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1. 发明公开

US20230277784A1 INHALATION DEVICE AND METHOD 审中-公开
公开(公告)号：US20230277784A1
公开(公告)日：2023-09-07
申请号：US18175301
申请日：2023-02-27
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M15/00 , A61M11/00
CPC分类号： A61M15/0086 , A61M11/007 , A61M15/0065 , A61M15/009 , A61M2202/0468 , A61M2205/3337 , A61M2205/3351 , A61M2205/3355 , A61M2205/8281
摘要： The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having improved flow characteristics. A inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), inside this housing (1) a reservoir (2) for storing a liquid (F), a pumping device with a hollow cylinder (9) providing a pumping chamber (3) for the generation of a pressure inside said pumping chamber (3), wherein the pumping chamber is fluidically connected with the reservoir (2) via an inlet check valve (4) which blocks in direction of the reservoir (2), a riser pipe (5) which can be received with at least one reservoir-facing, interior end (5A) in said hollow cylinder (9), and a nozzle (6) which is connected liquid-tight to an exterior end (5B) of the riser pipe (5), wherein the volume of the pumping chamber (3) is changeable by means of relative motion of the cylinder (9) to the riser pipe (5), and is characterised in that the riser pipe (5) is immobile and firmly attached to the housing (1) and to the nozzle (6), whereas the hollow cylinder (9) is moveable relative to the housing (1) and to the nozzle (6). The invention also discloses a method for the generation of an aerosol of a medically active liquid (F) by means of an inhalation device.

2. 发明申请

US20210146065A1 AEROSOL DELIVERY OF PIRFENIDONE 有权
公开(公告)号：US20210146065A1
公开(公告)日：2021-05-20
申请号：US16624224
申请日：2018-06-22
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M11/00 , A61K9/00 , A61K31/4412
摘要： The invention relates to the field of inhalation methods and inhalation devices for liquids. In particular, the invention relates to an inhalation method using an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of an aqueous formulation comprising pirfenidone by means of such inhalation device.

3. 发明申请

US20190232042A1 VALVE, IN PARTICULAR FOR A DEVICE FOR ADMINISTERING A LIQUID MEDICAMENT, AND A CORRESPONDING DEVICE FOR ADMINISTERING A LIQUID MEDICAMENT 审中-公开
公开(公告)号：US20190232042A1
公开(公告)日：2019-08-01
申请号：US16333791
申请日：2017-09-14
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M39/24 , A61M5/168
CPC分类号： A61M39/24 , A61M5/16881 , A61M11/00 , A61M16/208 , A61M2039/2493 , A61M2202/04 , B01L3/502738 , F04B13/00 , F04B19/006 , F04B23/02 , F04B53/10 , F16K99/0021 , F16K99/0057
摘要： The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

4. 发明申请

US20210196905A1 SEAL FOR AN INHALATION DEVICE 有权
公开(公告)号：US20210196905A1
公开(公告)日：2021-07-01
申请号：US16757544
申请日：2018-10-17
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M11/00
摘要： The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an improved seal construction for an inhalation device having a nebulizing nozzle and a piston which moves relative to a pumping chamber in order to generate pumping pressure and to an inhalation device comprising such seal.
An inhalation device for medically active liquids (F) for generation of an aerosol comprises a housing (1), an impingement-type nozzle (6) for generating the nebulised aerosol by collision of at least two liquid jets, the nozzle (6) being firmly affixed to the user-facing side of the housing (1) such as to be immobile relative to the housing (1), inside the housing (1) the inhalation device comprises a reservoir (2) for storing a liquid (F), a pumping device with a pumping chamber (3) for generation of a pressure inside said pumping chamber (3), wherein the pumping chamber (3) is fluidically connected with the reservoir (2), a riser pipe (5) which can be received with at least one reservoir-facing, interior end (5A) in said pumping chamber (3), and said nozzle (6) which is connected liquid-tight to an exterior end (5B) of the riser pipe (5), wherein the interior volume of the pumping chamber (3) is changeable by means of relative motion of the pumping chamber to the riser pipe (5) or vice versa.
A gap (10) can be present between an outside of said riser pipe (5) and an inside of said pumping chamber (3), and a seal (9) bridging said gap (10) in order to minimize pressure loss when a pressure is generated inside said pumping chamber (3).
Said seal (9) can be fixed to said outside of said riser pipe (5), and be moveable with respect to said inside of said pumping chamber (3).

5. 发明申请

US20220203082A1 VALVE, IN PARTICULAR FOR A DEVICE FOR ADMINISTERING A LIQUID MEDICAMENT, AND A CORRESPONDING DEVICE FOR ADMINISTERING A LIQUID MEDICAMENT 有权
公开(公告)号：US20220203082A1
公开(公告)日：2022-06-30
申请号：US17643310
申请日：2021-12-08
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M39/24 , F04B19/00 , A61M16/20 , F04B23/02 , F04B13/00 , F04B53/10 , F16K99/00 , A61M5/168
摘要： The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

6. 发明申请

US20210146069A1 INHALATION DEVICE WITH MULTILIQUID-NOZZLE AND METHOD 有权
公开(公告)号：US20210146069A1
公开(公告)日：2021-05-20
申请号：US16624221
申请日：2018-06-22
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M15/00
摘要： The invention relates to the field of inhalation devices for liquids. In particular, the invention relates to an inhalation device having a nebulizing nozzle, and to a method for the generation of an aerosol of a medically active liquid by means of such inhalation device.
An inhalation device comprises a housing (1), inside this housing (1) at least one reservoir (2) for storing a liquid (F, F1, F2), at least one pumping unit with at least one pumping chamber (3, 3A, 3B) for generation of a pressure inside said pumping chamber (3, 3A, 3B), at least one riser pipe (5, 5A, 5B) which can be received with at least one reservoir-facing, interior end (5A′, 5B′) in said pumping chamber (3, 3A, 3B), and a nozzle (6) which is connected to an exterior end (5A″, 5B″) of the riser pipe (5, 5A, 5B), wherein the interior volume of the at least one pumping chamber (3, 3A, 3B) is changeable by means of relative motion of the pumping chamber (3, 3A, 3B) to the riser pipe (5, 5A, 5B), and wherein the at least one riser pipe (5, 5A, 5B) is immobile and firmly attached to the housing (1) or to the nozzle (6), and the at least one pumping chamber (3, 3A, 3B) is moveable relative to the housing (1) or to the nozzle (6), wherein further, the nozzle (6) has a main axis (Z) and at least three ejection channels (6A, 6B, 6C, 6D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least one collision point (X, X1, X2) is provided at which at least two of said ejection trajectories intersect with one another.

7. 发明申请

US20210146068A1 MULTILIQUID-NOZZLE 有权
公开(公告)号：US20210146068A1
公开(公告)日：2021-05-20
申请号：US16624220
申请日：2018-06-22
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M11/06 , B05B1/26 , B05B1/14
摘要： The invention relates to the field of nozzles for inhalation devices for liquids. In particular, the invention relates to a nebulizing nozzle for an inhalation device, suitable for the generation of an aerosol of a medically active liquid, and to inhalation devices comprising such nozzle.
Such nozzle (1) for an inhalation device for medically active liquids (F, F1, F2) for generation of an aerosol has a main axis (Z) and at least three ejection channels (1A, 1B, 1C, 1D) adapted to eject liquid (F, F1, F2) along respective ejection trajectories, wherein at least two collision points (X1, X2) are provided at which at least two of said ejection trajectories intersect with one another, and/or wherein further, all ejection angles (A, A1, A2) at which the individual trajectories leave the nozzle (1) are identical, or at least one of said ejection angles (A, A1, A2) differs from the other ejection angles (A, A1, A2).

8. 发明申请

US20200023145A1 ATOMISER, IN PARTICULAR INHALER, FOR ATOMISING A LIQUID ACTIVE AGENT TO FORM AN AEROSOL AND A CORRESPONDING METHOD 审中-公开
公开(公告)号：US20200023145A1
公开(公告)日：2020-01-23
申请号：US16338083
申请日：2017-09-29
申请人： SOFTHALE NV
发明人： Frank BARTELS , Jürgen RAWERT
IPC分类号： A61M11/00 , A61M15/00
摘要： The invention relates to an atomiser, in particular an inhaler, for atomising a liquid active agent to form an aerosol, having an active agent reservoir (1), an atomiser nozzle (2) and a pump arrangement (3), wherein a suction side (4) of the pump arrangement (3) leads into the active agent reservoir (1) and a pressure side (5) of the pump arrangement (3) leads into the atomiser nozzle (2), and wherein the pump arrangement (3) has a plunger (7) that can be adjusted in a cylinder (6) in the axial direction (x) of the cylinder (6), characterised in that the plunger (7) is supported in portions along its outer circumference (8) in a form-fitting manner on an inner wall (9) of the cylinder (6) and a gap (10) is formed in portions between the inner wall (9) of the cylinder (6) and the plunger (7), wherein the plunger (7) is rotatably mounted around its longitudinal axis (x) in the cylinder (6) and can be adjusted between a suction position, in which a pump chamber (11) of the pump arrangement (3) is connected to the suction side (4) via the gap (10), and a pump position, in which the plunger (7) closes the suction side (4). A corresponding method is also described.

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