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1. 发明申请

WO2012054886A1 DYNAMIC RECONSTRUCTION OF A CALIBRATION STATE OF AN ABSORPTION SPECTROMETER 审中-公开
标题翻译：吸收光谱仪校准状态的动态重建
公开(公告)号：WO2012054886A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/057370
申请日：2011-10-21
申请人： SPECTRASENSORS, INC. , LIU, Xiang , LEWISON, John , JI, Wenhai , FEITISCH, Alfred
发明人： LIU, Xiang , LEWISON, John , JI, Wenhai , FEITISCH, Alfred
IPC分类号： G01N21/35 , G01N21/61 , G01N21/31 , G01N21/39
CPC分类号： G01J3/28 , G01J3/42 , G01N21/031 , G01N21/274 , G01N21/31 , G01N21/3504 , G01N21/3518 , G01N21/39 , G01N2021/399
摘要： A reference harmonic absorption curve of a laser absorption spectrometer, which can include a tunable or scannable laser light source and a detector, can have a reference curve shape and can include a first, second, or higher order harmonic signal of a reference signal generated by the detector in response to light passing from the laser light source through a reference gas or gas mixture. The reference gas or gas mixture can include one or more of a target analyte and a background gas expected to be present during analysis of the target analyte. The reference harmonic absorption curve can have been determined for the laser absorption spectrometer in a known or calibrated state. A test harmonic absorption curve having a test curve shape is compared with the reference harmonic absorption curve to detect a difference between the test curve shape and the reference curve shape that exceeds a predefined allowed deviation and therefore indicates a change in an output of the laser light source relative to the known or calibrated state. One or more operating and/or analytical parameters of the laser absorption spectrometer are adjusted to correct the test curve shape to reduce the difference between the test curve shape and the reference curve shape.
摘要翻译：可以包括可调谐或可扫描的激光光源和检测器的激光吸收光谱仪的参考谐波吸收曲线可以具有参考曲线形状，并且可以包括由第一，第二或更高次谐波信号产生的参考信号检测器响应于从激光源通过参考气体或气体混合物的光。参考气体或气体混合物可以包括目标分析物和预期在目标分析物的分析期间存在的背景气体中的一种或多种。参考谐波吸收曲线可以在已知或校准状态下为激光吸收光谱仪确定。将具有测试曲线形状的测试谐波吸收曲线与参考谐波吸收曲线进行比较，以检测超过预定义的允许偏差的测试曲线形状和参考曲线形状之间的差异，因此表示激光输出的变化源相对于已知或校准状态。调整激光吸收光谱仪的一个或多个操作和/或分析参数以校正测试曲线形状，以减小测试曲线形状与参考曲线形状之间的差异。

2. 发明申请

WO2012054095A1 SPECTROMETER WITH VALIDATION CELL 审中-公开
标题翻译：带有验证单元的光谱仪
公开(公告)号：WO2012054095A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/024919
申请日：2011-02-15
申请人： SPECTRASENSORS, INC. , FEITISCH, Alfred , KELLER, Lutz , LIU, Xiang , SCHREMPEL, Mathias , HELBLEY, Keith, Benjamin
发明人： FEITISCH, Alfred , KELLER, Lutz , LIU, Xiang , SCHREMPEL, Mathias , HELBLEY, Keith, Benjamin
IPC分类号： G01N21/35 , G01N21/61
CPC分类号： G01J3/28 , G01J3/42 , G01N21/031 , G01N21/274 , G01N21/31 , G01N21/3504 , G01N21/3518 , G01N21/39 , G01N2021/399
摘要： A valid state of an analytical system that includes a light source (102) and a detector (106) can be verified by determining that deviation of first light intensity data quantifying a first intensity of light received at the detector from the light source after the light has passed at least once through each of a reference gas in a validation cell (114) and a zero gas from a stored data set does not exceed a pre-defined threshold deviation. The stored data set can represent at least one previous measurement collected during a previous instrument validation process performed on the analytical system. The reference gas can include a known amount of an analyte. A concentration of the analyte in a sample gas in a measurement cell (112) can be determined by correcting second light intensity data quantifying a second intensity of the light received at the detector after the light passes at least once through each of the reference gas in the validation cell and a sample gas containing an unknown concentration of the analyte compound. Related systems, methods, and articles of manufacture are also described.
摘要翻译：包括光源（102）和检测器（106）的分析系统的有效状态可以通过确定量化光检测器上接收的第一光强与光源之后的光的第一光强度数据的偏差来验证已经通过至少一次通过验证单元（114）中的参考气体，并且来自存储的数据集的零气体不超过预定义的阈值偏差。存储的数据集可以表示在分析系统上执行的先前的仪器验证过程期间收集的至少一个以前的测量。参考气体可以包括已知量的分析物。测量单元（112）中的样本气体中的分析物的浓度可以通过校正第二光强度数据来确定，该第二光强数据定量在光通过至少一次通过每个参考气体之后在检测器处接收的光的第二强度验证单元和含有未知浓度的分析物的样品气体。还描述了相关系统，方法和制品。

3. 发明申请

WO2010144870A3 OPTICAL ABSORBANCE MEASUREMENTS WITH SELF-CALIBRATION AND EXTENDED DYNAMIC RANGE 审中-公开
公开(公告)号：WO2010144870A3
公开(公告)日：2010-12-16
申请号：PCT/US2010/038417
申请日：2010-06-11
申请人： SPECTRASENSORS, INC. , LIU, Xiang , FEITISCH, Alfred , ZHOU, Xin
发明人： LIU, Xiang , FEITISCH, Alfred , ZHOU, Xin
IPC分类号： G01J3/42 , G01N21/25
摘要： Detector data representative of an intensity of light that impinges on a detector after being emitted from a light source and passing through a gas over a path length can be analyzed using a first analysis method to obtain a first calculation of an analyte concentration in the volume of gas and a second analysis method to obtain a second calculation of the analyte concentration. The second calculation can be promoted as the analyte concentration upon determining that the analyte concentration is out of a first target range for the first analysis method.

4. 发明申请

WO2009018216A1 ENERGY METER FOR MIXED STREAMS OF COMBUSTIBLE COMPOUNDS 审中-公开
标题翻译：可燃混合物混合流量计的能量计
公开(公告)号：WO2009018216A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/071355
申请日：2008-07-28
申请人： SPECTRASENSORS, INC. , FEITISCH, Alfred , LIU, Xiang , ZHOU, Xin , LANGHAM, Dale , COOK, Charles, F.
发明人： FEITISCH, Alfred , LIU, Xiang , ZHOU, Xin , LANGHAM, Dale , COOK, Charles, F.
IPC分类号： G01N21/75 , G01N21/27 , G01N21/31
CPC分类号： G01N21/39 , G01N21/3504 , G01N21/75 , G01N2021/399 , Y10T436/20 , Y10T436/204998
摘要： An energy content meter can spectroscopically quantify oxidation products after oxidation of a combustible mixture. The measured oxidation product concentrations or mole fractions can be converted to an energy content of the un-oxidized combustible mixture using a conversion factor that relates oxygen consumption during oxidation of the combustible mixture to the energy content of the combustible mixture.
摘要翻译：能量含量计可以对可燃混合物氧化后的氧化产物进行光谱定量。测量的氧化产物浓度或摩尔分数可以转化为未氧化的可燃混合物的能量含量，该转换因子将可燃混合物的氧化期间的氧消耗量与可燃混合物的能量含量相关联。

5. 发明申请

WO2008130727A3 BACKGROUND COMPENSATION BY MULTIPLE-PEAK MEASUREMENTS FOR ABSORPTION SPECTROSCOPY-BASED GAS SENSING 审中-公开
公开(公告)号：WO2008130727A3
公开(公告)日：2008-10-30
申请号：PCT/US2008/051931
申请日：2008-01-24
申请人： SPECTRASENSORS, INC. , LIU, Xiang , ZHOU, Xin , FEITISCH, Alfred , SANGER, Gregory, M.
发明人： LIU, Xiang , ZHOU, Xin , FEITISCH, Alfred , SANGER, Gregory, M.
IPC分类号： G01N21/35 , G01N21/31 , G01N21/39
摘要： Concentrations of a target analyte in a gas mixture containing one or more background analytes having potentially interfering spectral absorption features can be calculated by compensating for background analyte absorption at a target wavelength used to quantify the target analyte. Absorption can be measured at a reference wavelength (302) chosen to quantify the concentration of the background analyte. Using a background gas adjustment factor or function, the absorption measured at the reference wavelength can be used to calculate absorption due to the background analyte at the target wavelength (304) and thereby compensate for this background absorption to more accurately calculate the target analyte concentration in real or near real time (306). Additional background analytes can optionally be compensated for by using one or more additional reference wavelengths.

6. 发明申请

WO2008128114A1 REACTIVE GAS DETECTION IN COMPLEX BACKGROUNDS 审中-公开
标题翻译：复杂背景下的反应性气体检测
公开(公告)号：WO2008128114A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/060128
申请日：2008-04-11
申请人： SPECTRASENSORS, INC. , ZHOU, Xin , LIU, Xiang , FEITISCH, Alfred , SANGER, Gregory, M.
发明人： ZHOU, Xin , LIU, Xiang , FEITISCH, Alfred , SANGER, Gregory, M.
IPC分类号： G01N21/35
CPC分类号： G01N21/3504 , G01N2021/3545 , G01N2021/399 , G01N2201/1215
摘要： A differential absorption spectrum for a reactive gas in a gas mixture can be generated for sample absorption data by subtracting background absorption data set from the sample absorption data. The background absorption data can be characteristic of absorption characteristics of the background composition in a laser light scan range that includes a target wavelength. The differential absorption spectrum can be converted to a measured concentration of the reactive gas using calibration data. A determination can be made whether the background composition has substantially changed relative to the background absorption data, and new background absorption data can be used if the background composition has substantially changed. Related systems, apparatus, methods, and/or articles are also described..
摘要翻译：可以通过从样品吸收数据中减去设置的背景吸收数据，为样品吸收数据产生气体混合物中的反应气体的差分吸收光谱。背景吸收数据可以是包括目标波长的激光扫描范围中背景组合物的吸收特性的特征。使用校准数据可以将差示吸收光谱转换为测量的反应气体浓度。可以确定背景组合物是否相对于背景吸收数据基本上改变，并且如果背景组合物已经基本上改变，则可以使用新的背景吸收数据。还描述了相关系统，装置，方法和/或物品。

7. 发明申请

WO2009029876A2 SCRUBBER FOR REACTIVE GASSES 审中-公开
标题翻译：活性气体洗涤器
公开(公告)号：WO2009029876A2
公开(公告)日：2009-03-05
申请号：PCT/US2008/074900
申请日：2008-08-29
申请人： SPECTRASENSORS, INC. , BAUM, Marc, M. , MOSS, John , FEITISCH, Alfred , ZHOU, Xin , LIU, Xiang , KWAN, Alex
发明人： BAUM, Marc, M. , MOSS, John , FEITISCH, Alfred , ZHOU, Xin , LIU, Xiang , KWAN, Alex
IPC分类号： B01D53/52 , B01D53/58 , B01D53/68 , G01N30/02
CPC分类号： B01D53/685 , B01D53/42 , B01D53/52 , B01D53/58 , B01D2251/512 , B01D2251/602 , B01D2251/606 , B01D2259/40
摘要： Scrubber media for reactive gases, that can include but are not necessarily limited to hydrogen chloride (HCl), hydrogen sulfide (H2S), hydrogen fluoride (HF), and ammonia (NH3), can include reactive particles, potentially as small as nano-scale, that can optionally be suspended on macro-scale carrier particles. Reactive gases can be converted to non-volatile compounds by being passed through a bed of such scrubber media. Such scrubber media can be used to remove reactive gases from gas mixtures. Potential applications include differential absorption spectroscopy, air pollutant emission controls, and the like. Methods of preparing scrubber media are also described.
摘要翻译：可包括但不一定限于氯化氢（HCl），硫化氢（H 2 S），氟化氢（HF）和氨（NH 3）的反应气体的洗涤器介质可包括反应性气体可能与纳米尺度一样小的颗粒，其可以任选地悬浮在宏观尺度的载体颗粒上。反应性气体可以通过穿过这种洗涤器介质床而转化为非挥发性化合物。这种洗涤器介质可以用来从气体混合物中除去反应气体。潜在的应用包括差示吸收光谱，空气污染物排放控制等。还描述了制备洗涤器介质的方法。

8. 发明申请

WO2008144372A1 ENERGY FLOW MEASUREMENT IN GAS PIPELINES 审中-公开
标题翻译：在气体管道中的能量流量测量
公开(公告)号：WO2008144372A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/063667
申请日：2008-05-15
申请人： SPECTRASENSORS, INC. , CLINE, Richard, L. , LIU, Xiang , SANGER, Gregory, M. , SMITH, Charles, E. , ZHOU, Xin
发明人： CLINE, Richard, L. , LIU, Xiang , SANGER, Gregory, M. , SMITH, Charles, E. , ZHOU, Xin
IPC分类号： G01N21/35 , G01N21/39
CPC分类号： G01N21/3504 , G01J3/02 , G01J3/027 , G01J3/4338 , G01N21/39 , G01N21/85 , G01N29/024 , G01N33/225 , G01N2021/399 , G01N2021/8578 , G01N2291/02809 , G01N2291/02836 , G01N2291/02881
摘要： Thermodynamic properties of a natural gas stream can be determined in real time utilizing modeling algorithms in conjunction with one or more sensors for quantifying physical and chemical properties of the natural gas. Related techniques, apparatus, systems, and articles are also described. A method and apparatus for determining the energy content of a gas stream in which spectroscopic measurements on carbon dioxide and hydrocarbons as well as a third measurement of temperature, pressure and sund velocity of the gas are input to a processor which uses an algorithm to calculate the energy contact.
摘要翻译：天然气流的热力学性质可以利用建模算法结合一个或多个传感器来实时确定，用于量化天然气的物理和化学性质。还描述了相关技术，装置，系统和制品。一种用于确定气流的能量含量的方法和装置，其中对二氧化碳和碳氢化合物的光谱测量以及气体的温度，压力和速度的第三测量输入到使用算法来计算能量接触。

9. 发明申请

WO2008048994A3 DETECTION OF MOISTURE IN REFRIGERANTS 审中-公开
公开(公告)号：WO2008048994A3
公开(公告)日：2008-04-24
申请号：PCT/US2007/081617
申请日：2007-10-17
申请人： SPECTRASENSORS, INC. , ZHOU, Xin , LIU, Xiang , SANGER, Gregory, M.
发明人： ZHOU, Xin , LIU, Xiang , SANGER, Gregory, M.
IPC分类号： G01N21/35 , G01N21/39
摘要： Moisture can be detected in a refrigerant background such as HFC (Hydroflurocarbon) HFC-134A and HFC-152A and exampled by HFC-23, HFC-32, HFC-143A, HFC-125, HFC-245FA, HFC-227EA, and the like. The system can include a light source operating at any one of several wavelengths within the water absorption bands at wavelengths such as 1.4, 1.9 and 2.7 μm and a detector that measures the transmitted light intensity through the HFC samples. In one variation, the light source is a tunable diode laser and the moisture level is determined by direct absorption and harmonic spectroscopy. Related techniques, apparatus, systems, and articles are also described.

10. 发明申请

WO2017087667A1 A SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：普拉地尼德吡啶类化合物的固态形式及使用方法
公开(公告)号：WO2017087667A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
申请人： EISAI R&D MANAGEMENT CO., LTD. , KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , CHAN, Betty , SMITH, Peter, G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian, Huat
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , KOTAKE, Yoshihiko , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , SMITH, Peter, G. , PAZOLLI, Ermira , LIM, Kian, Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
CPC分类号： C07D405/06
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译：本公开提供了一种新型固体形式的普拉二烯内酯吡啶化合物，包含至少一种此类固体形式的组合物，以及制备和使用方法及其相关方法。该新型固体形式的普拉二烯内酯吡啶化合物可用于治疗癌症，例如癌症，其中靶向剪接体的试剂及其突变已知是有用的。

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