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1. 发明申请

WO8701279A3 ANTITUMOR CHAMIGRENE DERIVATIVES AND THEIR METHODS OF USE 审中-公开
标题翻译：抗肿瘤药物衍生物及其使用方法
公开(公告)号：WO8701279A3
公开(公告)日：1987-07-30
申请号：PCT/US8601746
申请日：1986-08-22
申请人： SNADER KENNETH M , HIGA TATSUO
发明人： SNADER KENNETH M , HIGA TATSUO
IPC分类号： C07C69/145 , A61K31/025 , A61K31/045 , A61K31/075 , A61K31/095 , A61K31/12 , A61K31/13 , A61K31/22 , A61K31/34 , C07C49/653 , C07C49/693 , C07C49/743 , C07D307/00
CPC分类号： A61K31/075 , A61K31/025 , A61K31/045 , A61K31/095 , A61K31/12 , A61K31/13 , A61K31/22 , A61K31/34
摘要： Antitumor compositions, and a method for inhibiting, remitting or controlling the growth of tumors or tumor cells utilizing antitumor compositions. More particularly, the antitumor compositions comprise, as active ingredient, an antitumor effective amount of halogenated chamigrenes extracted and derived from red alga and sea hares which diet upon red alga.

2. 发明申请

WO9704783A3 BIS-1-OXAQUINOLIZIDINE ALKALOIDS FROM A MARINE SPONGE WITH ANTITUMOR ACTIVITY 审中-公开
标题翻译：来自具有抗肿瘤活性的海洋海绵中的BIS-1-氧杂喹喔啉酸
公开(公告)号：WO9704783A3
公开(公告)日：1997-04-17
申请号：PCT/GB9601852
申请日：1996-07-29
申请人： PHARMA MAR SA , RUFFLES GRAHAM KEITH , TANAKA JUN ICHI , HIGA TATSUO , GARCIA GRAVALOS DOLORES
发明人： TANAKA JUN-ICHI , HIGA TATSUO , GARCIA GRAVALOS DOLORES
IPC分类号： A61K31/5365 , C07D498/22 , A61K31/535
CPC分类号： C07D498/22 , A61K31/5365
摘要： Compounds of general formula (II), or a pharmaceutically acceptable salt thereof, are of use as antitumor agents, where R and R are the same or different, and each group is -H or -OH; the group R is -H or -CH3; and the group R is -H or -CH3; and can be isolated from marine sponges.

3. 发明申请

WO0160810B1 OXY-AND AMINO-SUBSTITUTED TETRAHYDROFURYL DERIVATIVES WITH ANTITUMOUR ACTIVITY 审中-公开
标题翻译：含氧和氨基取代的四氢呋喃衍生物的抗肿瘤活性
公开(公告)号：WO0160810B1
公开(公告)日：2001-11-29
申请号：PCT/GB0100655
申请日：2001-02-16
申请人： PHARMA MAR SA , RUFFLES GRAHAM KEITH , HIGA TATSUO , TANAKA JUNICHI , GARCIA GRAVALOS DOLORES
发明人： HIGA TATSUO , TANAKA JUNICHI , GARCIA GRAVALOS DOLORES
IPC分类号： A61K31/341 , A61K35/56 , A61P35/00 , A61P35/02 , A61P43/00 , C07D307/22
CPC分类号： C07D307/22
摘要： Compounds of formula (I) wherein the substituent groups defined by R1, R2, R3 and R4 are each independently selected of H, C(=O) R,P(=O)R'R",S(=O)R'R", substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl; wherein each of the R', R" groups is independently selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, =O, C(=O)H, C(=O)CH 3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstitued aryl; wherein R1, R2, R3 could form part of a heterocyclic ring; R2 can be independently an internal salt; wherein X1, X2 and X3 on formula (I) are independently placed in any particular position of the chain and independently selected of H, OH, OR', SH, SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, NHC(O)R', CN, halogen, =O, C(=O)H, C(=O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic; wherein substituent groups defined by R' are each independently selected from the group consisting of H, OH, OR', SH, SR', SOR', SO2R', NO2, NH2, NHR', N(R')2, NHC(O)R', CN, halogen, =O, C(=O)H, C(=O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18 alkyl, substituted or unsubstituted C2-C18 alkenyl, substituted or unsubstituted C2-C18 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic; wherein x can be between 6 and 20; and wherein the dotted line is one or several double bonds placed in any particular position of the side chain; are useful as antitumor compounds and include compound IK-8-73-4 of structure (a) which was isolated from a sponge Pachastrissa sp.
摘要翻译：其中由R 1，R 2，R 3和R 4定义的取代基各自独立地选自H，C（= O）R，P（= O）R'R“，S（= O）R' 取代或未取代的C 1 -C 18烷基，取代或未取代的C 2 -C 18烯基，取代或未取代的C 2 -C 18炔基，取代或未取代的芳基; 其中每个R'，R“基团独立地选自H，OH，NO 2，NH 2，SH，CN，卤素，= O，C（= O）H，C（= O）CH 3， CO2H，CO2CH3，取代或未取代的C1-C18烷基，取代或未取代的C2-C18烯基，取代或未取代的C2-C18炔基，取代或未取代的芳基;其中R1，R2，R3可以形成杂环的一部分; R2可以是其中式（I）中的X 1，X 2和X 3独立地位于链的任何特定位置并且独立地选自H，OH，OR'，SH，SR'，SOR'，SO 2 R'，NO 2， NH2，NHC（O）R'，CN，卤素，= O，C（= O）H，C（= O）CH3，CO2H，CO2CH3，取代或未取代的C1-C18 烷基，取代或未取代的C 2 -C 18烯基，取代或未取代的C 2 -C 18炔基，取代或未取代的芳基，取代或未取代的杂芳族基团;其中由R'定义的取代基各自独立地选自H，OH，O R'，SH，SR'，SOR'，SO2R'，NO2，NH2，NHR'，N（R'）2，NHC（O）R'，CN，卤素，= O，C（= O）（= O）CH3，CO2H，CO2CH3，取代或未取代的C1-C18烷基，取代或未取代的C2-C18烯基，取代或未取代的C2-C18炔基，取代或未取代的芳基，取代或未取代的杂芳族; 其中x可以在6和20之间; 并且其中虚线是放置在侧链的任何特定位置中的一个或多个双键; 作为抗肿瘤化合物是有用的，并且包括从海绵Pachastrissa sp分离的结构（a）的化合物IK-8-73-4。

4. 发明专利

CA2114777A1 CYTOTOXIC COMPOUNDS 未知
公开(公告)号：CA2114777A1
公开(公告)日：1994-08-04
申请号：CA2114777
申请日：1994-02-02
申请人： TANAKA JUN ICHI , HIGA TATSUO , SUWANOBORIRUX KHANIT , JEFFORD CHARLES W , BERNARDINELLI GERALD , GRAVALOS DOLORES G
发明人： TANAKA JUN-ICHI , HIGA TATSUO , SUWANOBORIRUX KHANIT , JEFFORD CHARLES W , BERNARDINELLI GERALD , GRAVALOS DOLORES G
IPC分类号： A61K31/19 , A61K31/215 , A61K31/335 , A61K31/357 , A61K35/56 , A61P31/12 , A61P35/00 , C07C59/11 , C07C69/675 , C07C69/708 , C07D319/02
摘要： Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: or (II) in which R1 is H or lower alkyl; R2 ia OH or CH3; R3 is OH or CH3, and R4 H or MPTA. The compounda have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.

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