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1. 发明申请

WO1994020538A1 EXTRACTION OF CELL-BOUND PROTEIN FROM BORDETELLA 审中-公开
标题翻译：从BORDETELLA提取细胞环境蛋白质
公开(公告)号：WO1994020538A1
公开(公告)日：1994-09-15
申请号：PCT/EP1994000597
申请日：1994-02-28
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , CAPAIU, Carine , COMBERBACH, Martin , ROELANTS, Piet , PETRE, Jean
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C07K15/00
CPC分类号： C07K14/235 , A61K39/00 , C12N1/02 , Y10S530/82 , Y10S530/825
摘要： Process for extracting a cell-bound protein of bacterial origin comprising contacting a suspension of the cell-bound protein with a flocculating agent prior to heat treatment.
摘要翻译：用于提取细菌来源的细胞结合蛋白的方法，包括在热处理之前使细胞结合蛋白的悬浮液与絮凝剂接触。

2. 发明申请

WO1995021928A1 PROCESS FOR THE PRODUCTION OF A HETEROLOGOUS PROTEIN FROM A METHYLOTROPHIC YEAST 审中-公开
标题翻译：从甲基化学生产异质蛋白的方法
公开(公告)号：WO1995021928A1
公开(公告)日：1995-08-17
申请号：PCT/EP1995000320
申请日：1995-01-30
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , COMBERBACH, Martin
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/81
CPC分类号： C07K14/005 , A61K39/00 , C07K14/195 , C07K14/235 , C12N15/815 , C12N2730/10122
摘要： A process for enhancing expression of a heterologous protein comprising culturing a methylotrophic yeast organism transformed with a vector containing DNA encoding the heterologous protein in a fermenter, characterised in that rate of MeOH addition is controlled during the induction phase of the cultivation, preferably using an automated feedback control loop system. Preferably, the concentration of MeOH in the fermenter broth, or the specific MeOH addition rate are maintained at substantially-constant levels during the induction phase.
摘要翻译：一种用于增强异源蛋白质表达的方法，包括培养在发酵罐中用含有编码异源蛋白质的DNA的载体转化的甲基营养酵母生物，其特征在于在培养的诱导阶段期间控制MeOH加入速率，优选使用自动化反馈控制回路系统。优选地，发酵罐肉汤中的MeOH浓度或特定的MeOH添加速率在诱导阶段保持在基本恒定的水平。

3. 发明申请

WO1994014962A1 VACCINES AGAINST VARICELLA-ZOSTER VIRUS (VZV) 审中-公开
标题翻译： VARICELLA-ZOSTER VIRUS（VZV）疫苗
公开(公告)号：WO1994014962A1
公开(公告)日：1994-07-07
申请号：PCT/EP1993003626
申请日：1993-12-17
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , JACOBS, Paul; , MASSAER, Marc; , HAUMONT, Michèle; , BOLLEN, Alex;
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/38
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K2319/02 , C07K2319/40 , C12N2710/16722
摘要： The present invention discloses methods for the production of Varicella-Zoster virus immediate early protein 175 (IEP 175) and derivatives thereof by recombinant technology - DNA and amino acid sequences are provided for IEP 175, structural or functional homologues, as well as fusion proteins and vectors adapted for eukaryotic host cells. Said protein and derivatives thereof are used as vaccines against VZV.
摘要翻译：本发明公开了通过重组技术生产水痘 - 带状疱疹病毒立即早期蛋白质175（IEP 175）及其衍生物的方法 - 为IEP 175，结构或功能同源物以及融合蛋白提供DNA和氨基酸序列，适用于真核宿主细胞的载体。所述蛋白质及其衍生物用作抗VZV疫苗。

4. 发明申请

WO1996032963A1 INDUCTION AND ENHANCEMENT OF THE IMMUNE RESPONSE TO POLYSACCHARIDES WITH BACTERIAL LIPOPROTEINS 审中-公开
标题翻译：诱导和增强对细菌脂多糖的多糖的免疫应答
公开(公告)号：WO1996032963A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005226
申请日：1996-04-16
申请人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE , SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
发明人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE , SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , SNAPPER, Clifford, M. , MOND, James, J. , CAPIAU, Carine , HAUSER, Pierre , PRIEELS, Jean-Paul
IPC分类号： A61K39/385
CPC分类号： C07K14/285 , A61K39/385 , A61K2039/55516 , A61K2039/55594 , A61K2039/6068 , Y02A50/482
摘要： The present invention provides a method of inducing or enhancing an immune response to polysaccharides or other T cell-independent antigen by the coadministration of the antigen with bacterial lipoproteins (including covalent attachment of the antigen and lipoproteins). In a preferred embodiment, the lipoprotein of the invention is lipoprotein D.
摘要翻译：本发明提供了通过将抗原与细菌脂蛋白（包括抗原和脂蛋白的共价连接）共同施用来诱导或增强对多糖或其它与T细胞无关的抗原的免疫应答的方法。在优选的实施方案中，本发明的脂蛋白是脂蛋白D.

5. 发明申请

WO1994014484A2 STORAGE DEVICES 审中-公开
标题翻译：存储设备
公开(公告)号：WO1994014484A2
公开(公告)日：1994-07-07
申请号：PCT/EP1993003665
申请日：1993-12-21
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , THILLY, Jacques
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61M05/00
CPC分类号： B01L9/543 , A61M5/008 , A61M2207/00
摘要： For storage of syringes, a support rack comprising a plurality of elongate fingers (2) connected together at one end by a spine member (1) is used. The fingers (2) define parallel support channels (5) open at one end, and the syringes are stored in the channels (5) with their lips or wings (4) resting on the elongate fingers (2). Also disclosed are support cradles, storage boxes, and lifting devices for handling the loaded racks. The support rack is better adapted than existing systems for cooperation with automated machinery since it can receive syringes into the channels by a horizontal translation movement, readily provided by a simple pushing device.
摘要翻译：为了存储注射器，使用支撑架，其包括通过脊部构件（1）在一端连接在一起的多个细长指状物（2）。手指（2）限定在一端开口的平行的支撑通道（5），并且注射器通过其嘴唇或翼（4）放置在细长指状物（2）上而储存在通道（5）中。还公开了用于处理装载的机架的支撑架，储物箱和提升装置。支撑架比现有的系统更适合与自动化机械配合使用，因为它可以通过简单推动装置容易提供的水平平移运动将注射器接收到通道中。

6. 发明申请

WO1992011366A1 CLONING AND EXPRESSION OF A PROTEIN ANTIGEN OF TOXOPLASMA GONDII 审中-公开
标题翻译：克隆和表达弓形虫GONDII蛋白抗原
公开(公告)号：WO1992011366A1
公开(公告)日：1992-07-09
申请号：PCT/EP1991002423
申请日：1991-12-16
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , INNOGENETICS S.A. , SAAVEDRA-DURAN, Rafael , HERION, Pascal
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , INNOGENETICS S.A.
IPC分类号： C12N15/30
CPC分类号： C07K14/45 , A61K39/00
摘要： A purified antigen of T. gondii having a molecular weight of 54-kDa (as determined by Western blotting) is provided which is reactive with antibodies raised against a recombinant protein obtained by expression of a defined T. gondii cDNA (Figure 2) in a host cell; also provided are immunogenic fragments of the 54-kDa antigen. Recombinant DNA encoding the 54-kDa antigen, host cells for expression of such DNA, a vaccine for treating or preventing toxoplasmosis infection in humans and animals, and test kits for detection of T. gondii antigen or antibody are also described.
摘要翻译：提供分子量为54-kDa（通过蛋白质印迹测定）的弓形体的纯化抗原，其与通过将定义的弓形虫cDNA（图2）表达获得的重组蛋白产生的抗体反应宿主细胞; 还提供了54-kDa抗原的免疫原性片段。还描述了编码54-kDa抗原的重组DNA，用于表达这种DNA的宿主细胞，用于治疗或预防人和动物弓形虫病感染的疫苗，以及用于检测弓形虫抗原或抗体的测试试剂盒。

7. 发明申请

WO1992001796A1 MYCOBACTERIAL EXPRESSION VECTOR 审中-公开
公开(公告)号：WO1992001796A1
公开(公告)日：1992-02-06
申请号：PCT/EP1991001332
申请日：1991-07-13
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , JACOBS, Paul , HAESELEER, Françoise , MASSAER, Marc , BOLLEN, Alex
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/74
CPC分类号： C07K14/445 , A61K39/00 , C12N15/74
摘要： The invention provides a mycobacterial expression vector containing exogenous DNA encoding a protein of interest (e.g. an antigen) under the control of the promoter and ribosomal binding site for the 64 KD protein of Mycobacterium bovis BCG. Also provided are mycobacteria transformed with the mycobacterial expression vectors and vaccine compositions comprising the transformed mycobacteria.
摘要翻译：本发明提供了含有编码目标蛋白质的外源DNA（例如抗原）的分枝杆菌表达载体，其在启动子和牛分枝杆菌BCG的64KD蛋白的核糖体结合位点的控制下。还提供了用分枝杆菌表达载体和包含转化的分枝杆菌的疫苗组合物转化的分枝杆菌。

8. 发明申请

WO1994000575A1 IMMEDIATE EARLY HSV-2 VIRAL PROTEIN ICP27 AS VACCINE 审中-公开
标题翻译：立即早期HSV-2病毒蛋白ICP27作为疫苗
公开(公告)号：WO1994000575A1
公开(公告)日：1994-01-06
申请号：PCT/EP1993001525
申请日：1993-06-15
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , SLAOUI, Moncef , PALA, Pietro , KOUTSOUKOS, Marguerite
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/38
CPC分类号： A61K39/39 , A61K39/015 , A61K39/12 , A61K39/245 , A61K2039/5256 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2710/24143
摘要： Immediate early HSV-2 viral protein ICP27 recognised by cytolytic T-lymphocyte (CTL) cells in humans, methods for preparation thereof and use in vaccine.
摘要翻译：由人体细胞溶解性T淋巴细胞（CTL）细胞识别的即时早期HSV-2病毒蛋白ICP27，其制备方法和用于疫苗。

9. 发明申请

WO1994000153A1 VACCINE COMPOSITION CONTAINING ADJUVANTS 审中-公开
标题翻译：含有ADJUVANTS的疫苗组合物
公开(公告)号：WO1994000153A1
公开(公告)日：1994-01-06
申请号：PCT/EP1993001524
申请日：1993-06-15
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , PRIEELS, Jean-Paul , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude , SLAOUI, Moncef , PALA, Pietro
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61K39/39
CPC分类号： A61K39/292 , A61K39/015 , A61K39/12 , A61K39/245 , A61K39/29 , A61K39/39 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , A61K2039/57 , C12N2710/16634 , C12N2730/10134 , Y02A50/412 , Y02A50/464
摘要： The present invention provides vaccine compositions comprising 3 De-O-acylated monophosphoryl lipid A and QS21. The vaccines compositions are potent inducers of CTL and (gamma) IFN responses.
摘要翻译：本发明提供包含3个De-O-酰化单磷酰脂质A和QS21的疫苗组合物。疫苗组合物是CTL和（γ）IFN应答的有效诱导剂。

10. 发明申请

WO1993024148A1 COMBINED VACCINES COMPRISING HEPATITIS B SURFACE ANTIGEN AND OTHER ANTIGENS 审中-公开
标题翻译：包含HEPATITIS B表面抗原和其他抗原的组合疫苗
公开(公告)号：WO1993024148A1
公开(公告)日：1993-12-09
申请号：PCT/EP1993001276
申请日：1993-05-15
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , PETRE, Jean , HAUSER, Pierre
IPC分类号： A61K39/295
CPC分类号： A61K39/292 , A61K39/0017 , A61K39/0018 , A61K39/05 , A61K39/08 , A61K39/099 , A61K39/12 , A61K39/39 , A61K2039/55505 , A61K2039/70 , C12N2730/10134 , C12N2770/32434 , Y02A50/464 , Y02A50/466
摘要： Stable and effective multivalent vaccine compositions comprising Hepatitis B surface antigen (HBsAg) are described wherein the HBsAg component is stable for one week at 37 DEG C and is highly immunogenic, for example when the vaccine is administered to infants. The compositions typically comprise HBsAg adsorbed to aluminium phosphate and other antigens, especially those suitable for use in a paediatric vaccine, adsorbed to aluminium phosphate or aluminium hydroxide. Methods for preparing the vaccines and the use of aluminium phosphate to stabilise HBsAg in a multivalent vaccine formulation are also described.
摘要翻译：描述了包含乙型肝炎表面抗原（HBsAg）的稳定和有效的多价疫苗组合物，其中HBsAg组分在37℃下稳定一周，并且是高度免疫原性的，例如当将疫苗给予婴儿时。组合物通常包含吸附到磷酸铝上的HBsAg和其它抗原，特别是适用于儿科疫苗的抗原，其吸附在磷酸铝或氢氧化铝上。还描述了制备疫苗的方法和使用磷酸铝来稳定多价疫苗制剂中的HBsAg。

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