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1. 发明申请

WO2005058950A3 METHODS FOR GENERATING IMMUNITY TO ANTIGEN 审中-公开
公开(公告)号：WO2005058950A3
公开(公告)日：2005-06-30
申请号：PCT/US2004/041690
申请日：2004-12-10
申请人： SIDNEY KIMMEL CANCER CENTER , DEISSEROTH, Albert , TANG, Yucheng , ZHANG, Wei-Wei , FANG, Xiang-Ming
发明人： DEISSEROTH, Albert , TANG, Yucheng , ZHANG, Wei-Wei , FANG, Xiang-Ming
IPC分类号： C07K14/705
摘要： Provided are methods of generating an immune response to an antigen. The method comprises priming an individual by administering an expression vector encoding the antigen. The vectors comprises a transcription unit encoding a secretable fusion protein, the fusion protein containing an antigen and CD40 ligand. Administration of a fusion protein containing the antigen and CD40 ligand is used to enhance the immune response above that obtained by vector administration alone. The invention methods may be used to generate an immune response against cancer expressing a tumor antigen such as a mucin or human papilloma viral tumor antigen and to generate an immune response against an infectious agent. Also provided is a method for simultaneously producing the expression vector and the fusion protein.

2. 发明申请

WO2007056266A3 CD40 LIGAND FUSION PROTEIN VACCINE 审中-公开
公开(公告)号：WO2007056266A3
公开(公告)日：2007-05-18
申请号：PCT/US2006/043164
申请日：2006-11-06
申请人： SIDNEY KIMMEL CANCER CENTER , TANG, Yucheng , DEISSEROTH, Albert
发明人： TANG, Yucheng , DEISSEROTH, Albert
IPC分类号： C12N5/00 , C07K1/00
摘要： Provided are methods of generating an immune response to any of various antigens including foreign antigens such as infectious agent antigens. In general, the method comprises administering an expression vector encoding a transcription unit encoding a secretable fusion protein, the fusion protein containing the foreign antigen and CD40 ligand and also administering the encoded fusion protein. In another approach, an immune response to the foreign antigen is elicited using the encoded fusion protein without administering the vector. The invention methods may be used to immunize an individual against an infectious agent such as influenza virus. Methods of obtaining an immune response in older individuals also is described.

3. 发明申请

WO2006130525A3 METHODS FOR IMMUNOTHERAPY OF CANCER 审中-公开
公开(公告)号：WO2006130525A3
公开(公告)日：2006-12-07
申请号：PCT/US2006/020652
申请日：2006-05-26
申请人： SIDNEY KIMMEL CANCER CENTER , TANG, Yucheng , DEISSEROTH, Albert
发明人： TANG, Yucheng , DEISSEROTH, Albert
IPC分类号： A61K48/00 , C07K14/47 , C07H21/04 , C12N15/861
摘要： Provided are methods of generating an immune response to an antigen specifically associated with tumor vascular endothelial cells (TVECA). The method comprises administering to an individual an expression vector encoding the TVECA. The vector comprises a transcription unit encoding a secretable fusion protein, the fusion protein containing a TVECA and CD40 ligand. In other methods, administration of a fusion protein containing the TVECA and CD40 ligand is used to enhance the immune response above that obtained by vector administration alone. Further methods comprise the combination therapy using an expression vector encoding a secretable TVECA fusion protein and a tumor antigen vaccine.

4. 发明申请

WO2005051991A2 MUCIN ANTIGEN VACCINE 审中-公开
标题翻译：粘蛋白抗原疫苗
公开(公告)号：WO2005051991A2
公开(公告)日：2005-06-09
申请号：PCT/US2004/039812
申请日：2004-11-23
申请人： SIDNEY KIMMEL CANCER CENTER , TANG, Yucheng , DIESSEROTH, Albert
发明人： TANG, Yucheng , DIESSEROTH, Albert
IPC分类号： C07K14/47
CPC分类号： A61K39/0011 , A61K9/127 , A61K48/00 , A61K48/005 , A61K2039/6031 , C07K14/4727 , C07K14/70578 , C07K2319/00 , C12N7/00 , C12N15/85 , C12N15/86 , C12N2710/10043
摘要： Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and CD40 ligand. Also provided are methods of generating an immune response against cells expressing a mucin by administering an effective amount of the vector. Further provided are methods of generating an immune response against cancer cells expressing a mucin in an individual by administering an effective amount of the vector. Still further provided are methods of overcoming anergy to a mucin self antigen by administering an effective amount of the vector.
摘要翻译：提供了用于产生对粘蛋白的免疫应答的表达载体。载体包含编码可分泌多肽的转录单元，所述多肽包含分泌信号，粘蛋白抗原和CD40配体。还提供了通过施用有效量的载体产生针对表达粘蛋白的细胞的免疫应答的方法。还提供了通过施用有效量的载体产生针对个体中表达粘蛋白的癌细胞的免疫应答的方法。还提供了通过施用有效量的载体克服粘蛋白自身抗原的无反应性的方法。

5. 发明公开

EP1951862A2 CD40 LIGAND FUSION PROTEIN VACCINE 有权转让
标题翻译： CD40配体融合蛋白疫苗
公开(公告)号：EP1951862A2
公开(公告)日：2008-08-06
申请号：EP06827550.2
申请日：2006-11-06
申请人： SIDNEY KIMMEL CANCER CENTER
发明人： TANG, Yucheng , DEISSEROTH, Albert
IPC分类号： C12N5/00 , C07K1/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/575 , A61K2039/585 , A61K2039/6031 , C07K14/005 , C07K14/70575 , C07K2319/02 , C07K2319/06 , C07K2319/33 , C12N2710/10034 , C12N2710/10043 , C12N2710/10343 , C12N2710/20034 , C12N2760/16122 , C12N2760/16134
摘要： Provided are methods of generating an immune response to any of various antigens including foreign antigens such as infectious agent antigens. In general, the method comprises administering an expression vector encoding a transcription unit encoding a secretable fusion protein, the fusion protein containing the foreign antigen and CD40 ligand and also administering the encoded fusion protein. In another approach, an immune response to the foreign antigen is elicited using the encoded fusion protein without administering the vector. The invention methods may be used to immunize an individual against an infectious agent such as influenza virus. Methods of obtaining an immune response in older individuals also is described.

6. 发明公开

EP1687334A2 MUCIN ANTIGEN VACCINE 失效转让
标题翻译：粘蛋白抗原疫苗
公开(公告)号：EP1687334A2
公开(公告)日：2006-08-09
申请号：EP04812348.3
申请日：2004-11-23
申请人： SIDNEY KIMMEL CANCER CENTER
发明人： TANG, Yucheng , DEISSEROTH, Albert
IPC分类号： C07K14/705 , C12N15/62 , A61K39/00
CPC分类号： A61K39/0011 , A61K9/127 , A61K48/00 , A61K48/005 , A61K2039/6031 , C07K14/4727 , C07K14/70578 , C07K2319/00 , C12N7/00 , C12N15/85 , C12N15/86 , C12N2710/10043
摘要： Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and CD40 ligand. Also provided are methods of generating an immune response against cells expressing a mucin by administering an effective amount of the vector. Further provided are methods of generating an immune response against cancer cells expressing a mucin in an individual by administering an effective amount of the vector. Still further provided are methods of overcoming anergy to a mucin self antigen by administering an effective amount of the vector.
摘要翻译：提供了用于产生对粘蛋白的免疫应答的表达载体。载体包含编码可分泌多肽的转录单元，所述多肽包含分泌信号，粘蛋白抗原和CD40配体。还提供了通过施用有效量的载体产生针对表达粘蛋白的细胞的免疫应答的方法。还提供了通过施用有效量的载体产生针对个体中表达粘蛋白的癌细胞的免疫应答的方法。还提供了通过施用有效量的载体来克服对粘蛋白自身抗原的无反应性的方法。

7. 发明公开

EP1720905A2 METHODS FOR GENERATING IMMUNITY TO ANTIGEN 审中-公开
标题翻译：用于生产免疫力抗原
公开(公告)号：EP1720905A2
公开(公告)日：2006-11-15
申请号：EP04813939.8
申请日：2004-12-10
申请人： SIDNEY KIMMEL CANCER CENTER
发明人： DEISSEROTH, Albert , TANG, Yucheng , ZHANG, Wei-Wei , FANG, Xiang-Ming
IPC分类号： C07K14/705 , C12N15/62 , A61K39/00
CPC分类号： C07K14/70575 , C07K2319/40
摘要： Provided are methods of generating an immune response to an antigen. The method comprises priming an individual by administering an expression vector encoding the antigen. The vectors comprises a transcription unit encoding a secretable fusion protein, the fusion protein containing an antigen and CD40 ligand. Administration of a fusion protein containing the antigen and CD40 ligand is used to enhance the immune response above that obtained by vector administration alone. The invention methods may be used to generate an immune response against cancer expressing a tumor antigen such as a mucin or human papilloma viral tumor antigen and to generate an immune response against an infectious agent. Also provided is a method for simultaneously producing the expression vector and the fusion protein.

8. 发明申请

WO2016106515A1 METHOD FOR MACHINING HOLES WITH PULSED LASER BEAMS, METHOD AND SYSTEM FOR DETECTING BREAKTHROUGH 审中-公开
标题翻译：用脉冲激光加工孔的方法，用于检测破裂的方法和系统
公开(公告)号：WO2016106515A1
公开(公告)日：2016-07-07
申请号：PCT/CN2014/095377
申请日：2014-12-29
申请人： SIEMENS AKTIENGESELLSCHAFT , LI, Hongtao , TANG, Yucheng , REN, Chao
发明人： LI, Hongtao , TANG, Yucheng , REN, Chao
IPC分类号： B23K26/38 , B23K26/03 , G01B11/22
CPC分类号： B23K26/382 , B23K26/032 , B23K26/0622 , B23K26/389 , B23K2201/001 , F01D5/147 , F05D2230/13
摘要： A method for machining at least one hole (14) through a first wall (11) of a component (10) with pulsed laser beams is provided. The component (10) has a second wall (13) with a hollow space (12) between the first wall (11) and the second wall (13). The cycle of each laser pulse comprises a pulse-on period and a pulse-off period. The method comprises: providing light-sensitive or heat-sensitive material at the hollow space (12) of the component (10); directing pulsed laser beams to the first wall (11) for machining a hole (14); acquiring a series of images in the incident direction of the pulsed laser beams; extracting features of images which are acquired during pulse-off periods; stopping pulsed laser beams when an extracted feature of at least one of the images fulfills a predetermined criterion. The breakthrough detection accuracy could be improved.
摘要翻译：提供了一种通过脉冲激光束来加工通过部件（10）的第一壁（11）的至少一个孔（14）的方法。部件（10）具有在第一壁（11）和第二壁（13）之间具有中空空间（12）的第二壁（13）。每个激光脉冲的周期包括脉冲接通周期和脉冲关闭周期。该方法包括：在组件（10）的中空空间（12）处提供感光或热敏材料; 将脉冲激光束引导到第一壁（11）以加工孔（14）; 在脉冲激光束的入射方向上获取一系列图像; 提取在脉冲关闭期间获取的图像的特征; 当至少一个图像的提取特征满足预定标准时停止脉冲激光束。突破检测精度可以提高。

9. 发明申请

WO2014205816A1 GUIDE VANE ACTUATOR OF A COMPRESSOR AND A COMPRESSOR USING IT 审中-公开
标题翻译：压缩机的指导执行器和使用它的压缩机
公开(公告)号：WO2014205816A1
公开(公告)日：2014-12-31
申请号：PCT/CN2013/078458
申请日：2013-06-28
申请人： SIEMENS AKTIENGESELLSCHAFT , TANG, Yucheng , HUANG, Yinshui , CAO, Diansong
发明人： TANG, Yucheng , HUANG, Yinshui , CAO, Diansong
IPC分类号： F01D17/16 , F04D29/44
CPC分类号： F01D17/20 , F01D17/162 , F04D29/058 , F04D29/563 , F05D2260/57 , F05D2270/62
摘要： A guide vane actuator (10) of a compressor comprises a plurality of journals (20), a plurality of operating levers (30), an adjusting ring (40) and a magnetic driving assembly (50). The journal can correspond to the guide vane of the compressor, and each journal comprises a vane end (22) connected to the guide vane and an actuation end (24). The operating lever (30) corresponds to the journal (20), and each operating lever (30) comprises a journal connecting portion (32) connected to the actuation end of the journal and a ring connecting portion (34). The adjusting ring (40) is arranged around the casing (60) of the compressor, which can be rotatablely connected to the adjusting ring. The magnetic driving assembly can rotatablely drive the adjusting ring with respect to the casing. The actuator for the guide vane of the compressor has simple actuating structure and lower cost of manufacture.
摘要翻译：压缩机的导向叶片致动器（10）包括多个轴颈（20），多个操作杆（30），调节环（40）和磁驱动组件（50）。轴颈可以对应于压缩机的导叶，并且每个轴颈包括连接到导向叶片的叶片端（22）和致动端（24）。操作杆（30）对应于轴颈（20），并且每个操作杆（30）包括连接到轴颈的致动端的轴颈连接部分（32）和环连接部分（34）。调节环（40）围绕压缩机的壳体（60）布置，该壳体可旋转地连接到调节环。磁驱动组件可相对于壳体旋转地驱动调节环。用于压缩机导叶的致动器具有简单的致动结构和较低的制造成本。

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