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1. 发明授权

US11383048B2 Device to deliver a predetermined amount of a substance to a natural orifice of the body 有权
公开(公告)号：US11383048B2
公开(公告)日：2022-07-12
申请号：US14433048
申请日：2014-08-21
申请人： SIPNOSE LTD
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/00 , A61M15/00 , A61M11/02 , A61M15/08 , A61M16/10
摘要： The present invention provides a device for delivering a predetermined amount of at least one substance to a body orifice of a subject; comprising: a. a container for containing said at least one substance; b. a delivery end for placement in proximity to said orifice, said delivery end being in fluid communication with said container; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d. a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; e. a fluid tight chamber.

2. 发明授权

US11992604B2 Devices and methods for delivering a substance to a body cavity 有权
公开(公告)号：US11992604B2
公开(公告)日：2024-05-28
申请号：US16809994
申请日：2020-03-05
申请人： SIPNOSE LTD
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/00 , A61M11/04 , A61M15/00 , A61M15/08
CPC分类号： A61M11/006 , A61M11/001 , A61M11/04 , A61M15/002 , A61M15/08 , A61M2205/3331 , A61M2210/0618 , A61M2210/065 , A61M2210/0662 , A61M2210/1089 , A61M2210/1475
摘要： The present invention provides methods and a BFS/FFS device for delivering either one or more substances within at least one body cavity, characterized by a vial comprising Vsub [ml] of said substances; said vial from a pierceable container, a blow-fill-seal and a form-fill-seal, having fluid inlet and a fluid discharging outlet of diameter D [mm], configured for placement in proximity to said body cavity; said fluid inlet configured by means of size and shape to interface in a sealable manner a puncturing member, configured to, upon coupling to said fluid inlet, piercing the same, thereby providing said substances in a fluid communication, via a valve, with a chamber configured to accept pressurized fluid at volume VPF [ml] and pressure PPF [barg]; said valve is commutable from an CLOSE to an OPEN CONFIGURATION within a short period of time,

3. 发明授权

US11278682B2 Device and method for aerosolized delivery of substance to a natural orifice of the body 有权
公开(公告)号：US11278682B2
公开(公告)日：2022-03-22
申请号：US15982630
申请日：2018-05-17
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/00 , A61M15/00 , A61M15/08 , A61M31/00 , A61M11/02 , A61M21/02 , A61K9/00 , A61M21/00 , B05B7/14 , B05B11/00 , B05B7/04
摘要： A device for delivering a predetermined amount of a substance within at least one body cavity of a subject, where the predetermined amount is at an effective amount for treatment of obesity or binge eating disorder. The device includes (a) A volume to contain the predetermined amount of the substance. (b) A delivery end placeable in proximity to the body cavity. The delivery end is in fluid communication with the volume and comprises at least one orifice. (c) A valve mechanically connected to the volume, with at least two configurations: (i) an active configuration configured to deliver the predetermined amount of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount of the substance. (d) A fluid tight chamber configured to contain a predetermined volume of pressurized gas at a predetermined pressure.

4. 发明授权

US10549052B2 Nasal delivery device 有权
公开(公告)号：US10549052B2
公开(公告)日：2020-02-04
申请号：US14381241
申请日：2013-02-28
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor , Yehuda Poran , Iftah Poran
IPC分类号： A61M15/08 , A61M15/00
摘要： The present invention provides a two-step mechanism for delivering a flowable substance to the nasal passages, comprising: a. a nosepiece adapted to be in fluid connection with said nasal passages; b. at least one air-tight enclosure, comprising predetermined amount of compressed gas in the same; said compressed gas is pressurized to predetermined amount of pressure; c. a charging mechanism, fluidly connected with said air-tight enclosure, characterized by at least two configurations: a retracted position and an extended position; where, when said charging mechanism is transformed from said extended position to said retracted position, said charging mechanism is adapted to enable delivery of said pressurized and predetermined amount of compressed gas from at least one first predetermined position in said air-tight enclosure to at least one second predetermined position; d. an activation mechanism, adapted to entrain said flowable substance within said pressurized and predetermined amount of compressed gas.

5. 发明授权

US11471618B2 Adjustable dosing delivery and multi sectioned drug compartment 有权
公开(公告)号：US11471618B2
公开(公告)日：2022-10-18
申请号：US15982996
申请日：2018-05-17
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/02 , A61M15/08 , A61M15/00 , B05B1/00 , A61M11/00
摘要： A device is provided for delivering a predetermined volume of at least one substance within a body cavity of a subject. The device contains a) a capsule for containing the predetermined volume of substances; b) a delivery end, having at least one orifice of diameter D, for placement in proximity to the body cavity; c) a valve mechanically connectable to the capsule, having at least two configurations: (i) an active configuration in which the valve enables delivery of the substances; and (ii) an inactive configuration, in which the valve prevents delivery of the substances from the capsule to the body cavity; and d) a fluid tight chamber configured to contain predetermined volume Vgas of pressurized gas at a predetermined pressure, Pgas. The capsule further contains at least one mixing mechanism that mixes the substances and the pressurized gas after the valve is reconfigured to the active configuration.

6. 发明授权

US11116914B2 Device and method for aerosolized delivering of substance to a natural orifice of the body 有权
公开(公告)号：US11116914B2
公开(公告)日：2021-09-14
申请号：US14733143
申请日：2015-06-08
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor , David Napchi
IPC分类号： A61M11/02 , A61M15/08 , A61M15/00 , A61M11/00 , A61M31/00
摘要： A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

7. 发明授权

US11083854B2 Device and method for aerosolized delivering of substance to a natural orifice of the body 有权
公开(公告)号：US11083854B2
公开(公告)日：2021-08-10
申请号：US14733143
申请日：2015-06-08
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor , David Napchi
IPC分类号： A61M11/02 , A61M15/08 , A61M15/00 , A61M11/00 , A61M31/00
摘要： A device for delivering a predetermined volume a substance within a body cavity. The device includes: at least one predefined volume sized and shaped to contain a predetermined volume the substance; a delivery end in fluid communication with a container; and at least one valve mechanically connected to the container and configurable between an active configuration in which the valve enables delivery of a volume of the substance and an inactive configuration, in which the valve prevents delivery.

8. 发明申请

US20190015613A1 ADJUSTABLE DOSING DELIVERY AND MULTI SECTIONED DRUG COMPARTMENT 审中-公开
公开(公告)号：US20190015613A1
公开(公告)日：2019-01-17
申请号：US15982996
申请日：2018-05-17
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M15/08 , A61M15/00
摘要： The present invention provides a device for delivering a predetermined volume of a substance, within at least one body cavity of a subject, comprising: a. a predefined volume for containing said predetermined volume of said at least one substance; b. a delivery end for placement in proximity to said body cavity; said delivery end comprises at least one orifice of diameter D [mm]; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an active configuration in which said valve enables delivery of predetermined volume Vsub [ml] of said substance; and, (ii) an inactive configuration, in which said valve prevents delivery of said predetermined volume Vsub [ml] of said substance from said container to said body cavity; d. a fluid tight chamber configured to contain predetermined volume Vgas [ml] of pressurized gas at a predetermined pressure, Pgas [barg].

9. 发明申请

US20180344951A1 DEVICE AND METHOD FOR AEROSOLIZED DELIVERY OF SUBSTANCE TO A NATURAL ORIFICE OF THE BODY 审中-公开
公开(公告)号：US20180344951A1
公开(公告)日：2018-12-06
申请号：US15982630
申请日：2018-05-17
申请人： SIPNOSE LTD.
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/00 , A61M31/00 , A61M15/00 , A61M21/02 , A61M15/08 , A61K9/00
摘要： A device for delivering a predetermined amount of a substance within at least one body cavity of a subject, where the predetermined amount is at an effective amount for treatment of obesity or binge eating disorder. The device comprises: (a) A volume to contain the predetermined amount of the substance. (b) A delivery end placeable in proximity to the body cavity. The delivery end is in fluid communication with the volume and comprises at least one orifice. (c) A valve mechanically connected to the volume, with at least two configurations: (i) an active configuration configured to deliver the predetermined amount of the substance; and, (ii) an inactive configuration, in which the valve prevents delivery of the predetermined amount of the substance. (d) A fluid tight chamber configured to contain a predetermined volume of pressurized gas at a predetermined pressure.

10. 发明申请

US20150258287A1 DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY 审中-公开
标题翻译：设备提供预期的一个物质的物质的自然组织的物质
公开(公告)号：US20150258287A1
公开(公告)日：2015-09-17
申请号：US14433048
申请日：2014-08-21
申请人： SIPNOSE LTD
发明人： Daniel Shahaf , Iris Shichor
IPC分类号： A61M11/00 , A61M15/08 , A61M15/00
CPC分类号： A61M11/007 , A61M11/02 , A61M15/0003 , A61M15/0005 , A61M15/0013 , A61M15/0021 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0071 , A61M15/009 , A61M15/0095 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M2202/0208 , A61M2202/0225 , A61M2202/025 , A61M2202/0283 , A61M2202/0291 , A61M2202/064 , A61M2205/073 , A61M2205/106 , A61M2205/3331 , A61M2205/3334 , A61M2205/8206 , A61M2205/8225 , A61M2205/8268 , A61M2205/8293 , A61M2206/16
摘要： The present invention provides a device for delivering a predetermined amount of at least one substance to a body orifice of a subject; comprising: a. a container for containing said at least one substance; b. a delivery end for placement in proximity to said orifice, said delivery end being in fluid communication with said container; c. a valve mechanically connectable to said container, characterized by at least two configurations: (i) an ACTIVE CONFIGURATION in which said valve enables delivery of predetermined amount of said substance from said container to said body orifice via said delivery end; and, (ii) an INACTIVE CONFIGURATION, in which said valve prevents delivery of said predetermined amount of said substance from said container to said body orifice; d. a trigger mechanism adapted to reconfigure said valve from said INACTIVE CONFIGURATION to said ACTIVE CONFIGURATION, and vice versa; e. a fluid tight chamber.
摘要翻译：本发明提供了一种用于将预定量的至少一种物质输送到受试者的体孔的装置; 包括：a。用于容纳所述至少一种物质的容器; b。用于放置在所述孔口附近的输送端，所述输送端与所述容器流体连通; C。机械地连接到所述容器的阀，其特征在于至少两种构造：（i）主动配置，其中所述阀能够通过所述输送端将所述物质从所述容器传送到所述主体孔; 和（ii）不活动配置，其中所述阀阻止所述预定量的所述物质从所述容器传送到所述主体孔口; d。触发机构，其适于将所述阀从所述不活动配置重新配置为所述活动配置，反之亦然; e。流体密封室。

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