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1. 发明申请

WO2007120614A2 HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION 审中-公开
标题翻译：均质的红细胞生成素和其他肽和蛋白质，其制备方法和中间体
公开(公告)号：WO2007120614A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008764
申请日：2007-04-11
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , DANISHEFSKY, Samuel, J. , WARREN, J., David , CHEN, Jiehao , WU, Bin , CHEN, Gong , WAN, Qian , TAN, Zhongping , KAN, Cindy , YUAN, Yu , HUA, Zihao , RANGANATHAN, Krishnakumar , TRZUPEK, John, D.
发明人： DANISHEFSKY, Samuel, J. , WARREN, J., David , CHEN, Jiehao , WU, Bin , CHEN, Gong , WAN, Qian , TAN, Zhongping , KAN, Cindy , YUAN, Yu , HUA, Zihao , RANGANATHAN, Krishnakumar , TRZUPEK, John, D.
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , C07K9/00 , C12P21/005
摘要： The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.
摘要翻译：本发明提供了分离的均相多官能化蛋白（例如促红细胞生成素），分离的糖肽，以及通过不含半胱氨酸的天然化学连接制备多官能化肽和/或蛋白质的方法。在某些实施方案中，本发明提供具有结构（I）的分离的均相多官能化蛋白质。在某些其他实施方案中，本发明提供了具有式（II）的分离的糖肽。在某些其他实施方案中，本发明的方法是制备包含由四个或更多个氨基酸组成的肽主链的多官能化肽的方法，其中两个或更多个不相邻氨基酸独立地被具有结构（III）的部分取代， -LH。其中A和L1如本文所定义。

2. 发明授权

EP2010556B1 HOMOGENEOUS ERYTHROPOIETIN AND METHOD FOR THEIR PREPARATION 有权
标题翻译：齐促红细胞生成素和方法及其制备
公开(公告)号：EP2010556B1
公开(公告)日：2015-09-23
申请号：EP07755136.4
申请日：2007-04-11
申请人： Sloan-Kettering Institute for Cancer Research
发明人： DANISHEFSKY, Samuel J. , WARREN, J. David , CHEN, Jiehao , WU, Bin , CHEN, Gong , WAN, Qian , TAN, Zhongping , KAN, Cindy , YUAN, Yu , HUA, Zihao , RANGANATHAN, Krishnakumar , TRZUPEK, John D.
IPC分类号： C07K14/505 , A61K38/16
CPC分类号： C07K14/505 , C07K9/00 , C12P21/005

3. 发明公开

EP2010556A2 HOMOGENEOUS ERYTHROPOIETIN AND OTHER PEPTIDES AND PROTEINS, METHODS AND INTERMEDIATES FOR THEIR PREPARATION 有权
标题翻译：齐促红细胞生成素和方法及其制备
公开(公告)号：EP2010556A2
公开(公告)日：2009-01-07
申请号：EP07755136.4
申请日：2007-04-11
申请人： Sloan-Kettering Institute for Cancer Research
发明人： DANISHEFSKY, Samuel J. , WARREN, J. David , CHEN, Jiehao , WU, Bin , CHEN, Gong , WAN, Qian , TAN, Zhongping , KAN, Cindy , YUAN, Yu , HUA, Zihao , RANGANATHAN, Krishnakumar , TRZUPEK, John D.
IPC分类号： C07K14/00 , A61K38/00 , A61K38/16
CPC分类号： C07K14/505 , C07K9/00 , C12P21/005
摘要： The present invention provides isolated homogeneous polyfunctionalized proteins (e.g., erythropoietin), isolated glycopeptides, and a method for preparing polyfunctionalized peptides and/or proteins via cysteine-free native chemical ligation. In certain embodiments, the invention provides an isolated homogeneous polyfunctionalized protein having the structure (I). In certain other embodiments, the invention provides an isolated glycopeptide having Formula (II). In certain other embodiments, the inventive method is a method for preparing a polyfunctionalized peptide comprising a peptidic backbone made up of four or more amino acids, wherein two or more non-adjacent amino acids are independently substituted with a moiety having the structure (III) -LH. wherein A and L1 are as defined herein.

4. 发明申请

WO2016200634A1 ONLINE SITES WITH ASSOCIATED FICTITIOUS GEOGRAPHICAL LOCATIONS 审中-公开
标题翻译：在线网站与相关的地理位置
公开(公告)号：WO2016200634A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/034845
申请日：2016-05-27
申请人： WU, Bin
发明人： WU, Bin
IPC分类号： G06Q10/06
CPC分类号： G06F17/30241 , G06F17/30554 , G06F17/30595 , G06F17/3087 , G06F17/30876 , G06F17/3089 , H04L67/10
摘要： A method, which provides a location context to an online object, includes (a) receiving identification information regarding the online object; (b) in a database, creating a relationship between the online object and a representation of a geographical location; (c) receiving a request for retrieving the relationship from the database based on the identification information or the geographical location; and (d) responding to the request by returning the relationship retrieved from the database. The request may originate from an application program that displays the representation of the geographical location graphically. The online object may correspond to an online business. In some implementations, the online object is unrelated in real life to a community located at the geographical location.
摘要翻译：向在线对象提供位置上下文的方法包括：（a）接收关于在线对象的识别信息; （b）在数据库中，创建在线对象与地理位置的表示之间的关系; （c）基于识别信息或地理位置接收从数据库检索关系的请求; 和（d）通过返回从数据库检索的关系来响应该请求。该请求可以源自以图形方式显示地理位置的表示的应用程序。在线对象可以对应于在线业务。在一些实现中，在线对象在现实生活中与位于地理位置的社区无关。

5. 发明申请

WO2010126895A1 INHIBITORS OF PI3 KINASE AND / OR MTOR 审中-公开
标题翻译： PI3激酶和/或MTOR的抑制剂
公开(公告)号：WO2010126895A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032593
申请日：2010-04-27
申请人： AMGEN INC. , ANDREWS, Kristin , BO, Yunxin, Y. , BOOKER, Shon , CEE, Victor, J. , D'ANGELO, Noel , HERBERICH, Bradley, J. , HONG, Fang-Tsao , JACKSON, Claire, L., M. , LANMAN, Brian, A. , LIAO, Hongyu , LIU, Longbin , NISHIMURA, Nobuko , NORMAN, Mark, H. , PETTUS, Liping, H. , REED, Anthony, B. , SMITH, Adrian, L. , TADESSE, Seifu , TAMAYO, Nuria, A. , WU, Bin , WURZ, Ryan , YANG, Kevin
发明人： ANDREWS, Kristin , BO, Yunxin, Y. , BOOKER, Shon , CEE, Victor, J. , D'ANGELO, Noel , HERBERICH, Bradley, J. , HONG, Fang-Tsao , JACKSON, Claire, L., M. , LANMAN, Brian, A. , LIAO, Hongyu , LIU, Longbin , NISHIMURA, Nobuko , NORMAN, Mark, H. , PETTUS, Liping, H. , REED, Anthony, B. , SMITH, Adrian, L. , TADESSE, Seifu , TAMAYO, Nuria, A. , WU, Bin , WURZ, Ryan , YANG, Kevin
IPC分类号： C07D401/14 , C07D473/00 , A61K31/52 , A61P35/00
CPC分类号： C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物，其中变量如本文所定义。

6. 发明申请

WO2003019783A3 PHASE-LOCKED LOOP WITH ANALOG PHASE ROTATOR 审中-公开
公开(公告)号：WO2003019783A3
公开(公告)日：2003-03-06
申请号：PCT/US2002/023801
申请日：2002-07-25
申请人： BITBLITZ COMMUNICATIONS, INC. , WU, Bin , ZHENG, Dong
发明人： WU, Bin , ZHENG, Dong
IPC分类号： H03L7/099
摘要： A phase-locked loop includes a phase detector which receives an input signal and a first internal periodic signal and provides a phase signal indicative of a phase difference between the input signal and the internal signal. A rotator then receives the phase signal and provides first and second periodic signals each having a frequency that is a function of the phase difference, the first and second periodic signals being 90 degrees out of phase with each other. An interpolator circuit then linearly combines the first and second periodic signals with third and fourth periodic signals to provide the first internal periodic signal. The interpolator circuit may provide a second internal periodic signal that is 90 degrees out of phase relative to the first internal periodic signal. The phase-locked loop may further include a low-pass filter provided between the phase detector and the rotator.

7. 发明申请

WO2016011677A1 LOCAL DATABASE CACHE 审中-公开
标题翻译：本地数据库缓存
公开(公告)号：WO2016011677A1
公开(公告)日：2016-01-28
申请号：PCT/CN2014/083898
申请日：2014-08-07
申请人： HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. , JU, Jing-Hao , WANG, Bo , WU, Bin
发明人： JU, Jing-Hao , WANG, Bo , WU, Bin
IPC分类号： G06F17/30
CPC分类号： G06F17/30463 , G06F12/0893 , G06F17/30457 , G06F17/3048 , G06F17/30554 , G06F2212/1021 , G06F2212/1024 , G06F2212/465
摘要： A stored procedure call may be transmitted to a database to execute a database query. As a result of the stored procedure call, results including a result record satisfying the database query and a set of records related to the result record may be received. The results may be stored in a local cache.
摘要翻译：可以将存储过程调用发送到数据库以执行数据库查询。作为存储过程调用的结果，可以接收包括满足数据库查询的结果记录和与结果记录相关的一组记录的结果。结果可能存储在本地缓存中。

8. 发明申请

WO2008021431A2 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING THE STATUS OF TRANSPLANT REJECTION AND IMMUNE DISORDERS 审中-公开
标题翻译：用于诊断和监测移植物排斥和免疫疾病状态的方法和组合物
公开(公告)号：WO2008021431A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/018135
申请日：2007-08-14
申请人： EXPRESSION DIAGNOSTICS, INC. , ROSENBERG, Steven , FRY, Kirk , WU, Bin , DEDRICK, Russell, L.
发明人： ROSENBERG, Steven , FRY, Kirk , WU, Bin , DEDRICK, Russell, L.
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , G01N2800/24 , G01N2800/245 , G01N2800/52
摘要： The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.
摘要翻译：本发明提供了使用剪接变体及其试剂用于诊断和监测移植物和免疫病症的状态的方法，包括诊断，监测和预测移植物排斥或非排斥，类固醇响应以及发作或眩光的免疫紊乱。

9. 发明申请

WO2005111174A1 POLYMERIC MATRICES FOR THE ENCAPSULATION OF PHOSPHORESCENT MOLECULES FOR ANALYTICAL APPLICATIONS 审中-公开
标题翻译：用于分析应用的磷酸盐分子的聚合物矩阵
公开(公告)号：WO2005111174A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/006357
申请日：2005-02-28
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , SONG, Xuedong , WU, Bin
发明人： SONG, Xuedong , WU, Bin
IPC分类号： C09K11/06
CPC分类号： C09K11/06 , C09K2211/18 , Y10T428/256 , Y10T428/2991 , Y10T428/2998
摘要： The invention involves encapsulation of phosphorescent molecules in polymeric matrices to prevent phosphorescence quenching. Specifically, polymers containing a significant portion of halogens have been found to be good matrices for encapsulation of phosphorescent molecules to provide strong phosphorescence at ambient conditions. Those encapsulated phosphorescent molecules can find a wide variety of applications for detection of many species, including biological and chemical molecules as well as micro-organisms.
摘要翻译：本发明涉及将磷光分子封装在聚合物基质中以防止磷光猝灭。具体地，已经发现含有相当大部分卤素的聚合物是用于封装磷光分子的良好基质，以在环境条件下提供强磷光。这些包封的磷光分子可以发现多种用于检测许多物种的应用，包括生物和化学分子以及微生物。

10. 发明申请

WO2002051922A3 POWDER COATING COMPOSITIONS CONTAINING REACTIVE NANOPARTICLES 审中-公开
公开(公告)号：WO2002051922A3
公开(公告)日：2002-07-04
申请号：PCT/US2001/047240
申请日：2001-12-10
申请人： UCB, S.A. , WU, Bin , WANG, Zhikai
发明人： WU, Bin , WANG, Zhikai
IPC分类号： C08K3/34
摘要： A powder coating composition comprising reactive nanoparticles and a thermocurable or radiation curable resin. The nanoparticles impart a wide range of enhanced properties to the compositions such as hardness and abrasion resistance.

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