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1. 发明申请

WO0135820A9 TISSUE INTERFACE DEVICE 审中-公开
标题翻译：组装界面装置
公开(公告)号：WO0135820A9
公开(公告)日：2002-05-16
申请号：PCT/US0031765
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECH INC , FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
发明人： FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
IPC分类号： G01N33/487 , A61B5/00 , G01N33/48
CPC分类号： A61B5/1486
摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.
摘要翻译：适于定位在生物体的生物膜中的一个或多个人造开口上或周围的组织界面装置（10），并用于耦合到监测和控制单元和真空源。组织接口装置（10）包括壳体（100），传感器通道（130）和传感器（150）。壳体（100）限定孔口（120），孔口（120）在壳体（100）的底端（102）上具有开放的入口端口（122）和远端（124），该远端端部与传感器通道（130）连接。孔口（120）与从生物膜中形成的人造开口流动的流体流体连通。传感器通道（130）用于耦合到真空源并与之流体连通。传感器（150）在流体的流动路径中位于传感器通道（130）中，用于感测流体从人造开口流出时的特性。传感器产生代表其的传感器信号。

2. 发明专利

CA2390893C TISSUE INTERFACE DEVICE 未知
公开(公告)号：CA2390893C
公开(公告)日：2010-10-05
申请号：CA2390893
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECH INC
发明人： FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
IPC分类号： A61B5/00 , G01N33/487 , G01N33/48
摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

3. 发明专利

BR0015716A 未知
公开(公告)号：BR0015716A
公开(公告)日：2003-05-06
申请号：BR0015716
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECH INC
发明人： FAUPEL MARK L , KUMAR KRISHNA S , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
IPC分类号： G01N33/487 , A61B5/00 , G01N33/48

4. 发明专利

AU1778601A Tissue interface device 未知
公开(公告)号：AU1778601A
公开(公告)日：2001-05-30
申请号：AU1778601
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECH INC
发明人： FAUPEL MARK L , KUMAR KRISHNA , FARQUHAR DAVID , VREEKE MARK , SMITH ALAN , HATCH MICHAEL , WOODS TERESA
IPC分类号： G01N33/487 , A61B5/00 , G01N33/48

5. 发明专利

AT375752T 未知
公开(公告)号：AT375752T
公开(公告)日：2007-11-15
申请号：AT99911184
申请日：1999-03-05
申请人： SPECTRX INC , ALTEA THERAPEUTICS CORP
发明人： EPPSTEIN JONATHAN , SAMUELS MARK , HATCH MICHAEL
IPC分类号： A61B10/00 , A61M37/00 , A61B5/00 , A61B17/00 , A61K41/00 , A61K45/00 , G01N33/50
摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.

6. 发明专利

AT380501T 未知
公开(公告)号：AT380501T
公开(公告)日：2007-12-15
申请号：AT99934149
申请日：1999-07-20
申请人： SPECTRX INC , ALTEA THERAPEUTICS CORP
发明人： SAMUELS MARK , EPPSTEIN JONATHAN , HATCH MICHAEL
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , A61B5/1459 , A61B17/00

7. 发明专利

CA2390893A1 TISSUE INTERFACE DEVICE 未知
公开(公告)号：CA2390893A1
公开(公告)日：2001-05-25
申请号：CA2390893
申请日：2000-11-17
申请人： SPECTRX INC , ALTEA TECHONOLOGIES INC
发明人： HATCH MICHAEL , WOODS TERESA , SMITH ALAN , KUMAR KRISHNA , FAUPEL MARK L , FARQUHAR DAVID , VREEKE MARK
IPC分类号： G01N33/487 , A61B5/00 , G01N33/48
摘要： A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channe l (130). The orifice (120) is in fluid communication with fluid that flows fro m the artificial opening formed in the biological membranes. The sensor channe l (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

8. 发明专利

AT385405T 未知
公开(公告)号：AT385405T
公开(公告)日：2008-02-15
申请号：AT99911191
申请日：1999-03-05
申请人： SPECTRX INC , ALTEA THERAPEUTICS CORP
发明人： EPPSTEIN JONATHAN , SAMUELS MARK , HATCH MICHAEL
IPC分类号： A61B10/00 , A61M37/00 , A61B5/00 , A61B17/00 , A61K41/00 , A61K45/00 , G01N33/50
摘要： An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum. In one embodiment, the photosensitizing assembly comprises photosensitizing material combined with a carrier, such as, for example, an adhesive or an ink, and the resulting combination is applied to a substrate, such as, for example, an inert polymeric substrate to form a photosensitizing assembly. In another embodiment, the photosensitizing assembly comprises photosensitizing material incorporated into a film-forming polymeric material.

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