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1. 发明申请

WO2007081542A2 TETRALONE-BASED MONOAMINE REUPTAKE INHIBITORS 审中-公开
标题翻译：基于四氢呋喃的单胺类复制抑制剂
公开(公告)号：WO2007081542A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/049069
申请日：2006-12-21
申请人： SEPRACOR INC. , SHAO, Liming , WANG, Fengjiang , MALCOLM, Scott, Christopher , HEWITT, Michael, Charles , BUSH, Larry, R. , VARNEY, Mark , CAMPBELL, Una , ENGEL, Sharon, Rae , HARDY, Larry, Wendell , KOCH, Patrick , MA, Jianguo
发明人： SHAO, Liming , WANG, Fengjiang , MALCOLM, Scott, Christopher , HEWITT, Michael, Charles , BUSH, Larry, R. , VARNEY, Mark , CAMPBELL, Una , ENGEL, Sharon, Rae , HARDY, Larry, Wendell , KOCH, Patrick , MA, Jianguo
IPC分类号： A61K31/4706
CPC分类号： C07C211/40 , C07C17/16 , C07C17/35 , C07C45/38 , C07C45/52 , C07C45/63 , C07C45/67 , C07C45/68 , C07C45/74 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/44 , C07C217/74 , C07C2601/14 , C07C2602/10 , C07D215/12 , C07C25/22 , C07C22/04 , C07C47/453 , C07C49/67 , C07C49/697 , C07C49/255 , C07C49/755 , C07C49/683
摘要： The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的四氢萘酮类胺及其用于治疗中枢神经系统（CNS）障碍，例如抑郁症，注意缺陷多动障碍（ADHD）和帕金森病。本发明还涉及含有本发明化合物和组合物的药物组合物以及抑制一种或多种单胺（例如多巴胺和去甲肾上腺素）从突触裂缝再摄取的方法，以及调节一种或多种单胺转运蛋白的方法。

2. 发明申请

WO2007006003A2 COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS 审中-公开
标题翻译：异佛尔酮和4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-氮杂吗啉或4-（3,4-二氯苯基）-1,2,3， 4-四氢-1-萘甲酰胺，以及治疗男性和儿童，男性和老年人的方法
公开(公告)号：WO2007006003A2
公开(公告)日：2007-01-11
申请号：PCT/US2006/026361
申请日：2006-07-06
申请人： SEPRACOR INC. , CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark , BAKALE, Roger, P. , SINGH, Surendra, P. , WILKINSON, H., Scott , SU, Xiping , HAN, Zhengxu , KOENIG, Stephan, G.
发明人： CARON, Judy , WESSEL, Thomas , LALJI, Karim , VARNEY, Mark , BAKALE, Roger, P. , SINGH, Surendra, P. , WILKINSON, H., Scott , SU, Xiping , HAN, Zhengxu , KOENIG, Stephan, G.
IPC分类号： A61K31/498
CPC分类号： A61K31/4985 , A61K31/135 , C07C211/42 , C07C2602/10 , A61K2300/00
摘要： One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.
摘要翻译：本发明的一个方面涉及含有两种或多种活性剂的药物组合物，当它们一起被用于治疗例如更年期，情绪障碍，焦虑障碍或认知障碍时。药物组合物的第一组分是镇静剂佐佐匹克。药物组合物的第二组分是反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺或反式4-（3,4-二氯苯基） -1,2,3,4-四氢-1-萘胺。本发明还涉及治疗绝经，围绝经期，情绪障碍，焦虑症和认知障碍的方法。

3. 发明申请

WO2008122806A1 RESPIRATORY SENSOR 审中-公开
标题翻译：呼吸传感器
公开(公告)号：WO2008122806A1
公开(公告)日：2008-10-16
申请号：PCT/GB2008/001251
申请日：2008-04-10
申请人： ANAXSYS TECHNOLOGY LTD , VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk
发明人： VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk
IPC分类号： A61B5/08 , A61B5/087 , G01N27/04 , G01N27/12 , G01N33/497 , A61M16/00
CPC分类号： A61B5/0816 , A61B5/087 , A61B5/4806 , A61B5/4818 , A61M16/024 , A61M16/0672 , A61M16/08 , A61M16/161 , A61M2016/0036 , A61M2202/062 , A61M2205/0233 , A61M2205/0244 , A61M2205/3317 , A61M2205/502 , A61M2205/8206 , A61M2230/30 , A61M2230/42 , A61M2230/435 , G01N27/121
摘要： A sensor assembly for monitoring the respiration pattern of a subject is disclosed, the sensor comprising a sensor element for exposing to a gas stream exhaled by the subject comprising a first electrode, a second electrode and an active layer extending between the first and second electrodes to provide an electrical path therebetween, the sensor element being responsive to the concentration of water vapour in the gas stream exhaled by the subject, whereby the conductivity of the path between the electrodes varies in response to changes in the concentration of water vapour; a processor for determining the pattern of respiration of the subject; and means for displaying information relating to the determined respiration pattern to a user. The sensor assembly is particular suitable for measuring the respiration rate and/or depth of respiration of the subject. The sensor and method find particular application in the diagnosis and treatment of sleep apnea.
摘要翻译：公开了一种用于监测受试者的呼吸模式的传感器组件，该传感器包括用于暴露于受试者呼出的气流的传感器元件，包括第一电极，第二电极和在第一和第二电极之间延伸的有源层，在它们之间提供电气路径，所述传感器元件响应受试者呼出的气流中的水蒸气的浓度，由此电极之间的路径的导电性响应于水蒸汽浓度的变化而变化; 用于确定所述对象的呼吸模式的处理器; 以及用于向用户显示与确定的呼吸模式相关的信息的装置。传感器组件特别适用于测量受试者的呼吸速率和/或呼吸深度。传感器和方法在睡眠呼吸暂停的诊断和治疗中有特别的应用。

4. 发明申请

WO2006054114A1 RESPIRATION MONITOR AND METHOD OF ITS OPERATION 审中-公开
标题翻译：呼吸监视器及其操作方法
公开(公告)号：WO2006054114A1
公开(公告)日：2006-05-26
申请号：PCT/GB2005/004495
申请日：2005-11-22
申请人： ASTHMA ALERT LIMITED , VARNEY, Mark , WILLIAMS, Deryk , GARRETT, Michael
发明人： VARNEY, Mark , WILLIAMS, Deryk , GARRETT, Michael
IPC分类号： A61B5/083
CPC分类号： A61B5/083
摘要： An apparatus for monitoring the respiration of a subject, the apparatus comprises means for detecting the concentration of each of oxygen, carbon dioxide and nitric oxide in an inspired and/or exhaled gaseous stream of a subject; and a display for displaying the concentration of each of oxygen, carbon dioxide and nitric oxide. A method for monitoring the respiration of a subject comprises analysing the composition of the inspired and/or exhaled gas of the subject and determing the concentration of carbon dioxide, oxygen and nitric oxide in the gas; and displaying the results of the analysis on a display to provide an indication of the respiratory state of the subject. A method of determining the extent of resuscitation of a patient comprises measuring the concentration of carbon dioxide, oxygen and nitric oxide in the inspired gas stream and/or exhaled gas stream of the subject.
摘要翻译：一种用于监测受试者的呼吸的装置，该装置包括用于检测受试者的启发和/或呼出的气流中的氧气，二氧化碳和一氧化氮中的每一种的浓度的装置; 以及显示用于显示氧气，二氧化碳和一氧化氮中的每一种的浓度的显示器。用于监测受试者的呼吸的方法包括分析受试者的启发和/或呼出气体的组成并确定气体中二氧化碳，氧气和一氧化氮的浓度; 并在显示器上显示分析结果，以提供对象的呼吸状态的指示。确定患者复苏程度的方法包括测量受试者的吸入气流和/或呼出气流中二氧化碳，氧气和一氧化氮的浓度。

5. 发明申请

WO2008047115A1 GAS SENSOR 审中-公开
标题翻译：气体传感器
公开(公告)号：WO2008047115A1
公开(公告)日：2008-04-24
申请号：PCT/GB2007/003957
申请日：2007-10-17
申请人： ANAXSYS TECHNOLOGY LIMITED , VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk
发明人： VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk
IPC分类号： G01N27/49 , A61B5/083 , G01N33/497
CPC分类号： G01N27/4045 , A61B5/0836 , G01N33/004 , G01N33/497
摘要： A method for the determination of the carbon dioxide content of an exhaled gas stream is provided, the method comprising measuring the water vapour content of the exhaled gas stream,- and determining the concentration of carbon dioxide in the exhaled gas stream from the measured water vapour content. A particular method comprises causing the gas stream to impinge on a sensing element comprising a working electrode and a counter electrode; applying an electric potential across the working electrode and counter electrode; measuring the current flowing between the working electrode and counter electrode as a result of the applied potential; and determining from the measured current flow an indication of the concentration of the water vapour in the gas stream. A sensor is also described.
摘要翻译：提供了一种用于确定呼出气体流的二氧化碳含量的方法，该方法包括测量呼出气流的水蒸气含量，以及确定来自测量的水蒸汽的呼出气流中二氧化碳的浓度内容。一种特定的方法包括使气流冲击到包括工作电极和对电极的感测元件上; 在工作电极和对电极两端施加电位; 测量作为施加电位的结果在工作电极和对电极之间流动的电流; 并根据所测量的电流流量确定气流中水蒸气浓度的指示。还描述了传感器。

6. 发明申请

WO2008009951A1 ELECTROCHEMICAL GAS SENSOR COMPRISING MESOPOROUS LAYER BETWEEN WORKING AND COUNTER ELECTRODES 审中-公开
标题翻译：电化学气体传感器包括工作和计数器电极之间的多孔层
公开(公告)号：WO2008009951A1
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002748
申请日：2007-07-18
申请人： ANAXSYS TECHNOLOGY LIMITED , VARNEY, Mark , GARRETT, Michael
发明人： VARNEY, Mark , GARRETT, Michael
IPC分类号： G01N27/407 , G01N33/497 , G01N27/403
CPC分类号： G01N27/4074 , A61B5/083 , A61B5/0836
摘要： A sensor for sensing a target substance in a gas stream is provided, the sensor comprising a sensing element disposed to be exposed to the gas stream, the sensing element comprising a working electrode; a counter electrode; and a layer of mesoporous material extending between the working electrode and the counter electrode; whereby contact of the mesoporous layer with the gas stream forms an electrical contact between the working and counter electrodes.
摘要翻译：提供了用于感测气流中的目标物质的传感器，所述传感器包括设置为暴露于所述气流的感测元件，所述感测元件包括工作电极; 对电极以及在工作电极和对电极之间延伸的介孔材料层; 由此介孔层与气流的接触在工作电极和对电极之间形成电接触。

7. 发明申请

WO2009056806A1 A METHOD OF MONITORING GAS COMPOSITION 审中-公开
标题翻译：监测气体组成的方法
公开(公告)号：WO2009056806A1
公开(公告)日：2009-05-07
申请号：PCT/GB2008/003628
申请日：2008-10-24
申请人： ANAXSYS TECHNOLOGY LTD , VARNEY, Mark , GARRETT, Michael
发明人： VARNEY, Mark , GARRETT, Michael
IPC分类号： G01N33/497 , A61B5/083
CPC分类号： A61B5/0836 , A61B2562/0215 , G01N33/497
摘要： A method of determining the general or a specific condition of a subject is disclosed, the method comprising measuring the concentration of each of a plurality of components in a single sample of the gas stream exhaled by the subject; and generating information regarding the concentration of each of the plurality of components such that the concentrations of the components are directly comparable. The method is particularly suitable for assessing the condition of the respiratory system of a subject. The method preferably employs electrochemical sensors to measure the concentration of the target components in the exhaled gas stream.
摘要翻译：公开了一种确定受试者的一般或特定条件的方法，所述方法包括测量由受试者呼出的气流的单个样品中的多个组分中的每一个的浓度; 并且产生关于多个组分中的每一个的浓度的信息，使得组分的浓度直接可比。该方法特别适用于评估受试者呼吸系统的状况。该方法优选采用电化学传感器来测量呼出气流中目标组分的浓度。

8. 发明申请

WO2008009980A1 GAS SENSOR 审中-公开
标题翻译：气体传感器
公开(公告)号：WO2008009980A1
公开(公告)日：2008-01-24
申请号：PCT/GB2007/002807
申请日：2007-07-20
申请人： ANAXSYS TECHNOLOGY LIMITED , VARNEY, Mark , GARRETT, Michael
发明人： VARNEY, Mark , GARRETT, Michael
IPC分类号： A61B5/083 , G01N27/49 , G01N33/497
CPC分类号： G01N27/407 , A61B5/0836 , G01N27/121 , G01N27/4045 , G01N33/497
摘要： A sensor for sensing a target substance in a gas stream is provided, the sensor comprising: a sensing element disposed to be exposed to the gas stream, the sensing element comprising: a working electrode; a counter electrode; and a layer of ion exchange material extending between the working electrode and the counter electrode; whereby contact of the ion exchange layer with the gas stream forms an electrical contact between the working and counter electrodes.
摘要翻译：提供了用于感测气流中的目标物质的传感器，该传感器包括：传感元件，被设置为暴露于气流，感测元件包括：工作电极; 对电极以及在工作电极和对电极之间延伸的一层离子交换材料; 由此离子交换层与气流的接触在工作电极和对电极之间形成电接触。

9. 发明申请

WO2008110830A1 ELECTROCHEMICAL SENSOR 审中-公开
标题翻译：电化学传感器
公开(公告)号：WO2008110830A1
公开(公告)日：2008-09-18
申请号：PCT/GB2008/000951
申请日：2008-03-17
申请人： ANAXSYS TECHNOLOGY LTD , VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk , MARKEN, Francis
发明人： VARNEY, Mark , GARRETT, Michael , WILLIAMS, Deryk , MARKEN, Francis
IPC分类号： G01N27/416 , G01N27/48
CPC分类号： G01N33/497
摘要： An electrochemical sensor (40) is provided, the sensor comprising a working electrode (44); a counter electrode (46); and an ionic liquid medium extending between the working electrode and the counter electrode, the ionic liquid medium comprising an ionic liquid retained in a support material. The ionic liquid may comprise a cation selected from 1-alkyl-3-methylimidazolium ([C n MIM]), N-alkytpyridinium, tetraalkylammonium or tetraalkylphosphonium cations and an anion selected from hexafluorophosphate [PF 6 ]; tetrafluoroborate [BF4]; trifluoromethylsulfonate [CF 3 SO 3 ]; bis[(trifluoromethyl) sulfonyl]amide [(CF 3 SO 2 ) 2 N]; trifluoroethanoate [CF 3 CO 2 ]; acetate [CH 3 CO 2 ]; nitrate, and halides, including fluoride [F]1 chloride [Cl], and bromide [Br]. The sensor is particularly useful in the detection of gaseous components in the exhaled breath of a subject and for use in monitoring the lung function of the subject, for example to identify the onset of asthma and/or COPD.
摘要翻译：提供一种电化学传感器（40），该传感器包括工作电极（44）; 对电极（46）; 以及在工作电极和对电极之间延伸的离子液体介质，离子液体介质包含保留在支撑材料中的离子液体。离子液体可以包括选自1-烷基-3-甲基咪唑鎓（[C n N n MIM]），N-烷基吡啶鎓，四烷基铵或四烷基鏻阳离子的阳离子和选自六氟磷酸盐[ 6 ]; 四氟硼酸盐[BF4]; 三氟甲基磺酸盐[CF 3 SO 3 3]; 双[（三氟甲基）磺酰基]酰胺[（CF 3）2 SO 2）2 N]; 三氟乙酸酯[CF 3 CO 2]; 乙酸酯[CH 3 CO 2 CO 2]; 硝酸盐和卤化物，包括氟化物[F] 1氯化物[Cl]和溴化物[Br]。传感器特别可用于检测受试者的呼出气中的气体组分并用于监测受试者的肺功能，例如用于鉴定哮喘和/或COPD的发作。

10. 发明申请

WO2007080381A1 GAS SENSOR 审中-公开
标题翻译：气体传感器
公开(公告)号：WO2007080381A1
公开(公告)日：2007-07-19
申请号：PCT/GB2007/000036
申请日：2007-01-09
申请人： ANAXSYS TECHNOLOGY LIMITED , VARNEY, Mark , LINDSELL, Alexandra
发明人： VARNEY, Mark , LINDSELL, Alexandra
IPC分类号： G01N27/04 , G01N27/49 , G01N33/497
CPC分类号： G01N27/048 , G01N27/4045 , G01N33/004 , G01N33/006 , G01N33/497
摘要： A sensor for detecting a target substance, in particular carbon dioxide and/or water, in a gas stream comprises a sensing element disposed to be exposed to the gas stream, the sensing element comprising a working electrode; and a counter electrode; whereby the gas stream may be caused to impinge directly upon at least a portion of both the working electrode and the counter electrode. A method of sensing a target substance in a gas stream comprises causing the gas stream comprising water vapour to impinge upon at least a portion of both a working electrode and a counter electrode; applying a electric potential across the working electrode and counter electrode; measuring the current flowing between the working electrode and counter electrode as a result of the applied potential; and determining from the measured current flow an indication of the concentration of the target substance. The sensor and method are particularly suitable for analyzing tidal carbon dioxide concentrations and humidity in the exhaled breath of a person, to diagnose and/or monitor a variety of respiratory conditions. The sensor design is particularly useful for applications requiring fast response times, e.g. personal respiratory monitoring of tidal breathing (“capnography”).
摘要翻译：用于在气流中检测目标物质，特别是二氧化碳和/或水的传感器包括设置为暴露于气流的感测元件，感测元件包括工作电极; 和对电极; 由此气流可以直接撞击工作电极和对电极的至少一部分。感测气流中的目标物质的方法包括使包含水蒸气的气流撞击工作电极和对电极的至少一部分; 在工作电极和对电极上施加电位; 测量作为施加电位的结果在工作电极和对电极之间流动的电流; 并从所测量的电流确定目标物质的浓度的指示。传感器和方法特别适用于分析人呼出气中的潮气二氧化碳浓度和湿度，诊断和/或监测各种呼吸状况。传感器设计对于需要快速响应时间的应用尤其有用。潮气呼吸的个人呼吸监测（“二氧化碳监测”）。

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