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1. 发明申请

WO2014039015A1 METHOD OF DESIGNING MOLECULES 审中-公开
标题翻译：设计分子的方法
公开(公告)号：WO2014039015A1
公开(公告)日：2014-03-13
申请号：PCT/SG2013/000393
申请日：2013-09-09
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： CHANDRA SHEKHAR, Verma , LI, Jianguo , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger Wilmer , LIU, Shouping
IPC分类号： C40B30/02 , G06F19/16 , C12Q1/18
CPC分类号： C12Q1/18 , G01N2500/10 , G06F19/701 , G06F19/704
摘要： The present disclosure relates to a method for identifying a compound that disrupts a membrane of a target cell, the method comprising the steps of: (a) identifying the structure of a test compound; (b) identifying the structure of a phospholipid membrane of the target cell; (c) using the identified structures of the test compound and the target cell to predict whether the test compound will disrupt the phospholipid membrane of the target cell.
摘要翻译：本公开涉及一种用于鉴定破坏靶细胞膜的化合物的方法，所述方法包括以下步骤：（a）鉴定测试化合物的结构; （b）鉴定靶细胞的磷脂膜的结构; （c）使用确定的测试化合物和靶细胞的结构来预测测试化合物是否会破坏靶细胞的磷脂膜。

2. 发明申请

WO2020236084A1 MOLECULAR DESIGN OF NEW ANTIBIOTICS AND ANTIBIOTIC ADJUVANTS AGAINST MCR STRAINS 审中-公开
公开(公告)号：WO2020236084A1
公开(公告)日：2020-11-26
申请号：PCT/SG2020/050292
申请日：2020-05-18
申请人： SINGAPORE HEALTH SERVICES PTE LTD , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TAN TOCK SENG HOSPITAL PTE LTD
发明人： AUNG, Thet Tun , LI, Jianguo , KOH, Jun Jie , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger , TAN, Tiang Hwee Donald , PERIAYAH, Mercy Halleluyah , VERMA, Chandra Shekhar , CHEN, Swaine , BARKHAM, Timothy
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4433 , A61K31/444 , A61P31/04
摘要： The present invention relates to a compound comprising a hydrophobic moiety, a linker and N-containing moiety. The present invention also relates to the method of synthesizing the compound and the use of the compound as an antibiotic or an adjuvant for an antibiotic.

3. 发明申请

WO2017007842A1 A POLYMER PRODUCT AND PREPARATION THEREOF 审中-公开
标题翻译：聚合物产品及其制备方法
公开(公告)号：WO2017007842A1
公开(公告)日：2017-01-12
申请号：PCT/US2016/041178
申请日：2016-07-06
申请人： SINGAPORE HEALTH SERVICES PTE LTD. , NATIONAL UNIVERSITY OF SINGAPORE
发明人： RAJAMANI, Lakshminarayanan , DHAND, Chetna , RAMAKRISHNA, Seeram , LIU, Shouping , BEUERMAN, Roger Wilmer
IPC分类号： B29C47/00
CPC分类号： A61F13/53 , C08G63/08 , C08K3/10 , C08K5/175 , C08L5/08 , C08L71/02 , C08L77/04 , C08L2203/12 , D01D5/003 , D01F1/10 , D01F1/103 , D01F11/00 , D01F11/02 , D01F11/06 , D01F11/08
摘要： The present invention provides a polymer product and a method for preparing the polymer product comprising electrospinning from a dope solution comprising at least one polymer and at least one cross-linking agent to prepare and/or fabricate the polymer product. In certain embodiments, the cross-linking agent comprises at least one catecholamine or at least one polyphenol, wherein the method comprises (i) electrospinning the biocompatible polymer product using a dope solution comprising a polymer and at least one catecholamine or at least one polyphenol and (ii) exposing the polymer product to at least one gaseous alkaline reagent. The dope solutions and polymer products of the invention can further include antimicrobial agents, metal ions, and other substances.
摘要翻译：本发明提供一种聚合物产品和一种制备聚合物产品的方法，其包括从包含至少一种聚合物和至少一种交联剂的涂料溶液中静电纺丝以制备和/或制备聚合物产品。在某些实施方案中，所述交联剂包含至少一种儿茶酚胺或至少一种多酚，其中所述方法包括（i）使用包含聚合物和至少一种儿茶酚胺或至少一种多酚的掺杂溶液静电纺生生物相容性聚合物产物，以及（ii）将聚合物产物暴露于至少一种气态碱性试剂中。本发明的涂料溶液和聚合物产品还可以包括抗微生物剂，金属离子和其它物质。

4. 发明申请

WO2019190402A1 BIOCOMPATIBLE OPHTHALMIC DEVICE 审中-公开
公开(公告)号：WO2019190402A1
公开(公告)日：2019-10-03
申请号：PCT/SG2019/050174
申请日：2019-03-28
申请人： SINGAPORE HEALTH SERVICES PTE LTD
发明人： RAJAMANI, Lakshminarayanan , DHAND, Chetna , BEUERMAN, Roger
IPC分类号： G02B1/04 , A61L12/14 , A61F9/00 , A61P31/02 , C08L77/02 , C08L77/04 , C08L65/02
摘要： Disclosed is a biocompatible ophthalmic device comprising: a core material; a first component which is coating the surface of the core material; and a second component which is linked to the first component by a bond; wherein the first component comprises cross-links of at least one catecholamine compound and the second component comprises at least one antimicrobial peptide and/or at least one antimicrobial polymer. Also disclosed are methods of preventing, suppressing and/or treating an ophthalmic infection in an eye of a subject, devices for use in preventing, suppressing and/or treating an ophthalmic infection, methods of manufacturing biocompatible ophthalmic devices, and a kit for preparing the ophthalmic device. Preferably the ophthalmic device is a contact lens and the catecholamine compound is dopamine.

5. 发明申请

WO2014039014A1 PEPTIDES AND THEIR USES 审中-公开
标题翻译：肽及其用途
公开(公告)号：WO2014039014A1
公开(公告)日：2014-03-13
申请号：PCT/SG2013/000392
申请日：2013-09-09
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： CHANDRA SHEKHAR, Verma , LI, Jianguo , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger Wilmer , LIU, Shouping , KOH, Jun Jie
IPC分类号： C07K14/00 , C07K7/00 , A61K38/04 , A61K38/10 , A61K38/16 , A61P31/04 , A61P31/10 , A61L12/14
CPC分类号： C07K14/00 , A61K38/00 , C07K7/08 , Y02A50/475 , Y02A50/492
摘要： Disclosed are antimicrobial peptides. Also disclosed are methods of treating bacterial infection and fungal infection and a method of removing biofilm. Also disclosed is the use of these peptides.
摘要翻译：公开了抗微生物肽。还公开了治疗细菌感染和真菌感染的方法以及去除生物膜的方法。还公开了这些肽的用途。

6. 发明申请

WO2021025618A1 USE OF AN OSMOLYTE IN MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF OCULAR DISORDERS 审中-公开
公开(公告)号：WO2021025618A1
公开(公告)日：2021-02-11
申请号：PCT/SG2020/050447
申请日：2020-08-03
申请人： SINGAPORE HEALTH SERVICES PTE LTD
发明人： MEHTA, Jodhbir Singh , RAJAMANI, Lakshminarayanan , VENKATRAMAN, Anandalakshmi
IPC分类号： A61K31/205 , A61K31/702 , A61K31/195 , A61K31/185 , A61P27/02
摘要： The present disclosure provides a use of an osmolyte in the manufacture of a medicament treating protein aggregation related disorders, specifically provides a use of an osmolyte in the manufacture of a medicament treating TGFBI corneal dystrophies. The osmolyte is selected from a group consisting of betaine, raffinose, sarcosine, taurine and/or any pharmaceutically acceptable derivatives thereof.

7. 发明申请

WO2018084807A1 ANTIMICROBIAL PEPTIDES COMPRISING EPSILON LYSINE RESIDUES 审中-公开
标题翻译：包含EPSILY赖氨酸残基的抗微生物肽
公开(公告)号：WO2018084807A1
公开(公告)日：2018-05-11
申请号：PCT/SG2017/050548
申请日：2017-10-31
申请人： SINGAPORE HEALTH SERVICES PTE LTD , NANYANG TECHNOLOGICAL UNIVERSITY
发明人： RAJAMANI, Lakshminarayanan , MAYANDI, Venkatesh , GOH, Tze Leng Eunice , BEUERMAN, Roger Wilmer , VERMA, Navin Kumar
IPC分类号： C07K14/00 , C07K7/02 , A61K38/08 , A61P31/04
摘要： The present disclosure relates to a peptide comprising at least five amino acid residues, wherein at least one amino acid residue is modified to an epsilon-lysine, delta-ornithine, gamma-2, 4-diaminobutyric acid, beta-2,3-diaminopropionic acid, with the peptide also comprising at least one non-epsilon lysine, non-delta-ornithine, non-gamma-2, 4-diaminobutyric acid or non-beta-2,3-diaminopropionic acid, and wherein the peptide displays a reduced or no cytotoxicity when compared to an equivalent non-modified peptide. In a preferred embodiment, the modifications are to the melittin or mastoparan B peptides, and comprise the substitution of at least one a-lysine residue for an ε-lysine residue, and the modified peptides display antimicrobial activity. The present disclosure is also directed to pharmaceutical compositions, kits, ophthalmic preparations comprising the modified antimicrobial peptides and use of the modified antimicrobial peptides in methods of inhibiting growth of microorganisms, methods of managing microbial colonization, methods of treating proliferative disease, and methods of treating inflammation. The present disclosure also relates to a method of improving the therapeutic index (safety) of an isolated peptide comprising the aforementioned modification.
摘要翻译：本公开内容涉及包含至少5个氨基酸残基的肽，其中至少一个氨基酸残基被修饰为ε-赖氨酸，δ-鸟氨酸，γ-2,4-二氨基丁酸，β-2,3-二氨基丙酸，所述肽还包含至少一个非ε赖氨酸，非δ-鸟氨酸，非γ-2,4-二氨基丁酸或非β-2,3-二氨基丙酸并且其中与等同的未修饰的肽相比，所述肽表现出降低的或没有细胞毒性。在一个优选的实施方案中，所述修饰是针对蜂毒肽或mastoparan B肽，并且包含至少一个α-赖氨酸残基取代ε-赖氨酸残基，并且所述修饰的肽显示出抗微生物活性。本公开还涉及包含修饰的抗微生物肽的药物组合物，试剂盒，眼用制剂和经修饰的抗微生物肽在抑制微生物生长的方法中的用途，控制微生物定殖的方法，治疗增殖性疾病的方法以及治疗炎。本公开还涉及改善包含上述修饰的分离的肽的治疗指数（安全性）的方法。

8. 发明申请

WO2014039013A8 TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF 审中-公开
公开(公告)号：WO2014039013A8
公开(公告)日：2014-03-13
申请号：PCT/SG2013/000390
申请日：2013-09-09
申请人： AGENCY OF SCIENCE, TECHNOLOGY AND RESEARCH , SINGAPORE HEALTH SERVICES PTE LTD
发明人： BEUERMAN, Roger , LIU, Shouping , RAJAMANI, Lakshminarayanan , VERMA, Chandra , LI, Jianguo
IPC分类号： C07K14/00 , C07K7/00 , A61K38/04 , A61K38/16 , A61L12/14 , A61P31/04
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR)2K]2KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.

9. 发明公开

EP3418294A1 TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF 审中-公开
公开(公告)号：EP3418294A1
公开(公告)日：2018-12-26
申请号：EP18173555.6
申请日：2013-09-09
申请人： Agency for Science, Technology and Research , Singapore Health Services Pte Ltd
发明人： BEUERMAN, Roger , LIU, Shouping , RAJAMANI, Lakshminarayanan , VERMA, Chandra , LI, Jianguo
IPC分类号： C07K14/00 , C07K7/00 , A61K38/04 , A61K38/16 , A61L12/14 , A61P31/04 , C07K7/06
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR) 2 K] 2 KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.

10. 发明公开

EP3519426A1 ANTIMICROBIAL PEPTIDES COMPRISING EPSILON LYSINE RESIDUES 有权
公开(公告)号：EP3519426A1
公开(公告)日：2019-08-07
申请号：EP17868131.8
申请日：2017-10-31
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University
发明人： RAJAMANI, Lakshminarayanan , MAYANDI, Venkatesh , GOH, Tze Leng Eunice , BEUERMAN, Roger Wilmer , VERMA, Navin Kumar
IPC分类号： C07K14/00 , C07K7/02 , A61K38/08 , A61P31/04

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