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1. 发明申请

WO2004048340A8 SINOMENINE AND SINOMENINE COMPOUNDS, SYNTHESIS AND USE 审中-公开
标题翻译：化学和化学化合物，合成和使用
公开(公告)号：WO2004048340A8
公开(公告)日：2005-07-07
申请号：PCT/EP0314841
申请日：2003-11-26
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB , QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
发明人： QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： C07D221/28 , A61K31/485 , C07D489/00
CPC分类号： C07D221/28
摘要： The invention relates to sinomenine and compounds thereof and also to compounds of formula (I), wherein R1 represents an alkyl group; R2 represents a hydrogen atom or an alkylcarbonyl group, an haloalkylcarbonyl group or an arylcarbonyl; Y represents a group (II), (III) or (IV); R3 ,R4, R'4, R5, R'5 and R6 are as defined in the description; and X represents a halogen atom. Medicaments.
摘要翻译：本发明涉及青藤碱及其化合物，还涉及式（I）化合物，其中R 1表示烷基; R2表示氢原子或烷基羰基，卤代烷基羰基或芳基羰基; Y代表（II），（III）或（IV）; R3，R4，R'4，R5，R'5和R6如说明书中所定义; X表示卤素原子。药物。

2. 发明专利

NZ537405A Acutumine and acutumine compounds, synthesis and use for treating neurodegenerative diseases and cerebral diseases of aging 未知
公开(公告)号：NZ537405A
公开(公告)日：2006-03-31
申请号：NZ53740503
申请日：2003-06-16
申请人： SERVIER LAB , SHANGHAI INST MATERIA MEDICA
发明人： QIN GUO-WEI , TANG XI-CAN , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： A61K31/47 , A61P25/28 , C07D209/96 , C07D217/20 , A61K31/403 , A61P25/16
摘要： Acutumine compounds of formula (I) are described wherein: R1 and R2 are hydrogen or together form an additional bond R3 is hydrogen or an alkoxy group R4 is hydrogen, or a hydroxy, alkoxy, alkylcarbonyloxy or arylcarbonyloxy group R5 is hydrogen or a halogen group R6 is hydrogen or an alkyl, alkylcarbonyl or aroyl group R7 and R10 are alkoxy groups R8 and R9 together form an additional bond or R8 and R13 together form a sulphide bridge and in the case R9 and R10 together form an oxo group and R14 is a chlorine group R11 is a hydroxy or alkoxy group R12 is hydrogen or R11 and R12 together form an oxo, oxime, or O-alkyl-oxime group R13 and R14 are hydrogen or together form an oxo group. Acutumine and acutumine compounds are useful in pharmaceutical compositions for the treatment of deficiencies of memory associated with cerebral ageing and neurodegenerative diseases, such as AlzheimerÆs disease, ParkinsonÆs disease. PickÆs disease, KorsakoffÆs disease and frontal lobe and subcortical dementias.

3. 发明专利

AR042225A1 SINOMENINA Y COMPUESTOS DE SINOMENINA, SINTESIS Y USO 未知
公开(公告)号：AR042225A1
公开(公告)日：2005-06-15
申请号：ARP030104372
申请日：2003-11-27
申请人： SERVIER LAB , SHANGHAI INST MATERIA MEDICA
发明人： QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： C07D221/28 , A61K31/485 , A61P25/00 , A61P25/16 , A61P25/28
摘要： Compuestos de fórmula (1) para medicamentos y composición farmacéutica. Reivindicación 1: Compuestos de fórmula (1), donde: R1 representa un grupo alquilo; R2 representa un átomo de hidrógeno o un grupo alquilcarbonilo, un grupo haloalquilcarbonilo o un arilcarbonilo; Y representa un resto de grupo de fórmula (2), donde R7 y R'7, idénticos o diferentes, representan cada uno un grupo alquilo, y Z- representa un anión de halógeno; R3 representa un grupo hidroxi o alcoxi; cada uno de R4 y R'4 representa un átomo de hidrógeno o forman un enlace adicional, o R3 y R4 juntos forman un grupo oxo o =N-OR8 (donde R8 representa un átomo de hidrógeno o un grupo alquilo); R6 representa un grupo hidroxi, alquilcarboniloxi (donde la parte alquilo puede ser sustituida por un grupo hidroxi, alcoxi, carboxi o alquiloxicarbonilo) o alcoxi; cada uno de R5 y R'5 representa un átomo de hidrógeno o juntos forman un enlace adicional, o R5 y R6 forman juntos un grupo oxo, =N-OR9 o =N-NR10R11 (donde R9, R10 y R11, que pueden ser iguales o diferentes, representan cada uno un átomo de hidrógeno o un grupo alquilo); y X representan un átomo de halógeno, proveyéndose que el compuesto de fórmula (1) no puede representar 1-bromo-4-hidroxi-3,7-dimetoxi-17-metil-7,8-didehidromorfinan-6-ona; entendiéndose que: "alquilo" se refiere a un grupo alquilo C1-6 que puede ser lineal o ramificado; "alcoxi" se refiere a un grupo alquiloxi C1-6 que puede ser lineal o ramificado, a sus enantiómeros y diastereoisómeros, y a sus sales de adición con un ácido o base farmacéuticamente aceptable. Reivindicación 26: Uso de sinomenina y/o compuetos de sinomenina en la obtención de composiciones farmacéuticas destinadas al tratamiento de deficiencias de la memoria asociadas con el envejecimiento cerebral y enfermedades neurodegenerativas tale como la enfermedad de Alzheimer, el mal de Parkinson, la enfermedad de Pick, la enfermedad de Korsakoff y las demencias del lóbulo frontal y subcortical.

4. 发明专利

EA007229B1 АКУТУМИН И СОЕДИНЕНИЯ АКУТУМИНА, СИНТЕЗ И ПРИМЕНЕНИЕ 未知
公开(公告)号：EA007229B1
公开(公告)日：2006-08-25
申请号：EA200500081
申请日：2003-06-16
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB
发明人： QIN GUO-WEI , TANG XI-CAN , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： C07D217/20 , A61K31/47 , A61P25/28 , C07D209/96
摘要： Изобретениеотноситсяк акутуминуи егосоединениям, атакжек соединениямформулы (I)вкоторых Rи R, каждыйпредставляетсобойатомводородаиливместеобразуютдополнительнуюсвязь, Rпредставляетсобойатомводородаилиалкоксигруппу, Rпредставляетсобойатомводородаилихлора, Rпредставляетсобойатомводородаилиалкильную, алкилкарбонильнуюилиароильнуюгруппу, Rи R, каждыйпредставляетсобойалкоксигруппу, Rпредставляетсобойалкоксигруппу, R, R, R, R, R, Rи Rимеютзначения, указанныев описании. Лекарственныесредства.

5. 发明专利

BR0316609A 未知
公开(公告)号：BR0316609A
公开(公告)日：2005-10-11
申请号：BR0316609
申请日：2003-11-26
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB
发明人： QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL HENRI , RENARD PIERRE
IPC分类号： C07D221/28 , C07D489/00 , A61K31/485
摘要： The invention relates to sinomenine and compounds thereof and also to compounds of formula (I): wherein R 1 represents alkyl, R 2 represents hydrogen or alkylcarbonyl, haloalkylcarbonyl or arylcarbonyl, Y represents a group R 3 , R 4 , R' 4 , R 5 , R' 5 and R 6 are as defined in the description, and X represents halogen and medicinal products containing the same which are useful in treating mnemocognitive disorders.

6. 发明专利

MA27573A1 SINOMENINE ET DERIVES DE SINOMENINE, SYNTHESE ET UTILISATION. 未知
公开(公告)号：MA27573A1
公开(公告)日：2005-10-03
申请号：MA28362
申请日：2005-06-27
申请人： SERVIER LAB , SHANGHAI INST MATERIA MEDICA
发明人： QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： C07D221/28 , C07D489/00 , A61K31/485
摘要： SINOMENINE ET DERIVES DE SINOMENINE , SYNTHESE ET UTILISATION L'invention concerne la sinoménine et ses dérivés, ainsi que les composés de formule (I) dans laquelle - R1 représente un groupement alkyle, - R2 représente un atome d'hydrogène ou un groupement alkylcarbonyle, haloalkylcarbonyle ou arylcarbonyle - Y represent un groupe R3 ,R4, R'4, R5, R'5 et R6 sont tels que définis dans la description, - et X représente un atome d'halogène. Médicaments.

7. 发明专利

MA27264A1 Acutumine et dérivés d'acutumine, synthèse et utilisation 未知
公开(公告)号：MA27264A1
公开(公告)日：2005-03-01
申请号：MA28062
申请日：2005-01-24
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB
发明人： QIN GUO-WEI , TANG XI-CAN , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： A61K31/47 , A61P25/28 , C07D209/96 , C07D217/20
摘要： ACUTUMINE ET DERIVES D'ACUTUMINE, SYNTHESE ET UTILISATION L'invention concerne l'acutumine et ses dérivés, ainsi que les composés de formule (I) : dans laquelle „ R1 et R2 représentent un atome d'hydrogène ou forment ensemble une liaison supplémentaire, „ R3 représente un atome d'hydrogène ou un groupement alkoxy, „ R5 représente un atome d'hydrogène ou de chlore, „ R6 représente un atome d'hydrogène ou un groupement alkyle, alkylecarbonyle ou aroyle, „ R7 et R10 représentent un groupement alkoxy, „ R10 représente un groupement alkoxy, „ R4, R8, R9, R11, R12, R13 et R14 sont tels que définis dans la description. Médicaments

8. 发明专利

CA2507067A1 SINOMENINE AND SINOMENINE COMPOUNDS, SYNTHESIS AND USE 未知
公开(公告)号：CA2507067A1
公开(公告)日：2004-06-10
申请号：CA2507067
申请日：2003-11-26
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB
发明人： CAIGNARD DANIEL-HENRI , LESTAGE PIERRE , WANG RUI , ZHOU TIAN-XI , TANG XI-CAN , QIN GUO-WEI , RENARD PIERRE
IPC分类号： C07D221/28 , C07D489/00 , A61K31/485
摘要： The invention relates to sinomenine and compounds thereof and also to compounds of formula (I), wherein R1 represents an alkyl group; R2 represent s a hydrogen atom or an alkylcarbonyl group, an haloalkylcarbonyl group or an arylcarbonyl; Y represents a group (II), (III) or (IV); R3 ,R4, R~4, R5, R~5 and R6 are as defined in the description; and X represents a halogen atom. Medicaments.

9. 发明专利

GEP20074178B ACUTUMINE AND ACUTUMINE COMPOUNDS, SYNTHESIS AND USE 未知
公开(公告)号：GEP20074178B
公开(公告)日：2007-08-10
申请号：GEAU2003008597
申请日：2003-06-16
申请人： SERVIER LAB , SHANGHAI INST MATERIA MEDICA
发明人： RENARD PIERRE , QIN GUO-WEI , TANG XI-CAN , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI
IPC分类号： C07D217/20 , A61K31/47 , A61P25/28 , C07D209/96
摘要： A compound of the formula (1) (wherein Rl – R14 are indicated in the description), a method for its production, a pharmaceutical composition containing them and use thereof for treatment of memory abnormalities.

10. 发明专利

ZA200504055B Sinomenine and sinomenine compounds, synthesis and use 未知
公开(公告)号：ZA200504055B
公开(公告)日：2006-08-30
申请号：ZA200504055
申请日：2005-05-19
申请人： SHANGHAI INST MATERIA MEDICA , SERVIER LAB
发明人： QIN GUO-WEI , TANG XI-CAN , WANG RUI , ZHOU TIAN-XI , LESTAGE PIERRE , CAIGNARD DANIEL-HENRI , RENARD PIERRE
IPC分类号： A61K20060101 , C07D20060101 , C07D221/28
摘要： The invention relates to sinomenine and compounds thereof and also to compounds of formula (I): wherein R 1 represents alkyl, R 2 represents hydrogen or alkylcarbonyl, haloalkylcarbonyl or arylcarbonyl, Y represents a group R 3 , R 4 , R' 4 , R 5 , R' 5 and R 6 are as defined in the description, and X represents halogen and medicinal products containing the same which are useful in treating mnemocognitive disorders.

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