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1. 发明申请

WO2005007105A3 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2005007105A3
公开(公告)日：2005-05-19
申请号：PCT/US2004022082
申请日：2004-07-09
申请人： SMITHKLINE BEECHAM CORP , ADUSUMILLI PRASAD , KIM CHUNGBIN , LECH STANLEY J , MEHTA NARESH I , DINNER DARA L
发明人： ADUSUMILLI PRASAD , KIM CHUNGBIN , LECH STANLEY J , MEHTA NARESH I , DINNER DARA L
IPC分类号： A61K20060101 , A61K9/00 , A61K9/10 , A61K9/20
CPC分类号： A61K9/2009 , A61K9/0056 , A61K9/0065 , A61K9/2013 , A61K9/2018 , A61K9/205
摘要： A pharmaceutical composition in the form of a chewable tablet for the suppression of gastric reflux comprising an alginic acid or salt thereof, a water-soluble carbonate radical precursor, a calcium salt, a first bulk sweetener, and a binding agent. The calcium salt and either or both of the bulk sweetener and the binding agent may be blended via any of wet granulation, spray drying, or compression processes prior to admixture with the alginic acid and the carbonate radical precursor.
摘要翻译：包含藻酸或其盐，水溶性碳酸酯基前体，钙盐，第一增量甜味剂和粘合剂的用于抑制胃反流的咀嚼片形式的药物组合物。在与藻酸和碳酸根前体混合之前，钙盐和任何一种或两种本体甜味剂和粘合剂可以通过湿法制粒，喷雾干燥或压缩方法中的任何一种混合。

2. 发明申请

WO2008005432A3 SYSTEM AND METHOD FOR MANUFACTURING FULL AND PARTIAL DENTURES 审中-公开
标题翻译：用于制造全部和部分牙体的系统和方法
公开(公告)号：WO2008005432A3
公开(公告)日：2008-12-24
申请号：PCT/US2007015355
申请日：2007-07-02
申请人： SMITHKLINE BEECHAM CORP , ADUSUMILLI PRASAD , LECH STANLEY J
发明人： ADUSUMILLI PRASAD , LECH STANLEY J
IPC分类号： G06F19/00 , A61C3/00 , A61C8/00
CPC分类号： A61C13/0004 , A61C13/01 , B22F3/008 , B22F3/1055 , B22F2003/1056 , B33Y50/00 , B33Y80/00 , Y02P10/295
摘要： There is provided a system for fabricating 100 at least a portion of a denture. The system includes a three-dimensional scanning device 105 for scanning a surface of a denture template, and a computer-readable medium 110 including a computer program for receiving data from the scanning device, creating a 3-dimensional model 315 of the surface, and optionally modifying the 3-dimensional model 315 and/or adding features to the 3- dimensional model 315. The system also includes a fabricator 115 for creating the at least the portion of the denture, from a selected material, based on the 3- dimensional model. The fabricator 115 may be a device including a lathe 805, or a rapid prototyping machine. There is also provided a method for fabricating at least a portion of a denture 810.
摘要翻译：提供了一种用于制造至少一部分义齿的系统。该系统包括用于扫描义齿模板的表面的三维扫描装置105和包括用于从扫描装置接收数据的计算机程序的计算机可读介质110，创建表面的三维模型315，以及可选地修改三维模型315和/或将特征添加到三维模型315.该系统还包括制造者115，用于根据所选择的材料，基于三维形状来创建义齿的至少一部分模型。制造商115可以是包括车床805或快速原型机的设备。还提供了一种用于制造义齿810的至少一部分的方法。

3. 发明申请

WO2009105700A2 METHODS AND APPARATUS FOR PRODUCING DENTAL STONES AND BASE PLATES USED IN MAKING DENTURES 审中-公开
标题翻译：用于生产牙科用途的方法和装置和用于制造牙齿的基板
公开(公告)号：WO2009105700A2
公开(公告)日：2009-08-27
申请号：PCT/US2009034759
申请日：2009-02-20
申请人： SMITHKLINE BEECHAM CORP , ADUSUMILLI PRASAD , LECH STANLEY J , LOEWY ZVI G
发明人： ADUSUMILLI PRASAD , LECH STANLEY J , LOEWY ZVI G
IPC分类号： G06F19/00 , A61C13/34
CPC分类号： A61C13/0004 , A61C9/00 , A61C13/34
摘要： A method for manufacturing a denture includes making a physical model of a first device, digitally scanning the physical model, computer modeling a second device based on the scan where the second device is complimentary to the first device, and making a physical model of the second device from the computer modeling. There is also provided an apparatus for making a denture.
摘要翻译：一种用于制造义齿的方法包括制作第一装置的物理模型，数字地扫描物理模型，基于第二装置与第一装置互补的扫描对第二装置进行计算机建模，以及制作第二装置的物理模型设备从计算机建模。还提供了一种制造假牙的装置。

4. 发明申请

WO2008016869A2 DENTURE ADHESIVE COMPOSITION 审中-公开
标题翻译：牙膏粘合剂组合物
公开(公告)号：WO2008016869A2
公开(公告)日：2008-02-07
申请号：PCT/US2007074699
申请日：2007-07-30
申请人： SMITHKLINE BEECHAM CORP , ADUSUMILLI PRASAD , LECH STANLEY J , DENG FANG
发明人： ADUSUMILLI PRASAD , LECH STANLEY J , DENG FANG
IPC分类号： C08K5/053
CPC分类号： C09J101/284 , A61K6/0026 , A61K6/0058 , C08K5/0008 , C09J171/02 , C08L71/02 , C08L1/28 , C08L33/08 , C08L33/10 , C08L35/08 , C08L39/06 , C08L29/04
摘要： The present invention is directed to an improved denture adhesive composition. In particular, this invention is directed to a denture adhesive composition free of a hydrocarbon vehicle, such as petrolatum or mineral oil.
摘要翻译：本发明涉及一种改进的义齿粘合剂组合物。特别地，本发明涉及一种不含烃类载体如义石油或矿物油的义齿粘合剂组合物。

5. 发明申请

WO0119901A3 PROCESS FOR MAKING AQUEOUS COATED BEADLETS 审中-公开
标题翻译：制造水性涂层珠粒的方法
公开(公告)号：WO0119901A3
公开(公告)日：2001-09-27
申请号：PCT/US0025279
申请日：2000-09-14
申请人： SMITHKLINE BEECHAM CORP , ACHANTA ANAND , ADUSUMILLI PRASAD , DESHPANDE GANESH , LECH STANLEY J , OTHS PHIL , VINEN ARTHUR , WALSH BRENDAN
发明人： ACHANTA ANAND , ADUSUMILLI PRASAD , DESHPANDE GANESH , LECH STANLEY J , OTHS PHIL , VINEN ARTHUR , WALSH BRENDAN
IPC分类号： A61K9/16 , A61K9/22 , A61K9/26 , A61K9/50 , A61K9/54 , A61K31/137 , A61K31/192 , A61K31/4402 , A61K31/485 , A61K47/32 , A61K47/38 , A61P11/04 , A61K9/14 , A61K9/20
CPC分类号： A61K31/4402 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/485
摘要： The present invention is directed to application of novel process conditions for aqueous coating techniques of water soluble active agents, and its application to production of sustained release beadlets of said agents. The improvement lies in the determination and use of the glass transition point for the water swellable polymer used to produce the sustained release effect, and control of the moisture content of the air by dew point.
摘要翻译：本发明涉及用于水溶性活性剂的水性涂布技术的新型工艺条件的应用，以及其用于生产所述试剂的缓释小珠的应用。其改进在于确定和使用用于产生持续释放效果的水溶胀性聚合物的玻璃化转变点以及通过露点控制空气的含水量。

6. 发明申请

WO2006065239A8 CLEANSER COMPOSITIONS COMPRISING A SENSORY SIGNAL 审中-公开
标题翻译：包含感官信号的清洁剂组合物
公开(公告)号：WO2006065239A8
公开(公告)日：2006-09-08
申请号：PCT/US2004041956
申请日：2004-12-15
申请人： SMITHKLINE BEECHAM CORP , DULLEA CHARLES V , LECH STANLEY J , MEHTA NARESH I , WILENSKY STUART
发明人： DULLEA CHARLES V , LECH STANLEY J , MEHTA NARESH I , WILENSKY STUART
IPC分类号： A23G3/00 , A61K8/04 , A61K8/11 , A61K8/19 , A61K8/37 , A61K8/60 , A61Q11/02
CPC分类号： A61K8/19 , A61K8/11 , A61K8/60 , A61K2800/222 , A61K2800/412 , A61Q11/02 , C11D3/0052 , C11D3/221 , C11D11/0011
摘要： A cleanser composition suitable for use with oral appliances, which provides a sensory signal to the user. The sensory signal is such that the user believes the signal to indicate that cleansing of the oral device is occuring or, alternatively, that cleansing action has ceased.
摘要翻译：一种适用于口腔器具的清洁剂组合物，其向使用者提供感觉信号。感官信号使得用户相信该信号表明正在发生口服装置的清洁，或者该清洁动作已经停止。

7. 发明申请

WO2007062346A3 ADHESIVE LINER 审中-公开
标题翻译：胶粘衬垫
公开(公告)号：WO2007062346A3
公开(公告)日：2007-11-01
申请号：PCT/US2006061089
申请日：2006-11-20
申请人： SMITHKLINE BEECHAM CORP , WONG EDDIE , WILENSKY STUART B , BIDDESCOMB JOHN R , LECH STANLEY J
发明人： WONG EDDIE , WILENSKY STUART B , BIDDESCOMB JOHN R , LECH STANLEY J
IPC分类号： A61C13/12
CPC分类号： A61K6/0026 , C08L1/28 , C08L5/04 , C08L29/04 , C08L35/08 , C08L71/02
摘要： The present invention provides a denture adhesive liner in the form of an extruded film or sheet, comprising (a) a denture adhesive effective amount of alginate; (b) thermoplastic polymer; and (c) plasticizer, wherein said composition is extrudable into a film that is capable of adhering to a wet mucous surface. The present invention also provides a method for preparing a denture adhesive liner comprising the steps of : (a) preparing a composition of a denture adhesive effective amount of alginate; thermoplastic polymer; and plasticizer; and (b) forming a denture adhesive liner from the composition.
摘要翻译：本发明提供了一种挤出膜或片形式的义齿粘合剂衬垫，其包含（a）义齿粘合剂有效量的藻酸盐; （b）热塑性聚合物; 和（c）增塑剂，其中所述组合物可挤出成能够粘附到湿粘液表面的膜。本发明还提供了一种制备义齿粘合剂衬垫的方法，其包括以下步骤：（a）制备义齿粘合剂有效量的藻酸盐的组合物; 热塑性聚合物和增塑剂; 和（b）由该组合物形成假牙粘合剂衬里。

8. 发明申请

WO2007062347A2 FOAMED SUBSTRATE AND METHOD FOR MAKING SAME 审中-公开
标题翻译：泡沫基材及其制造方法
公开(公告)号：WO2007062347A2
公开(公告)日：2007-05-31
申请号：PCT/US2006061090
申请日：2006-11-20
申请人： SMITHKLINE BEECHAM CORP , DENG FANG , LECH STANLEY J
发明人： DENG FANG , LECH STANLEY J
IPC分类号： A61K8/81
CPC分类号： A61K6/0026 , A61C13/0025 , A61C19/066 , A61K9/006 , C08L29/04 , C08L71/02 , C08L35/08 , C08L5/04 , C08L1/28
摘要： The present invention provides a foamed and/or aerated substrate for transmucosal and/or transdermal applications. The foamed and/or aerated substrate may be in the form of a film, sheet, strip or wafer. The foamed and/or aerated substrate is suitable for use in applications such as, for example, adhesive denture liners, tooth whitening, and smoking control/cessation. The foamed and/or aerated substrate is polymeric in nature and comprises one or more polymers and one or more foaming agents. Additionally, the foamed and/or aerated substrate may include, but not limited to, one or more plasticizers, hydrophobic barrier agents, tooth whitening agents, antioxidants, preservatives, super-disintegrants or absorbents, flavorants, deodorants, breath freshening agents, colorants, surfactants, film modifiers, cross-linking agents, antimicrobial agents, control release agents, other therapeutic agents, or any combinations thereof.
摘要翻译：本发明提供用于经粘膜和/或透皮应用的泡沫和/或充气底物。发泡和/或充气底物可以是薄膜，片，条或晶片的形式。发泡和/或充气基底适合用于例如粘合剂义齿衬垫，牙齿美白和吸烟控制/停止等应用中。发泡和/或充气底物本质上是聚合物，并且包含一种或多种聚合物和一种或多种发泡剂。另外，泡沫和/或充气底物可以包括但不限于一种或多种增塑剂，疏水屏障剂，牙齿增白剂，抗氧化剂，防腐剂，超级崩解剂或吸收剂，调味剂，除臭剂，呼吸清新剂，着色剂，表面活性剂，膜改性剂，交联剂，抗微生物剂，控制释放剂，其它治疗剂或其任何组合。

9. 发明申请

WO2007112250A3 DENTAL APPLIANCE CLEANSER 审中-公开
标题翻译：牙科器具清洁剂
公开(公告)号：WO2007112250A3
公开(公告)日：2009-01-08
申请号：PCT/US2007064596
申请日：2007-03-22
申请人： SMITHKLINE BEECHAM CORP , BROGDEN KYLE N , OTHS PHILIP J , LECH STANLEY J , MEHTA NARESH I
发明人： BROGDEN KYLE N , OTHS PHILIP J , LECH STANLEY J , MEHTA NARESH I
IPC分类号： A61K31/4745
CPC分类号： A61K8/922 , A61K8/925 , A61Q11/02
摘要： This invention relates to a dental appliance cleanser which is a metastable emulsion comprising about 50- 99% w/w of an aqueous phase, about 1-50% w/w of a water immiscible oily phase, the oily phase having a combination of a one or more immiscible oils and one or more flavor oils. The dental appliance cleanser is applied to the dental appliance, outside the wearer's mouth, in the form of an aerated foam.
摘要翻译：本发明涉及一种牙科器具清洁剂，其是包含约50-99％w / w的水相，约1-50％w / w的水不混溶的油相的亚稳态乳液，所述油相具有一种或多种不混溶的油和一种或多种调味油。牙科器具清洁剂以充气泡沫的形式施加到牙科器具，在穿着者的嘴外。

10. 发明申请

WO2008028003A3 DENTURE CARE COMPOSITION 审中-公开
标题翻译：牙齿保健组合物
公开(公告)号：WO2008028003A3
公开(公告)日：2008-12-31
申请号：PCT/US2007077167
申请日：2007-08-30
申请人： SMITHKLINE BEECHAM CORP , DULLEA CHARLES V , LECH STANLEY J , DENG FANG
发明人： DULLEA CHARLES V , LECH STANLEY J , DENG FANG
IPC分类号： C11D1/72
CPC分类号： A61K8/86 , A61K8/345 , A61K8/39 , A61K8/731 , A61K8/8135 , A61K8/8152 , A61K8/8176 , A61K8/8182 , A61Q11/02
摘要： This invention relates to a new denture care composition and method of use. In particular, this invention relates to a film-forming denture care composition that kills odor causing bacteria, maintains prolonged fresh breath for two or more hours and is an effective guard against denture odor.
摘要翻译：本发明涉及新的义齿护理组合物和使用方法。特别地，本发明涉及杀死引起臭气的细菌的成膜义齿护理组合物，保持长时间的新鲜呼吸两个或更多小时，并且是有效防止义齿异味的保护。

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