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1. 发明申请

WO2010064435A8 METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 审中-公开
标题翻译：测定人体液中胱氨酸C的方法
公开(公告)号：WO2010064435A8
公开(公告)日：2010-09-16
申请号：PCT/JP2009006590
申请日：2009-12-03
申请人： SEKISUI MEDICAL CO LTD , NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
发明人： NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577
CPC分类号： G01N33/543 , G01N33/6893 , G01N2333/8139
摘要： Disclosed is a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity, is more inexpensive, and can be automated more readily compared with conventional assay methods in which polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor aggregability have been used in large quantities. The particle-enhanced immunoassay method utilizes a combination of an antibody-sensitized particle comprising an insoluble carrier particle and an anti-human cystatin C monoclonal antibody having higher affinity and bound to the particle and an antibody-sensitized particle comprising the insoluble carrier particle and an anti-human cystatin C monoclonal antibody having a different recognition site from that of the aforementioned monoclonal antibody and having a relatively lower affinity, wherein the quantity of each of the human cystatin C monoclonal antibodies bound to the insoluble carrier particle is less than 5 wt% relative to the weight of the antibody-sensitized particle.
摘要翻译：公开了一种人体液中半胱氨酸蛋白酶抑制剂C的颗粒增强免疫测定方法，与特异性低的多克隆抗体或特异性高的单克隆抗体的常规测定方法相比，该方法具有更高的特异性，更便宜，并且可以更容易自动化但具有较差的可聚合性已被大量使用。颗粒增强免疫测定方法利用包含不溶性载体颗粒的抗体敏化颗粒和具有较高亲和力且结合于颗粒的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体的组合以及包含不溶性载体颗粒和抗体敏化颗粒与上述单克隆抗体具有不同识别位点并具有相对较低亲和力的抗人半胱氨酸蛋白酶抑制剂C单克隆抗体，其中与不溶性载体颗粒结合的每种人半胱氨酸蛋白酶抑制剂C单克隆抗体的量小于5重量％相对于抗体致敏颗粒的重量。

2. 发明专利

JPS61240910A TOOTH POLISHING APPARATUS 失效
公开(公告)号：JPS61240910A
公开(公告)日：1986-10-27
申请号：JP8032285
申请日：1985-04-17
申请人： INOUE JAPAX RES , SHIMIZU TOMO
发明人： INOUE KIYOSHI , SHIMIZU TOMO
IPC分类号： A46B11/02

3. 发明专利

JPH0312150A ARTIFICIAL DENTAL ROOT 失效
公开(公告)号：JPH0312150A
公开(公告)日：1991-01-21
申请号：JP14779889
申请日：1989-06-09
申请人： INOUE K , SHIMIZU TOMO , IWAMIZU KATSUHIKO , MIYAJI TOSHIYUKI , MIYAZAKI TAKASHI
发明人： INOUE KIYOSHI , SHIMIZU TOMO , IWAMIZU KATSUHIKO , MIYAJI TOSHIYUKI , MIYAZAKI TAKASHI
IPC分类号： A61C8/00
摘要： PURPOSE:To improve holding ability and to obtain stable holding by almost parallelly providing two blades, forming a planting part, coupling these blades in the shape of a saddle, for which an upper part is opened, and forming a planting tip edge in one circular arc shape or in a shape where two circular arcs are crossed at least. CONSTITUTION:Two blades 1 with the same dimension are parallelly fixed at an interval A of 2-3mm. The central parts in the upper ends of the blades 1 are coupled by a U-shaped bridge coupling part 4 for fixing and just formed in the shape of the saddle, for which the upper part is opened. Then, nutrition is supplied through an opening window to a bone and the bone is reproduced to swell up. By using a rotary machine tool 5 for which a rotary radius is almost equal with a radius (r) for a circular arc 1b of the blade 1 and thickness is almost equal with thickness (t) of the blade, a bone 6 is notched from the top of an alveolus, whose dental root is opened, and cut to depth at a degree that the blades 1 can be just embedded. Thus, since the two blades 1 are parallelly coupled at the interval A, an artificial dental root is strongly fixed to the bone without fail and planting can be executed with the high holding ability.

4. 发明专利

JPS6411539A ARTIFICIAL DENTAL ROOT 失效
公开(公告)号：JPS6411539A
公开(公告)日：1989-01-17
申请号：JP16645287
申请日：1987-07-03
申请人： SHIMIZU TOMO , INOUE K
发明人： SHIMIZU TOMO , INOUE KIYOSHI
IPC分类号： A61C8/00
摘要： PURPOSE:To prevent the danger of damage when an upper jaw or lower jaw tube is inserted, by molding an artificial dental root by punching the same from a rolled or forged plate material composed of titanium or a titanium alloy by a wire cutting discharge machining method. CONSTITUTION:An artificial dental root is composed of a rolled or forged plate material having a thickness of about 1.2-2.5mm of titanium or a titanium alloy and processed and molded by a method wherein one plate material or a desired number of the plate materials in a laminated and integrated state is punched into a predetermined shape and predetermined dimensions by a wire cutting discharge machining method. Through-holes 3A having a diameter of about 2-4mmphi for strengthening the bonding with the dental root after implantation are formed to the flat part between the corner parts 3a and bottom part 3b of a leg part in an up-and-down direction in a distributed state and the inner wall surface of each through-hole 3A becomes a fine uneven surface by discharge machining to increase in its surface area and the adhesion and bonding with a tooth bone is well performed.

5. 发明专利

MX2011003927A METODO DE MEDICION DE INSULINA. 未知
公开(公告)号：MX2011003927A
公开(公告)日：2011-07-20
申请号：MX2011003927
申请日：2010-07-21
申请人： SEKISUI MEDICAL CO LTD
发明人： SHIMIZU TOMO , NAKAMURA YASUSHI , KONDOU JUNICHI , YAMAMOTO MITSUAKI
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545
摘要： Se describe un método de medición y un reactivo de medición, ambos son específicos para insulina y hacen posible la medición precisa solamente de insulina con alta sensibilidad sin la influencia de proinsulina o algún compuesto similar a insulina. Específicamente se describe un método de medición y un reactivo, ambos hacen posible la medición específica de insulina mediante la utilización de un anticuerpo incapaz de reaccionar con insulina que no está unida a un anticuerpo antiinsulina, pero capaz de reaccionar con insulina que está unida a un anticuerpo antiinsulina.

6. 发明专利

MY189968A MONOCLONAL ANTIBODY, AND IMMUNOASSAY USING THE SAME 未知
公开(公告)号：MY189968A
公开(公告)日：2022-03-22
申请号：MYPI2018000889
申请日：2009-09-03
申请人： SEKISUI MEDICAL CO LTD
发明人： TAKAHASHI YUKI , SHIMIZU TOMO , TAKAHASHI HIROSHI , NAKAMURA YASUSHI
IPC分类号： C12P21/08 , C07K16/42 , C12N5/10 , G01N33/53
摘要： An objective of the present invention is to provide an anti-human IgM monoclonal antibody that is capable of reacting specifically with human IgM and inducing immunoagglutination based on an antigen-antibody reaction with human IgM in solution, and an immunoassay using the said monoclonal antibody. Another objective of the present invention is to provide an agent for suppressing non-specific reactions caused by human lgM that could not be prevented by conventional methods, and an immunoassay in which non-specific reactions caused by human IgM are suppressed. By selecting a monoclonal antibody that reacts with human lgM on the basis of evaluation of reactivity with human IgM in solution, a novel monoclonal antibody capable of agglutinating human IgM by itself and performing a practical immunoagglutination assay has been obtained, and the objectives above have been thus achieved.

7. 发明专利

CA2964771C ANTI-HUMAN IGM MONOCLONAL ANTIBODY AND IMMUNOASSAY USING THE SAME 未知
公开(公告)号：CA2964771C
公开(公告)日：2019-01-15
申请号：CA2964771
申请日：2009-09-03
申请人： SEKISUI MEDICAL CO LTD
发明人： TAKAHASHI YUKI , SHIMIZU TOMO , TAKAHASHI HIROSHI , NAKAMURA YASUSHI
IPC分类号： G01N33/577 , C07K16/42
摘要： An immunoassay for determining the quantity of an analyte in a sample based on an antigen-antibody reaction between the analyte and an assay antibody or an assay antigen, wherein non-specific reactions are suppressed by the addition of an anti-human IgM monoclonal antibody that reacts specifically with human IgM and is capable of inducing immunoagglutination by itself based on an antigen-antibody reaction with human IgM in solution, or a functional fragment derived from said anti-human IgM antibody, wherein the functional fragment comprises a Fab region derived from the said anti-human IgM antibody, and wherein the analyte is not human IgM.

8. 发明专利

CA2745610C METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 未知
公开(公告)号：CA2745610C
公开(公告)日：2017-10-31
申请号：CA2745610
申请日：2009-12-03
申请人： SEKISUI MEDICAL CO LTD
发明人： NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577
摘要： There is provided a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity and is easily automatable at low cost as compared with conventional assay methods that use large amounts of polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor agglutinability. Disclosed is an assay method specific to cystatin C in a human body fluid, which is a particle-enhanced immunoassay method utilizes a combination of antibody-coated particles in which some insoluble carrier particles are coated with anti-human cystatin C monoclonal antibodies of one type which have high affinity and in which some other insoluble carrier particles are coated with anti-human cystatin C monoclonal antibodies of one type which recognize an epitope different from that of the monoclonal antibody of the first-mentioned type and which have relatively low affinity, wherein the binding amount of the anti-human cystatin C monoclonal antibodies relative to the total weight of the particles being coated with the corresponding antibodies is less than 5% by weight.

9. 发明专利

AU2010274320B2 Insulin measurement method 未知
公开(公告)号：AU2010274320B2
公开(公告)日：2013-08-01
申请号：AU2010274320
申请日：2010-07-21
申请人： SEKISUI MEDICAL CO LTD
发明人： KONDOU JUNICHI , SHIMIZU TOMO , YAMAMOTO MITSUAKI , NAKAMURA YASUSHI
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545
摘要： Disclosed are a measurement method and a measurement reagent, both of which are specific to insulin and enable the accurate measurement of only insulin with high sensitivity without the influence from proinsulin or any insulin-like compound. Specifically disclosed are a measurement method and a reagent, both of which enable the specific measurement of insulin by utilizing an antibody incapable of reacting with insulin that is not bound to an anti-insulin antibody but capable of reacting with insulin that is bound to an anti-insulin antibody.

10. 发明专利

CA2745610A1 METHOD FOR MEASURING CYSTATIN C IN HUMAN BODY FLUID 未知
公开(公告)号：CA2745610A1
公开(公告)日：2010-06-10
申请号：CA2745610
申请日：2009-12-03
申请人： SEKISUI MEDICAL CO LTD
发明人： NAKAYAMA SHINYA , TAKAHASHI HIROSHI , NAKAMURA YASUSHI , SHIMIZU TOMO
IPC分类号： G01N33/53 , G01N33/543 , G01N33/577
摘要： Disclosed is a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity, is more inexpensive, and can be automated more readily compared with conventional assay methods in which polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor aggregability have been used in large quantities. The particle-enhanced immunoassay method utilizes a combination of an antibody-sensitized particle comprising an insoluble carrier particle and an anti-human cystatin C monoclonal antibody having higher affinity and bound to the particle and an antibody-sensitized particle comprising the insoluble carrier particle and an anti-human cystatin C monoclonal antibody having a different recognition site from that of the aforementioned monoclonal antibody and having a relatively lower affinity, wherein the quantity of each of the human cystatin C monoclonal antibodies bound to the insoluble carrier particle is less than 5 wt% relative to the weight of the antibody-sensitized particle.

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