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1. 发明申请

WO2005045038A8 RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (siNA) 审中-公开
标题翻译： RNA干扰介导的GPRA和AAA1基因表达的抑制使用短核酸（siNA）
公开(公告)号：WO2005045038A8
公开(公告)日：2005-07-14
申请号：PCT/US2004027231
申请日：2004-08-20
申请人： SIRNA THERAPEUTICS INC , RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES
发明人： RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES
IPC分类号： A01N43/04 , A61K31/713 , A61K38/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/87 , C12P19/34 , C12N15/11
CPC分类号： C12N15/87 , A61K38/00 , A61K49/0008 , C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating G protein-coupled receptor for asthma susceptibility (GPRA) and asthma-associated alternatively spliced gene 1 (AAA1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GPRA and/or AAA1 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GPRA and/or AAA1 genes.
摘要翻译：本发明涉及使用短干扰核酸（siNA）分子调节G蛋白偶联受体哮喘易感性（GPRA）和哮喘相关性剪接基因1（AAA1）基因表达的化合物，组合物和方法。本发明还涉及可用于通过使用小核酸分子调节涉及GPRA和/或AAA1基因表达和/或活性通过RNA干扰（RNAi）的途径的其它基因的表达和活性的方法。特别地，本发明具有小的核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA））分子和用于调节GPRA和/或AAA1基因表达的方法。

2. 发明专利

CA2543030A1 RNA INTERFERENCE MEDIATED INHIBITION OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 未知
公开(公告)号：CA2543030A1
公开(公告)日：2005-05-19
申请号：CA2543030
申请日：2004-08-19
申请人： SIRNA THERAPEUTICS INC
发明人： MCSWIGGEN JAMES , POLISKY BARRY
IPC分类号： A01N43/04 , A61K31/713 , A61K38/00 , A61K47/48 , A61K49/00 , C07H21/02 , C07H21/04 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , C12P19/34

3. 发明专利

CA2543029A1 RNA INTERFERENCE MEDIATED INHIBITION OF GPRA AND AAA1 GENE EXPRESSION USING SHORT NUCLEIC ACID (SINA) 未知
公开(公告)号：CA2543029A1
公开(公告)日：2005-05-19
申请号：CA2543029
申请日：2004-08-20
申请人： SIRNA THERAPEUTICS INC
发明人： RICHARDS IVAN , MCSWIGGEN JAMES , POLISKY BARRY
IPC分类号： A01N43/04 , A61K31/713 , A61K38/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/87 , C12P19/34

4. 发明专利

AU2003211058A8 Rna interference mediated target discovery and target validation using short interfering nucleic acid (sina) 未知
公开(公告)号：AU2003211058A8
公开(公告)日：2003-09-09
申请号：AU2003211058
申请日：2003-02-14
申请人： SIRNA THERAPEUTICS INC
发明人： POLISKY BARRY , THOMPSON JAMES , USMAN NASSIM , BEIGELMAN LEONID
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , C12N15/113 , C12Q1/68 , C07H21/02 , A61K48/00 , C07H21/04 , C12N15/85 , C12N15/86 , C12P19/34

5. 发明申请

WO2006060598A2 RNA INTERFERENCE MEDIATED INHIBITION OF INTERLEUKIN AND INTERLEUKIN RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
标题翻译： RNA干扰介导的抑制干扰素和白介素受体基因表达使用短暂的核酸（siNA）
公开(公告)号：WO2006060598A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043510
申请日：2005-12-01
申请人： SIRNA THERAPEUTICS INC , RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES
发明人： RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES
IPC分类号： A61K48/00 , C12N15/113 , C12N15/85 , C12Q1/68
CPC分类号： A61K49/0008 , A61K38/00 , C12N15/1136 , C12N15/1138 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/3519 , C12N2310/53 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating interleukin and/or interleukin receptor gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of interleukin and/or interleukin receptor gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of interleukin and/or interleukin receptor genes, such as IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-11, IL-12, IL-13, IL-14, IL-15, IL-16, IL-17, IL-18, IL-19, IL-20, IL-21, IL-22, IL-23, IL24, IL-25, IL-26, and IL-27 genes and IL-1R, IL-2R, IL-3R, IL-4R, IL-5R, IL-6R, IL-7R, IL8R, IL-9R, IL-10R, IL-11R, IL-12R, IL-13R, IL-14R, IL-15R, IL-16R, IL-17R, IL-18R, IL19R, IL-20R, IL-21R, IL-22R, IL-23R, IL-24R, IL-25R, IL-26R, and IL-27R. Such small nucleic acid molecules are useful, for example, for treating, preventing, inhibiting, or reducing cancer, inflammatory, respiratory, autoimmune, cardiovascular, neurological, and/or proliferative diseases, disorders, or conditions in a subject or organism, and for any other disease, trait, or condition that is related to or will respond to the levels of interleukin and/or interleukin receptor in a cell or tissue, alone or in combination with other treatments or therapies.
摘要翻译：本发明涉及可用于使用短干扰核酸（siNA）分子调节白介素和/或白细胞介素受体基因表达的化合物，组合物和方法。本发明还涉及可用于通过使用小核酸分子通过RNA干扰（RNAi）调节参与白细胞介素和/或白细胞介素受体基因表达和/或活性的途径的其它基因的表达和活性的化合物，组合物和方法。特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA））分子和用于调节白介素和/或白介素受体基因如IL-1，IL-2，IL-3，IL-4，IL-5，IL-6，IL-7，IL- 8，IL-9，IL-10，IL-11，IL-12，IL-13，IL-14，IL-15，IL-16，IL-17，IL-18，IL-19， IL-21，IL-22，IL-23，IL24，IL-25，IL-26和IL-27基因和IL-1R，IL-2R，IL-3R，IL-4R，IL-5R， 6R，IL-7R，IL8R，IL-9R，IL-10R，IL-11R，IL-12R，IL-13R，IL-14R，IL-15R，IL-16R，IL-17R，IL-18R， IL-20R，IL-21R，IL-22R，IL-23R，IL-24R，IL-25R，IL-26R和IL-27R。这样的小核酸分子可用于例如治疗，预防，抑制或减少受试者或生物体内的癌症，炎症，呼吸，自身免疫，心血管，神经和/或增殖性疾病，病症或病症，与细胞或组织中白细胞介素和/或白细胞介素受体水平相关或将会对其单独或与其它治疗或疗法结合的任何其它疾病，性状或病症。

6. 发明申请

WO2005045038A3 RNA interference mediated inhibition of GPRA and AAA1 gene expression using short nucleic acid (siNA) 审中-公开
标题翻译： RNA干扰介导的使用短核酸（siNA）的GPRA和AAA1基因表达的抑制
公开(公告)号：WO2005045038A3
公开(公告)日：2006-03-02
申请号：PCT/US2004027231
申请日：2004-08-20
申请人： RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES , SIRNA THERAPEUTICS INC
发明人： RICHARDS IVAN , POLISKY BARRY , MCSWIGGEN JAMES
IPC分类号： A01N43/04 , A61K31/713 , A61K38/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/87 , C12P19/34
CPC分类号： C12N15/87 , A61K38/00 , A61K49/0008 , C12N15/113 , C12N15/1138 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating G protein-coupled receptor for asthma susceptibility (GPRA) and asthma-associated alternatively spliced gene 1 (AAA1) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of GPRA and/or AAA1 gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of GPRA and/or AAA1 genes.

7. 发明申请

WO2004097020A3 RNA INTERFERENCE MEDIATED INHIBITION OF MAP KINASE GENE EXPRESSION 审中-公开
标题翻译： RNA干扰介导的MAP激酶基因表达的抑制
公开(公告)号：WO2004097020A3
公开(公告)日：2006-01-05
申请号：PCT/US2004012517
申请日：2004-04-23
申请人： SIRNA THERAPEUTICS INC , MCSWIGGEN JAMES , BEIGELMAN LEONID , USMAN NASSIM , HAEBERLI PETER , CHOWRIRA BHARAT , POLISKY BARRY
发明人： MCSWIGGEN JAMES , BEIGELMAN LEONID , USMAN NASSIM , HAEBERLI PETER , CHOWRIRA BHARAT , POLISKY BARRY
IPC分类号： A61K38/00 , C12N15/11 , C12N15/113 , C12N15/87 , A61K31/713
CPC分类号： C12N15/111 , A61K38/00 , C12N15/1137 , C12N15/87 , C12N2310/14 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2330/30 , C12Y207/11024 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating mitogen activated protein kinase (MAP kinase ) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of MAP kinase and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of mitogen activated protein kinase (MAP kinase ) genes such as c-JUN, JNK1, JNK2, p38, ERK1, or ERK2.
摘要翻译：本发明涉及使用短干扰核酸（siNA）分子调节有丝分裂原活化蛋白激酶（MAP激酶）基因表达的化合物，组合物和方法。本发明还涉及可用于通过使用小核酸分子调节涉及MAP激酶和/或活性通过RNA干扰（RNAi）的途径的其它基因的表达和活性的化合物，组合物和方法。特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA））分子和用于调节丝裂原活化蛋白激酶（MAP激酶）基因如c-JUN，JNK1，JNK2，p38，ERK1或ERK2的表达的方法。

8. 发明申请

WO2005045041A2 RNA INTERFERENCE MEDIATED INHIBITION OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 审中-公开
标题翻译： RNA干扰介导的抑制胆固醇转运蛋白（CETP）使用短暂干扰核酸（SINA）的基因表达
公开(公告)号：WO2005045041A2
公开(公告)日：2005-05-19
申请号：PCT/US2004027404
申请日：2004-08-19
申请人： SIRNA THERAPEUTICS INC , MCSWIGGEN JAMES , POLISKY BARRY
发明人： MCSWIGGEN JAMES , POLISKY BARRY
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07H21/02 , C12N15/11 , C12N15/113 , C12N15/115 , C12N15/87 , A01N43/04 , A61K31/713 , C07H21/04 , C12P19/34
CPC分类号： C12N15/113 , A61K38/00 , A61K49/0008 , C07H21/02 , C12N15/111 , C12N15/1132 , C12N15/1137 , C12N15/1138 , C12N15/115 , C12N15/87 , C12N2310/111 , C12N2310/12 , C12N2310/121 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/346 , C12N2310/53 , C12N2320/32 , C12N2330/30 , C12Y103/01022 , C12Y104/03003 , C12Y114/19001 , C12Y207/07049 , C12Y207/11001 , C12Y207/11013 , C12Y301/03048 , C12Y604/01002 , C12N2310/3521
摘要： This invention relates to compounds, compositions, and methods useful for modulating cholesteryl ester transfer protein (CETP) gene expression using short interfering nucleic acid (siNA) molecules. This invention also relates to compounds, compositions, and methods useful for modulating the expression and activity of other genes involved in pathways of CETP gene expression and/or activity by RNA interference (RNAi) using small nucleic acid molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules and methods used to modulate the expression of CETP genes.
摘要翻译：本发明涉及使用短干扰核酸（siNA）分子调节胆固醇酯转移蛋白（CETP）基因表达的化合物，组合物和方法。本发明还涉及可用于通过使用小核酸分子调节涉及CETP基因表达和/或通过RNA干扰（RNAi）的活性的其它基因的其他基因的表达和活性的化合物，组合物和方法。特别地，本发明的特征在于小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA））分子和用于调节CETP基因表达的方法。

9. 发明公开

EP1474433A4 RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开
标题翻译：通过RNA干扰介导的靶定位与WITH的短干扰核酸验证（的siNA）
公开(公告)号：EP1474433A4
公开(公告)日：2005-02-23
申请号：EP03742746
申请日：2003-02-14
申请人： SIRNA THERAPEUTICS INC
发明人： USMAN NASSIM , POLISKY BARRY , THOMPSON JAMES , BEIGELMAN LEONID
IPC分类号： C12N15/09 , A61K38/00 , A61K47/48 , C12N15/113 , C12Q1/68 , C07H21/02 , A61K48/00 , C07H21/04 , C12N15/85 , C12N15/86 , C12P19/34
CPC分类号： C12N15/1137 , A61K38/00 , A61K47/54 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/53 , C12N2320/12 , C12N2330/31 , C12Y301/03048 , C12N2310/3521

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