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1. 发明申请

WO2007096251A1 INHIBITORS OF CPT IN THE CENTRAL NERVOUS SYSTEM AS ANTIDIABETIC AND/OR ANTI-OBESITY DRUGS 审中-公开
标题翻译： CPT在中枢神经系统中的抑制剂作为抗生素和/或抗体药物
公开(公告)号：WO2007096251A1
公开(公告)日：2007-08-30
申请号：PCT/EP2007/051197
申请日：2007-02-08
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , TASSONI, Emanuela , GIANNESSI, Fabio , DELL' UOMO, Natalina , GALLO, Grazia , CONTI, Roberto , TINTI, Maria Ornella
发明人： TASSONI, Emanuela , GIANNESSI, Fabio , DELL' UOMO, Natalina , GALLO, Grazia , CONTI, Roberto , TINTI, Maria Ornella
IPC分类号： C07D211/14 , C07D295/08 , C07D295/12 , A61K31/455 , A61K31/4965 , A61P3/06
CPC分类号： C07D295/088 , C07D211/14 , C07D295/13
摘要： The invention relates to a new class of compounds with inhibitory action on carnitine palmitoyl transferase (CPT) in the central nervous system (SNC), derived from trimetazidine and perhexiline, preferentially selective for the hepatic form of CPT1 (CPT1L), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment and/or in the prevention of obesity, hyperglycaemia, diabetes and disorders associated with them, such as, for example, diabetic retinopathy, diabetic neuropathy and cardiovascular disorders. The compounds of the present invention are also used in the prevention and/or treatment of heart disorders such as CHF (congestive heart failure).
摘要翻译：本发明涉及一种新型的具有抑制作用的中枢神经系统（SNC）中的肉碱棕榈酰转移酶（CPT）的化合物，其衍生自曲美他嗪和过己胺，对CPT1（CPT1L）的肝脏形式优先选择，其含有至少一种根据本发明的新化合物及其治疗和/或预防肥胖症，高血糖症，糖尿病和与其相关的病症（例如糖尿病性视网膜病变，糖尿病性神经病和心血管病）的治疗用途。本发明的化合物也可用于预防和/或治疗心脏病如CHF（充血性心力衰竭）。

2. 发明申请

WO2008015081A1 DERIVATIVES OF 4-TRIMETHYLAMMONIUM-3-AMINOBUTYRATE AND 4-TRIMETHYLPHOSPHONIUM-3-AMINOBUTYRATE AS CPT-INHIBITORS 审中-公开
标题翻译： 4-三甲基磺酰胺-3-氨基丁酸酯和4-三甲基磷酰基-3-氨基丁酸酯作为CPT抑制剂的衍生物
公开(公告)号：WO2008015081A1
公开(公告)日：2008-02-07
申请号：PCT/EP2007/057030
申请日：2007-07-10
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , GIANNESSI, Fabio , TASSONI, Emanuela , DELL' UOMO, Natalina , CONTI, Roberto , TINTI, Maria Ornella
发明人： GIANNESSI, Fabio , TASSONI, Emanuela , DELL' UOMO, Natalina , CONTI, Roberto , TINTI, Maria Ornella
IPC分类号： C07C275/34 , C07C275/24 , C07C275/16 , C07C235/20 , C07F9/54 , A61K31/205 , A61K31/66 , A61P3/10
CPC分类号： C07C275/16 , C07C235/20 , C07C275/24 , C07C275/34 , C07F9/5407
摘要： The invention provides a new class of compounds capable of inhibiting carnitine palmitoyl transferase (CPT) having formula (I). The invention also relates to pharmaceutical compositions, which comprise at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, such as for example congestive heart failure and obesity.
摘要翻译：本发明提供能够抑制具有式（I）的肉碱棕榈酰转移酶（CPT）的新一类化合物。本发明还涉及药物组合物，其包含至少一种根据本发明的新化合物及其治疗高血糖病症如糖尿病及其相关病理学的治疗用途，例如充血性心力衰竭和肥胖症。

3. 发明申请

WO2006092204A1 DERIVATIVES OF AMINOBUTANOIC ACID INHIBITING CPT 审中-公开
标题翻译：氨基丁酸抑制CPT的衍生物
公开(公告)号：WO2006092204A1
公开(公告)日：2006-09-08
申请号：PCT/EP2006/001290
申请日：2006-02-13
申请人： SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , GIANNESSI, Fabio , TASSONI, Emanuela , TINTI, Maria, Ornella , CONTI, Roberto , DELL'UOMO, Natalina , BRUNETTI, Tiziana
发明人： GIANNESSI, Fabio , TASSONI, Emanuela , TINTI, Maria, Ornella , CONTI, Roberto , DELL'UOMO, Natalina , BRUNETTI, Tiziana
IPC分类号： C07C275/16 , C07D211/90 , C07D213/82 , A61K31/17 , A61P3/10
CPC分类号： C07C275/16 , C07D211/90 , C07D213/82
摘要： The invention relates to a new class of compounds with action inhibiting carnitine palmitoyl transferase (CPT), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, congestive heart failure and obesity.
摘要翻译：本发明涉及一类具有抑制作用的肉碱棕榈酰转移酶（CPT）的化合物，其含有至少一种本发明新化合物的药物化合物及其治疗用于治疗高血糖病症如糖尿病和相关病理伴有它，充血性心力衰竭和肥胖。

4. 发明公开

EP2046734A1 DERIVATIVES OF 4-TRIMETHYLAMMONIUM-3-AMINOBUTYRATE AND 4-TRIMETHYLPHOSPHONIUM-3-AMINOBUTYRATE AS CPT-INHIBITORS 审中-公开
标题翻译： 4-甲基-3-氨基丁酸酯和4-三甲基-3-氨基丁ALS抑制剂CPT衍生物
公开(公告)号：EP2046734A1
公开(公告)日：2009-04-15
申请号：EP07787305.7
申请日：2007-07-10
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
发明人： GIANNESSI, Fabio , TASSONI, Emanuela , DELL' UOMO, Natalina , CONTI, Roberto , TINTI, Maria Ornella
IPC分类号： C07C275/34 , C07C275/24 , C07C275/16 , C07C235/20 , C07F9/54 , A61K31/205 , A61K31/66 , A61P3/10
CPC分类号： C07C275/16 , C07C235/20 , C07C275/24 , C07C275/34 , C07F9/5407
摘要： The invention provides a new class of compounds capable of inhibiting carnitine palmitoyl transferase (CPT) having formula (I). The invention also relates to pharmaceutical compositions, which comprise at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, such as for example congestive heart failure and obesity.

5. 发明公开

EP1853556A1 DERIVATIVES OF AMINOBUTANOIC ACID INHIBITING CPT 审中-公开
标题翻译： CPT抑制氨基丁酸衍生物
公开(公告)号：EP1853556A1
公开(公告)日：2007-11-14
申请号：EP06706901.3
申请日：2006-02-13
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
发明人： GIANNESSI, Fabio , TASSONI, Emanuela , TINTI, Maria, Ornella , CONTI, Roberto , DELL'UOMO, Natalina , BRUNETTI, Tiziana
IPC分类号： C07C275/16 , C07D211/90 , C07D213/82 , A61K31/17 , A61P3/10
CPC分类号： C07C275/16 , C07D211/90 , C07D213/82
摘要： The invention relates to a new class of compounds with action inhibiting carnitine palmitoyl transferase (CPT), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, congestive heart failure and obesity.

6. 发明申请

WO2009063370A3 MACHINE FOR MAKING PODS CONTAINING INFUSION PRODUCTS 审中-公开
公开(公告)号：WO2009063370A3
公开(公告)日：2009-05-22
申请号：PCT/IB2008/054661
申请日：2008-11-07
申请人： IMA FLAVOUR S.r.l. , CONTI, Roberto
发明人： CONTI, Roberto
IPC分类号： B65B9/04 , B65B11/50 , B65D85/80 , B65B29/02
摘要： A machine for making pods (2) containing products for infusion comprises means (3) for feeding a first web (4) of filtering paper material along a predetermined path (P), means (5) for feeding a second web (6) of filtering paper material along a predetermined path (P'), a station (7) for dispensing and successively placing individual charges (8) of product on the first web (4), and means (11) for superposing and joining the first web (4) and the second web (6) in such a way as to form a continuous succession (12) of pods (2); the machine also comprises, upstream of the dispensing station (7), relative to the path (P), means (13) for successively feeding a series of elements (14) for containing the infusion product and means (21) for forming impressions in the first web (4) and positioning the elements (14) thereon.

7. 发明申请

WO2011039709A2 MACHINE FOR PACKING INFUSION PRODUCTS INTO CAPSULES AND FEATURING SEALING UNIT 审中-公开
标题翻译：用于将输液产品装入胶囊和密封装置的机器
公开(公告)号：WO2011039709A2
公开(公告)日：2011-04-07
申请号：PCT/IB2010/054384
申请日：2010-09-29
申请人： IMA FLAVOUR S.r.l. , CONTI, Roberto
发明人： CONTI, Roberto
IPC分类号： B65B9/06
CPC分类号： B65B9/067 , B29C65/02 , B29C65/08 , B29C65/18 , B29C65/7441 , B29C65/749 , B29C65/7861 , B29C65/7897 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/133 , B29C66/24221 , B29C66/4312 , B29C66/4322 , B29C66/53461 , B29C66/81435 , B29C66/8226 , B29C66/82265 , B29C66/8322 , B29C66/83413 , B29C66/83543 , B29C66/8432 , B29C66/849 , B65B7/164 , B65B7/2878 , B65B29/02 , B65B29/022 , B65B43/44 , B65B43/46 , B65B51/16 , B65B51/225 , B65B51/306 , B65B61/02 , B65B61/08 , B65B61/12 , B65B2220/16 , B65D77/003 , B65D85/8043
摘要： A machine for packing infusion products into capsules (2) comprises a plurality of stations along a feed line (L), including a coupling and sealing station (27) for coupling an overwrapping film (F1) and the capsules (2) after the latter have been sealed and for sealing the overwrapping film (Fl) around a respective capsule (2) to form an individual pack (C); the coupling and sealing station (27) comprises a frame (40) for continuously forming the second, overwrapping film (F1) into the shape of a tube, a pusher device (41) for pushing the capsule (2) along a sliding feed table (39) and designed to position the capsule (2) at a predetermined point, and means (43) for guiding and retaining the capsule (2) feeding out of the frame (40), to allow coordinated feeding of the capsule (2) and of the overwrapping film (F1) in such a manner as to keep the capsule (2) and the tube of overwrapping film (F1) in a stable position relative to each other.
摘要翻译：用于将灌注产品包装到胶囊（2）中的机器包括沿着供给线（L）的多个站，包括用于将外包裹膜（F1）和胶囊（2）在其被密封后密封并用于密封相应胶囊（2）周围的外包装膜（F1）以形成单个包装（C）; 连接和密封站（27）包括用于将第二外包装膜（F1）连续形成为管状的框架（40），用于沿着滑动进给台（2）推动胶囊（2）的推动装置（41）（39）并且被设计成将胶囊（2）定位在预定点处;以及用于引导和保持从框架（40）输出的胶囊（2）的装置（43），以允许胶囊（2）和外包装薄膜（F1）的外表面上，以使包装薄膜（2）和外包装薄膜（F1）的管相对于彼此保持稳定的位置。

8. 发明申请

WO2005108209A1 BLISTERING MACHINE FOR PRODUCING BLISTER PACKS 审中-公开
标题翻译：用于生产泡罩的泡沫机
公开(公告)号：WO2005108209A1
公开(公告)日：2005-11-17
申请号：PCT/IB2005/001269
申请日：2005-05-06
申请人： I.M.A. INDUSTRIA MACCHINE AUTOMATICHE S.P.A. , CONTI, Roberto
发明人： CONTI, Roberto
IPC分类号： B65B9/04
CPC分类号： B65B9/045 , B65B65/02
摘要： A blistering machine (M1) for producing blister packs (B1) has production line including arranged in a series: at least one thermoforming station (101) of a first continuous band (102) of thermoformable material, in order to define a blister band (102) with blisters containing products (104); a station (105) for feeding the products (104) and filling the blister band (102) with the latter; a feeding station (106) of a second band (107), feeding continuously the second band (107) over the blister band (1 band (NB1); a closing station (108), where the first blister 15 band (102) is sealed by the second band (107) to obtain a blister pack a station (200) for processing the blister pack band (NB1); and a cutting station (R1), in which the blister pack band is cut into respective blister packs (B1). 02) filled with the products (104); The production line extends, at least beginning from the products feeding station (105), along a continuous feeding path (A1), substantially horizontal. The processing station (200), along the path (Al), is defined by at least one printing/debossing station (109,110) of the blister pack band (NB1), which includes printing/debossing means (135,136), moving continuously toward and away from the blister pack band (NB1) and following the blister pack band (NB1) along the path (A1).
摘要翻译：一种用于生产泡罩包装（B1）的起泡机（M1）具有生产线，其包括串联布置：至少一个可热成型材料的第一连续带（102）的热成型工位（101），以便限定起泡带 102）含有产品的气泡（104）; 用于馈送产品（104）并用其填充泡罩带（102）的工位（105）; 第二带（107）的馈送站（106），连续地将第二带（107）供给到泡罩带（1带（NB1））上;关闭站（108），其中第一泡罩15带（102）通过第二带（107）密封以获得用于处理泡罩包装带（NB1）的泡罩包装站（200）;以及切割站（R1），其中将泡罩包装带切成各个泡罩包装（B1 ）02）填充产品（104）; 生产线至少从产品供给站（105）开始沿着连续进给路径（A1），基本上水平地延伸。沿着路径（A1）的处理站（200）由泡罩包装带（NB1）的至少一个印刷/凹陷台（109,110）限定，包括印刷/凹陷装置（135,136）远离泡罩包装带（NB1）并且沿着路径（A1）沿着泡罩包装带（NB1）。

9. 发明申请

WO2006008624A1 UNIT FOR FEEDING INFUSION MATERIAL TO A MACHINE PRODUCING FILTER PACKS 审中-公开
标题翻译：将输送材料输送到生产过滤袋的机器
公开(公告)号：WO2006008624A1
公开(公告)日：2006-01-26
申请号：PCT/IB2005/002005
申请日：2005-06-30
申请人： I.M.A. INDUSTRIA MACCHINE AUTOMATICHE S.P.A. , CONTI, Roberto
发明人： CONTI, Roberto
IPC分类号： B65B29/02
CPC分类号： B65B29/02 , B65B29/025
摘要： Described is a unit (1) for feeding powdered infusion material to a machine (M) producing packs (3) made from filter material (5). The machine (M) comprises a production line (2) for making such packs (3) and consists of a conveyor (4) with mobile recesses (7) moving in a feed direction (L) designed to be covered with filter material (5) and to form impressions (8) in the filter material (5); rotary feeders (10) fitted to the unit (1) designed to feed an amount or dose (C) of the powdered infusion material into the impressions (8), and rotary precompactors (14) mounted on the rotary feeders (10) acting together with rotary feeders (10) to distribute the doses (C) uniformly inside the impressions (8).
摘要翻译：描述了一种用于将粉状输液材料供给到由过滤材料（5）制成的包装（3）的机器（M）的单元（1）。机器（M）包括用于制造这种包装（3）的生产线（2），并由具有移动凹槽（7）的输送机（4）组成，该输送机（4）沿设计成被过滤材料（5）覆盖的进给方向（L）移动）并且在过滤材料（5）中形成印模（8）; 安装到单元（1）的旋转进料器（10），设计成将粉末状输注材料的量或剂量（C）进料到印模（8）中，以及安装在一起作用的旋转进料器（10）上的旋转预压缩机（14）使用旋转进料器（10）将剂量（C）均匀地分布在印模（8）内。

10. 发明申请

WO2012117308A1 MACHINE FOR PRODUCING FILTER BAGS WITH PRODUCTS FOR INFUSION AND WITH AN OUTER WRAPPER ENVELOPE. 审中-公开
标题翻译：用于生产带有产品的过滤袋用于输送和外包裹包装的机器。
公开(公告)号：WO2012117308A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050601
申请日：2012-02-10
申请人： IMA INDUSTRIES S.r.l. , CONTI, Roberto
发明人： CONTI, Roberto
IPC分类号： B65B29/02 , B65B51/30
CPC分类号： B65B29/04 , B65B11/28 , B65B11/48 , B65B29/02 , B65B51/14
摘要： A machine for packaging filter bags (1) for products for infusion in related closed outer wrappers (2) comprises: a carrousel (6) for moving the filter bag (1) along a circular operating path (C); a wrapping station (7) positioned along the operating path (C) for folding a flat sheet (2) of outer wrapper material along a transversal axis around the filter bag (1) thus forming a "U"-shaped outer wrapper around the filter bag (1); sealing units (9) operating on the sheet (2) folded in a "U"-shape, for forming an individual closed outer wrapper; the sealing units (9) being positioned along the circular operating path (C), downstream of the wrapping station (7), and being designed to join at least two longitudinal end edges (2a, 2b) of the outer wrapper sheet (2) which is positioned, together with the filter bag (1), on the carrousel (6).
摘要翻译：一种用于包装过滤袋（1）的机器，用于在相关的封闭外包装纸（2）中输注的产品包括：用于沿着圆形操作路径（C）移动过滤袋（1）的转盘（6）; 沿着操作路径（C）定位的包装站（7），用于沿着围绕过滤袋（1）的横向轴线折叠外包装材料的平板（2），从而在过滤器周围形成“U”形的外包装袋（1）; 操作在以“U”形折叠的片材（2）上的密封单元（9），用于形成单个封闭的外包装; 所述密封单元（9）沿着所述圆形操作路径（C）定位在所述包装站（7）的下游，并且被设计成连接所述外包装纸（2）的至少两个纵向端边缘（2a，2b）其与过滤袋（1）一起定位在转盘（6）上。

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