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1. 发明申请

WO2007146120A2 RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING NOVEL TASTE CELL GENES AND SALTY TASTE RECEPTOR TARGETS AND ASSAYS USING THESE IDENTIFIED GENES OR GENE PRODUCTS 审中-公开
标题翻译：用于鉴定新型重组细胞基因和盐酸受体靶标的方法和方法以及使用这些鉴定基因或基因产物的测定
公开(公告)号：WO2007146120A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013502
申请日：2007-06-08
申请人： SENOMYX INC , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , KALABAT DALIA , GAO NA , HEVEZI PETER
发明人： MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , KALABAT DALIA , GAO NA , HEVEZI PETER
IPC分类号： C12Q1/68
CPC分类号： C12N15/1072 , C12N15/1086 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158
摘要： This invention relates to novel rationale and methods for identifying taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste- specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salt, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Further, the invention provides specific methods of purifying, enriching, isolating or marking desired taste cell subtypes or lineages such as sweet, umami, bitter, salty, sour, fat or stem cells et al. e.g., by use of FACS, magnetic beads or other selection methods that purify, enrich, mark, or eliminate such as by use of labeled cytotoxins, cells that express or do not express one or more taste specific genes.
摘要翻译：本发明涉及用于鉴定味道特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感知的基因以及参与其他基因的基因味觉细胞或味觉受体相关活性如消化功能和消化相关疾病，味觉细胞周转，口腔和消化道的免疫调节，以及代谢调节如糖尿病和肥胖症，使用这些方法鉴定的基因，以及用于鉴定味道的测定调节剂（增强子或阻断剂）和使用这些基因的潜在治疗剂。这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。此外，本发明涉及用于鉴定可用作不同味道细胞类型（包括哺乳动物中的甜味，苦味，鲜味，酸味，盐类和其他味觉细胞）的标记物的味道特异性基因的新方法，以及测量在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染。此外，本发明提供了纯化，富集，分离或标记所需味道细胞亚型或谱系如甜味，鲜味，苦味，咸味，酸性，脂肪或干细胞等的具体方法。例如通过使用FACS，磁珠或其它选择方法来纯化，富集，标记或消除，例如通过使用标记的细胞毒素，表达或不表达一种或多种味道特异性基因的细胞。

2. 发明申请

WO2009008950A3 IDENTIFICATION OF TRPML3 (MCOLN3) AS A SALTY TASTE RECEPTOR AND USE IN ASSAYS FOR IDENTIFYING TASTE (SALTY) MODULATORS AND/OR THERAPEUTICS THAT MODULATE SODIUM TRANSPORT, ABSORPTION OR EXCRETION AND/OR ALDOSTERONE AND/OR VASOPRESSIN PRODUCTION OR REL 审中-公开
标题翻译：鉴定作为盐酸受体的TRPML3（MCOLN3）和用于鉴定调节运输，吸收或/或阿尔斯酮和/或维生素C生产或替代物的硫酸盐（SALTY）调节剂和/或治疗剂的测定中的用途
公开(公告)号：WO2009008950A3
公开(公告)日：2009-12-30
申请号：PCT/US2008007101
申请日：2008-06-06
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK , KALABAT DALIA , WHITE EVAN CARL , SAGANICH MICHAEL , LAITA BIANCA , DAHAN DAVID
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK , KALABAT DALIA , WHITE EVAN CARL , SAGANICH MICHAEL , LAITA BIANCA , DAHAN DAVID
IPC分类号： C12N5/00
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5044 , G01N33/566 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： High-throughput mammalian and medium-throughput oocyte-based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers are disclosed Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans The electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3 The assays provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function and thereby modulate salty taste In addition, these compounds may be used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels
摘要翻译：公开了用于鉴定人TRPML3调节剂（优选TRPML3增强子）的高通量哺乳动物和中等吞吐量的基于卵母细胞的电生理测定法，优选调节TRPML3功能的化合物预期影响人体的咸味。电生理测定，例如两电极电压钳技术，有助于鉴定特异性调节人TRPML3的化合物。该测定提供了一个强大的屏幕，可用于检测促进（增强）或抑制TRPML3功能，从而调节咸味的化合物。此外，这些化合物可用于调节钠排泄，泌尿生产等与钠水平相关的生物功能

3. 发明申请

WO2008153924A2 RATIONALE, METHODS, AND ASSAYS FOR IDENTIFYING HUMAN AND NON-HUMAN PRIMATE TASTE SPECIFIC GENES AND USE THEREOF IN TASTE MODULATOR AND THERAPEUTIC SCREENING ASSAYS 审中-公开
标题翻译：识别人类和非人类初乳特定基因的原理，方法和测定及其在制剂调制剂和治疗筛选试验中的应用
公开(公告)号：WO2008153924A2
公开(公告)日：2008-12-18
申请号：PCT/US2008007102
申请日：2008-06-06
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , KALABAT DALIA , LU MIN , GAO NA , WHITE EVAN
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , KALABAT DALIA , LU MIN , GAO NA , WHITE EVAN
IPC分类号： C40B30/04 , C12N5/10 , C12Q1/68
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.
摘要翻译：本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染。特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定的味细胞，例如来自味细胞悬浮液。

4. 发明申请

WO2010065863A3 ASSAYS FOR IDENTIFYING GENES ENCODING SALTY TASTE RECEPTORS AND MODULATORS 审中-公开
标题翻译：用于识别编码盐类受体和调节剂的基因的测定
公开(公告)号：WO2010065863A3
公开(公告)日：2010-10-14
申请号：PCT/US2009066788
申请日：2009-12-04
申请人： SENOMYX INC , MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
发明人： MOYER BRYAN , ZLOTNIK ALBERT , HEVEZI PETER , SOTO HORTENSIA , LU MIN , GAO NA , SAGANICH MICHAEL , DAHAN MICHAEL , LAITA BIANCA , SERVANT GUY , BRUST PAUL , WILLIAMS MARK
IPC分类号： C07K14/705
CPC分类号： G01N33/5008 , A01K2267/03 , C07K14/705 , G01N2333/705
摘要： The present invention relates to rationales for selecting salty taste receptors from a discrete set of taste specific genes disclosed infra by use of methods including electrophysiology, bioiirformatics, and quantitative gene expression assays using transgenic animals as well as functional assays wherein these salty taste receptors may be expressed alone or in association with other taste specific polypeptides such as TRPML3, PKD2L1 or GPRl 13. In addition the invention relates to the use of the identified salty taste receptors in assays, preferably high- throughput, in order to identify modulators which maybe used as flavor additives to modulate salty taste. Preferably, the invention provides high- throughput mammalian and medium- throughput oocyte- based electrophysiological assays for identifying human TRPML3 modulators, preferably TRPML3 enhancers. Compounds that modulate TRPML3 function in the assay are expected to affect salty taste in humans. The inventive electrophysiological assays, such as the two-electrode voltage-clamp technique, facilitate the identification of compounds which specifically modulate human TRPML3. The assays of the invention provide a robust screen useful to detect compounds that facilitate (enhance) or inhibit TRPML3 function. Compounds that enhance or block TRPML3 channel activity should thereby modulate salty taste. In addition, these compounds maybe used to regulate sodium excretion, urinary output and other biological functions relating to sodium levels. This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The TRPML3 gene also modulates one or more of sodium metabolism, sodium excretion, blood pressure, fluid retention, cardiac function and urinary functions such as urine production and excretion.
摘要翻译：本发明涉及通过使用包括电生理学，生物信息学和使用转基因动物的定量基因表达测定的方法以及其中这些咸味受体可能的功能测定法从下文所公开的离散的味道特异性基因组中选择咸味受体的理由单独表达或与其它味道特异性多肽如TRPML3，PKD2L1或GPR113共同表达。此外，本发明涉及鉴定的咸味受体在测定中的应用，优选高通量，以便鉴定可用作风味添加剂调味咸味。优选地，本发明提供用于鉴定人类TRPML3调节剂（优选TRPML3增强子）的高通量哺乳动物和中等通量的基于卵母细胞的电生理测定。在测定中调节TRPML3功能的化合物预期会影响人体的咸味。本发明的电生理测定，例如双电极电压钳技术，有助于鉴定特异性调节人TRPML3的化合物。本发明的测定法提供了一种可用于检测促进（增强）或抑制TRPML3功能的化合物的稳健筛选。增强或阻断TRPML3通道活性的化合物应该调节咸味。此外，这些化合物也可用于调节与钠水平相关的钠排泄，泌尿生产和其他生物学功能。本发明涉及TRPML3涉及包括人和可能的其他哺乳动物在内的灵长类动物的咸味感知（给出钠和其它离子对生理功能和条件的重要性，该表型可能在不同动物中强烈保守）。 TRPML3基因还调节钠代谢，钠排泄，血压，流体保留，心脏功能和尿液功能如尿液产生和排泄中的一种或多种。

5. 发明申请

WO2007092185A3 ASSAYS AND ENHANCERS OF THE HUMAN DELTA ENAC SODIUM CHANNEL 审中-公开
标题翻译：人类DELTA ENAC SODIUM CHANNEL的测定和增强
公开(公告)号：WO2007092185A3
公开(公告)日：2008-02-28
申请号：PCT/US2007002293
申请日：2007-01-26
申请人： SENOMYX INC , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO
发明人： MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/02 , G01N33/14
摘要： This invention relates to electrophysiological assays that measure sodium conductance activity of a delta human epithelial sodium channel (ENaC) in the presence and absence of delta hENaC enhancers. Also, the invention generally relates to assays for identifying compounds that enhance the activity of delta hENaC, especially in an oocyte expression system. These compounds have potential application in modulating (enhancing) salty taste perception.
摘要翻译：本发明涉及在存在和不存在δHENaC增强子的情况下测量δ人上皮钠通道（ENaC）的钠电导活性的电生理测定。此外，本发明一般涉及用于鉴定增强δHENaC活性的化合物的测定法，特别是在卵母细胞表达系统中。这些化合物在调节（增强）咸味感觉方面具有潜在的应用。

6. 发明申请

WO2007047127A3 OPTIMIZED TRPM8 NUCLEIC ACID SEQUENCES AND THEIR USE IN CELL BASED ASSAYS AND TEST KITS TO IDENTIFY TRPM8 MODULATORS 审中-公开
标题翻译：优化的TRPM8核酸序列及其在基于细胞的测定和试剂盒中识别TRPM8调节子的应用
公开(公告)号：WO2007047127A3
公开(公告)日：2007-07-26
申请号：PCT/US2006038962
申请日：2006-10-04
申请人： SENOMYX INC , SERVANT GUY , BRUST PAUL , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , DAHAN DAVID , ZOLLER MARK , WILLIAMS MARK , KIMMICH RACHEL , KAMDAR POONIT , DITSCHUN TANYA , PATRON ANDREW
发明人： SERVANT GUY , BRUST PAUL , MOYER BRYAN , LU MIN , ECHEVERRI FERNANDO , DAHAN DAVID , ZOLLER MARK , WILLIAMS MARK , KIMMICH RACHEL , KAMDAR POONIT , DITSCHUN TANYA , PATRON ANDREW
IPC分类号： G01N33/53 , C07H21/04 , C07K1/00
CPC分类号： C07K14/705
摘要： Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative to a wild-type human TRPM8 nucleic acid sequence in order to optimize ion channel expression in desired cells. Assays using these modified TRPM8 sequences have been shown to identify compounds that modulate the human TRPM8 ion channel better or comparably to known coolants such as menthol and icilin.
摘要翻译：提供了在人细胞中有效表达的修饰的人TRPM8核酸序列和基于细胞的测定法以及包含其的测试试剂盒。这些测定法使用表达根据本发明的修饰的人TRPM8核酸序列的细胞鉴定TRPM8调节剂，其中所述序列相对于野生型人TRPM8核酸序列进行了修饰以优化所需细胞中的离子通道表达。已显示使用这些修饰的TRPM8序列的测定鉴定了比已知的冷却剂如薄荷醇和icilin更好或更可比的调节人TRPM8离子通道的化合物。

7. 发明申请

WO03022869A2 HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE CLYCOPROTEIN MUTANTS AND USES THEREOF 审中-公开
标题翻译：人类免疫缺陷病毒包涵体突变体及其用途
公开(公告)号：WO03022869A2
公开(公告)日：2003-03-20
申请号：PCT/US0228331
申请日：2002-09-06
申请人： PROGENICS PHARM INC , CORNELL RES FOUNDATION INC , MOORE JOHN P , BINLEY JAMES M , LU MIN , OLSON WILLIAM C , SCHULKE NORBERT , GARDNER JASON , MADDON PAUL J , SANDERS ROGIER
发明人： MOORE JOHN P , BINLEY JAMES M , LU MIN , OLSON WILLIAM C , SCHULKE NORBERT , GARDNER JASON , MADDON PAUL J , SANDERS ROGIER
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/48 , A61P31/18 , C07K20060101 , C07K14/16 , C07K16/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/48 , C12P21/02 , C07K
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/505 , A61K2039/545 , A61K2039/55522 , A61K2039/55555 , A61K2039/55577 , A61K2039/60 , A61K2039/6056 , A61K2039/622 , A61K2039/64 , C12N2740/16122 , C12N2740/16134
摘要： This invention provides stable HIV-1 pre-fusion envelope glycoprotein trimeric complexes. This invention also provides related polypeptides and compositions comprising pharmaceutically acceptable particles and the trimeric complexes operably affixed thereto. This invention further provides related nucleic acids, vectors, host cells, compositions, production methods, and prophylactic and therapeutic methods.
摘要翻译：本发明提供稳定的HIV-1预融合包膜糖蛋白三聚体复合物。本发明还提供了相关多肽和包含药学上可接受的颗粒的组合物和可操作地固定于其上的三聚体复合物。本发明还提供了相关的核酸，载体，宿主细胞，组合物，生产方法以及预防和治疗方法。

8. 发明申请

WO2015096105A1 DUAL-ROTOR MAGNETIC PERMEANCE HARMONIC TYPE AC PERMANENT MAGNETIC COMPOSITE MOTOR 审中-公开
标题翻译：双转子磁性渗透型谐波型永磁复合电机
公开(公告)号：WO2015096105A1
公开(公告)日：2015-07-02
申请号：PCT/CN2013090592
申请日：2013-12-26
申请人： LU MIN , YU HONGJIN
发明人： LU MIN , YU HONGJIN
IPC分类号： H02K16/02
CPC分类号： H02K16/02 , H02K7/11
摘要： A dual-rotor magnetic permeance harmonic type AC permanent magnetic composite motor, which may be applied to the field of industrial drives, such as wind power generation, hybrid drives, ship drives and servo drives. The motor is composed of a stator having a 2ps pole stator winding (1), a hollow permanent magnetic rotor having a 2pr pole rotor permanent magnet (5) and a salient pole type magnetic permeance wave rotor (10) having a number of Zb magnetic permeance waves which make up main drive components of the rotor; all three of the stator, the hollow permanent magnetic rotor and the salient pole type magnetic permeance wave rotor are in a concentric type distributed structure, and they have an air gap between each other and are coupled through a radial air gap magnetic field, and by using the principle of magnetic permeance harmonic gear transmission and AC permanent magnetic motor, high-speed rotational electromagnetic field motion and mechanical rotation motion are modulated into a resultant motion for outputting same through the salient pole type magnetic permeance wave rotor, so as to realize the controllable driving of the power of variable speed and variable torque without mechanical contact and without friction.
摘要翻译：双转子磁导谐波型交流永磁复合电机，可应用于风力发电，混合动力驱动，船舶驱动和伺服驱动等工业驱动领域。电动机由具有2ps极定子绕组（1）的定子，具有2pr极转子永磁体（5）的空心永磁转子和具有多个Zb磁性的凸极型磁导波转子（10）组成构成转子主驱动部件的磁导波; 所有三个定子，中空永磁转子和凸极型磁导波转子均为同心型分布结构，它们之间具有气隙，并通过径向气隙磁场耦合，并通过使用磁导率谐波齿轮传动和交流永磁电动机的原理，将高速旋转电磁场运动和机械旋转运动调制成通过凸极型磁导波转子输出的合成运动，从而实现可控驱动变速和可变转矩的功率，无机械接触和无摩擦。

9. 发明申请

WO2006052835A3 CRYOPRESERVATION OF CELLS 审中-公开
标题翻译：细胞CRYOPRESERVATION
公开(公告)号：WO2006052835A3
公开(公告)日：2007-03-01
申请号：PCT/US2005040183
申请日：2005-11-04
申请人： DOW AGROSCIENCES LLC , AINLEY WILLIAM MICHAEL , BERINGER JEFFREY R , LARSEN CORY MICHELLE LEATHERMA , LU MIN , SHEN LIU YIN , JAYAKUMAR PON SAMUEL , GARRISON ROBBI JANETTE , PAREDDY DAYAKAR REDDY
发明人： AINLEY WILLIAM MICHAEL , BERINGER JEFFREY R , LARSEN CORY MICHELLE LEATHERMA , LU MIN , SHEN LIU YIN , JAYAKUMAR PON SAMUEL , GARRISON ROBBI JANETTE , PAREDDY DAYAKAR REDDY
IPC分类号： C12N5/02 , C12N5/04 , C12N5/14
CPC分类号： A01N3/00 , A01N1/02 , A01N1/0278 , C12N5/04
摘要： The present invention relates to methods for the cryopreservation of transformed and non-transformed cells. Also provided by the subject invention are methods of recovering cells that have been cryopreserved. Cultures of cells that have been successfully recovered from cryopreservation are also provided.
摘要翻译：本发明涉及用于转化和未转化细胞的低温保存的方法。本发明还提供了回收已被冷冻保存的细胞的方法。还提供了从冷冻保存中成功回收的细胞培养物。

10. 发明申请

WO2004114293A8 A NON-HOLE OPTICAL DISC FOR DATA STORAGE AND READING 审中-公开
标题翻译：用于数据存储和读取的非孔光盘
公开(公告)号：WO2004114293A8
公开(公告)日：2005-02-17
申请号：PCT/CN2004000676
申请日：2004-06-23
申请人： UNIV TSINGHUA , CHENGDU TOSUN SCIENCE AND TECH , GONG MALI , HUANG LEI , PAN LONGFA , YAO YUAN , LU MIN , MA SHURONG
发明人： GONG MALI , HUANG LEI , PAN LONGFA , YAO YUAN , LU MIN , MA SHURONG
IPC分类号： G11B7/007 , G11B7/24012 , G11B7/24
CPC分类号： G11B7/24012
摘要： The present invention relates to a non-hole optical disc for data storage and reading, it belongs to the field of the high density digital optical storage technique. The optical disc includes a substrate layer, a cover layer and an information record layer, The substrate layer, the cover layer and the information record layer are stacked together in this order. From the center to the periphery, the information record layer is divided into a lead-out area, a data area and a lead-in area, or is divided into a lead-in area, a data area and a lead-out area, or is formed as a data record layer in its entirety. The data area of the non-hole optical disc has closely-arranged circular information tracks or spiral information tracks. The non-hole optical disc further comprises a decorating area; it is provided on the periphery of the disc, the shape of the decorating area could be square, circle or other geometric shape. The material of the periphery part of the center of the optical disc can be the same as or different from that of other parts of the optical disc. The non-hole optical disc according to the present invention increases the data storage area of optical disc; therefore it has larger memory capacity. The present invention is suitable for the optical information pick up/record apparatus for the optical disc or other information pick up/record mechanism.
摘要翻译：本发明涉及用于数据存储和读取的非孔光盘，它属于高密度数字光存储技术领域。光盘包括基板层，覆盖层和信息记录层。基板层，覆盖层和信息记录层依次堆叠在一起。从中心到外围，信息记录层被划分为导出区，数据区和导入区，或者分为导入区，数据区和导出区，或者形成为完整的数据记录层。非孔光盘的数据区域具有紧密排列的循环信息轨道或螺旋信息轨迹。非孔光盘还包括装饰区域; 它设置在圆盘的周边上，装饰区域的形状可以是正方形，圆形或其它几何形状。光盘中心的外围部分的材料可以与光盘的其它部分的材料相同或不同。根据本发明的非孔光盘增加了光盘的数据存储区域; 因此它具有更大的内存容量。本发明适用于光盘或其他信息拾取/记录机构的光信息拾取/记录装置。

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