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1. 发明申请

WO0190737A3 PLURALITY OF CAPILLARIES FOR SIMULTANEOUS MULTIPLE ANALYSIS OF A LIQUID SAMPLE 审中-公开
标题翻译：用于同时多次分析液体样品的毛巾的多重性
公开(公告)号：WO0190737A3
公开(公告)日：2003-01-30
申请号：PCT/US0116769
申请日：2001-05-23
申请人： SPECTRUMEDIX CORP
发明人： LI QINGBO , KANE THOMAS E
IPC分类号： G01N27/447
CPC分类号： G01N27/44743 , G01N27/44782
摘要： The present invention provides a capillary electrophoresis system and method for multiple simultaneous analysis of a sample. The system and method of the invention allow the ends of a plurality of capillaries to simultaneously contact a single body of electrophoresis sample contained in a compartment of a container, such as a sample contained in a well of a micro-titer tray.
摘要翻译：本发明提供了一种用于多次同时分析样品的毛细管电泳系统和方法。本发明的系统和方法允许多个毛细管的端部同时接触包含在容器隔室中的单体电泳样品，例如包含在微量滴定盘的孔中的样品。

2. 发明专利

CA2425413A1 SYSTEM AND METHOD FOR DETERMINING THE PRESENCE OF METHYLATEDCYTOSINES IN POLYNUCLEOTIDES 未知
公开(公告)号：CA2425413A1
公开(公告)日：2002-04-18
申请号：CA2425413
申请日：2001-10-10
申请人： SPECTRUMEDIX CORP
发明人： LIU ZHAOWEI , LI QINGBO
IPC分类号： C12Q1/68 , C12Q1/6827 , C12Q1/6858 , C07H21/04 , C12P19/34
摘要： The present invention relates to a method for determining the presence of a methylated cytosine in a first sample comprising a first nucleotide containing compound. The first sample and a reference NCC are subjected to electrophoresis in the presence of at least one intercalating dye. During electrophoresis the temperature of the first NCC and the reference NCC is changed by an amount sufficient to change an electrophoretic mobility of at least one of the first or reference NCCs. Fluorescence intensity data are obtained. The fluorescence intensity data are indicative of the presence of the first and reference NCCs.

3. 发明专利

CA2407124A1 DENATURANT-FREE ELECTROPHORESIS OF BIOLOGICAL MOLECULES UNDER HIGH TEMPERATURE CONDITIONS 未知
公开(公告)号：CA2407124A1
公开(公告)日：2001-11-01
申请号：CA2407124
申请日：2001-04-25
申请人： SPECTRUMEDIX CORP
发明人： MONROE HEIDI , LEVAN KEVIN J , LI QINGBO
IPC分类号： C12N15/09 , C12Q1/68 , G01N27/447 , G01N27/26
摘要： The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to eletrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear copolymer comprising a first comonomer of acrylamide and at least one secondary comonomer. A temperature of at least a portion of the matrix is at least about 80 ~C.

4. 发明公开

EP1010004A4 AUTOMATED PARALLEL CAPILLARY ELECTROPHORETIC SYSTEM 失效
标题翻译： AUTOMATISCHE PARALLELKOPILLARELEKTROFORESEVORGHHTUNG
公开(公告)号：EP1010004A4
公开(公告)日：2002-04-03
申请号：EP98933038
申请日：1998-06-30
申请人： SPECTRUMEDIX CORP
发明人： KANE THOMAS E , LI QINGBO , LIU CHANGSHENG , SONNENCHEIN BERNARD , SHARER MICHAEL V , KERNAN JOHN R
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44782 , G01N27/44721
摘要： An automated electrophoretic system (30) that employs a capillary cartridge having a plurality of capillary tubes (32). The cartridge has a first array of capillary ends projecting from one side of a microtitre plate (68) so as to simultaneously perform capillary electrophoresis on samples present in each of the wells of the plate. The system includes a stacked dual carousel arrangement, gel delivery module, multi-wavelength beam generator (52), and off-line capillary reconditioner.
摘要翻译：一种使用具有多个毛细管（32）的毛细管盒的自动电泳系统（30）。盒具有从微量滴定板（68）的一侧突出的第一毛细管端部阵列，以便同时对存在于板的每个孔中的样品进行毛细管电泳。该系统包括堆叠的双转盘布置，凝胶递送模块，多波长束发生器（52）和离线毛细管修复器。

5. 发明专利

CA2407124C DENATURANT-FREE ELECTROPHORESIS OF BIOLOGICAL MOLECULES UNDER HIGH TEMPERATURE CONDITIONS 未知
公开(公告)号：CA2407124C
公开(公告)日：2010-09-28
申请号：CA2407124
申请日：2001-04-25
申请人： SPECTRUMEDIX CORP
发明人： LI QINGBO , LEVAN KEVIN J , MONROE HEIDI
IPC分类号： G01N27/26 , C12N15/09 , C12Q1/68 , G01N27/447
摘要： The present invention relates to a method of separating a sample comprising biological compounds, such as nucleic acids. The nucleic acids are subjected to eletrophoresis using a matrix that is essentially free of denaturants and having at least one random, linear copolymer comprising a first comonomer of acrylamide and at least one secondary comonomer. A temperature of at least a portion of the matrix is at least about 80°C.

6. 发明专利

AU2008599A Detector having a transmission grating beam splitter for multi-wavelength sampleanalysis 未知
公开(公告)号：AU2008599A
公开(公告)日：1999-07-12
申请号：AU2008599
申请日：1998-12-22
申请人： SPECTRUMEDIX CORP
发明人： LIU CHANGSHENG , LI QINGBO
IPC分类号： G01N21/64 , G01N27/447
摘要： A detector for DNA sample identification is provided with a transmission grating beam splitter (TGBS). The TGBS split fluoresced light from a tagged DNA sample into 0th order and a 1st order components, both of which are detected on a two-dimensional detector array of a CCD camera. The 0th and 1st order components are detected along a column of pixels in the detector array, and are spaced apart from one another. The DNA samples are tagged with four fluorescent dyes, one dye specific for each nucleotide, and all four dyes responding in slightly different manner to the same monochromatic excitation signal. The TGBS splits fluoresced incoming light into 0th and 1st order components, which are then spread out among a number of pixels in the detector array. The 1st component of this light is received by pixels whose position relative to the 0th order component depends on the frequency of fluorescence. Thus, the position at which signal energy is detected on the array is indicative of the particular dye, and therefore, the corresponding nucleotide tagged by that dye. Monitoring signal energy at the 0th order pixel and selected 1st order pixels, provides a set of data from which one may then identify the particular nucleotide.

7. 发明专利

CA2295227C AUTOMATED PARALLEL CAPILLARY ELECTROPHORETIC SYSTEM 未知
公开(公告)号：CA2295227C
公开(公告)日：2004-09-07
申请号：CA2295227
申请日：1998-06-30
申请人： SPECTRUMEDIX CORP
发明人： KERNAN JOHN R , SHARER MICHAEL V , SONNENCHEIN BERNARD , KANE THOMAS E , LIU CHANGSHENG , LI QINGBO
IPC分类号： G01N27/447 , G01N37/00
摘要： An automated electrophoretic system (30) that employs a capillary cartridge having a plurality of capillary tubes (32). The cartridge has a first array of capillary ends projecting from one side of a microtitre pla te (68) so as to simultaneously perform capillary electrophoresis on samples present in each of the wells of the plate. The system includes a stacked dual carousel arrangement, gel delivery module, multi-wavelength beam generator (52), and off-line capillary reconditioner.

8. 发明专利

AU1456902A System and method for determining the presence of methylated cytosines in polynucleotides 未知
公开(公告)号：AU1456902A
公开(公告)日：2002-04-22
申请号：AU1456902
申请日：2001-10-10
申请人： SPECTRUMEDIX CORP
发明人： LI QINGBO , LIU ZHAOWEI
IPC分类号： C12Q1/68 , C12Q1/6827 , C12Q1/6858 , C07H21/04 , C12P19/34

9. 发明专利

CA2383912C AUTOMATED PARALLEL CAPILLARY ELECTROPHORESIS SYSTEM WITH HYDRODYNAMIC SAMPLE INJECTION 未知
公开(公告)号：CA2383912C
公开(公告)日：2009-11-10
申请号：CA2383912
申请日：2000-08-29
申请人： SPECTRUMEDIX CORP
发明人： LIU CHANGSHENG , KANE THOMAS E , LI QINGBO
IPC分类号： G01N27/26 , G01N27/447
摘要： An automated capillary zone electrophoretic system is disclosed. The system employs a capillary cartridge (102) having a plurality of capillary tubes. The cartridge has a first array of capillary ends (108) projecting from one side of a plate. The first array of capillary ends (108) are spaced apart in substantially the sa me manner as the wells of a microtitre tray of standard size. The system also a container (100) connected to the detection end of the capillaries (107). The container is provided with valving (116, 120, 124, 128, 134) which facilitates cleaning the capillaries, loadin g buffer into the capillaries, introducing samples to be electrophoresced into the capillaries, and performing capillary zone electrophoresis on the thus introduced samples.

10. 发明专利

AU5725501A Denaturant-free electrophoresis of biological molecules under high temperature conditions 未知
公开(公告)号：AU5725501A
公开(公告)日：2001-11-07
申请号：AU5725501
申请日：2001-04-25
申请人： SPECTRUMEDIX CORP
发明人： LI QINGBO , LEVAN KEVIN J , MONROE HEIDI
IPC分类号： C12N15/09 , C12Q1/68 , G01N27/447 , G01N27/26

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