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1. 发明专利

CA2646620A1 THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS 未知
公开(公告)号：CA2646620A1
公开(公告)日：2007-10-25
申请号：CA2646620
申请日：2007-03-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SAKUMA MAKOTO , OTSUKA AKIRA
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00 , A61P43/00
摘要： A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid arthritis, which comprises an antibody that binds to a hepatocyte growth factor receptor as an active ingredient.

2. 发明专利

AT517126T 未知
公开(公告)号：AT517126T
公开(公告)日：2011-08-15
申请号：AT07739097
申请日：2007-03-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C07K16/28 , A61K39/395 , A61P19/02 , A61P29/00 , A61P43/00
摘要： A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid arthritis, which comprises an antibody that binds to a hepatocyte growth factor receptor as an active ingredient.

3. 发明专利

ES2369739T3 AGENTE TERAPEUTICO PARA LA ARTRITIS REUMATOIDE. 未知
公开(公告)号：ES2369739T3
公开(公告)日：2011-12-05
申请号：ES07739097
申请日：2007-03-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C07K16/28 , A61K39/395 , A61P19/02 , A61P29/00 , A61P43/00
摘要： Un agente terapéutico para uso en el tratamiento de la artritis reumatoide, que comprende un anticuerpo que se une específicamente al receptor del factor de crecimiento de hepatocitos (HGFR) como principio activo, en el que el anticuerpo tiene la capacidad de inhibir la unión entre el factor de crecimiento de hepatocitos (HGF) y el HGFR.

4. 发明专利

CA2646620C THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS 未知
公开(公告)号：CA2646620C
公开(公告)日：2015-07-14
申请号：CA2646620
申请日：2007-03-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： A61K39/395 , A61P19/02 , A61P29/00 , A61P43/00
摘要： A therapeutic agent for rheumatoid arthritis, particularly a therapeutic agent for ameliorating an inflammatory symptom or bone deformity in rheumatoid arthritis, which comprises an antibody that binds to a hepatocyte growth factor receptor as an active ingredient.

5. 发明公开

EP1997511A4 THERAPEUTIC AGENT FOR RHEUMATOID ARTHRITIS 有权
标题翻译：治疗剂用于治疗类风湿性关节炎
公开(公告)号：EP1997511A4
公开(公告)日：2010-01-27
申请号：EP07739097
申请日：2007-03-20
申请人： SEIKAGAKU KOGYO CO LTD
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C07K16/28 , A61K39/395 , A61P19/02 , A61P29/00 , A61P43/00
CPC分类号： C07K16/2863 , A61K2039/505

6. 发明专利

JP2009247220A Carrier for gene subtraction and use thereof 审中-公开
标题翻译：载体用于遗传物质和其使用
公开(公告)号：JP2009247220A
公开(公告)日：2009-10-29
申请号：JP2008095116
申请日：2008-04-01
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a tool which can simply, quickly, highly precisely and widely apply a gene subtraction method to genes, and to provide a gene subtraction method by which the tool can simply, quickly, highly precisely and widely be applied to genes.
SOLUTION: Provided are the carrier for gene subtraction, to which [a nucleic acid holding a nucleotide sequence annealing to (a nucleotide sequence common to a gene family as the target of the gene subtraction)] is bound, and a gene subtraction method using the same. The (gene family as the target of the gene subtraction) is preferably a protein kinase gene family, and the (protein kinase gene family) preferably comprises tyrosine kinase family and serine/threonine kinase family.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种可以简单，快速，高度精确和广泛地将基因减法方法应用于基因的工具，并提供一种基因减法方法，通过该方法，该工具可以简单，快速，高度精确和广泛地应用于基因。提供了基因减法的载体，[将基因家族的碱基序列退火（作为基因减去的靶标的基因家族共有的核苷酸序列）的核酸结合到其上并进行基因减法方法使用相同。（基因家族作为基因减法的靶）优选为蛋白激酶基因家族，（蛋白激酶基因家族）优选包含酪氨酸激酶家族和丝氨酸/苏氨酸激酶家族。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2009089697A Screening method of active component candidate substance 有权
标题翻译：活性成分候选物质的筛选方法
公开(公告)号：JP2009089697A
公开(公告)日：2009-04-30
申请号：JP2007266133
申请日：2007-10-12
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C12Q1/68 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To provide a simple, rapid, efficient and accurate screening method for active component candidate substances of treating agents against arthrorheumatism. SOLUTION: The screening method of candidate substances for active components of treating agents against arthrorheumatism includes at least the following step: a step for selecting substances, having inhibiting action to activity of "protein kinase changed in appearance in cells of an animal suffering from arthrorheumatism, in comparison with cells of an animal which do not suffer from arthrorheumatism". Before the step, the following step is preferably included: a step of selecting "protein kinase changed in appearance in cells of an animal suffered from arthrorheumatism, in comparison with cells of an animal not suffered from arthrorheumatism". Furthermore, this step is preferably performed by a gene subtraction method. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种简单，快速，有效和准确的筛选方法，用于治疗药物的抗焦虑作用的活性成分候选物质。解决方案：用于治疗抗感染性药物的活性成分的候选物质的筛选方法至少包括以下步骤：选择物质的步骤，对动物细胞中的蛋白激酶的外观变化具有抑制作用来自arthallheumatism，与不患有arthallheumatism的动物的细胞相比“。在该步骤之前，优选包括以下步骤：选择“与不伴有感冒性动物的动物的细胞相比，具有相对于感冒的动物的细胞中的外观变化的蛋白激酶变化”的步骤。此外，该步骤优选通过基因减法方法进行。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2009089696A Carrier for gene subtraction and utilization thereof 有权
标题翻译：携带者遗传和遗传利用
公开(公告)号：JP2009089696A
公开(公告)日：2009-04-30
申请号：JP2007266132
申请日：2007-10-12
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： OTSUKA AKIRA , SAKUMA MAKOTO
IPC分类号： C12N15/09 , C12M1/00
摘要： PROBLEM TO BE SOLVED: To provide a tool for enabling a gene subtraction method to be applied simply, rapidly and highly accurately to wide genes, and to provide the gene subtraction method by using the tool and applicable to the wide genes simply, rapidly and highly accurately.
SOLUTION: The carrier for the gene subtraction is obtained by binding a nucleic acid having a nucleotide sequence annealing with a nucleotide sequence common to a gene family targeted by the gene subtraction. The gene subtraction method uses the carrier. The gene family targeted by the gene subtraction is preferably a protein kinase gene family, and the protein kinase gene family preferably comprises a tyrosine kinase family and a serine/threonine kinase family.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种使基因减法方法能够简单，快速，高度准确地应用于广泛基因的工具，并且通过使用该工具并简单地适用于宽基因来提供基因减法方法，快速，高度准确。解决方案：通过将具有核苷酸序列退火的核酸与通过基因减法靶向的基因家族共有的核苷酸序列结合，获得基因扣除载体。基因减法方法使用载体。基因减法所靶向的基因家族优选为蛋白激酶基因家族，蛋白激酶基因家族优选包含酪氨酸激酶家族和丝氨酸/苏氨酸激酶家族。版权所有（C）2009，JPO＆INPIT

9. 发明专利

JP2004002369A Pharmaceutical composition 有权
公开(公告)号：JP2004002369A
公开(公告)日：2004-01-08
申请号：JP2003102368
申请日：2003-04-07
申请人： Seikagaku Kogyo Co Ltd , 生化学工業株式会社
发明人： MIYAUCHI SATOSHI , SAKUMA MAKOTO , TAWADA AKIRA , SAITO KAZUKO , TAKAHASHI KATSUYA
IPC分类号： A61K31/737 , A61K31/7008 , A61P17/02 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a substance exhibiting wound-healing promoting action and more useful as a medicine than a conventional medicine and a medicine using the substance.
SOLUTION: The present invention provides a composition composed of heparan sulfate and glucosamine, and a glucosamine salt of heparan sulfate, based on expression of synergistic wound-healing effect obtained when heparan sulfate and glucosamine are administered at the same time and also provides a medicine using these substances as active ingredients, particularly a medicine useful for healing diseases accompanying damages in skin, mucous membrane, corneal upper cortex, etc.
COPYRIGHT: (C)2004,JPO

10. 发明专利

JP2002322089A NITROGEN OXIDE PRODUCTION INHIBITOR 失效
公开(公告)号：JP2002322089A
公开(公告)日：2002-11-08
申请号：JP2001126160
申请日：2001-04-24
申请人： SEIKAGAKU KOGYO CO LTD
发明人： SAKUMA MAKOTO , MIYAUCHI SATOSHI , FUJII NORIHISA
IPC分类号： A61K38/46 , A61P19/02 , A61P29/00 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a new application of a chondroitinase, especially chondroitinase ABC, specifically to provide a pharmaceutical preparation making use of the activity to prevent or inhibit cyto/histotoxicities due to nitrogen oxides or anti-inflammatory activity. SOLUTION: A chondroitinase, for example, chondroitinase ABC, is used as the objective nitrogen oxide production inhibitor, as a pharmaceutical preparation for the administration to the intervertebral disk or dura mater spinalis outer cavity, e.g. for treating hernia of the intervertebral disk, as a prophylactic agent or inhibitor for cyto/histotoxicities, or as an anti-inflammatory agent.

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