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1. 发明专利

AU2015317877A1 Methods and compositions for treating psychotic disorders 未知
公开(公告)号：AU2015317877A1
公开(公告)日：2017-05-04
申请号：AU2015317877
申请日：2015-09-15
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN
IPC分类号： A61P25/18
摘要： Disclosed herein are novel drug combinations comprising a glutathione peroxidase (GPx) mimic compound and an antipsychotic agent, pharmaceutical compositions comprising one or more of such combinations, methods of preparing pharmaceutical compositions comprising one or more such combinations, and methods of treatment, prevention, inhibition or amelioration of one or more diseases associated with GPx mediated disorders, psychotic disorders or complications from administering an antipsychotic agent at high dose or long term using such combination or pharmaceutical compositions. Furthermore, a method is disclosed for reducing the antipsychotic agent's dosages that comprises co-administering a therapeutically effective amount of a glutathione peroxidase mimic compound.

2. 发明专利

CA2825792C OTOPROTECTANT COMPOSITIONS OF GLUTATHIONE PEROXIDASE MIMICS FOR AMELIORATING HEARING LOSS 未知
公开(公告)号：CA2825792C
公开(公告)日：2016-08-16
申请号：CA2825792
申请日：2003-01-03
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN , LYNCH ERIC D
IPC分类号： A61K31/41 , C07D487/04 , A61K31/195 , A61K31/198 , A61K31/4162 , A61K31/519 , A61K31/555 , A61K31/724 , A61P27/16 , C08B37/16
摘要： In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic and at least one otoprotectant selected from the group consisting of a xanthine oxidase inhibitor and a glutathione or glutathione precursor. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic, at least one xanthine oxidase inhibitor, at least one glutathione or glutathione precursor. In another aspect, the present invention provides methods for ameliorating hearing loss by administering to a subject an amount of an otoprotective composition that is effective to ameliorate hearing loss.

3. 发明专利

CA3026007A1 TREATMENT OF MENIERE'S DISEASE 未知
公开(公告)号：CA3026007A1
公开(公告)日：2017-11-23
申请号：CA3026007
申请日：2017-05-18
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN
IPC分类号： A61K31/195 , A61K31/198 , A61K31/519
摘要： Disclosed herein are novel methods and compositions for treating MD and/or endolymphatic hydrops. The composition comprises ebselen and optionally one or more a glutathione peroxidase (GPx) modulator or mimic compounds and'or one or more prescription diuretic compounds. Also disclosed are methods of increasing GPx activity and reducing free radical species and cochlear or vestibular inflammation in a subject.

4. 发明专利

AU2001288219C1 Stimulation of cellular regeneration and differentiation in the inner ear 未知
公开(公告)号：AU2001288219C1
公开(公告)日：2009-12-03
申请号：AU2001288219
申请日：2001-07-10
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： GU RENDU , GRIGEUR CORINNE , KIL JONATHAN , LOWENHEIM HUBERT
IPC分类号： C12N15/09 , A61K31/282 , A61K31/519 , A61K31/711 , A61K33/14 , A61K33/24 , A61K38/00 , A61K38/17 , A61K45/00 , A61K45/06 , A61K48/00 , A61P27/16 , A61P43/00 , C12N5/0793
摘要： The present invention provides methods for stimulating the formation of inner ear cells, including inner ear sensory hair cells and inner ear support cells. The methods of the present invention damage and/or kill inner ear cells, and stimulate the formation of new, inner ear cells.

5. 发明专利

AU2002352982B2 Methods and compositions for ameliorating the undesirable effects of chemotherapy 未知
公开(公告)号：AU2002352982B2
公开(公告)日：2008-03-06
申请号：AU2002352982
申请日：2002-11-27
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN , LYNCH ERIC D
IPC分类号： C07D277/20 , A61K31/145 , A61K31/197 , A61K31/198 , A61K31/41 , A61K31/426 , A61K31/519 , A61K31/7056 , A61K31/7076 , A61K31/724 , A61K33/24 , A61K38/00 , A61K38/04 , A61K45/06 , A61P35/00 , A61P39/00 , C07D277/56 , C07D293/12 , C07D487/04 , C07H19/167 , C08B37/16
摘要： In one aspect, the present invention provides chemoprotectant compositions that each comprise at least two of the chemoprotectants disclosed herein. The chemoprotectant compositions of the invention are useful, for example, for ameliorating at least one adverse effect of chemotherapy. In another aspect, the present invention provides methods of ameliorating at least one adverse effect of chemotherapy, the methods each comprising the step of administering to a subject undergoing chemotherapy an amount of a chemoprotectant composition that is effective to ameliorate at least one adverse effect of the chemotherapy.

6. 发明专利

AU2017267732A1 Treatment of Meniere's disease 未知
公开(公告)号：AU2017267732A1
公开(公告)日：2018-12-20
申请号：AU2017267732
申请日：2017-05-18
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN
IPC分类号： A61K31/195 , A61K31/198 , A61K31/519
摘要： Disclosed herein are novel methods and compositions for treating MD and/or endolymphatic hydrops. The composition comprises ebselen and optionally one or more a glutathione peroxidase (GPx) modulator or mimic compounds and'or one or more prescription diuretic compounds. Also disclosed are methods of increasing GPx activity and reducing free radical species and cochlear or vestibular inflammation in a subject.

7. 发明专利

CA2961380A1 METHODS AND COMPOSITIONS FOR TREATING PSYCHOTIC DISORDERS 未知
公开(公告)号：CA2961380A1
公开(公告)日：2016-03-24
申请号：CA2961380
申请日：2015-09-15
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN
IPC分类号： A61K38/06 , A61K31/198 , A61K31/395 , A61K31/426 , A61K31/428 , A61K31/4515 , A61K31/4704 , A61K31/519 , A61K31/5415 , A61K31/551 , A61K31/554 , A61K31/724 , A61P25/18
摘要： Disclosed herein are novel drug combinations comprising a glutathione peroxidase (GPx) mimic compound and an antipsychotic agent, pharmaceutical compositions comprising one or more of such combinations, methods of preparing pharmaceutical compositions comprising one or more such combinations, and methods of treatment, prevention, inhibition or amelioration of one or more diseases associated with GPx mediated disorders, psychotic disorders or complications from administering an antipsychotic agent at high dose or long term using such combination or pharmaceutical compositions. Furthermore, a method is disclosed for reducing the antipsychotic agent's dosages that comprises co-administering a therapeutically effective amount of a glutathione peroxidase mimic compound.

8. 发明专利

AU2003202219B2 Methods for treating hearing loss 未知
公开(公告)号：AU2003202219B2
公开(公告)日：2008-10-23
申请号：AU2003202219
申请日：2003-01-03
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： LYNCH ERIC D , KIL JONATHAN
IPC分类号： C07D487/04 , A61K31/195 , A61K31/198 , A61K31/4162 , A61K31/519 , A61K31/555 , A61K31/724 , A61P27/16 , C08B37/16
摘要： In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic and at least one otoprotectant selected from the group consisting of a xanthine oxidase inhibitor and a glutathione or glutathione precursor. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic, at least one xanthine oxidase inhibitor, at least one glutathione or glutathione precursor. In another aspect, the present invention provides methods for ameliorating hearing loss by administering to a subject an amount of an otoprotective composition that is effective to ameliorate hearing loss.

9. 发明专利

AU2021200583A1 Methods and compositions for treating psychotic disorders 未知
公开(公告)号：AU2021200583A1
公开(公告)日：2021-03-04
申请号：AU2021200583
申请日：2021-01-29
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN
IPC分类号： A61P25/18
摘要： Disclosed herein are novel drug combinations comprising a glutathione peroxidase (GPx) mimic compound and an antipsychotic agent, pharmaceutical compositions comprising one or more of such combinations, methods of preparing pharmaceutical compositions comprising one or more such combinations, and methods of treatment, prevention, inhibition or amelioration of one or more diseases associated with GPx mediated disorders, psychotic disorders or complications from administering an antipsychotic agent at high dose or long term using such combination or pharmaceutical compositions. Furthermore, a method is disclosed for reducing the antipsychotic agent's dosages that comprises co-administering a therapeutically effective amount of a glutathione peroxidase mimic compound.

10. 发明专利

CY1115564T1 ΜΕΘΟΔΟΙ ΘΕΡΑΠΕΥΤΙΚΗΣ ΑΝΤΙΜΕΤΩΠΙΣΗΣ ΤΗΣ ΑΠΩΛΕΙΑΣ ΑΚΟΗΣ 未知
公开(公告)号：CY1115564T1
公开(公告)日：2017-01-04
申请号：CY141100744
申请日：2014-09-15
申请人： SOUND PHARMACEUTICALS INCORPORATED
发明人： KIL JONATHAN , LYNCH ERIC D
IPC分类号： A61K31/198 , A61K31/41 , A61K31/519 , A61P27/16
摘要： Σεμίαεκδοχή, ηπαρούσαεφεύρεσηπαρέχειωτοπροστατευτικέςσυνθέσειςχρήσιμεςστηβελτίωσητηςαπώλειαςακοής. Σεκάποιεςεφαρμογές, οιωτοπροστατευτικέςσυνθέσειςπεριλαμβάνουντουλάχιστονέναμιμητικόυπεροξειδάσηςτηςγλουταθειόνης. Σεκάποιεςεφαρμογές, οιωτοπροστατευτικέςσυνθέσειςπεριλαμβάνουντουλάχιστονέναμιμητικόυπεροξειδάσηςτηςγλουταθειόνηςκαιτουλάχιστονέναωτοπροστατευτικόπουεπιλέγεταιαπότηνομάδαπουπεριλαμβάνειαναστολέαοξειδάσηςτηςξανθίνηςκαιγλουταθειόνηή πρόδρομογλουταθειόνης. Σεκάποιεςεφαρμογές, οιωτοπροστατευτικέςσυνθέσειςπεριλαμβάνουντουλάχιστονέναμιμητικόυπεροξειδάσηςτηςγλουταθειόνης, τουλάχιστονέναναναστολέαοξειδάσηςτηςξανθίνης, τουλάχιστονμίαγλουταθειόνηή ένανπρόδρομογλουταθειόνης. Σεάλληεκδοχή, ηπαρούσαεφεύρεσηπαρέχειμεθόδουςβελτίωσηςτηςαπώλειαςακοήςμεχορήγησησεασθενήποσότηταςωτοπροστατευτικήςσύνθεσης, πουείναιαποτελεσματικήγιατηβελτίωσητηςαπώλειαςακοής.

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