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1. 发明申请

WO2008119744A1 HETEROCYCLIC SPIRO-COMPOUNDS 审中-公开
标题翻译：杂环螺旋化合物
公开(公告)号：WO2008119744A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053671
申请日：2008-03-27
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , STUTZ, Stefan , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , BENNACER, Bibia
发明人： HEROLD, Peter , MAH, Robert , STUTZ, Stefan , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , BENNACER, Bibia
IPC分类号： C07D491/20 , A61P5/00 , A61P9/00 , A61K31/4188
CPC分类号： C07D491/20
摘要： The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R 1 , R 2 , Q, T, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新杂环化合物，其中R 1，R 2，R 2，Q，T，n和p具有定义在描述中更详细地阐明，制备它们的方法以及这些化合物作为药物，特别是作为醛固酮合酶抑制剂的用途。

2. 发明申请

WO2007116098A1 SPIRO-IMIDAZO COMPOUNDS 审中-公开
标题翻译： SPIRO-IMIDAZO化合物
公开(公告)号：WO2007116098A1
公开(公告)日：2007-10-18
申请号：PCT/EP2007/053584
申请日：2007-04-12
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JELAKOVIC, Stjepan , BENNACER, Bibia , STUTZ, Stefan
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , MARTI, Christiane , JELAKOVIC, Stjepan , BENNACER, Bibia , STUTZ, Stefan
IPC分类号： C07D491/04 , C07D513/04 , A61K31/5383 , A61K31/542 , A61P5/00
CPC分类号： C07D498/04 , C07D513/04
摘要： Novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof, in which R, R 1 , R 1' , Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：通式（I）的新型杂环化合物及其盐，优选其药学上可接受的盐，其中R 1，R 1，R 1，Q 1，m和n 具有在描述中详细解释的含义，其制备方法和这些化合物作为药物的用途，特别是醛固酮合酶抑制剂。

3. 发明申请

WO2006005741A3 PIPERDINE DERIVATIVES AS RENIN INHIBITORS 审中-公开
公开(公告)号：WO2006005741A3
公开(公告)日：2006-01-19
申请号：PCT/EP2005/053306
申请日：2005-07-11
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , JOTTERAND, Nathalie , BEHNKE, Dirk
发明人： HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , JOTTERAND, Nathalie , BEHNKE, Dirk
IPC分类号： C07D413/14 , C07D413/12 , A61K31/538
摘要： The application relates to novel substituted piperidines of the general formula (I) in which R 1 , R 2 , R 3 , R 4 , W, X, Z, m and n are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.

4. 发明申请

WO2005090304A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005090304A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/051241
申请日：2005-03-17
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , QUIRMBACH, Michael , BEHNKE, Dirk , MARTI, Christiane
发明人： HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , QUIRMBACH, Michael , BEHNKE, Dirk , MARTI, Christiane
IPC分类号： C07D209/12
CPC分类号： C07D209/12 , C07D401/06
摘要： The invention relates to novel amino alcohols of the general formula (I) where X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本发明涉及通式（I）的新型氨基醇，其中X，R 1，R 2，R 3，R 4，R 5和R 6各自如上所定义在描述中详细描述了它们的制备方法和这些化合物作为药物的用途，特别是作为肾素抑制剂。

5. 发明申请

WO2005061457A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005061457A1
公开(公告)日：2005-07-07
申请号：PCT/EP2004/052389
申请日：2004-09-30
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , JOTTERAND, Nathalie
发明人： HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , JOTTERAND, Nathalie
IPC分类号： C07D211/42
CPC分类号： C07D211/42 , C07D401/12 , C07D413/12
摘要： Novel substituted piperidines of the general formulae (I) and (II) with the substituent definitions as explained in detail in the description are described. The compounds are suitable in particular as renin inhibitors and are highly potent.
摘要翻译：描述通式（I）和（II）的新颖取代的哌啶与具有如在说明书中详细说明的取代基定义。该化合物特别适合作为肾素抑制剂，并且是非常有效的。

6. 发明申请

WO2007082907A1 SUBSTITUTED 4-PHENYLPIPERIDINES 审中-公开
标题翻译：取代的4-苯基哌啶
公开(公告)号：WO2007082907A1
公开(公告)日：2007-07-26
申请号：PCT/EP2007/050481
申请日：2007-01-18
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , BEHNKE, Dirk , JOTTERAND, Nathalie , STOJANOVIC, Aleksandar , STUTZ, Stefan , JELAKOVIC, Stjepan , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , BEHNKE, Dirk , JOTTERAND, Nathalie , STOJANOVIC, Aleksandar , STUTZ, Stefan , JELAKOVIC, Stjepan , QUIRMBACH, Michael
IPC分类号： C07D413/12 , C07D413/14 , A61P9/12 , A61K31/538
CPC分类号： C07D401/12 , C07D413/12 , C07D413/14
摘要： The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R 2 , R 3 , W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及通式的取代的4-苯基哌啶及其盐，优选其药学上可接受的盐，其中R 2，R 3，W和X具有如下含义：在说明书中解释，其制备方法和这些化合物作为药物的使用，特别是作为肾素抑制剂。

7. 发明申请

WO2008040764A1 SUBSTITUTED 4-PHENYL PIPERIDINES FOR USE AS RENIN INHIBITORS 审中-公开
标题翻译：用作RENIN抑制剂的取代的4-苯基哌啶
公开(公告)号：WO2008040764A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060510
申请日：2007-10-03
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , STUTZ, Stefan , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , BEHNKE, Dirk , JOTTERAND, Nathalie , JELAKOVIC, Stjepan
发明人： HEROLD, Peter , MAH, Robert , STUTZ, Stefan , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , BEHNKE, Dirk , JOTTERAND, Nathalie , JELAKOVIC, Stjepan
IPC分类号： C07D413/12 , A61K31/445 , A61P9/12
CPC分类号： C07D413/12
摘要： Compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R 1 is straight-chain C 1-8 -alkanoyloxy, straight-chain C 1-8 -alkoxy, straight-chain C 1-8 - alkoxy-straight-chain-C 1-8 -alkoxy, straight-chain C 1-8 -alkoxycarbonylamino, straight- chain C 0-8 -alkylcarbonylamino, optionally N-mono- or N,N-di-C 1-8 -alkylated amino or hydroxy or straight-chain omega-hydroxy-C 1-8 -alkyl.
摘要翻译：通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R 1是直链C 1-8 - 烷酰氧基，直链C 1-8 - 烷氧基，直链C 1-8烷基 - 烷氧基 - 直链-C 1-8烷氧基，直链C 1-8烷氧基羰基氨基，直链C 1-8烷基，链C 0-8烷基羰基氨基，任选的N-单或N，N-二-C 1-8 - 烷基化氨基或羟基或直链ω-羟基 -C _{1-8 - 烷基。}

8. 发明申请

WO2006103275A1 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS 审中-公开
标题翻译：作为RENIN抑制剂的3,4,5-取代的哌啶
公开(公告)号：WO2006103275A1
公开(公告)日：2006-10-05
申请号：PCT/EP2006/061193
申请日：2006-03-30
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , JOTTERAND, Nathalie , BEHNKE, Dirk , STOJANOVIC, Aleksandar , STUTZ, Stefan , QUIRMBACH, Michael , JELAKOVIC, Stjepan
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , JOTTERAND, Nathalie , BEHNKE, Dirk , STOJANOVIC, Aleksandar , STUTZ, Stefan , QUIRMBACH, Michael , JELAKOVIC, Stjepan
IPC分类号： C07D211/42 , C07D413/12 , C07D405/12 , A61K31/445 , A61P9/00 , A61P27/06
CPC分类号： C07D413/14 , C07D413/12
摘要： The application relates to novel substituted piperidines of the general formula (II) in which R 1 , R 2' , R 2'' , R 4' , X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及通式（II）的新的取代哌啶，其中R 1，R 2，R 2，R 2，R 2，R X，Z，m和n具有本说明书中定义的含义，其制备方法以及这些化合物作为药物，特别是作为肾素抑制剂的用途。

9. 发明申请

WO2005090305A1 5-AMINO-4-HYDROXY-7-(1H-INDOLMETHYL)-8-METHYLNONAMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION 审中-公开
标题翻译：作为治疗高血压的RININ抑制剂的5-氨基-4-羟基-7-（1H-吲哚基甲基）-8-甲基壬酰胺衍生物
公开(公告)号：WO2005090305A1
公开(公告)日：2005-09-29
申请号：PCT/EP2005/051244
申请日：2005-03-17
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , QUIRMBACH, Michael , BEHNKE, Dirk , MARTI, Christiane
发明人： HEROLD, Peter , STUTZ, Stefan , MAH, Robert , TSCHINKE, Vincenzo , STOJANOVIC, Aleksandar , JOTTERAND, Nathalie , QUIRMBACH, Michael , BEHNKE, Dirk , MARTI, Christiane
IPC分类号： C07D209/20
CPC分类号： C07C237/06 , C07C237/22 , C07D209/12 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The application relatés to novel alkanamides of the general formula (I) where X is -CH 2 - or >CH-OH; (A) R 1 is e.g. an optionally substituted heterocyclyl radical or an optionally substituted polycyclic, unsaturated hydrocarbon radical where X is hydroxymethylene; R 2 is C 1 -C 6 -alkyl or C 3 -C 6 -cydoalkyl; R 3 are each independently H, C 1 -C 6 -alkyl, C 1-6 -alkoxycarbonyl or C 1 -C 6 -alkanoyl; R 4 is C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl or unsubstituted or substituted arylC 1 -C 6 -alkyl; R 5 is C l -C 6 -alkyl, C 1 -C 6 -hydroxyalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkanoyloxy C 1 -C 6 -alkyl, C 1 -C 6 -aminoalkyl, C 1 -C 6 -alkylamino-C 1 -C 6 -alkyl, C 1 -C 6 -dialkylamino-C l -C 6 -alkyl, C 1 -C 6 -alkanoylamido-C 1 -C 6 -alkyl, HO(O)C-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-O-(O)C-C 1 -C 6 -alkyl, H 2 N-C(O)-C 1 -C 6 -alkyl, C 1 -C 6 -alkyl-HN-C(O)-C 1 -C 6 -alkyl, (C 1 ,-C 6 -alkyl) 2 N-C(O)-C 1 -C 6 -alkyl, C 2 -C 8 -alkenyl, C 2 -C 8 -alkynyl, cyano-C 1 -C 6 -alkyl, halo-C l -C 6 -alkyl, optionally substituted aryl-C o -C 6 -alkyl, optionally substituted C 3 -C 8 -cycloalkyl-C o -C 6 -alkyl or optionally substituted heterocydyl-C o -C 6 -alkyl; to a process for their preparation and to the use of these compounds as medicines, especially as renin inhibitors for the treatment of hypertension.
摘要翻译：本发明涉及通式（I）的新型烷酰胺，其中X为-CH 2 - 或> CH-OH; （A）R 1是例如。任选取代的杂环基或任选取代的多环不饱和烃基，其中X是羟基亚甲基; R 2是C 1 -C 6 - 烷基或C 3 -C 6 - 环烷基; R 3各自独立地为H，C 1 -C 6 - 烷基，C 1-6 - 烷氧基羰基或C 1 -C 6 - 烷酰基; R 4是C 1 -C 6 - 烷基，C 3 -C 6 - 环烷基，C 2 -C 6 - 烯基或未取代或取代的芳基C 1 -C 6烷基; R 5是C 1 -C 6烷基，C 1 -C 6羟基烷基，C 1 -C 6烷氧基-C 1 -C 6烷基，C 1 -C 6烷酰氧基C 1 -C 6烷基，C 1 -C 6氨基烷基，C 1 -C 6 - 烷基氨基-C 1 -C 6 - 烷基，C 1 -C 6 - 二烷基氨基-C 1 -C 6 - 烷基，C 1 -C 6 - 烷酰基氨基-C 1 -C 6烷基，HO（O）C 1 -C 6 - （O）C 1 -C 6烷基，H 2 N-C（O）-C 1 -C 6 - 烷基，C 1 -C 6烷基-NH-C（O）-C 1 -C 6 - 烷基，（C 1 -C 6） - 烷基）N 2 -C（O）-C 1 -C 6 - 烷基，C 2 -C 8 - 烯基，C 2 -C 8 - 炔基，氰基-C 1 -C 6烷基，卤代-C 1 -C 6烷基，任选取代的芳基-Co- C 6 - 烷基，任选取代的C 3 -C 8 - 环烷基-C 0 -C 6 - 烷基或任选取代的杂环-Co-C 6 - 烷基; 其制备方法和这些化合物作为药物的使用，特别是用作治疗高血压的肾素抑制剂。

10. 发明申请

WO2009053452A1 4,4-DISUBSTITUTED PIPERIDINES 审中-公开
标题翻译： 4,4-取代的哌啶
公开(公告)号：WO2009053452A1
公开(公告)日：2009-04-30
申请号：PCT/EP2008/064417
申请日：2008-10-24
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , BEHNKE, Dirk , JELAKOVIC, Stjepan , JOTTERAND, Nathalie , STUTZ, Stefan , LYOTHIER, Isabelle
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , BEHNKE, Dirk , JELAKOVIC, Stjepan , JOTTERAND, Nathalie , STUTZ, Stefan , LYOTHIER, Isabelle
IPC分类号： C07D413/14 , C07D413/12 , A61K31/538 , A61P9/12
CPC分类号： C07D413/12 , C07D413/14
摘要： The application relates to 4,4-disubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R 2 , has the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及通式（I）的4,4-二取代哌啶及其盐，优选其药学上可接受的盐，其中R2具有说明书中所述的含义，其制备方法和这些化合物的用途作为药物，特别是作为肾素抑制剂。

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