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1. 发明专利

MX2009012479A DERIVADOS DE QUINOLINA COMO INHIBIDORES DE LA PI3 QUINASA. 未知
公开(公告)号：MX2009012479A
公开(公告)日：2009-12-02
申请号：MX2009012479
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： BURGESS JOELLE LORRAINE , NEWLANDER KENNETH ALLEN , DARCY MICHAEL GERARD , KNIGHT STEVEN DAVID , ADAMS NICHOLAS D , SCHMIDT STANLEY J , DONATELLI CARLA A , RIDGERS LANCE , SARPONG MARTHA
IPC分类号： A61K31/47
摘要： Se inventa un método para inhibir la actividad/función de PI3 quinasas usando derivados de quinolina. También se inventa un método para tratar una o más patologías seleccionadas entre: trastornos autoinmunes, enfermedades inflamatorias, enfermedades cardiovasculares, enfermedades neurodegenerativas, alergia, asma, pancreatitis, fallo multiorgánico, enfermedades renales, agregación plaquetaria, cáncer, motilidad de los espermatozoides, rechazo de trasplantes, rechazo de injertos y lesiones pulmonares, mediante la administración de derivados de quinolina.

2. 发明专利

AU2008254915A1 Quinoline derivatives as PI3 kinase inhibitors 未知
公开(公告)号：AU2008254915A1
公开(公告)日：2008-11-27
申请号：AU2008254915
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , RIDGERS LANCE , BURGESS JOELLE LORRAINE , NEWLANDER KENNETH ALLEN , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： A61K31/47
摘要： Invented is a method of inhibiting the activity/function of P13 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.

3. 发明专利

MY158843A QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS 未知
公开(公告)号：MY158843A
公开(公告)日：2016-11-15
申请号：MYPI20094867
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , NEWLANDER KENNETH ALLEN , RIDGERS LANCE , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： A61K31/47
摘要： INVENTED IS A METHOD OF INHIBITING THE ACTIVITY/FUNCTION OF P13 KINASES USING QUINOLINE DERIVATIVES. ALSO INVENTED IS A METHOD OF TREATING ONE OR MORE DISEASE STATES SELECTED FROM: AUTOIMMUNE DISORDERS, INFLAMMATORY DISEASES, CARDIOVASCULAR DISEASES, NEURODEGENERATIVE DISEASES, ALLERGY, ASTHMA, PANCREATITIS, MULTIORGAN FAILURE, KIDNEY DISEASES, PLATELET AGGREGATION, CANCER, SPERM MOTILITY, TRANSPLANTATION REJECTION, GRAFT REJECTION AND LUNG INJURIES BY THE ADMINISTRATION OF QUINOLINE DERIVATIVES

4. 发明专利

BRPI0811761A2 未知
公开(公告)号：BRPI0811761A2
公开(公告)日：2014-11-11
申请号：BRPI0811761
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , NEWLANDER KENNETH ALLEN , RIDGERS LANCE , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： A61K31/47
摘要： Invented is a method of inhibiting the activity/function of P13 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.

5. 发明专利

AU2012202710A1 Quinoline derivatives as P13 kinase inhibitors 未知
公开(公告)号：AU2012202710A1
公开(公告)日：2012-05-31
申请号：AU2012202710
申请日：2012-05-09
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , NEWLANDER KENNETH , RIDGERS LANCE , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： C07D401/14 , A61K31/47
摘要： C \NRPortihlDCC\KXG\4 ()d I DOC5-9A 12W 2 Invented is a method of inhibiting the activity/function of P13 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases. allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer. sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.

6. 发明专利

AU2008254915B2 Quinoline derivatives as PI3 kinase inhibitors 未知
公开(公告)号：AU2008254915B2
公开(公告)日：2012-02-09
申请号：AU2008254915
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , RIDGERS LANCE , BURGESS JOELLE LORRAINE , NEWLANDER KENNETH ALLEN , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： C07D401/14 , A61K31/47
摘要： Invented is a method of inhibiting the activity/function of PB kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives.

7. 发明专利

CO6241101A2 DERIVADOS DE QUINOLINA COMO INHIBIDORES DE LA P13 QUINASA 未知
公开(公告)号：CO6241101A2
公开(公告)日：2011-01-20
申请号：CO09130508
申请日：2009-11-17
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICOLAS , BURGESS JOELLE LORRAINE , SCHMIDT STANLEY J , SARPONG MARTHA A , RIDGERS LANCE , NEWLANDER KENNETH ALLEN , KNIGHT STEVEN D , DONATELLI CARLA A , DARCY MICHAEL G
IPC分类号： A61K31/47
摘要： 1.- Un compuesto de Fórmula (I):en la que R2 es un grupo piridinilo o piridinilo sustituido, R1 se selecciona entre un grupo que consiste en: heterocicloalquilo, heterocicloalquilo sustituido, arilo, arilo sustituido, heteroarilo y heteroarilo sustituido; cada R3 y R4 se selecciona independientemente entre: hidrógeno, halógeno, acilo, amino, amino sustituido, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-7, cicloalquilo C3-7 sustituido, heterocicloalquilo C3-7, heterocicloalquilo C3-7 sustituido, alquilcarboxi, aminoalquilo, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, arilalquilo, arilalquilo sustituido, arilcicloalquilo, arilcicloalquilo sustituido, heteroarilalquilo, heteroarilalquilo sustituido, ciano, hidroxilo, alcoxi, nitro, aciloxi y ariloxi; n es 1-2; o una sal farmacéuticamente aceptable del mismo. 2.- Un compuesto de acuerdo con la reivindicación 1, en el que el compuesto es un compuesto de fórmula (l)(G):en la que cada R1, R3, R4 y R5 se selecciona independientemente entre: hidrógeno, halógeno, acilo, amino, amino sustituido, arilamino, acilamino, heterocicloalquilamino, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-7, cicloalquilo C3-7 sustituido, heterocicloalquilo C3-7, heterocicloalquilo C3-7 sustituido, alquilcarboxi, aminoalquilo, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, arilalquilo, arilalquilo sustituido, arilcicloalquilo, arilcicloalquilo sustituido, heteroarilalquilo, heteroarilalquilo sustituido, ciano, hidroxilo, alcoxi, aciloxi y ariloxi; n es 1-2, m es 0-3; o R5 es R6, donde R6 es -SO2NR80 o -NSO2R80, donde R80 se selecciona entre un grupo que consiste en: alquilo C1-C6, cicloalquilo C1-C6, heterocicloalquilo C1-C6, ...

8. 发明专利

MA31443B1 DERIVES DE QUINOLINE EN TANT QU'INHIBITEURS DE PI3 KINASE 未知
公开(公告)号：MA31443B1
公开(公告)日：2010-06-01
申请号：MA32417
申请日：2009-12-14
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , NEWLANDER KENNETH ALLEN , RIDGERS LANCE , SARPONG MARTHA , SCHMIDT STANLEY J
IPC分类号： A61K31/47
摘要： PROCÉDÉ D'INHIBITION D'ACTIVITÉ/DE FONCTION DE PI3 KINASES REPOSANT SUR L'UTILISATION DE DÉRIVÉS DE QUINOLINE. ÉGALEMENT, PROCÉDÉ DE TRAITEMENT, PAR ADMINISTRATION DE DÉRIVÉS DE QUINOLINE, D'UNE OU PLUSIEURS MALADIES POUVANT ÊTRE: TROUBLES AUTOIMMUNES, MALADIES INFLAMMATOIRES, CARDIO-VASCULAIRES, NEURODÉGÉNÉRATIVES, ALLERGIE, ASTHME, PANCRÉATITE, DÉFAILLANCE DE PLUSIEURS ORGANES, MALADIES RÉNALES, AGRÉGATION PLAQUETTAIRE, CANCER, MOTILITÉ DU SPERME, REJET DE TRANSPLANT, REJET DE GREFFON, ET LÉSIONS PULMONAIRES.

9. 发明专利

CA2686016A1 QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS 未知
公开(公告)号：CA2686016A1
公开(公告)日：2008-11-27
申请号：CA2686016
申请日：2008-05-16
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , SCHMIDT STANLEY J , KNIGHT STEVEN DAVID , DONATELLI CARLA A , NEWLANDER KENNETH ALLEN , RIDGERS LANCE , SARPONG MARTHA , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD
IPC分类号： C07D401/14 , A61K31/4709 , A61K31/495 , A61K31/5377 , A61P35/00 , C07D401/10 , C07D405/14 , C07D413/14 , C07D471/04 , C07D493/04 , C07D498/04
摘要： Invented is a method of inhibiting the activity/function of PB kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative discase, allergy, asthma, pancreatitis, multiorgan failure , kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by th e administration of quinoline derivatives.

10. 发明专利

DOP2012000227A DERIVADOS DE QUINOLINA COMO INHIBIDORES DE LA PI3 QUINASA 未知
公开(公告)号：DOP2012000227A
公开(公告)日：2012-11-30
申请号：DO2012000227
申请日：2012-08-21
申请人： SMITHKLINE BEECHAM CORP
发明人： ADAMS NICHOLAS D , BURGESS JOELLE LORRAINE , DARCY MICHAEL GERARD , DONATELLI CARLA A , KNIGHT STEVEN DAVID , NEWLANDER KENNETH ALLEN , RIDGERS LANCE , SARPONG MARTHA , SCHMIDT STANLEY J
摘要： LA PRESENTE INVENCIÓN SE REFIERE AL USO DE DERIVADOS DE QUINOLINA PARA INHIBIR LA ACTIVIDAD/FUNCIÓN DE PI3 QUINASAS. TAMBIÉN SE INVENTA UN MÉTODO PARA TRATAR UNA O MÁS PATOLOGÍAS SELECCIONADAS ENTRE: TRASTORNOS AUTOINMUNES, ENFERMEDADES INFLAMATORIAS, ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES NEURODEGENERATIVAS, ALERGIA, ASMA, PANCREATITIS, FALLO MULTIORGÁNICO, ENFERMEDADES RENALES, AGREGACIÓN PLAQUETARIA, CÁNCER, MOTILIDAD DE LOS ESPERMATOZOIDES, RECHAZO DE TRASPLANTES, RECHAZO DE INJERTOS Y LESIONES PULMONARES, MEDIANTE LA ADMINISTRACIÓN DE DERIVADOS DE QUINOLINA.

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