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1. 发明申请

WO2007111952A3 METHOD OF PREPARING GLYCOPEPTIDES 审中-公开
标题翻译：制备糖蛋白的方法
公开(公告)号：WO2007111952A3
公开(公告)日：2009-04-02
申请号：PCT/US2007007142
申请日：2007-03-22
申请人： SCRIPPS RESEARCH INST , WONG CHI-HUEY , BRIK ASHRAF , YANG YU-YING , FICHT SIMON , PAYNE RICHARD
发明人： WONG CHI-HUEY , BRIK ASHRAF , YANG YU-YING , FICHT SIMON , PAYNE RICHARD
IPC分类号： A61K38/15 , C07C29/00 , C07K11/02 , C12N5/02
CPC分类号： C07K9/00 , C07K9/001
摘要： A method is provided for the synthesis of glycopeptides using a sugar assisted ligation strategy, wherein an N-terminal peptide portion in the form of a thioester is coupled with a C-terminal peptide portion bearing a carbohydrate moiety comprising a thiol group.
摘要翻译：提供了使用糖辅助连接策略合成糖肽的方法，其中硫酯形式的N-末端肽部分与含有硫醇基团的碳水化合物部分的C末端肽部分偶联。

2. 发明申请

WO2006002382A3 ARRAYS WITH CLEAVABLE LINKERS 审中-公开
标题翻译：带有可拆卸连接器的阵列
公开(公告)号：WO2006002382A3
公开(公告)日：2006-10-12
申请号：PCT/US2005022517
申请日：2005-06-24
申请人： SCRIPPS RESEARCH INST , WONG CHI-HUEY
发明人： WONG CHI-HUEY
IPC分类号： G01N33/53 , A61K31/702 , C07H3/06
CPC分类号： G01N33/54353 , A61K31/716 , C07H3/06 , G01N33/56972 , G01N33/56988 , G01N33/57415 , G01N2400/02 , G01N2400/14
摘要： The invention provides arrays of molecules where the molecules (e.g., glycans) are attached to the arrays by cleavable linkers. The invention also provides methods for using these arrays, methods for identifying the structural elements of molecules bound to these arrays by using the cleavable linkers, especially the structural elements that are important for binding to test samples. The invention further provides methods for evaluating whether test samples and test molecules can bind to distinct glycans on the arrays and useful glycans identified using the methods and arrays provided herein.
摘要翻译：本发明提供了分子阵列，其中分子（例如，聚糖）通过可切割接头连接到阵列上。本发明还提供了使用这些阵列的方法，通过使用可切割接头，特别是结合测试样品重要的结构元件来鉴定与这些阵列结合的分子的结构元件的方法。本发明还提供了用于评价测试样品和测试分子是否可以结合阵列上的不同聚糖和使用本文提供的方法和阵列鉴定的有用聚糖的方法。

3. 发明申请

WO03077868A3 SYNTHESIS OF SYNTHONS FOR THE MANUFACTURE OF BIOACTIVE COMPOUNDS 审中-公开
标题翻译：合成生物活性化合物的合成
公开(公告)号：WO03077868A3
公开(公告)日：2004-04-01
申请号：PCT/US0307982
申请日：2003-03-14
申请人： SCRIPPS RESEARCH INST , DIVERSA CORP , WONG CHI-HUEY , LIU JUNJIE , DE SANTIS GRACE , BURK MARK
发明人： WONG CHI-HUEY , LIU JUNJIE , DE SANTIS GRACE , BURK MARK
IPC分类号： C12N15/09 , C12N1/21 , C12N9/88 , C12P17/02 , C12P17/06 , C12P19/02 , C12Q1/02 , C12R1/19 , C12Q1/00 , C12N9/00 , C12P1/00 , C12P33/00
CPC分类号： C12P19/02 , C12N9/88 , C12P17/06 , C12R1/19
摘要： The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.
摘要翻译：本发明基于以下发现：2-脱氧核糖-5-磷酸醛缩酶（DERA，EC 4.1.2.4）及其变体可用于催化多种供体和受体醛之间的顺序不对称醛醇反应。反应产物通常含有至少两个新的立体中心并且可以以对映体纯的形式制备。因此，DERA催化的不对称醛醇化学可以被利用来产生用于合成各种生物活性分子的合成物。

4. 发明申请

WO9808854A3 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO9808854A3
公开(公告)日：1998-08-20
申请号：PCT/EP9704649
申请日：1997-08-26
申请人： CIBA GEIGY AG , SCRIPPS RESEARCH INST , WONG CHI HUEY , LIN CHUN CHENG , WOLTERING THOMAS J , MARRON THOMAS G , MORIS VARAS FRANCISCO , JABLONOWSKI JILL , WEITZ SCHMIDT GABRIELE
发明人： WONG CHI-HUEY , LIN CHUN-CHENG , WOLTERING THOMAS J , MARRON THOMAS G , MORIS-VARAS FRANCISCO , JABLONOWSKI JILL , WEITZ-SCHMIDT GABRIELE
IPC分类号： C07H7/02 , C07H15/00
CPC分类号： C07H7/02 , C07H15/00
摘要： Sialyl Lewis X mimetics which mimic the inhibition of selectin-mediated cellular adhesion by sialyl X having a core of formula (I).

5. 发明申请

WO02067860A3 SELECTION BY MIRROR IMAGE DISPLAY 审中-公开
标题翻译：通过镜子图像显示选择
公开(公告)号：WO02067860A3
公开(公告)日：2003-02-20
申请号：PCT/US0205193
申请日：2002-02-22
申请人： SCRIPPS RESEARCH INST , WONG CHI-HUEY
发明人： WONG CHI-HUEY
IPC分类号： C12N15/10 , C12P19/26 , C12Q1/68 , C40B40/02 , C07H1/00 , C07H5/04 , C12Q1/00 , G01N33/53 , G01N33/543 , G01N33/566
CPC分类号： C40B40/02 , C12N15/1037 , C12N15/1048 , C12P19/26
摘要： Non-naturally occurring binders to cell surface carbohydrates and sugars are identified by a screening process that employs immobilized enantiomers of such cell surface carbohydrates and sugars. Preferred non-naturally occurring binders include D- peptides and L- nucleic acids and are resistance to enzymatic degradation and clearance. Single-chain Fab sequences that bind to sialic acid and KDO in nano-molar affinity were identified by this process. Exemplary screening procedures employed D-KDO, L-sialic acid and an L-sialo-disaccharide have been attached to a solid support for selection of high-affinity binders.
摘要翻译：通过使用这种细胞表面碳水化合物和糖的固定对映异构体的筛选方法来鉴定非天然存在的与细胞表面碳水化合物和糖类的粘合剂。优选的非天然存在的粘合剂包括D-肽和L-核酸，并且具有对酶降解和清除的抗性。通过该过程鉴定了以纳摩尔亲和力结合唾液酸和KDO的单链Fab序列。使用D-KDO，L-唾液酸和L-唾液酸二糖的示例性筛选方法已经连接到用于选择高亲和力结合剂的固体支持物上。

6. 发明申请

WO9414954A3 KDO ALDOLASE AND CONDENSATION REACTIONS EMPLOYED THEREWITH 审中-公开
标题翻译： KDO ALDOLASE和冷凝反应
公开(公告)号：WO9414954A3
公开(公告)日：1994-09-29
申请号：PCT/US9312367
申请日：1993-12-17
申请人： SCRIPPS RESEARCH INST , WONG CHI HUEY , SUGAI TAKESHI , SHEN GWO JENN
发明人： WONG CHI-HUEY , SUGAI TAKESHI , SHEN GWO-JENN
IPC分类号： C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , C12P19/02 , C07H7/02 , C12N1/20
CPC分类号： C12P19/02 , C07H7/027 , C12N9/88 , C12P7/58 , C12P9/00 , Y10S435/822
摘要： Aureobacterium barkerei strain KDO-37-2 (ATCC 49977) KDO aldolase (EC 4.1.2.23) isolated therefrom are disclosed. The DKDO aldolase is further disclosed to have a broad substrate specificity with respect to its reverse reaction, i.e. the condensation of aldoses with pyruvate to form a wide range of 2-keto-3-deoxy-onic acids, including 2-keto-3-deoxy-nonulosonic acid, 2-keto-3-deoxy-octulosonic acid, 2-keto-3-deoxy-heptulosonic acid, and 2-keto-3-deoxy-hexulosonic acid. In particular, 3-deoxy-D-manno-2-octulosonic acid (D-KDO), a vital component of lipopolysaccharides found in the bacterial outer membrane may be synthesized from D-arabinose and pyruvate in 67 % yield. Additionally, protected forms of the KDO aldolase products, e.g. hexaacetyl 2-keto-3-deoxy-nonulosonic acid and pentaacetyl 2-keto-3-deoxy-octulosonic acid, may be decarboxylated to form the corresponding 2-deoxy-aldoses, e.g. 2-deoxy-octulose and 2-deoxy-heptulose respectively.
摘要翻译：公开了从其分离的巴氏杆菌菌株KDO-37-2（ATCC 49977）和KDO醛缩酶（EC 4.1.2.23）。进一步公开KDO醛缩酶相对于其逆反应具有广泛的底物特异性，即醛糖与丙酮酸的缩合形成宽范围的2-酮-3-脱氧酸，包括2-酮-3- 脱氧 - 非酮酸，2-酮-3-脱氧 - 八环酮酸，2-酮-3-脱氧 - 庚酮酸和2-酮-3-脱氧 - 己酸。特别地，在D-细菌外膜中发现的脂多糖的重要组分3-脱氧-D-壬烯-2-辛酮酸（D-KDO）可由D-阿拉伯糖和丙酮酸合成，产率67％。另外，保护形式的KDO醛缩酶产物，例如，六乙酰基2-酮-3-脱氧 - 非酮缩酮酸和五乙酰基2-酮-3-脱氧 - 八环酮酸可以脱羧以形成相应的2-脱氧醛糖，例如。 2-脱氧 - 八酮糖和2-脱氧 - 七氟醚。

7. 发明申请

WO2006045116A2 IN VIVO SITE-SPECIFIC INCORPORATION OF N-ACETYL-GALACTOSAMINE AMINO ACIDS IN EUBACTERIA 审中-公开
标题翻译： N-乙酰半乳糖氨基酸氨基酸在体内的特异性结合
公开(公告)号：WO2006045116A2
公开(公告)日：2006-04-27
申请号：PCT/US2005038250
申请日：2005-10-20
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , HANSON SARAH R , XU RAN , ZHANG ZHIWEN , WONG CHI-HUEY
发明人： SCHULTZ PETER G , HANSON SARAH R , XU RAN , ZHANG ZHIWEN , WONG CHI-HUEY
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C12N9/22 , C12N15/74 , C12P19/34
CPC分类号： C12P21/005 , C12N9/93 , C12N15/67
摘要： Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-cetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
摘要翻译：提供了用于在体外和体内制备糖蛋白的方法和组合物。一种方法涉及将具有N-十六烷基半乳糖胺部分的非天然氨基酸掺入蛋白质中; 任选地，可以用另外的糖进一步修饰含有N-乙酰半乳糖胺的非天然氨基酸。

8. 发明公开

EP3013347A4 GLYCAN CONJUGATES AND USE THEREOF 有权
标题翻译： GLYKANKONJUGATE UND VERWENDUNG DAVON
公开(公告)号：EP3013347A4
公开(公告)日：2017-01-18
申请号：EP14818055
申请日：2014-06-27
申请人： ACAD SINICA , WONG CHI-HUEY , WU CHUNG-YI , WANG CHIA-HUNG , LI SHIOU-TING
发明人： WONG CHI-HUEY , WU CHUNG-YI , WANG CHIA-HUNG , LI SHIOU-TING
IPC分类号： C07H15/04 , A61K31/70 , C07H1/00 , C07H15/18
CPC分类号： A61K39/095 , A61K31/715 , A61K39/385 , A61K39/39 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , A61K2039/55577 , A61K2039/6037 , A61K2039/627 , C07H1/00 , C07H15/04 , C07H15/18 , C08B37/006
摘要： Described herein are synthetic glycan conjugates comprising a carrier and a glycan moiety derived from Neisseria meningitidis, wherein the glycan moiety is covalently linked to the carrier through a linker. Also provided herein are a mixture of the glycan conjugates thereof, immunogenic compositions thereof, and kits thereof. The invention further provides methods of using the synthetic glycan conjugates and immunogenic compositions thereof to treat and/or reduce the risk of infectious diseases such as bacterial infections.
摘要翻译：本文描述的是包含载体和衍生自脑膜炎奈瑟氏球菌的聚糖部分的合成聚糖缀合物，其中聚糖部分通过连接体与载体共价连接。本文还提供其聚糖缀合物，其免疫原性组合物及其试剂盒的混合物。本发明还提供了使用合成聚糖缀合物及其免疫原性组合物治疗和/或降低感染性疾病如细菌感染的风险的方法。

9. 发明专利

IL286492D0 Sialidase-resistant saccharide and method of making and using the same 未知
公开(公告)号：IL286492D0
公开(公告)日：2021-12-01
申请号：IL28649221
申请日：2021-09-19
申请人： ACADEMIA SINICA , WONG CHI HUEY , LO HONG JAY
发明人： WONG CHI-HUEY , LO HONG-JAY
IPC分类号： A61P35/00 , C07H15/18 , C07K16/28 , C07K16/32
摘要： Disclosed are a method of preparing a saccharide that contains a 3-fluoro-sialic acid and a method of bonding it to a homogeneous antibody. Also within the scope of this invention are compounds each containing a 3-fluoro-sialic acid, monoclonal antibodies bonded to α2,6-linked 3-fluoro-sialoside terminated N-glycans, and treatment of cancer with such monoclonal antibodies.

10. 发明专利

AU2017231749A1 Methods for modular synthesis of N-glycans and arrays thereof 未知
公开(公告)号：AU2017231749A1
公开(公告)日：2018-09-20
申请号：AU2017231749
申请日：2017-03-08
申请人： WONG CHI HUEY , ACADEMIA SINICA
发明人： WONG CHI-HUEY , WU CHUNG-YI , SHIVATARE SACHIN S
IPC分类号： C08B37/00 , C12P19/04 , G01N33/50 , G01N33/532 , G01N33/68
摘要： The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycansand glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.

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