

WO2012083174A3 ELECTROCHEMICAL ACTUATORS 审中-公开
标题翻译：电化学驱动器
公开(公告)号：WO2012083174A3
公开(公告)日：2012-09-07
申请号：PCT/US2011065508
申请日：2011-12-16
申请人： MASSACHUSETTS INST TECHNOLOGY , SPRINGLEAF THERAPEUTICS , CHIANG YET-MING , CHIN TIMOTHY E , CIMA MICHAEL J , GYORY J RICHARD
发明人： CHIANG YET-MING , CHIN TIMOTHY E , CIMA MICHAEL J , GYORY J RICHARD
IPC分类号： F03G7/00 , H01M4/02
CPC分类号： H01M14/00 , F03G7/005 , H01M4/131 , H01M4/134 , H01M10/052 , H01M10/058
摘要： Devices and methods for providing electrochemical actuation are described herein. In one embodiment, an actuator device includes an electrochemical cell including a negative electrode and a positive electrode At least a portion of the negative electrode is formed with a material formulated to at least one of intercalate, de-intercalate, alloy with, oxidize, reduce, or plate with a first portion of the positive electrode to an extent different than with a second portion of the positive electrode such that a differential strain is imparted between the first portion and the second portion of the positive electrode and such that at least a portion of the electrochemical cell is displaced. The electrochemical cell includes a portion that is pre-bent along an axis of the electrochemical cell to define a fold axis and the displacement of the at least a portion of the electrochemical cell is maximized along the fold axis.
摘要翻译：这里描述了用于提供电化学致动的装置和方法。在一个实施例中，致动器装置包括电化学电池，该电化学电池包括负电极和正电极。负电极的至少一部分由配制成插入，脱嵌，合金化，氧化，还原，或者用正电极的第一部分电镀至与正电极的第二部分不同的程度，使得在正电极的第一部分和第二部分之间施加差异应变，并且使得至少一部分电化学电池的位移。电化学电池包括沿电化学电池的轴线预先弯曲的部分以限定折叠轴线，并且电化学电池的至少一部分的位移沿折叠轴线最大化。

4. 发明申请

WO2004040260A2 RAISED SURFACE ASSAY PLATE 审中-公开
标题翻译：升高的表面测试板
公开(公告)号：WO2004040260A2
公开(公告)日：2004-05-13
申请号：PCT/US0333875
申请日：2003-10-27
申请人： TRANSFORM PHARMACEUTICALS INC , CIMA MICHAEL J , PRYCE LEWIS WENDY , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY , MONAGLE JULIE
发明人： CIMA MICHAEL J , PRYCE LEWIS WENDY , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY , MONAGLE JULIE
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/00 , C12Q1/24 , C12Q1/68 , G01N20060101 , G01N
CPC分类号： B01L3/5088 , B01L2300/0829
摘要： The assay plate includes a substrate having a substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one sharp edge at the junction between a sidewall coupling the sample receiving surface to the substrate surface. The sample receiving surface is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample. A method of using the above described assay plate is also provided. Once a raised pad extending from a substrate is formed, a sample is deposited on the raised pad. Experiments are subsequently performed using the sample on the raised pad.
摘要翻译：测定板包括具有基底表面的基底和从基底表面延伸的至少一个凸起垫。凸起垫包括基本平坦的样品接收表面，其构造成用于将样品保持在其上用于原位实验。样品接收表面优选在将样品接收表面耦合到衬底表面的侧壁之间的接合处具有至少一个尖锐边缘。样品接收表面优选为圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形，其尺寸适于保持样品的预定体积。还提供了使用上述测定板的方法。一旦形成了从衬底延伸的凸起垫，则将样品沉积在凸起垫上。随后使用凸起垫上的样品进行实验。

5. 发明申请

WO2004102158A3 RAISED SURFACE ASSAY PLATE 审中-公开
标题翻译：升高的表面测试板
公开(公告)号：WO2004102158A3
公开(公告)日：2005-02-03
申请号：PCT/US2004014904
申请日：2004-05-13
申请人： TRANSFORM PHARMACEUTICALS INC , CIMA MICHAEL J , LEWIS WENDY PRYCE , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY V , MONAGLE JULIE
发明人： CIMA MICHAEL J , LEWIS WENDY PRYCE , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY V , MONAGLE JULIE
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/00 , C12Q1/24 , C12Q1/68 , G01N20060101
CPC分类号： B01L3/5085 , B01L3/5025 , B01L3/5088 , B01L2300/0609 , B01L2300/0819 , B01L2300/0829
摘要： The assay plate (100) includes a substrate (102) having an substrate surface (108) and at least one raised pad (104) extending from the substrate surface (108). The raised pad (104) includes a substantially planar sample receiving surface (200) configured for holding a sample (106) thereon for in situ experimentation. The sample receiving surface (200) preferably has at least one sharp edge (210) at the junction between a sidewall (208) coupling the sample receiving surface (200) to the substrate surface (108). The sample receiving surface (200) is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample (106). A method of using the above described assay plate (100) is also provided. Once a raised pad (104) extending from a substrate (102) is formed, a sample (106) is deposited on the raised pad (104). Experiments are subsequently performed using the sample (106) on the raised pad (104).
摘要翻译：测定板（100）包括具有衬底表面（108）和从衬底表面（108）延伸的至少一个凸起垫（104）的衬底（102）。凸起垫（104）包括基本平坦的样品接收表面（200），其被配置用于在其上保持样品（106）用于现场实验。样品接收表面（200）优选在连接到样品接收表面（200）与衬底表面（108）的侧壁（208）之间的接合处具有至少一个尖锐边缘（210）。样品接收表面（200）优选为尺寸适于保持样品（106）的预定体积的圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形。还提供了使用上述测定板（100）的方法。一旦形成从衬底（102）延伸的凸起垫（104），样品（106）沉积在凸起垫（104）上。随后使用凸起垫（104）上的样品（106）进行实验。

6. 发明申请

WO2004047753A3 FREEZE-DRYING MICROSCOPE STAGE APPARATUS AND PROCESS OF USING THE SAME 审中-公开
标题翻译：冷冻干燥显微镜台阶装置及其使用方法
公开(公告)号：WO2004047753A3
公开(公告)日：2004-09-16
申请号：PCT/US0337518
申请日：2003-11-20
申请人： TRANSFORM PHARMACEUTICALS INC , GYORY J RICHARD , GONZALEZ-ZUGASTI JAVIER , PUTNAM DAVID
发明人： GYORY J RICHARD , GONZALEZ-ZUGASTI JAVIER , PUTNAM DAVID
IPC分类号： A61K20060101 , F26B5/06 , G02B21/28
CPC分类号： G02B21/28 , F26B5/06
摘要： The invention concerns methods, systems, and devices for screening arrays comprising hundreds, thousands, or hundreds of thousands of samples. These methods are useful to optimize, select, and discover compositions, or conditions for cost-effective freeze-drying of preparations and freezing of biologicals while maintaining structural integrity and/or viability. Such freeze-dried compositions are easily reformulated for treating or preventing diseases, the cause of the diseases, or the symptoms of the diseases. Moreover, optimized freezing of biological samples enables viable preservation of a wide variety of biologicals.
摘要翻译：本发明涉及用于筛选包含数百，数千或数十万个样本的阵列的方法，系统和设备。这些方法可用于优化，选择和发现组合物或条件，以便在保持结构完整性和/或生存力的同时对制剂进行成本有效的冷冻干燥和冻结生物制剂。这种冷冻干燥的组合物很容易重新配制用于治疗或预防疾病，疾病的原因或疾病的症状。而且，生物样品的优化冷冻能够保存各种各样的生物。

7. 发明申请

WO2004068107A3 APPARATUS AND METHOD FOR TRANSCELLULAR TESTING 审中-公开
标题翻译：用于体外测试的装置和方法
公开(公告)号：WO2004068107A3
公开(公告)日：2005-03-24
申请号：PCT/US2004001275
申请日：2004-01-20
申请人： TRANSFORM PHARMACEUTICALS INC , GYORY J RICHARD , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , LEMMO ANTHONY
发明人： GYORY J RICHARD , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , LEMMO ANTHONY
IPC分类号： C12M3/00 , C12M3/06 , C12Q1/00 , C12Q1/02 , G01N20060101
CPC分类号： G01N33/5008 , G01N33/502
摘要： The present invention relates to a device and method for facilitating high throughput transcellular flux testing of compounds, such as pharmaceuticals or drugs, other compounds, or compound combinations. In one embodiment, the system and methods of the present invention may be used to identify the optimal components (e.g., solvents, carriers, transport enhancers, adhesives, additives, inhibitors, or other excipients) for pharmaceutical compositions or formulations that are delivered to a patient via tissue transport, including without limitation, pharmaceutical compositions or formulations administered or delivered transcellularly, topically, and ocularly.
摘要翻译：本发明涉及促进化合物如药物或药物，其它化合物或化合物组合的高通量跨细胞通量测试的装置和方法。在一个实施方案中，本发明的系统和方法可用于鉴定用于药物组合物或制剂的最佳组分（例如，溶剂，载体，运输增强剂，粘合剂，添加剂，抑制剂或其它赋形剂）患者通过组织运输，包括但不限于药物组合物或通过跨细胞，局部和眼睛施用或递送的制剂。

8. 发明申请

WO2004040260A9 RAISED SURFACE ASSAY PLATE 审中-公开
标题翻译：升高的表面测试板
公开(公告)号：WO2004040260A9
公开(公告)日：2004-10-21
申请号：PCT/US0333875
申请日：2003-10-27
申请人： TRANSFORM PHARMACEUTICALS INC , CIMA MICHAEL J , PRYCE LEWIS WENDY , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY , MONAGLE JULIE
发明人： CIMA MICHAEL J , PRYCE LEWIS WENDY , GONZALEZ-ZUGASTI JAVIER , GYORY J RICHARD , LEMMO ANTHONY , MONAGLE JULIE
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/00 , C12Q1/24 , C12Q1/68 , G01N20060101
CPC分类号： B01L3/5088 , B01L2300/0829
摘要： The assay plate (100) includes a substrate (102) having a substrate surface (108) and at least one raised pad (104) extending from the substrate surface (108). The raised pad (104) includes a substantially planar sample receiving surface (200) configured for holding a sample (106) thereon for in situ experimentation. The sample receiving surface (200) preferably has at least one sharp edge (210) at the junction between a sidewall (208) coupling the sample receiving surface (200) to the substrate surface (108). The sample receiving surface (200) is preferably a circle, oval, square, rectangle, triangle, pentagon, hexagon, or octagon shape that is sized to hold a predetermined volume of the sample (106). A method of using the above described assay plate (100) is also provided. Once a raised pad (104) extending from a substrate (102) is formed, a sample (106) is deposited on the raised pad (104). Experiments are subsequently performed using the sample (106) on the raised pad (104).
摘要翻译：测定板（100）包括具有衬底表面（108）和从衬底表面（108）延伸的至少一个凸起垫（104）的衬底（102）。凸起垫（104）包括被配置用于将样品（106）保持在其上的基本平坦的样品接收表面（200）用于现场实验。样品接收表面（200）优选在连接到样品接收表面（200）与衬底表面（108）的侧壁（208）之间的接合处具有至少一个尖锐边缘（210）。样品接收表面（200）优选为尺寸适于保持样品（106）的预定体积的圆形，椭圆形，正方形，矩形，三角形，五边形，六边形或八边形。还提供了使用上述测定板（100）的方法。一旦形成从衬底（102）延伸的凸起垫（104），样品（106）沉积在凸起垫（104）上。随后使用凸起垫（104）上的样品（106）进行实验。

9. 发明申请

WO2009015389A3 SKIN-PATCH PUMP COMPRISING A CHANGING-VOLUME ELECTROCHEMICAL ACTUATOR 审中-公开
标题翻译：包含变化量电化学致动器的皮肤泵
公开(公告)号：WO2009015389A3
公开(公告)日：2009-05-14
申请号：PCT/US2008071368
申请日：2008-07-28
申请人： ENTRA PHARMACEUTICALS INC , CHIANG YET-MING , CIMA MICHAEL J , GYORY J RICHARD , BOOMA GLENN R
发明人： CHIANG YET-MING , CIMA MICHAEL J , GYORY J RICHARD , BOOMA GLENN R
IPC分类号： A61M5/145 , A61M5/148 , A61M5/155
CPC分类号： A61M5/14248 , A61M5/1452 , A61M5/148 , A61M5/1723 , A61M2005/14204 , A61M2005/14252 , A61M2005/14268 , A61M2005/14513 , A61M2005/1726 , A61M2205/8231
摘要： A patch pump device generally includes at least one fluid source (604), a fluid communicator, and an electrochemical actuator (602). The fluid communicator is in fluid communication with the fluid source. The electrochemical actuator is operative to cause fluid to be delivered from the fluid source into the fluid communicator. Preferably, the electrochemical actuator comprises a charged electrochemical cell, and at least a portion of the electrochemical cell changes its volume or position in response to an applied current or voltage to cause the fluid to be delivered.
摘要翻译：贴剂泵装置通常包括至少一个流体源（604），流体通信器和电化学致动器（602）。流体通信器与流体源流体连通。电化学致动器可操作以使流体从流体源输送到流体通信器中。优选地，电化学致动器包括带电的电化学电池，并且电化学电池的至少一部分响应于所施加的电流或电压而改变其体积或位置以引起流体的输送。

10. 发明申请

WO2004041435A3 METHODS OF MANIPULATING SMALL AMOUNTS OF SOLIDS 审中-公开
标题翻译：控制固体微量元素的方法
公开(公告)号：WO2004041435A3
公开(公告)日：2005-03-03
申请号：PCT/US0335169
申请日：2003-11-03
申请人： TRANSFORM PHARMACEUTICALS INC , KANE NATHAN , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , CHERNG JEAN-PEI , LEMMO ANTHONY V , GYORY J RICHARD , PRYCE-LEWIS WENDY , CHEN HONGMING
发明人： KANE NATHAN , CIMA MICHAEL , GONZALEZ-ZUGASTI JAVIER , CHERNG JEAN-PEI , LEMMO ANTHONY V , GYORY J RICHARD , PRYCE-LEWIS WENDY , CHEN HONGMING
IPC分类号： B01F3/18 , B01F7/00 , B01F7/18 , B01F11/00 , B01F13/00 , B01F13/02 , B01F13/08 , B01L3/02 , G01F11/02 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/28 , G01N1/36 , G01N35/00 , G01N1/10 , B01L3/00 , B32B27/04 , B32B27/12 , G01N31/00 , G01N33/00 , G01N35/08
CPC分类号： B01F3/18 , B01F7/00258 , B01F7/18 , B01F11/0065 , B01F13/0059 , B01F13/0272 , B01F13/08 , B01L3/0217 , B01L2200/0657 , G01F11/021 , G01F11/10 , G01F11/18 , G01G19/00 , G01N1/286 , G01N1/36 , G01N35/0099 , G01N2001/368 , Y10T436/2575
摘要： The invention relates to methods and apparatuses for manipulating small amounts of solids. Specific embodiments of the invention are particularly suited for the automated transfer of small amounts of solids. In one embodiment, a uniform powder bed is lightly compressed into plugs of powder and dispensed. In another embodiment, the solid is placed in a liquid carrier to form a slurry, dispensed, and the liquid component is subsequently removed. In yet another embodiment, solids are manipulated using adhesive surfaces.
摘要翻译：本发明涉及用于操作少量固体的方法和装置。本发明的具体实施方案特别适用于少量固体的自动转移。在一个实施方案中，将均匀的粉末床轻轻地压制成粉末塞并分配。在另一个实施方案中，将固体置于液体载体中以形成浆液，分配，随后除去液体组分。在另一个实施方案中，使用粘合剂表面操纵固体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式