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1. 发明申请

WO2007143267A3 TREATMENT OF PAIN DISORDERS WITH TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE AND ITS FORMAMIDE 审中-公开
标题翻译：用4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘甲酸及其甲酰胺治疗疼痛症状
公开(公告)号：WO2007143267A3
公开(公告)日：2008-12-04
申请号：PCT/US2007065585
申请日：2007-03-30
申请人： SEPRACOR INC , TARANTINO PAUL , CAMPBELL UNA , BUSH LARRY
发明人： TARANTINO PAUL , CAMPBELL UNA , BUSH LARRY
IPC分类号： A61P25/00 , A61P25/06
CPC分类号： A61K31/135 , A61K31/165
摘要： Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful in treatment of pain disorders.
摘要翻译：用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺治疗疼痛障碍; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢化萘-1-基]甲酰胺的全部四种异构体，它们也可用于治疗疼痛障碍。

2. 发明申请

WO2005079772A3 COMBINATION OF (S)-AMLODIPINE AND AN ACE INHIBITOR, AND METHODS FOR REDUCING HYPERTENSION 审中-公开
标题翻译：（S） - 氨氯地平与ACE抑制剂的组合以及降低高血压的方法
公开(公告)号：WO2005079772A3
公开(公告)日：2005-11-03
申请号：PCT/US2005004460
申请日：2005-02-14
申请人： SEPRACOR INC , BUSH LARRY , GROGAN DONNA ROY
发明人： BUSH LARRY , GROGAN DONNA ROY
IPC分类号： A61K31/401 , A61K31/4422 , A61K38/55 , A61K45/06 , A61P9/00
CPC分类号： A61K45/06 , A61K31/401 , A61K31/4422 , A61K2300/00
摘要： The present invention generally relates to pharmaceutical compositions comprising optically pure (S)-amlodipine and an ACE inhibitor. In a preferred embodiment the (S)-amlodipine is (S)-amlodipine-L-malate, or a polymorph, pseudopolymorph or solvate thereof. In a preferred embodiment, the ACE inhibitor is ramipril. The pharmaceutical compositions of the invention are useful in the treatment of hypertension. The present invention also relates to a method of treating a patient suffering from hypertension or a cardiac disorder, comprising co-administering a therapeutically effective amount of optically pure (S)-amlodipine and an ACE inhibitor. In a preferred embodiment the (S)-amlodipine is (S)-amlodipine-L-malate, or a polymorph, pseudopolymorph or solvate thereof. In a preferred embodiment, the ACE inhibitor is ramipril.
摘要翻译：本发明一般涉及包含光学纯（S） - 氨氯地平和ACE抑制剂的药物组合物。在一个优选实施方案中，（S） - 氨氯地平是（S） - 氨氯地平-L-苹果酸盐，或其多晶型物，假多晶型物或溶剂化物。在一个优选的实施方案中，ACE抑制剂是雷米普利。本发明的药物组合物可用于治疗高血压。本发明还涉及治疗患有高血压或心脏疾病的患者的方法，其包括共同施用治疗有效量的光学纯（S） - 氨氯地平和ACE抑制剂。在一个优选实施方案中，（S） - 氨氯地平是（S） - 氨氯地平-L-苹果酸盐，或其多晶型物，假多晶型物或溶剂化物。在一个优选的实施方案中，ACE抑制剂是雷米普利。

3. 发明专利

CA2653498A1 TREATMENT OF PAIN DISORDERS WITH TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE AND ITS FORMAMIDE 未知
公开(公告)号：CA2653498A1
公开(公告)日：2007-12-13
申请号：CA2653498
申请日：2007-03-30
申请人： SEPRACOR INC
发明人： TARANTINO PAUL , CAMPBELL UNA , BUSH LARRY
IPC分类号： A61P25/00 , A61P25/06
摘要： Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2 ,3,4-tetrahydro-1-naphthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-naphthalenamine is disclosed. A process for preparing 4 -(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine is also disclosed . The process includes the preparation of all four isomers of N-[4-(3,4-dich lorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also usef ul in treatment of pain disorders.

4. 发明专利

MX2008015048A TRATAMIENTO CONTRA TRASTORNOS DE DOLOR CON TRANS 4-(3,4-DICLOROFENIL)-1,2,3,4-TETRAHIDRO-1-NAFTALENAMINA Y SU FORMAMIDA. 未知
公开(公告)号：MX2008015048A
公开(公告)日：2008-12-10
申请号：MX2008015048
申请日：2007-03-30
申请人： SEPRACOR INC
发明人： TARANTINO PAUL , CAMPBELL UNA , BUSH LARRY
IPC分类号： A61K31/135 , A61K31/165 , A61P25/00 , A61P25/02
摘要： Se describe un tratamiento contra trastornos de dolor con (1R, 4S)-trans 4-(3,4-diclorofenil)-1,2,3,4-tetrahidro-1-naftalenamina; y (1S, 4R)-trans 4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-1-naftalenamina. También se describe un proceso para preparar 4-(3,4-diclorofenil)-1,2,3,4- tetrahidro-1-naftalenamina. El proceso incluye la preparación de cuatro isómeros de N-[4-(3,4-diclorofenil)-1,2,3,4-tetrahidronaftalen-1-il]formamida , que también son útiles en el tratamiento contra trastornos del dolor.

5. 发明专利

AU2007254751A1 Treatment of pain disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine and its formamide 未知
公开(公告)号：AU2007254751A1
公开(公告)日：2007-12-13
申请号：AU2007254751
申请日：2007-03-30
申请人： SEPRACOR INC
发明人： BUSH LARRY , TARANTINO PAUL , CAMPBELL UNA
IPC分类号： A61K31/135 , A61K31/165 , A61P25/00 , A61P25/02
摘要： Treatment of pain disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro- 1 -napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful in treatment of pain disorders.

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