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1. 发明专利

AU7952700A Gene detecting chip, detector, and detecting method 未知
公开(公告)号：AU7952700A
公开(公告)日：2001-04-30
申请号：AU7952700
申请日：2000-10-20
申请人： SHIGEORI TAKENAKA , KAZUHIKO UCHIDA , TAKATOSHI MIYAHARA
发明人： TAKENAKA SHIGEORI , UCHIDA KAZUHIKO , MIYAHARA TAKATOSHI
IPC分类号： B01L3/00 , G01N27/07 , G01N27/403 , G01N35/10 , G01N27/30 , G01N27/416 , G01N33/53 , G01N33/566
摘要： A detecting chip (2) comprises a body (5) and a frame (4) both detachable from each other. A large number of projecting pin electrodes (10) are arranged in a matrix inside the body (5). Oligonucleotide consisting of different gene sequences is fixed to the pin electrodes (10). A common electrode is so disposed in a recess (8) in a frame (4) as to be out of contact with the pin electrodes (10). A DNA sample is placed in the recess (8). By applying a voltage between the common electrode and the pin electrodes (10), a current is detected to detect a hybridized two-strand DNA, thus analyzing a gene DNA.

2. 发明专利

JP2006170615A Method of, device for, and chip of detecting gene 审中-公开
标题翻译：检测基因的方法，装置和芯片
公开(公告)号：JP2006170615A
公开(公告)日：2006-06-29
申请号：JP2001012413
申请日：2001-01-19
申请人： Shigeori Takenaka , Tum-Gene Inc , 株式会社Tumジーン , 繁織竹中
发明人： TAKENAKA SHIGEORI
IPC分类号： G01N27/416 , B01L3/00 , B01L7/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N27/49 , G01N33/483 , G01N33/53 , G01N33/566 , G01N37/00
CPC分类号： B01L3/508 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00722 , B01L7/52 , B01L2300/042 , B01L2300/046 , B01L2300/0636 , B01L2300/0645 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , G01N27/3277 , C12Q2565/102 , C12Q2563/113 , C12Q2545/101 , C12Q2565/607 , C12Q2563/173
摘要： PROBLEM TO BE SOLVED: To grasp quantitatively an immobilization quantity of a probe onto an electrode, and to thereby quantitatively detect gene in large quantities with high sensitivity at high speed.
SOLUTION: This method for detecting gene electrochemically by hybridizing gene having a specific arrangement with the probe is characterized by detecting the probe electrochemically.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：定量地掌握探针在电极上的固定量，从而以高速高灵敏度大量定量检测基因。解决方案：通过将具有特定布置的基因与探针杂交进行电化学检测的方法的特征在于电化学检测探针。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2005331387A Ligand-receptor interaction detecting method 审中-公开
标题翻译：配体 - 受体相互作用检测方法
公开(公告)号：JP2005331387A
公开(公告)日：2005-12-02
申请号：JP2004150357
申请日：2004-05-20
申请人： Takahiko Nojima , Shigeori Takenaka , 繁織竹中 , 高彦野島
发明人： NOJIMA TAKAHIKO , OTSUKA KEIICHI , TAKENAKA SHIGEORI
IPC分类号： G01N27/62 , C12Q1/68 , G01N21/78 , G01N27/447 , G01N33/15 , G01N33/53 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To provide a ligand-receptor interaction detecting method capable of reducing troublesome complication in preparation of a biomolecule array, and capable of measuring a ligand-receptor interaction without requiring masking. SOLUTION: An aggregate with respective ligand candidate molecules conjugated with a double-stranded oligonucleotide is formed into a solid phase on a carrier to generate the ligand-receptor interaction, and the double-stranded oligonucleotide is taken out sequence-specifically from a reaction system to conduct detection about a receptor. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供能够减少制备生物分子阵列中麻烦的并发症并能够测量配体 - 受体相互作用而不需要掩蔽的配体 - 受体相互作用检测方法。解决方案：具有与双链寡核苷酸缀合的各配体候选分子的聚集体在载体上形成固相以产生配体 - 受体相互作用，并且双链寡核苷酸从反应体系进行受体的检测。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2005320270A New electrochemical response compound, method for producing the compound and method for detecting bond between target substance and probe molecule using the same 有权
标题翻译：新的电化学反应化合物，该化合物的制备方法和用于检测目标物质与探针分子之间的键的方法
公开(公告)号：JP2005320270A
公开(公告)日：2005-11-17
申请号：JP2004138543
申请日：2004-05-07
申请人： Shigeori Takenaka , Tum-Gene Inc , 株式会社Tumジーン , 繁織竹中
发明人： TAKENAKA SHIGEORI
IPC分类号： G01N33/483 , C07F15/02 , C07F17/02 , C12Q1/68 , G01N27/327 , G01N27/416 , G01N33/53 , G01N33/566 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a new high-sensitivity electrochemical response compound that may directly bond to a target molecule or a probe molecule and also can synthesize an intercalator by using the same. SOLUTION: The compound is represented by formula (1) (wherein R 1 is a 2-5C alkylene, R 2 and R 3 are each independently a group that becomes an electron donating group or an electron attracting group in an aqueous solution, m and n are each independently an integer of 0 to 2). COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供可以直接键合到靶分子或探针分子的新的高灵敏度电化学应答化合物，并且还可以通过使用它来合成嵌入剂。解决方案：化合物由式（1）表示（其中R 1 是2-5C亚烷基，R SP＆gt; 2＆lt; SP＆gt;和R SP 3 >各自独立地为在水溶液中成为给电子基团或吸电子基团的基团，m和n各自独立地为0〜2的整数。版权所有（C）2006，JPO＆NCIPI

5. 发明专利

JP2005265617A Nucleic acid labelling method and carbodiimide derivative used therein 审中-公开
标题翻译：核酸标记方法和使用的碳二亚胺衍生物
公开(公告)号：JP2005265617A
公开(公告)日：2005-09-29
申请号：JP2004078900
申请日：2004-03-18
申请人： Shigeori Takenaka , 繁織竹中
发明人： TAKENAKA SHIGEORI , NOJIMA TAKAHIKO , MUKUMOTO KOSUKE , TABATA EIICHI
IPC分类号： G01N33/58 , C07F17/02 , C12N15/09 , G01N21/78 , G01N27/416 , G01N27/447 , G01N30/06
摘要： PROBLEM TO BE SOLVED: To provide a new single-stranded nucleic acid and twin-stranded nuleic acid labelling method and a new carbodiimide derivative used therein. SOLUTION: By merely mixing the carbodiimide derivative having a signal group such as a carbodiimide group, an electrochemical active group or the like with twin-stranded nucleic acid, at least one of thymine, uracil and a guanine base present in the mismatch region of twin-stranded nucleic acid or present in the vicinity thereof or at least one of thymine, uracil and a guanine base present in the unstable region of a hydrogen bond on twin-stranded nucleic acid is reacted with the carbodiimide derivative to label twin-stranded nucleic acid. Further, by merely mixing the carbodiimide derivative and single-stranded nucleic acid to react them, at least one of thymine, uracil and guanyl base on single-stranded nucleic acid is reacted to label single-stranded nucleic acid. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供新的单链核酸和双链核酸酸标记方法和其中使用的新的碳二亚胺衍生物。解决方案：通过将具有信号组的碳二亚胺衍生物如碳二亚胺基团，电化学活性基团等与双链核酸混合，存在于错配中的胸腺嘧啶，尿嘧啶和鸟嘌呤碱基中的至少一种与存在于双链核酸的氢键的不稳定区域中存在的双链核酸的区域或存在于其附近或胸腺嘧啶，尿嘧啶和鸟嘌呤碱基中的至少一个与碳二亚胺衍生物反应，双链核酸。此外，通过仅仅将碳二亚胺衍生物和单链核酸混合来使其反应，将单链核酸上的胸腺嘧啶，尿嘧啶和鸟苷碱中的至少一种反应来标记单链核酸。版权所有（C）2005，JPO＆NCIPI

6. 发明专利

JP2005343888A New ferrocene-modified polycyclic hydrocarbon derivative, method for producing the same, and method for detecting target nucleic acid 有权
标题翻译：新的改性聚环烷烃衍生物，其生产方法和用于检测目标核酸的方法
公开(公告)号：JP2005343888A
公开(公告)日：2005-12-15
申请号：JP2005128522
申请日：2005-04-26
申请人： Shigeori Takenaka , Tum-Gene Inc , 株式会社Tumジーン , 繁織竹中
发明人： TAKENAKA SHIGEORI
IPC分类号： G01N33/483 , C07F17/02 , C12N15/09 , C12Q1/68 , G01N27/48 , G01N33/53 , G01N33/58
摘要： PROBLEM TO BE SOLVED: To provide a new compound high in double-stranded nucleic acid selectivity and useful as an intercalator that forms a stable conjugate with a double-stranded nucleic acid.
SOLUTION: The new compound is a new ferrocene-modified polycyclic hydrocarbon derivative of the formula(1)[ wherein, A is a polycyclic hydrocarbon; X is an alkylene group, (CH
2 )
x -B-(CH
2 )
y or the like; R
1 is H, an alkyl or the like; and R
2 and R
3 are each a group convertible to an electron-donating or electron-attracting group in an aqueous solution ] or a salt or hydrate thereof.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供高双链核酸选择性的新化合物，并且可用作与双链核酸形成稳定缀合物的嵌入剂。解决方案：新化合物是式（1）的新二茂铁改性多环烃衍生物[其中，A是多环烃; X是亚烷基，（CH 2 SB 2）SB SB-B - （CH 2 SP / 2） ; R 1是H，烷基等; 和R 2 和R 3 分别是可转化为水溶液中给电子或吸电子基团的基团]或其盐或水合物。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2004045390A Analysis method for specimen by molecular array using spectroscopy 有权
标题翻译：用分光光度法分析样品的分析方法
公开(公告)号：JP2004045390A
公开(公告)日：2004-02-12
申请号：JP2003136458
申请日：2003-05-14
申请人： Shigeori Takenaka , 竹中繁織
发明人： TAKENAKA SHIGEORI , NOJIMA TAKAHIKO , YAMASHITA KENICHI , MIZUSHIRO KEIJI , OTSUKA KEIICHI , TAKAGI MAKOTO
IPC分类号： G01N21/65 , G01N21/00 , G01N21/27 , G01N21/33 , G01N21/35
摘要： PROBLEM TO BE SOLVED: To provide a new analysis method using molecular arrays. SOLUTION: The specimen is allowed to operate on the molecular array where a probe molecule is fixed onto a substrate for arranging, the minute spot of a probe is scanned by a micro Fourier transform infrared spectroscopy, and an organism molecule in the specimen that is specifically combined to the probe is detected by measuring infrared absorption, thus extremely simply and sensitively analyzing the molecule in the specimen without labeling. COPYRIGHT: (C)2004,JPO

8. 发明专利

JP2004024114A New intercalator as electrochemical double-stranded dna detection reagent 审中-公开
公开(公告)号：JP2004024114A
公开(公告)日：2004-01-29
申请号：JP2002185555
申请日：2002-06-26
申请人： Shigeori Takenaka , Tum-Gene Inc , 株式会社Tumジーン , 竹中繁織
发明人： TAKENAKA SHIGEORI , KAMIYAMA HIROYUKI , TAKAGI MAKOTO
IPC分类号： G01N33/53 , C07K5/103 , C12N15/09 , C12Q1/68 , G01N27/327 , G01N27/416 , G01N27/48
摘要： PROBLEM TO BE SOLVED: To obtain a new intercalator for controlling the influence of mismatch DNA and single-stranded DNA as much as possible and for raising the detection sensitivity of double-stranded DNA. SOLUTION: Since an intercalating part represented by formula and formula (I) is a bis structure, the compound forms a stable complex when intercalated with double-stranded DNA. When the compound is combined with double-stranded DNA, two oxidation-reduction activity parts are made into a form in parallel in a DNA base pair and an electron transfer (electron hopping, namely oxidation-reduction reaction) transmitted between the base pair is efficiently carried out. COPYRIGHT: (C)2004,JPO

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