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1. 发明申请

WO2004024130A2 TREATMENT OF CNS DISORDERS WITH trans 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE 审中-公开
标题翻译：反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺治疗中枢神经系统疾病
公开(公告)号：WO2004024130A2
公开(公告)日：2004-03-25
申请号：PCT/US0329112
申请日：2003-09-16
申请人： SEPRACOR INC , JERUSSI THOMAS P , FANG QUN KEVIN , CURRIE MARK
发明人： JERUSSI THOMAS P , FANG QUN KEVIN , CURRIE MARK
IPC分类号： A61K31/135 , A61K45/06 , A61P25/00 , C07C209/50 , C07C211/42 , C07C231/12 , C07C313/06
CPC分类号： C07C211/42 , A61K31/135 , A61K45/06 , C07C209/50 , C07C231/12 , C07C313/06 , C07C2601/14 , C07C2602/10 , C07C233/14
摘要： Treatment of central nervous system disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine and with (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine is also disclosed.
摘要翻译：（1R，4S） - 反式4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺和（1S，4R） - 反式公开了4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺。还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-N-甲基-1-萘胺的方法。

2. 发明专利

IL167319A Trans 4 - (3,4 - dichlorophenyl) - 1,2,3,4 - tetrahydro -1 -naphthalenamine for use in treating cns disorders 未知
公开(公告)号：IL167319A
公开(公告)日：2013-10-31
申请号：IL16731905
申请日：2005-03-08
申请人： SUNOVION PHARMACEUTICALS INC , JERUSSI THOMAS P , FANG KEVIN QUN , CURRIE MARK
发明人： JERUSSI THOMAS P , FANG KEVIN QUN , CURRIE MARK
IPC分类号： A61K20060101 , A61K9/20 , A61K9/48 , A61K31/135 , A61P20060101 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07C20060101 , C07C209/62 , C07C211/42
摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

3. 发明申请

WO0067741A3 (S,R) FORMOTEROL METHODS AND COMPOSITIONS 审中-公开
标题翻译：（S，R）甲基酚方法和组合物
公开(公告)号：WO0067741A3
公开(公告)日：2001-03-15
申请号：PCT/US0012648
申请日：2000-05-09
申请人： SEPRACOR INC , JERUSSI THOMAS P , SENANAYAKE CHRIS HUGH
发明人： JERUSSI THOMAS P , SENANAYAKE CHRIS HUGH
IPC分类号： A61K31/167 , A61P11/00
CPC分类号： A61K31/167 , Y10S514/826
摘要： A method and composition are disclosed utilizing the pure (S,R) isomer of formoterol, which is a bronchodilator with reduced adverse effects. (S,R)-Formoterol may be conveniently and safely formulated for aerosol administration.
摘要翻译：公开利用福莫特罗的纯（S，R）异构体的方法和组合物，福莫特罗是不利影响减轻的支气管扩张剂。（S，R） - 孕甾醇可以方便，安全地配制用于气雾剂给药。

4. 发明申请

WO0071108A3 METHODS FOR TREATMENT OF ASTHMA USING S-OXYBUTYNIN 审中-公开
标题翻译：使用S-OXYBUTYNIN治疗哮喘的方法
公开(公告)号：WO0071108A3
公开(公告)日：2001-05-17
申请号：PCT/US0013341
申请日：2000-05-16
申请人： SEPRACOR INC , JERUSSI THOMAS P
发明人： JERUSSI THOMAS P
IPC分类号： A61K9/10 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/48 , A61K9/52 , A61K9/70 , A61K9/72 , A61K31/216 , A61P11/06
CPC分类号： A61K9/008 , A61K9/2018 , A61K9/2059 , A61K31/216 , Y10S514/826
摘要： Substantially optically pure S-oxybutynin, or a pharmaceutically acceptable salt thereof, is administered as a treatment for asthma. Such treatment is provided while reducing the adverse effects associated with the administration of racemic oxybutynin.
摘要翻译：施用基本上光学纯的S-奥昔布宁或其药学上可接受的盐作为哮喘治疗。提供这样的治疗，同时减少与外消旋奥昔布宁的施用相关的不良反应。

5. 发明申请

WO02069951A3 COMPOSITION CONTAINING A NEFAZONOID SUCH AS NEFAZODONE AND A SEROTONIN-INHIBITOR SUCH AS FLUOXETINE 审中-公开
标题翻译：含有NEFAZONOID等作为NEFAZODONE的组合物和作为氟尿嘧啶的丝氨酸蛋白酶抑制剂
公开(公告)号：WO02069951A3
公开(公告)日：2003-03-06
申请号：PCT/US0206204
申请日：2002-03-01
申请人： SEPRACOR INC , CURRIE MARC G , SENANAYAKE CHRIS H , JERUSSI THOMAS P , RUBIN PAUL
发明人： CURRIE MARC G , SENANAYAKE CHRIS H , JERUSSI THOMAS P , RUBIN PAUL
IPC分类号： A61K31/00 , A61K31/135 , A61K31/165 , A61K31/496 , A61K31/497 , A61P25/00 , A61K31/495
CPC分类号： A61K31/135 , A61K31/00 , A61K31/165 , A61K31/496 , A61K31/497 , A61K2300/00
摘要： The present invention provides methods and compositions for conjoint administration of a nefazodonoid and a fluoxetinoid for the treatment of depression and other neurological conditions.
摘要翻译：本发明提供了用于联合施用奈非唑酮和氟西汀以治疗抑郁症和其它神经病症的方法和组合物。

6. 发明申请

WO02060424A3 METHODS OF USING AND COMPOSITIONS COMPRISING SIBUTRAMINE METABOLITES OPTIONALLY IN COMBINATION WITH OTHER PHARMACOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：使用和组合物包含SIBUTRAMINE代谢物的方法可选地与其他药物活性化合物组合
公开(公告)号：WO02060424A3
公开(公告)日：2003-02-06
申请号：PCT/US0202040
申请日：2002-01-23
申请人： SEPRACOR INC
发明人： JERUSSI THOMAS P , SENANAYAKE CHRISANTHA H , FANG QUN K
IPC分类号： A61K9/20 , A61K31/11 , A61K31/135 , A61K31/137 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/475 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/52 , A61K45/06 , A61P15/00 , A61P25/00 , A61K31/15
CPC分类号： A61K31/50 , A61K9/2054 , A61K9/2059 , A61K31/11 , A61K31/135 , A61K31/137 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/475 , A61K31/495 , A61K31/505 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of disorders and conditions such as, but are not limited to: eating disorders; weight gain; obesity; irritable bowel syndrome; obessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders, restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. Pharmaceutical compositions and dosage forms are also disclosed which comprise a racemic or optically pure sibutramine metabolite and an optional additional pharmacologically active compound.
摘要翻译：公开了用于治疗和预防疾病和病症的方法，例如但不限于：进食障碍; 体重增加; 肥胖; 过敏性肠综合征; 强迫症; 血小板粘附; 呼吸暂停; 情感障碍，如注意力缺陷障碍，抑郁症和焦虑症; 男性和女性性功能障碍，不宁腿综合征; 骨关节炎; 药物滥用，包括尼古丁和可卡因成瘾; 发作性睡病; 疼痛如神经性疼痛，糖尿病性神经病和慢性疼痛; 偏头痛; 脑功能障碍; 慢性疾病如经前期综合征; 和失禁。还公开了药物组合物和剂型，其包含外消旋或光学纯的西布曲明代谢物和任选的另外的药理活性化合物。

7. 发明公开

EP1434575A4 METHODS OF PREPARING AND USING 2-HYDROXY DERIVATIVES OF SIBUTRAMINE AND ITS METABOLITES 审中-公开
标题翻译：方法制备和使用西布曲明及其代谢产物2-羟基衍生物的
公开(公告)号：EP1434575A4
公开(公告)日：2006-03-29
申请号：EP02761634
申请日：2002-09-12
申请人： SEPRACOR INC
发明人： SENANAYAKE CHRIS H , JERUSSI THOMAS P , CURRIE MARK G , FANG QUN K , HSU BOB
IPC分类号： A61P1/00 , A61K31/135 , A61K31/137 , A61K31/194 , A61P1/14 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/00 , A61P5/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/10 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/12 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/34 , A61P29/00 , A61P35/00 , A61P43/00 , C07C215/28 , C07C217/48 , C07C211/08
CPC分类号： C07C215/28 , A61K31/135 , C07C2601/04

8. 发明公开

EP1183030A4 METHODS OF MAKING AND USING N-DESMETHYLZOPICLONE 审中-公开
标题翻译：制备方法及其使用N-去甲基明珠酮的方法
公开(公告)号：EP1183030A4
公开(公告)日：2007-11-21
申请号：EP00930565
申请日：2000-05-11
申请人： SEPRACOR INC
发明人： JERUSSI THOMAS P , SENANAYAKE CHRISANTHA H , RUBIN PAUL D , HONG YAPING , BAKALE ROGER A , XIANG TINGJIAN , MCCONVILLE FRAN A
IPC分类号： A61K9/20 , A61K31/495 , A61K9/48 , A61K31/4985 , A61P5/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/32 , C07D487/04
CPC分类号： A61K31/4985 , A61K31/498 , C07B2200/07 , C07D487/04

9. 发明申请

WO02060427A2 METHODS OF USING AND COMPOSITIONS COMPRISING (+) SIBUTRAMINE OPTIONALLY IN COMBINATION WITH OTHER PHARMACOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：使用和组合物（+）SIBUTRAMINE选择性地与其他药物活性化合物组合使用
公开(公告)号：WO02060427A2
公开(公告)日：2002-08-08
申请号：PCT/US0202038
申请日：2002-01-23
申请人： SEPRACOR INC
发明人： YOUNG JAMES W , JERUSSI THOMAS P
IPC分类号： A61K31/135 , A61K45/06 , A61P15/00 , A61P25/00
CPC分类号： A61K45/06 , A61K31/135 , A61K2300/00 , A61K31/00
摘要： This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; c erebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (+) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.
摘要翻译：本发明包括治疗和预防包括但不限于进食障碍的疾病的方法; 体重增加; 肥胖; 过敏性肠综合征; 强迫症; 血小板粘附; 呼吸暂停; 情感障碍，如注意力缺陷障碍，抑郁症和焦虑症; 男性和女性性功能障碍; 不安腿综合征骨关节炎; 药物滥用，包括尼古丁和可卡因成瘾; 发作性睡病; 疼痛如神经性疼痛，糖尿病性神经病和慢性疼痛; 偏头痛; 脑功能障碍慢性疾病如经前期综合征; 和失禁。本发明还包括药物组合物和剂型，其包含光学纯的（+）西布曲明，任选与磷酸二酯酶抑制剂或脂肪酶抑制剂组合。

10. 发明申请

WO0010551A3 METHODS OF USING AND COMPOSITIONS COMPRISING DOPAMINE REUPTAKE INHIBITORS 审中-公开
标题翻译：使用和组合物包含多巴胺复苏抑制剂的方法
公开(公告)号：WO0010551A3
公开(公告)日：2000-09-21
申请号：PCT/US9919167
申请日：1999-08-23
申请人： SEPRACOR INC
发明人： JERUSSI THOMAS P , SENANAYAKE CHRISANTHA H , FANG QUN K
IPC分类号： A61K45/00 , A61K20060101 , A61K31/00 , A61K31/11 , A61K31/13 , A61K31/135 , A61K31/137 , A61K31/166 , A61K35/48 , A61K45/06 , A61P1/00 , A61P1/08 , A61P3/04 , A61P15/10 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00
CPC分类号： A61K45/06 , A61K31/11 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional disorders, pain, obsessive-compulsive disorder, substance abuse, chronic disorders, anxiety, eating disorders, migraines, and incontinence. The methods comprise the administration of a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Pharmaceutical compositions and dosage forms are also disclosed that comprise a dopamine reuptake inhibitor and optionally an additional pharmacologically active compound. Preferred dopamine reuptake inhibitors are racemic or optically pure sibutramine metabolites like desmethylsibutramine and didesmethylsibutramine and pharmaceutically acceptable salts, solvates, and clathrates thereof. Preferred additional pharmacologically active compounds include drugs that affect the central nervous system, such as 5-HT3, antagonists.
摘要翻译：公开了用于治疗和预防疾病和病症的方法，包括但不限于勃起功能障碍，情感障碍，体重增加，脑功能障碍，疼痛，强迫症，药物滥用，慢性障碍，焦虑，进食障碍，偏头痛和失禁。所述方法包括施用多巴胺再摄取抑制剂和任选的另外的药理活性化合物。还公开了包含多巴胺再摄取抑制剂和任选的另外的药理学活性化合物的药物组合物和剂型。优选的多巴胺再摄取抑制剂是外消旋或光学纯的西布曲明代谢物，如去甲基西布曲明和二甲基西布曲明及其药学上可接受的盐，溶剂化物和包合物。优选的另外的药理活性化合物包括影响中枢神经系统的药物，例如5-HT3拮抗剂。

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